Clinical trials: Cancer
Prostate Carcinoma
Building Community Living Labs in Black Communities to Advance Prostate Health Equity and Reduce Prostate Cancer Disparities in Black Men
This clinical trial the possibility of establishing a Community Living Labs (CoLLab) Learning Health System to facilitate access to prostate health Risk, Education, and Assessment in the Community with Help (REACH) services in…
- Trial name
- CoLLab (NCT06541210)
- Testing
- Community Health Service, Questionnaire Administration
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Mechanical Ventilation Complication, Pediatric ALL
Measuring Thickness of the Normal Diaphragm in Children Via Ultrasound.
Critically ill children treated with invasive mechanical ventilation (iMV) in a paediatric intensive care unit (PICU) may suffer from complications leading to prolonged duration of ventilation and PICU stay.
- Conditions
- Mechanical Ventilation Complication, Pediatric ALL, Intensive Care Unit Acquired Weakness
- Trial name
- NCT04589910
- Testing
- diaphragm thickness and thickening fraction
- Where
- Netherlands
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Quality of Life
Integrative Care and Acupuncture in MOHS Surgery
MOHS method is an effective surgical technique to remove skin cancerous tumors in the head-neck area. Patients undergoing MOHS surgery are struggled with emotional stress during the day of surgery, due to fear of significant…
- Trial name
- NCT03569982
- Testing
- Integrative medicine care
- Where
- Israel
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Obesity, Hyperandrogenemia
Etiological Factors of Obesity-Associated Hyperandrogenemia in Peripubertal Girls
The purpose of this study is to learn if obese pre- and early pubertal girls with hyperandrogenemia (HA) are more insulin resistant (i.e., have lower insulin-stimulated glucose disposal) compared to obese peripubertal girls…
- Conditions
- Obesity, Hyperandrogenemia, Polycystic Ovary Syndrome
- Trial name
- CRM002 (NCT00928759)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
B Acute Lymphoblastic Leukemia With t(v;11q23.3); KMT2A Rearranged, Recurrent B Acute Lymphoblastic Leukemia
CD19-Specific T Cells Post AlloSCT
This phase I trial investigates the side effects and best dose of CD19 positive (+) specific CAR-T cells in treating patients with CD19+ lymphoid malignancies, such as acute lymphoblastic leukemia, non-Hodgkin lymphoma, small…
- Conditions
- B Acute Lymphoblastic Leukemia With t(v;11q23.3); KMT2A Rearranged, Recurrent B Acute Lymphoblastic Leukemia, Recurrent Chronic Lymphocytic Leukemia, Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
- Trial name
- NCT03579888
- Testing
- Autologous CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T Cells, Cyclophosphamide, Fludarabine
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Advanced Solid Tumor
Effect of Omeprazole on PK of Fluzoparib in Healthy Male Subjects
The purpose of this study is to evaluate the Effect of Omeprazole on the Pharmacokinetics of Fluzoparib in Healthy male Adults.
- Trial name
- NCT04108676
- Testing
- Fluzoparib, Omeprazole
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Frailty, Oncology
Approaches and Metrics in Fraily Patients During COVID-19 Era
The COVID-19 pandemic started in December 2019 in Wuhan, the Chinese province of Hubei. Compared to the period of the first epidemic wave (March to May 2020), in the period of the second epidemic wave (October 2020 to July 2021)…
- Conditions
- Frailty, Oncology, Immune Deficiency
- Trial name
- COMETA (NCT05792891)
- Testing
- Collecting biological material from frail patients, with or without COVID-19
- Where
- 2 sites in Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Regina Elena Cancer Institute
Human Papillomavirus-Related Cervical Carcinoma
Self-Collection for Cervical Cancer Screening and HPV Vaccination for Cancer Prevention Among Women in Emergency Care in Northeast Florida
Human Papilloma Virus (HPV) is a cause of cervical cancer in women. This study is being done to identify sites for cervical cancer screening and education regarding HPV vaccination outside of the traditional settings of primary…
- Trial name
- NCT06607874
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Colorectal (Colon or Rectal) Cancer, Leak, Anastomotic
Predictive Model For Anastomotic Leakage After Colorectal Cancer Surgery
This pilot study aimed to develop a simplified early postoperative model for AL risk stratification using readily available clinical and laboratory variables.
- Conditions
- Colorectal (Colon or Rectal) Cancer, Leak, Anastomotic, Surgery Complications
- Trial name
- Doesn't exist (NCT07709923)
- Where
- Italy
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Foggia
Esophageal Squamous Cell Carcinoma, Esophagectomy
Surgery Versus Non-surgical Treatment for Esophageal Squamous Cell Carcinoma in Patients Older Than 70 Years
To determine whether older patients who underwent esophagectomy had better outcome survival than those who were non-surgically treated.
- Conditions
- Esophageal Squamous Cell Carcinoma, Esophagectomy, Radiotherapy, Chemotherapy
- Trial name
- NCT05604950
- Testing
- Since the data were collected retrospectively, there were no interventions
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Yongtao Han
Tumor
A Drug-drug Interaction Study of Famitinib Malate With a Proton Pump Inhibitor in Healthy Adult Subjects
The primary objective is to evaluate the effect of omeprazole on the pharmacokinetics of famitinib malate in healthy adult subjects.
- Trial name
- NCT05041920
- Testing
- famitinib、omeprazole
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
CNS Germinoma, CNS Tumor
Development of Asian Consortium for Data Collection and Clinical Trial of CNS Tumors
<Purpose of the Research> Primary Establishing an Asian consortium to establish a database of pediatric CNS tumors in the prospective manner The target disease of this research focuses on pediatric tumors, and initially the…
- Conditions
- CNS Germinoma, CNS Tumor, Asian Consortium
- Trial name
- NCT05982691
- Testing
- Radiation Therapy
- Where
- South Korea
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Prostate Cancer
APACA-Apheresis/acoustophoresis and Molecular Characterization of Prostate Cancer
The goal of this clinical study is to to improve diagnosis, follow-up and treatment for patients with disseminated prostate cancer. The aim is to isolate tumour cells before image diagnostic methods find the metastases.
- Trial name
- NCT06709326
- Testing
- Apheresis, Androgen deprivation therapy, Anti androgen therapy
- Where
- Sweden
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Umeå University
Breast Cancer
INVINCIBLE TRIAL: Intratumoral INT230-6 in Breast Cancer
This is a phase II, randomized, multi-center, parallel design, window of opportunity trial evaluating intratumoral INT230-6 in up to 90 patients with early stage breast cancer.
- Trial name
- NCT04781725
- Testing
- INT230-6, Saline injection
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Breast Cancer, Aromatase Inhibitors
Combined Training on Body Composition of Postmenopausal Women Undergoing Treatment for Breast Cancer
Breast cancer is a multifactorial disease affecting women, and one of the treatments for its healing and survival is hormone therapy.
- Conditions
- Breast Cancer, Aromatase Inhibitors, Postmenopausal
- Trial name
- NCT02804308
- Testing
- Combined Training
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Barrett's Esophagus, Eosinophilic Esophagitis
Study to Image the Esophagus Using the OFDI Capsule
The main purpose of this research is to test the feasibility and tolerability of the tethered capsule Optical Frequency Domain Imaging (OFDI)
- Trial name
- NCT02204150
- Testing
- OFDI Capsule
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Colorectal Cancer, High Cholesterol
Online Trial Examining Validity of the Shared Decision Making Process Survey With Video Vignettes
This study will recruit subjects online and randomly assigned them to one of four arms. The arms vary by clinical decision (colorectal cancer screening or treatment of high cholesterol) by video order (poor shared decision making…
- Trial name
- NCT04317274
- Testing
- Good high cholesterol video, Poor high cholesterol video, Good colon cancer screening video
- Where
- United States
- Volunteers
- 401 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pilonidal Sinus
Combined Open and Closed Approach for Management of Pilonidal Sinus by Special U-shaped Sutures Without Drain.
Introduction: Pilonidal sinus disease (PSD) is a common surgical disease frequently seen in the intergluteal cleft. The treatment of this problem is mainly surgical.
- Trial name
- NCT04017260
- Testing
- open and closed approach, Rhomboid flap technique, Karydakis technique
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Neuroendocrine Tumors
177Lu-DOTA-EB-TATE in Patients With Advanced Neuroendocrine Tumors
This is an open-label, non-controlled, non-randomized study to investigate the long-lasting radiolabeled somatostatin analogue based peptide receptor radionuclide therapy and evaluation safety and dosimetry of 177Lu-DOTA-EB-TATE…
- Trial name
- NCT03308682
- Testing
- 177Lu-DOTA-EB-TATE
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Cancer, Breast Cancer
An EORTC Study Updating the QLQ-BR23 to BR45
Female breast cancer is still the most frequent type of cancer in Europe with 21 per 100,000 women .The EORTC QLQ-BR23 was one of the first modules developed to be used in conjunction with the core questionnaire EORTC QLQ-C30 and…
- Trial name
- NCT04270123
- Testing
- EORTC QLQ-BR45 questionnaire
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Leeds
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