Clinical trials: Cancer
HPV-Related Carcinoma
Integrating Primary & Secondary Interventions for Cervical Cancer Prevention in Primary Care Settings
The purpose of this study is to determine whether a mobile health educational intervention for Human PapillomaVirus (HPV) Vaccination promotion and cervical cancer screening in Primary Care settings is a feasible behavioral…
- Trial name
- NCT03033550
- Testing
- brief negotiated mobile application
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Gastric Cancer, Gastric Intestinal Metaplasia
Surveillance of Patients With Precancerous Lesions of the Stomach
The project will aim to identify and determine subgroups of patients with different risks of progression to gastric cancer and to assess appropriate follow-up intervals.
- Conditions
- Gastric Cancer, Gastric Intestinal Metaplasia, Gastric Atrophy, Gastric Dysplasia
- Trial name
- NCT03250091
- Testing
- Upper endoscopy with biopsies, Plasma/serum sampling, Biopsies for gastric microbiota
- Where
- Latvia
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Polycystic Ovary Syndrome, Adolescent Behavior
Adolescent Polycystic Ovary Syndrome on a Low-carbohydrate Diet
The aim of the study was to investigate the changes in the clinical and biochemical parameters of adolescents on a low-carbohydrate diet in relation to their PCOS phenotype in the 3rd trimester.
- Conditions
- Polycystic Ovary Syndrome, Adolescent Behavior, Diet Habit
- Trial name
- PCOS (NCT06429618)
- Testing
- Low carbonhydrate diet
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital
Little Cigars and Cigarillos (LCC) Use
Little Cigar and Cigarillo Warnings for Youth
This study explores the effect of the little cigars and cigarillos (LCC) warnings on youth who currently use, have ever used, or are susceptible to using LCCs.
- Trial name
- NCT06413797
- Testing
- FDA warnings + Image, FDA Warnings Text-Only, Surgeon General Text-Only Warnings
- Where
- United States
- Volunteers
- 928 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Colorectal Cancer
A Study of the Possible Effects of Medication on Young Onset Colorectal Cancer (YOCRC)
This study will collect biospecimens (including blood, tissue, and stool samples) and health information to create a database-a type of collection of information-for better understanding young onset colorectal cancer (YOCRC).
- Trial name
- NCT05568420
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Ovarian Cancer
Ovarian Cancer Individualized Scoring System Scoring System
This project aims at creating an individualized prognostic model using patient characteristics and disease features to determine disease prognosis using machine learning technology.
- Trial name
- OCISS (NCT05496517)
- Where
- 2 sites in Egypt
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Assiut University
Thyroid Nodule, Thyroid Cancer
The Safety and Feasibility of Radiofrequency Ablation to Treat Low-risk Thyroid Cancer
The goal of this clinical trial is to test radiofrequency ablation (RFA) in thyroid cancers ≤2 cm in diameter. The main question it aims to answer is: What is the feasibility of RFA use for low-risk thyroid cancers (≤2 cm)?…
- Trial name
- NCT06929650
- Testing
- Radiofrequency ablation
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma
Genetic Analysis Using Blood or Bone Marrow From Participants With Neuroblastoma or Noncancerous Conditions
This laboratory study is looking at genes in participants with neuroblastoma or noncancerous conditions. Identifying genes related to cancer may help in the study of cancer.
- Conditions
- Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma, Recurrent Neuroblastoma, Regional Neuroblastoma
- Trial name
- NCT00436696
- Testing
- Laboratory Biomarker Analysis
- Where
- 2 sites in United States
- Volunteers
- 9,350 people, healthy volunteers welcome
- Sponsor
- Children's Oncology Group
Propofol, Glioma
Effects of Propofol on Auditory Event-related Potentials and Brain Functional Connectivity in Patients With Supratentorial Glioma
The growth of gliomas often infiltrates important brain tissues and impairs subcortical fiber transmission, resulting in changes in global brain network connectivity.
- Conditions
- Propofol, Glioma, Auditory Event-related Potential (AERP), Electroencephalogram (EEG)
- Trial name
- NCT05352685
- Testing
- Propofol Injection
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Colorectal Cancer
Educate, Assess Risk and Overcoming Barriers to Colorectal Screening Among African Americans
The burden of colorectal cancer (CRC) is unequal among various populations within the United States. This inequality is most notable among African Americans, who exhibit the highest CRC mortality of all US populations.
- Trial name
- NCT03640208
- Testing
- Education presented by trained caregiver
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Cancer
Cancer Prevention Among Individuals with Mental Ill-health: Patient Navigation for Primary Cancer Prevention
Prevention is essential for reducing cancer-related mortality. However, people with mental ill-health often face difficulties in accessing cancer prevention services.
- Trial name
- CO-CAPTAIN (NCT06435117)
- Testing
- Patient Navigation
- Where
- 9 sites in Austria, Greece and 2 more
- Volunteers
- 1,240 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Colorectal Cancer
RCT of Air Insufflation Versus Water Infusion Colonoscopy
Compared with the conventional (air) method, patients examined by the study (water) method have lower pain scores and require less medication but have similar cecal intubation rate and willingness to repeat future colonoscopy.
- Trial name
- NCT00785889
- Testing
- water infusion colonoscopy
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- East Bay Institute for Research and Education
Hepatitis C, Hepatocellular Carcinoma
STOP HCC: Mailed HCV Treatment Outreach Program for HCC Prevention for Elevated LFTs
The investigators will conduct a randomized controlled trial comparing two strategies to promote HCV screening, follow-up testing, and treatment among Parkland patients who are 18 years or older who have elevated liver…
- Trial name
- STOP-HCC (NCT04395118)
- Testing
- Mailed Outreach
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Thyroid Cancer
Outcome of RAI131 Therapy in Patients With Differentiated Thyroid Cancer (Low and Intermediate Risk)
Thyroid cancer is a universally relatively rare neoplasm, accounting for nearly 1-5% of all female cancers and less than 2% of male cancers.
- Trial name
- NCT07056218
- Testing
- neck ultrasound, thyroglobulin
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Endoscopic Mucosal Resection With Circumferential Incision
Endoscopic Mucosal Resection With Circumferential Incision for Colorectal Neoplasms
This is a prospective randomized trial to improve the results of treatment of patients with colorectal neoplasms.
- Trial name
- C-EMR (NCT05690490)
- Testing
- Endoscopic mucosal resection with circumferential incision, Endoscopic submucosal dissection
- Where
- Russia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Metastatic Breast Cancer
Study of ESR1 Mutations in Metastatic Breast Cancer
The purpose of the study is to determine the frequency ESR1 mutations by Digital PCR in patient with metastatic breast cancer.
- Trial name
- FMER (NCT02473120)
- Testing
- Determination of ESR1 mutations
- Where
- France
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Centre Henri Becquerel
Cervical Intraepithelial Neoplasia Grade 2/3, Adenocarcinoma in Situ
Effectiveness of Cervical Screening in Unvaccinated, Herd Effect Protected Women (HPV400)
To identify: 1) Whether being informed infrequently results about screening is at least as a) safe and b) accurate as frequently obtaining all information from (the present combination of opportunistic/organized) cervical…
- Trial name
- HPV400 (NCT04755517)
- Testing
- Frequent information of cytological/ HPV DNA screening results
- Where
- 18 sites in Finland
- Volunteers
- 14,000 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Polycystic Ovary Syndrome
Functional Study of the Hypothalamus in Magnetic Resonance Imaging (MRI) in Polycystic Ovary Syndrome (PCOS)
The aim to evaluate whether activation of the hypothalamic-pituitary-gonadal axis in PCOS is associated with transient microstructural and metabolic changes in the female hypothalamus using MRI approaches to assess water…
- Trial name
- MRI-PCOS (NCT03043924)
- Testing
- Cyproterone Acetate + estradiol, Levonorgestrel, Ethinyl Estradiol 0.1-0.02Mg Oral Tablet
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Colorectal Cancer, Colorectal Adenoma
Protocol to Validate the Performance of the LifeKit® Prevent Colorectal Neoplasia Test for CRC Screening
The purpose of this study is to determine the sensitivity and specificity for LifeKit Prevent Colorectal Neoplasia Test for colorectal cancer (CRC) and for adenoma, including advanced adenoma.
- Trial name
- PREVENT (NCT04693546)
- Testing
- LifeKit Prevent Colorectal Neoplasia Test, FIT Test
- Where
- United States
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Metabiomics Corp
Cervical Cancer, Intraepithelial Neoplasia
Cervical And Self-Sample In Screening Study
The proposed study seeks to compare the diagnostic performance of Human Papillomavirus (HPV) testing in self-collected samples via the Eve Medical self-collection system© (Eve) with standard physician-collected samples for the…
- Trial name
- CASSIS (NCT02397252)
- Testing
- Eve Medical self-collection system©, cobas® PCR Female swab self-sampling, Physician-collected sampling
- Where
- Canada
- Volunteers
- 1,225 people, healthy volunteers welcome
- Sponsor
- McGill University
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