Clinical trials: Cancer, Gastrointestinal
Colon Cancer
Study to Assess the Tolerability, Safety and Efficacy of an Adapted Gut Cleansing Solution in Routine Colon Cleansing Prior to Colonoscopies
It is particularly important that thorough gut cleansing is achieved prior to the colonoscopy for the procedure to be successful.
- Trial name
- NCT01251237
- Testing
- NRL0706
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Norgine
Metastatic Pancreatic Ductal Adenocarcinoma
Study Evaluating the Ketogenic Diet in Patients With Metastatic Pancreatic Cancer
This study will evaluate the effects of the ketogenic diet in patients with metastatic pancreatic cancer while receiving chemotherapy.
- Trial name
- NCT04631445
- Testing
- Ketogenic Diet
- Where
- 6 sites in United States
- Volunteers
- 32 people
- Sponsor
- Translational Drug Development
Colorectal Polyp, Colorectal Neoplasms
Real-time AI-assisted Endocyroscopy for the Diagnosis of Colorectal Lesions
Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related death worldwide. Colonoscopy is considered the preferred method of screening for colorectal cancer, and early and…
- Trial name
- NCT06791395
- Testing
- Computer-aided diagnosis (CADx) support tool
- Where
- 3 sites in China
- Volunteers
- 570 people
- Sponsor
- The First Hospital of Jilin University
Pancreatic Insufficiency, Pancreatic Cancer
PERT for Treatment of Exocrine Pancreatic Insufficiency in Patients With Unresectable Pancreatic Cancer
Does pancreas enzyme replacement (PERT) decrease weight loss and improve quality of life in patients with unresectable pancreatic cancer?
- Conditions
- Pancreatic Insufficiency, Pancreatic Cancer, Pancreatic Enzyme Abnormality
- Trial name
- NCT02985801
- Testing
- Pancrelipase
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Massimo Raimondo, M.D.
Rectal Cancer
Ultrasound Elastography in Patients With Rectal Cancer
The aim of this study is to recruit 50 rectal cancer patients planned to receive standard radiochemotherapy. A baseline ultrasonic elastography is performed prior to radiochemotherapy and followed by re-scans two and six weeks…
- Trial name
- NCT01379612
- Testing
- Ultrasonic Elastography
- Where
- 2 sites in Denmark
- Volunteers
- 31 people
- Sponsor
- Vejle Hospital
Colorectal Cancer
Neo-adjuvant Chemoradiation With Oxaliplatin/5-FU in Rectal Cancer
RATIONALE: 5FU based neoadjuvant chemoradiation (nCRT) is the standard of care for Stage II/III rectal cancer. Pathologic complete response (pCR) and downstaging have been associated with improved outcomes.
- Trial name
- NCT00831181
- Testing
- 5-FU, Oxaliplatin, leucovorin
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Beth Israel Medical Center
Colon Cancer, Chemotherapy
PK/PD Investigation of Calciumfolinat in Blood, Tumor and Adjacent Mucosa in Patient With Colon Cancer
This is an open randomized single site Pharmacokinetic and Pharmacodynamic study,of Calciumfolinat 60 mg/m², 200 mg/m² or 500 mg/ m² in blood, tumor and adjacent mucosa from patients with colon cancer
- Trial name
- NCT02959541
- Testing
- Leucovorin
- Where
- Sweden
- Volunteers
- 48 people
- Sponsor
- Vastra Gotaland Region
Colorectal Cancer
Probiotic Supplementation During Neoadjuvant Chemoradiotherapy in Colorectal Cancer
This prospective randomized, double-blind, placebo-controlled study evaluated the effects of multistrain probiotic supplementation in patients with stage II-III colorectal cancer undergoing neoadjuvant chemoradiotherapy.
- Trial name
- NCT07863154
- Testing
- Multistrain Probiotic Formulation
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- University of Malaga
Pancreatic Cancer
Gemcitabine, Capecitabine, and Erlotinib in Treating Patients With Advanced Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy, such as gemcitabine and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00885066
- Testing
- capecitabine, erlotinib hydrochloride, gemcitabine hydrochloride
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Antoine Lacassagne
Colorectal Cancer, Colorectal Adenoma
Adenoma Detection Rate in Artificial Intelligence-assisted Colonoscopy
The goal of this quasi randomized multicenter controlled clinical trial (RCT) is to investigate whether a combined real time computer-aided polyp detection (CADe) and computer-aided polyp characterization (CADx) system (GI…
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Neoplasms
- Trial name
- NCT05740137
- Testing
- AI-assisted colonoscopy
- Where
- 4 sites in Denmark
- Volunteers
- 795 people, healthy volunteers welcome
- Sponsor
- Ismail Gögenur
Gastrointestinal Stromal Tumor
Imatinib Mesylate With or Without Surgery in Treating Patients With Metastatic Gastrointestinal Stromal Tumor That is Responding to Imatinib Mesylate
RATIONALE: Surgery may remove residual disease in patients with gastrointestinal stromal tumor that is responding to imatinib mesylate.
- Trial name
- NCT00956072
- Testing
- imatinib mesylate, therapeutic conventional surgery
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Colorectal Carcinoma, Cancer
Primary Colorectal Signet Ring Cell Carcinoma and the Risk of Multiple Primary Gastrointestinal Malignancies
This original research investigates the critical issue of gastrointestinal (GI) second primary malignancies (SPMs) in patients with signet ring cell carcinoma (SRCC), a rare and aggressive subtype of colorectal cancer.
- Conditions
- Colorectal Carcinoma, Cancer, Signet Ring Adenocarcinoma of the Colon
- Trial name
- NCT06978595
- Where
- Egypt
- Volunteers
- 8,171 people
- Sponsor
- asmaa salama ibrahim
Hepatocellular Carcinoma
Cemiplimab +/- Fianlimab Post Y90 Radioembolization in Patients With Hepatocellular Carcinoma
Randomized, 2-arm, non-comparative, pilot study assessing the efficacy of cemiplimab with or without fianlimab after treatment with yttrium-90 (Y90).
- Trial name
- CLeAR (NCT07365839)
- Testing
- Arm 1 cemiplimab, Arm 2 cemiplimab and fianlimab
- Sponsor
- Virginia Commonwealth University
Colorectal Cancer Prevention, Colorectal Cancer (Diagnosis)
Study Comparing the Quality of Colon Cleanliness With Prepackaged LRD (Low-residue Diet) vs. Guided (POG).
Low-residue diet (LRD) in patient improves the quality of the colon cleanliness and thus the adenoma detection rate (ADR). This is a key criterion in colonoscopy screening for colorectal cancer (CRC).
- Conditions
- Colorectal Cancer Prevention, Colorectal Cancer (Diagnosis), Colorectal Adenocarcinoma
- Trial name
- POG (NCT07361575)
- Testing
- Colonoscopy, Questionnaires, Pre-colonoscopy diet according to the investigator's oral instructions
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Clinique Paris-Bercy
Nutritional Deficiency, Gastrointestinal Cancer
Effect of Silkworm Pupa Tablets in Gastrointestinal Malignancies at Nutritional Risk Following Radical Surgery
This is a randomized, double-blind, very low dose parallel-controlled, prospective, multi-center trial evaluating the improvement of nutritional status and frailty with silkworm pupa tablets after radical resection of…
- Conditions
- Nutritional Deficiency, Gastrointestinal Cancer, Frailty Syndrome
- Trial name
- NCT06551675
- Testing
- Silkworm pupa tablets, Control product
- Where
- 4 sites in China
- Volunteers
- 120 people
- Sponsor
- Xiaosun Liu, MD
Hepatocellular Carcinoma
A RCT of Oral S-1 in Combination With Sequential HAIC of Oxaliplatin After TACE in Patients With Advanced HCC
Hepatocellular carcinoma (HCC) is one of the most commonly malignant tumors around the world and causes death of about 600000~1000000 people each year.
- Trial name
- SOON (NCT01997957)
- Testing
- S-1
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Zhu Xu
Hepatocellular Cancer
A Randomized Phase II Trial of Surgery Plus Sorafenib vs. Sorafenib Alone for Hepatocellular Cancer (HCC) With Portal Vein Invasion
Patients with HCC with portal vein involvement not involving the bifurcation (vP1-vP3) and no evidence of extra-hepatic spread will be enrolled.
- Trial name
- NCT03971201
- Testing
- hepatic resection, Sorafenib
- Where
- China
- Volunteers
- 200 people
- Sponsor
- White Plains Hospital
Colorectal Cancer
An Observational Study on Bevacizumab (Avastin) as First-Line Treatment in Colorectal Cancer Participants With Potentially Resectable Liver Metastases
This observational study will evaluate the efficacy and safety of bevacizumab as first-line treatment in participants with colorectal cancer and potentially resectable liver metastases.
- Trial name
- PICASSO (NCT01343901)
- Testing
- Bevacizumab
- Where
- 126 sites in France
- Volunteers
- 210 people
- Sponsor
- Hoffmann-La Roche
Barrett's Esophagus
The Captivator EMR Registry
To confirm performance of the Captivator™ EMR device for resection of early neoplasia in Barrett's Esophagus.
- Trial name
- NCT02482701
- Testing
- Captivator™ EMR
- Where
- 13 sites in United States, Belgium and 4 more
- Volunteers
- 291 people
- Sponsor
- Boston Scientific Corporation
Colorectal Neoplasms
A Study of Cetuximab in Patients Who Have Stage IV Colorectal Cancer
The purpose of this clinical research study is to learn about the safety of cetuximab in patients with stage IV colorectal cancer, and who may benefit from cetuximab.
- Trial name
- NCT00055419
- Testing
- Cetuximab
- Where
- 29 sites in United States
- Volunteers
- 744 people
- Sponsor
- Eli Lilly and Company
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