Clinical trials: Cancer, suspended
Oral Cavity Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma
Identification of Breath Biomarkers in Head and Neck Squamous Cell Carcinoma
In this study the Investigators aim to determine specific volatile compounds present in breath samples of patients with oral cavity or oropharyngeal squamous cell carcinoma before and after tumour resection or before and after…
- Trial name
- NCT02156180
- Where
- Australia
- Volunteers
- 13 people
- Sponsor
- Queensland Centre of Excellence for Head and Neck Cancer
Acute Myeloid Leukemia, Lymphoid Leukemia
Oshadi D & Oshadi R Combined With Salvage Chemotherapy for Relapsed Acute Myeloid Leukemia or Lymphoid Leukemia Patients
The study will be a prospective open-label single-center study in previously treated patients with Acute Myeloid Leukemia (AML) or Acute Lymphoid Leukemia (ALL).
- Trial name
- NCT02462265
- Testing
- Oshadi D & Oshadi R;, salvage therapy cytosar and mitoxantrone
- Volunteers
- 15 people
- Sponsor
- Oshadi Drug Administration
Breast Cancer
The Impact of Surgeon-Interpreted Intraoperative Margin Assessment During Breast Conserving Surgery on Postoperative Treatment
To learn if Pegulicianine Fluorescence-Guided Surgery (pFGS), which is part of the Lumicell Direct Visualization System, and Digital Breast Tomosynthesis (DBT) can improve the identification of tumor margins during a partial…
- Trial name
- NCT07140965
- Testing
- Pegulicianine Fluorescence-Guided Surgery, Digital Breast Tomosynthesis, Breast Conserving Therapy
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- M.D. Anderson Cancer Center
Acute Myeloid Leukemia, Myelodysplastic Syndrome
Safety and Efficacy Study of AS101 to Treat Elderly Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Patients
The purpose of this study is to determine whether addition of AS101 to the standard chemotherapy regimen is effective in the treatment of newly diagnosed elderly (≥60) AML patients and AML transformed myelodysplastic syndrome…
- Trial name
- NCT01010373
- Testing
- AS101
- Where
- Israel
- Volunteers
- 12 people
- Sponsor
- BioMAS Ltd
Breast Cancer
Early Predictor of Herceptin Cardio Toxicity in Breast Cancer Patients
Early identification of patients at risk for cardiotoxicity represent a primary goal for cardiologist and oncologist From all adjuvant trials echocardiography is ideal for evaluating Left Ventricular function though its operator…
- Trial name
- NCT02062983
- Testing
- Herceptin
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- National Guard Health Affairs
Neoplasms, Musculoskeletal Diseases
Therapy Study of Automated Protocolized vs. Physician-Directed Non-Protocolized Weaning
The purpose of this study was to determine whether computer-driven protocolized weaning is superior to physician-directed non-protocolized weaning in over-24-hours-ventilated surgical intensive care unit (ICU) patients.
- Conditions
- Neoplasms, Musculoskeletal Diseases, Digestive System Diseases, Respiratory Tract Diseases
- Trial name
- NCT00606788
- Testing
- SmartCare/PS (Automated Weaning), Conventional weaning
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Luebeck
Prostatic Neoplasm
A Phase 1a/1b Study to Evaluate the Safety of EZN-4176, in Adult Patients With Castration-Resistant Prostate Cancer
This study will evaluate an experimental drug called EZN-4176 to determine the anticancer effects when it is given to patients with an advanced form of prostate cancer called castration-resistant prostate cancer (CRPC).
- Trial name
- NCT01337518
- Testing
- EZN-4176
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 150 people
- Sponsor
- Enzon Pharmaceuticals, Inc.
Non Small Cell Lung Cancer, Lung Cancer
Targeting ODC as an Immunotherapeutic Target in STK11 (LKB1) Pathway-Deficient NSCLC (DFMO)
The purpose of this study is to establish the safety, toxicity, and tolerability of Difluoromethylornithine (DFMO) in combination with pembrolizumab in advanced/metastatic Non-Small Cell Lung Cancer (NSCLC).
- Trial name
- NCT06219174
- Testing
- Pembrolizumab, Difluoromethylornithine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Glioblastoma
Early Stereotactic Gamma Knife Radiosurgery to Residual Tumor After Surgery of Newly Diagnosed Glioblastoma
Gamma GBM is a single-arm phase II trial that prospectively measures the progression-free survival time after addition of an early gamma knife boost to areas of residual tumor to standard-of-care (surgery, chemo-radiotherapy…
- Trial name
- Gamma-GBM (NCT03055208)
- Testing
- gamma knife radiosurgery (15 Gy to 50% isodose)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universitätsmedizin Mannheim
Prostate Carcinoma
Brain and Pelvic Floor Muscle Activity of Patients Who Had or Are Undergoing Robot-Assisted Radical Prostatectomy
This trial investigates brain and pelvic floor muscle activity in patients undergoing robot-assisted radical prostatectomy. This trial may help identify the brain waves that are associated with muscles involved in giving patients…
- Trial name
- NCT04646434
- Testing
- Electroencephalography, Electromyography, Questionnaire Administration
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Roswell Park Cancer Institute
Solid Tumors
A Study to Test Different Doses of BI 3923948 Alone and in Combination With an Anti-PD-1 Antibody in People With Different Types of Advanced Cancer (Solid Tumors)
This study is open to adults aged 18 and over or above legal age with different types of recurrent advanced cancer (solid tumors) that have spread to other parts of the body and that are accessible for injection and biopsy.
- Trial name
- NCT07395258
- Testing
- BI 3923948, Ezabenlimab
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Boehringer Ingelheim
Melanoma
Neoadjuvant T-VEC in High Risk Early Melanoma
Despite the recent notable advances in the treatment of advanced melanoma with application of growing immunotherapies, patterns of response and factors resulting in treatment failure are poorly understood.
- Trial name
- NCT04427306
- Testing
- T-Vec
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Colorectal Cancer
Real-Time Feedback (RTFB) to Improve Colonoscopy
To test whether real-time feedback will improve quality of endoscopic examination.
- Trial name
- NCT05241210
- Testing
- AI program for colonoscopy
- Where
- 3 sites in United States
- Volunteers
- 4,150 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Glioma
IL13Rα2 CAR-T for Patients With r/r Glioma
This is a dose exploration clinical trial to assess the safety and feasibility of the IL13Ra2-targeted CAR-T in glioma.
- Trial name
- ENHANCING (NCT06355908)
- Testing
- IL13Rα2 CAR-T
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Yang Zhang
Melanoma, Soft Tissue Sarcoma
Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization
The goal of this phase I trial is to evaluate the toxicity and feasibility of a tumor-specific RNA-NP vaccine in patients with stage IIB-IV melanoma who have evidence of progressive disease by RECIST 1.1 criteria while receiving…
- Trial name
- NCT05264974
- Testing
- Autologous total tumor mRNA loaded DOTAP liposome vaccine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Florida
Pancreatic Cancer
A Study of ABTL0812 in Pancreatic Cancer
A Randomized Phase I/II Open Label Study to Assess the Efficacy and Safety of ABTL0812 in Combination With Gemcitabine and Nab-paclitaxel in Patients With Advanced Metastatic Pancreatic Cancer at First Line Therapy.
- Trial name
- Pancreatic (NCT03417921)
- Testing
- ABTL0812, Gemcitabine and nab-paclitaxel
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Ability Pharmaceuticals SL
Multiple Myeloma
Iberdomide Versus Observation Off Therapy After Idecabtagene Vicleucel CAR-T for Multiple Myeloma
This phase II trial compares iberdomide maintenance therapy to disease monitoring for improving survival in patients who have received idecabtagene vicleucel (a type of chimeric antigen receptor T-cell [CAR-T] therapy) for…
- Trial name
- NCT06179888
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy
- Where
- 74 sites in United States
- Volunteers
- 84 people
- Sponsor
- National Cancer Institute (NCI)
Clear Cell Renal Cell Carcinoma
68Ga-NYM096/177Lu-NYM096 in Metastatic ccRCC
This is a single-center, phase I study. Patients with metastatic clear cell renal cell carcinoma will be recruited in this study to (Phase A) evaluate using 68Ga-NYM096 PET/CT and to (Phase B) treat with 177Lu-NYM096.
- Trial name
- NYCRRLT (NCT06649682)
- Testing
- 68Ga-NYM096 PET/CT and 177Lu-NYM096
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking Union Medical College Hospital
Gastric Cancer
Phase II Study of Oral S-1 Plus Irinotecan in Patients With Advanced Gastric Cancer
To assess the usefulness of irinotecan plus S-1 therapy based on the antitumor effect and survival period. by performing a phase II study of this combination in patients with inoperable or with postoperative gastric cancer
- Trial name
- NCT00209664
- Testing
- irinotecan, S-1
- Where
- Japan
- Volunteers
- 40 people
- Sponsor
- Hokkaido Gastrointestinal Cancer Study Group
Head and Neck Cancer, Pregnancy Related
Study on the Occurrence of Head and Neck Cancers During Pregnancy
Head and neck cancers that occurred during pregnancy
- Trial name
- REFCORbirth (NCT03738267)
- Where
- 8 sites in France
- Volunteers
- 14 people
- Sponsor
- Centre Francois Baclesse