Clinical trials: Cancer, Therapy-Related
Neuropathic
Pulsed Electromagnetic Field Therapy to a Tailored Exercise Program for Patients Suffering From Chemotherapy-induced Neuropathy Related to Breast Cancer
This research studied the usefulness of a targeted intervention designed to manage chemotherapy-induced symptoms, particularly focusing on pain relief, balance deviations and functional improvements.
- Trial name
- PEMFTEPCHIN (NCT06947577)
- Testing
- pulsed electromagnetic field (PEMF) therapy and a tailored exercise program (TEP), Tailored Exercise Program
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Breast Cancer, HER2-positive Breast Cancer
Investigating the Long-term Cardiac Sequelae of Trastuzumab Therapy
The introduction of trastuzumab for the treatment of patients with human epidermal growth factor receptor 2 (HER2) positive breast cancer has had a major impact upon cancer outcomes.
- Conditions
- Breast Cancer, HER2-positive Breast Cancer, Cardiotoxicity
- Trial name
- NCT05019365
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Prostatic Neoplasms, Exercise
Health Effects of Soccer Training in Men With Prostate Cancer Receiving Androgen Deprivation Therapy
Androgen Deprivation Therapy (ADT) is standard treatment for locally advanced or advanced Prostate Cancer (PC). The musculoskeletal toxicity associated with ADT is well established, leading to a decrease in muscle mass, increased…
- Conditions
- Prostatic Neoplasms, Exercise, Soccer Training, Androgen Deprivation Therapy
- Trial name
- NCT01711892
- Testing
- Soccer training
- Where
- Denmark
- Volunteers
- 57 people
- Sponsor
- University of Copenhagen
All Tumor Entities Treated With TKI Therapy
Reduction of Cancer Related Fatigue in Patients During TKI Therapy
The purpose of this pilot study is to determine the effects of a 12-week resistance training program on cancer related fatigue in cancer patients receiving tyrosine kinase inhibitor (TKI) therapy.
- Trial name
- RECAP (NCT01645150)
- Testing
- Progressive strength training
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- German Cancer Research Center
Predicting Chemotherapy Related Toxicity in Elderly Patients
G8, VES-13 and CARG Scores in Predicting Chemotherapy Toxicity in Geriatric Cancer Patients
All participants' medical information will be collected for use as a baseline, including tumor-specific variables, nutritional status, functional status, psychological status, cognitive function, social support, and…
- Trial name
- NCT04992455
- Testing
- Older Patients Receiving Chemotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Namik Kemal University
Colorectal Cancer, Fatigue
UNTIRE: Cancer-related Fatigue With Digital Treatment
This research is being done to find out if using a smartphone app as digital treatment to reduce Cancer Related Fatigue is feasible and easy to use.
- Trial name
- NCT05584540
- Testing
- UNTIRE App
- Where
- United States
- Sponsor
- Dana-Farber Cancer Institute
Non-Hodgkin Lymphoma, Hodgkin Lymphoma
Nelfinavir for the Treatment of Gammaherpesvirus-Related Tumors
The goals of this study is to determine if nelfinavir can target Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) in patients with certain cancers.
- Conditions
- Non-Hodgkin Lymphoma, Hodgkin Lymphoma, Kaposi Sarcoma, Gastric Cancer
- Trial name
- NCT02080416
- Testing
- Nelfinavir
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Acute Myeloid Leukemia (AML), Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
Vosaroxin and Infusional Cytarabine in Treating Patients With Untreated Acute Myeloid Leukemia
This phase II trial studies how well vosaroxin and cytarabine work in treating patients with untreated acute myeloid leukemia. Drugs used in chemotherapy, such as vosaroxin and cytarabine, work in different ways to stop the…
- Conditions
- Acute Myeloid Leukemia (AML), Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, Acute Myeloid Leukemia With Multilineage Dysplasia, Myeloid Sarcoma
- Trial name
- VITAL (NCT02658487)
- Testing
- Cytarabine, Vosaroxin
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Breast Cancer
Health-Related Quality of Life Coupled With Therapeutic Information on Compliance to Endocrine Therapy in Breast Cancer
Only 59% of women with breast cancer (BC) treated with Endocrine Therapy (ET) remain compliant one year upon initial prescription, despite its proven effectiveness in reducing recurrence and improving survival.
- Trial name
- COMPLIANCE (NCT04176809)
- Testing
- Routine Assessment of HRQoL coupled with Therapeutic Information
- Where
- France
- Volunteers
- 342 people
- Sponsor
- Centre Georges Francois Leclerc
AIDS-related Diffuse Large Cell Lymphoma, AIDS-related Diffuse Mixed Cell Lymphoma
Topotecan Hydrochloride in Treating Children With Meningeal Cancer That Has Not Responded to Previous Treatment
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. This phase II trial is studying how well topotecan hydrochloride works in treating children with meningeal cancer that…
- Conditions
- AIDS-related Diffuse Large Cell Lymphoma, AIDS-related Diffuse Mixed Cell Lymphoma, AIDS-related Diffuse Small Cleaved Cell Lymphoma, AIDS-related Immunoblastic Large Cell Lymphoma
- Trial name
- NCT00005811
- Testing
- topotecan hydrochloride, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer Lymphedema
Kinesio Taping Versus Compression Garments for Breast Cancer-Related Lymphedema
Breast cancer-related lymphedema (BCRL) tends to become chronic and progressive. Current therapies have modest results for this condition.
- Trial name
- NCT03051776
- Testing
- Kinesio Taping, Compression Garment
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Violeta Pajero Otero
Substance Use Disorder, Opioid Use Disorder, Moderate
EXHIT ENTRE Comparative Effectiveness Trial
This study is a multi-site open-label randomized comparative effectiveness trial of a 28-day formulation of extended-release buprenorphine (XR-BUP) versus treatment as usual (TAU) for hospitalized patients with a moderate or…
- Conditions
- Substance Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
- Trial name
- EXHITENTRE (NCT04345718)
- Testing
- Extended Release Buprenorphine, Treatment as Usual
- Where
- 6 sites in United States
- Volunteers
- 344 people
- Sponsor
- Gavin Bart
Perimenopause, Perimenopause-Related Depression
Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY)
This observational study examines the safety and effects of injecting Muse cells (a type of naturally occurring stem like cells found in adult tissues such as fat or bone marrow) directly into the ovaries of women aged 28 to 70…
- Conditions
- Perimenopause, Perimenopause-Related Depression, Premature Ovarian Insufficiency, Premature Ovarian Failure (POF)
- Trial name
- MUSE-OVARY (NCT07511660)
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- Healing Hope International
Pain Related to Cancer
Evaluation of the Efficacy and Safety of Two Methadone Titration Methods for the Treatment of Cancer-related Pain With Inadequate Pain Relief or Intolerable Side Effects When Treated With Level 3 Opioids.
This is a multicentric, randomized, open-label, phase IIIb national study, to evaluate the clinical effects (success/failure) of methadone for the treatment of cancer-related-pain in patients with inadequate pain relief or…
- Trial name
- EQUIMETH2 (NCT01793480)
- Testing
- Methadone
- Where
- 16 sites in France
- Volunteers
- 146 people
- Sponsor
- RECORDATI GROUP
Neuroendocrine Tumours (NET)
United Kingdom (UK) Patient Preference Study of Somatuline Autogel and Treatment Administration Setting
The aim of the study is to generate real-world evidence to describe the patient experience of administration of Somatuline® Autogel® (lanreotide) in homecare and hospital settings, and the associated impact on healthcare…
- Trial name
- PREF-NET (NCT04649580)
- Where
- 5 sites in United Kingdom
- Volunteers
- 80 people
- Sponsor
- Ipsen
Breast Cancer Lymphedema, Secondary Lymphedema
Lymphaticovenous Anastomosis as Treatment for Lymphedema
The primary aim of this study is to investigate and test whether the use of combined indocyanine green (ICG) lymphography and ultra high frequency ultrasonography can correctly identify lymphatic vessels and venoles in close…
- Conditions
- Breast Cancer Lymphedema, Secondary Lymphedema, Iatrogenic Lymphedema, Lymphedema
- Trial name
- NCT05441943
- Testing
- Lymphovenous anastomosis
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Odense University Hospital
Breast Carcinoma, Cancer Survivor
Supportive Care Questionnaires in Gathering Data on Unmet Needs and Health-Related Quality of Life in Latina Breast Cancer Survivors After Surgery, Chemotherapy, or Radiation Therapy
This phase I/II research trial studies supportive care questionnaires in gathering data on unmet needs and health-related quality of life in Latina breast cancer survivors after surgery, chemotherapy, or radiation therapy.
- Trial name
- NCT02545023
- Testing
- Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Southern California
Esophageal Cancer
Defining the Radiotherapy Dose and Volume Parameters Affecting Postoperative Complications in Esophageal Cancer Patients
The purpose of this study is to identify features of the cumulative dose-volume histogram (DVH) for patients treated with trimodality therapy in oesophageal cancer and correlate these with postoperative complications.
- Trial name
- NCT02323776
- Testing
- Trimodality protocol
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Maastricht Radiation Oncology
Breast Edema, Breast Cancer Related Lymphoedema
Effectiveness of Kinesio Taping in Patients With Chronic Breast and/or Truncal Oedema After Treatment for Breast Cancer.
The goal of the KiTaLymph trial is to investigate whether the application of kinesio tape is effective in women with persistent (>6 months) breast and/or truncal oedema after treatment for breast cancer.
- Conditions
- Breast Edema, Breast Cancer Related Lymphoedema, Breast Cancer Related Lymphedema, Truncal Lymphedema
- Trial name
- KiTaLymph (NCT07080476)
- Testing
- Decongestive lymphatic therapy, Kinesio tape, Compression bra (sub-study)
- Where
- 4 sites in Belgium
- Volunteers
- 128 people
- Sponsor
- Universiteit Antwerpen
Advanced Malignant Solid Tumor
Cannabis extrAct in Oncology Patients for the Treatment of TUmor Related Symptom Burden
CAPTURE is a prospective, interventional, randomized, phase 2, double-blind, placebo-controlled study assessing the therapeutic add-on effect of the balanced THC/CBD extract (Cannabis extract Avextra 10/10 oral solution) on…
- Trial name
- CAPTURE (NCT07459920)
- Testing
- Cannabis Extract Oil
- Where
- Italy
- Volunteers
- 156 people
- Sponsor
- National Cancer Institute, Naples
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