Clinical trials: Cancer, Ovarian
Polycystic Ovarian Syndrome
The Effects of Letrozole And Clomiphene Citrate For Induction of Ovulation In Polycystic Ovarian Syndrome(PCOS)
As both medications i.e. CC and letrozole have been shown to be effective in inducing ovulation in PCOS patients, this study was performed in order to evaluate which regime (whether CC or letrozole) is the best to be used as the…
- Trial name
- NCT01577017
- Testing
- Letrozole
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Nik Hazlina
Adnexal Mass, Adnexal Tumor
Masses in Young Patients - International Ovarian Tumour Analysis (MY-IOTA)
This multicenter observational study aims to validate the IOTA Simple Rules, Benign Descriptors, and ADNEX model in a cohort of patients equal or under the age of 20.
- Conditions
- Adnexal Mass, Adnexal Tumor, Adnexal Cyst, Adnexal Masses in Young Girls and Adolescents
- Trial name
- MY-IOTA (NCT06693596)
- Testing
- Group 2: Conservative management (follow-up), Group 1: Surgical management
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lung Cancer, Breast Cancer
Plasma Metabolic Biomarkers for Multi-Cancer Diagnosis
The aim of this observational study is to comprehensively analyze the metabolites in plasma samples from multi-cancer patients using advanced mass spectrometry detection technology, in conjunction with metabolomics approaches.
- Conditions
- Lung Cancer, Breast Cancer, Colorectal Cancer, Thyroid Cancer
- Trial name
- NCT06363123
- Where
- 4 sites in China
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Polycystic Ovary Syndrome
A Multi-omic Approach to Evaluate and Characterize the Polycystic Ovary Syndrome (PCOS) Phenotype
The purpose of this research study is to explore the relationship between the gut microbiome and hormone levels in women diagnosed with PCOS and determine whether there are differences in the gut microbiome between women with…
- Trial name
- NCT04981275
- Testing
- No intervention study
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Onegevity Health
Polycystic Ovary Syndrome
Clinical and Biochemical Presentation of Polycystic Ovary Syndrome in Different Age Group
To study the clinical and biochemical characteristics women with polycystic ovary syndrome (PCOS) in different aged groups.
- Trial name
- NCT01350895
- Where
- Taiwan
- Volunteers
- 781 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Ovarian Cancer, Caregiver Burden
Multidimensional Burden of Platinum Resistant Ovarian Cancer (PROC) on Patients and Caregivers in Canada
Filling the gap in Canadian evidence on the burden of PROC on QoL is essential. It will help better understand the impact of PROC on multiple aspects of the lives of patients and their caregivers and the real-life hurdles faced…
- Conditions
- Ovarian Cancer, Caregiver Burden, Patient Burden
- Trial name
- NCT07035067
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- PeriPharm
Polycystic Ovarian Disease
The Influence of Polycystic Ovairan Syndrome on Embryonic Developmental Timing
Polycystic ovary syndrome is one of the most common causes of female infertility. The cause of infertility in PCOS is unknown. Factors other than anovulation, including inherited or induced changes in the embryo quality have been…
- Trial name
- PCOS (NCT01953146)
- Where
- Denmark
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Polycystic Ovary Syndrome
Effect of Increased Circulating Androgens on Granulosa Cell Responses to FSH.
The purpose of this study is to evaluate the effect of increased circulating androgens on estradiol production by the granulosa cells in response to FSH stimulus.
- Trial name
- NCT02389088
- Testing
- Letrozole
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Polycystic Ovary Syndrome
The Role of Autoimmunity and Obesity in Polycystic Ovary Syndrome
The goal of the study is to detect autoantibodies in the serum of the women with PCOS and evaluate the obesity markers to investigate the the role of autoimmunity and obesity in PCOS
- Trial name
- NCT05929950
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sohag University
Polycystic Ovary Syndrome
Effects of Metformin vs Oral Contraceptives on CV Risk Markers in PCOS
Cardiovascular risk factors cluster in hyperandrogenic women - including those presenting with the polycystic ovary syndrome - in association with insulin resistance, obesity, and other metabolic disorders.
- Trial name
- NCT00428311
- Testing
- Metformin, Ethynyl-estradiol plus cyproterone acetate
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Ramon y Cajal
PCOS
A Metabolomic Study of Polycystic Ovary Syndrome With Insulin Resistance and Its Relationship With TCM Syndrome Types
The type-2 diabetes mellitus（T2DM）, metabolic syndrome, cardiovascular disease complications induced by polycystic ovary syndrome(PCOS) with insulin resistance(IR）, which become serious threat to public health.
- Trial name
- NCT02992093
- Testing
- all the indicators
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fujian Maternity and Child Health Hospital
Malignancies, Stomach Cancer
The Use of 18F-ALF-NOTA-PRGD2 PET/CT Scan to Predict the Efficacy and Adverse Events of Apatinib in Malignancies.
This is an open-label, single arm study to explore whether 18F-ALF-NOTA-PRGD2 PET/CT scan can predict the efficacy and adverse events of apatinib in patients with malignancies.
- Conditions
- Malignancies, Stomach Cancer, Non-small Cell Lung Cancer, Esophageal Cancer
- Trial name
- NCT03384511
- Testing
- Apatinib
- Where
- China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Shandong Cancer Hospital and Institute
Polycystic Ovary Syndrome, Obesity
Insulin and the Polycystic Ovary Syndrome--Weight Reduction Study
The polycystic ovary syndrome is the leading cause of female infertility in the United States. The disorder affects approximately 6-10% of women of reproductive age.
- Trial name
- NCT00436865
- Testing
- Weight loss
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Ovarian Cancer
Ovarian Screening Study
The objectives of this study are: To identify women at increased risk for developing ovarian cancer To detect ovarian cancers at an early stage To investigate the role of tumor membrane fragments as tumor markers for early…
- Trial name
- NCT00267072
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Epithelial Ovarian Cancer
Plasma ctDNA Detection in Diagnosis of Epithelial Ovarian Cancer.
Epithelial ovarian cancer constitutes one of the most common gynecological malignancies.Because the ovaries lie in the deep pelvic cavity,most ovarian cancer patients are asymptomatic, rendering the majority often diagnosed at an…
- Trial name
- ctDNA_EOC (NCT03155451)
- Testing
- methylation markers screening
- Where
- China
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Polycystic Ovarian Syndrome (PCOS), Insulin Resistance
Potential Impact of Polycystic Ovarian Syndrome on Protein Modifications and Accumulation
A goal of this study is to use a novel methodology to determine whether insulin resistance in women with polycystic ovary syndrome (PCOS) is related to the accumulation of proteins with modifications.
- Conditions
- Polycystic Ovarian Syndrome (PCOS), Insulin Resistance, Overweight, Obese
- Trial name
- NCT02105428
- Testing
- Aerobic Exercise Training
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Ovarian Cyst
Assessment of Ovarian Cysts Using Machine Learning
The study aims at creating a prediction model using machine learning algorithms that is capable of predicting malignant potential of ovarian cysts/masses based on patient characteristics, sonographic findings, and biochemical…
- Trial name
- OCID (NCT05342298)
- Testing
- prediction model
- Where
- 2 sites in Egypt
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Assiut University
Puberty, Hyperandrogenism
Acute Progesterone Suppression of Wake vs. Sleep Luteinizing Hormone Pulse Frequency in Pubertal Girls With and Without Hyperandrogenism
The purpose of this study is two-fold. (1) We will determine if in mid- to late pubertal girls without hyperandrogenism (HA), progesterone (P4) acutely reduces waking luteinizing hormone (LH) frequency to a greater extent than…
- Trial name
- CRM003 (NCT00929006)
- Testing
- Micronized progesterone suspension
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome
Effect Of Cryolipolysis On Visceral Adiposity Index In Polycystic Ovarian Syndrome Patients
this study will be carried to investigate the effect of cryolipolysis on visceral adiposity index in pco women randomized controlled trial
- Trial name
- NCT04745338
- Testing
- 3max cool shaping device, low calolric diet
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Coronary Heart Disease, Stroke
Evaluating Tools for Health Promotion and Disease Prevention
The study will evaluate the effect of familial risk assessment and prevention prompts tailored to familial risk on health behaviors and use of preventive services among adults who are members of primary care practices in the U.S.
- Conditions
- Coronary Heart Disease, Stroke, Diabetes, Breast Cancer
- Trial name
- NCT00164658
- Testing
- Familial risk assessment and personalized prevention messages
- Where
- 3 sites in United States
- Volunteers
- 8,400 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention