Clinical trials: Cancer Colon
Colorectal Cancer, Inflammatory Bowel Diseases
Microbiota-anastomotic Leak Among Colorectal Surgery Patients : Pilot Study
The study is based on the hypothesis that patients with postoperative anastomotic leakage have a different bacterial profile contributing to poor tissue healing, and that patients operated for colon cancer presumably have a…
- Conditions
- Colorectal Cancer, Inflammatory Bowel Diseases, Microbiota, Anastomotic Leak
- Trial name
- NCT03496441
- Testing
- Fecal sample collection for analysis
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Metastatic Colorectal Cancer
Fruquintinib Combined With mFOLFOX6/FOLFIRI in First-line Treatment for Metastatic Colorectal Cancer
The purpose of this study is to evaluate the efficacy and safety of Fruquintinib Combined With mFOLFOX6/FOLFIRI as the first-line treatment of Metastatic Colorectal Cancer
- Trial name
- NCT05004441
- Testing
- Fruquintinib Combined With mFOLFOX6/FOLFIRI
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Zhou Fuxiang
Angiogenesis, Colon Cancer
Postoperative VEGF and Recurrence After Colon Cancer Surgery
The purpose of this trial is to study the relationship between the angiogenic response to surgical aggression, determined through the serum levels of vascular endothelial growth factor (VEGF) on postoperative day four, and the…
- Conditions
- Angiogenesis, Colon Cancer, Surgery, Recurrence
- Trial name
- NCT04851054
- Testing
- Surgery for colon cancer with intention to cure
- Volunteers
- 280 people
- Sponsor
- Hospital del Mar
Colorectal Cancer Stage II and III
Fuzheng Yiliu-1010
Real world study was used to evaluate the therapeutic effect of Fuzheng anti-tumor therapy on colorectal cancer patients in stage II and III after surgery and standard chemotherapy, and the prediction model of dominant population…
- Trial name
- NCT04459754
- Testing
- Fuzheng Yiliu Formulation
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Adult Patients, Intestinal Continuity (Anastomosis)
Anastomotic Leakage After Colon Cancer Surgery
Anastomotic leak (AL) is one of the most feared complications after colon cancer (CC) surgery. The incidence varies according to the studies, the definition used and the location of the excised segment.
- Conditions
- Adult Patients, Intestinal Continuity (Anastomosis), Colon Cancer
- Trial name
- ANACO II (NCT05643105)
- Testing
- Any kind of colectomy
- Where
- Spain
- Volunteers
- 1,628 people
- Sponsor
- Hospital San Carlos, Madrid
Colorectal Cancer
MRI in Predicting Response in Patients Receiving Combination Chemotherapy and Bevacizumab For Advanced or Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, leucovorin, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00602329
- Testing
- bevacizumab, fluorouracil, leucovorin calcium
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Colorectal Cancer
Increasing Colorectal Cancer Screening Among Filipino Americans
Develop and evaluate in a randomized trial an educational small group intervention to increase colorectal cancer screening among Filipino Americans.
- Trial name
- NCT00742729
- Testing
- Arm 1, Arm 2, Arm 3
- Where
- United States
- Volunteers
- 906 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Metastatic Colorectal Cancer
Re-challenge Therapy With Chemotherapy & Panitumumab in Metastatic Colorectal Cancer Patients Treated With an Anti-EGFR
patients with metastatic colorectal cancer who were initially RAS wild and failed at least 2 lines of chemotherapy will be enrolled. Anti-EGFR must have been given in 1st line.
- Trial name
- REPAN (NCT03940131)
- Testing
- Panitumumab
- Where
- Saudi Arabia
- Volunteers
- 30 people
- Sponsor
- King Abdullah Medical City
Colorectal Cancer
Neoadjuvant Electrochemotherapy for Colorectal Cancer - a Randomized Controlled Trial
This is a randomized controlled trial investigating efficacy of electrochemotherapy for early colorectal cancer
- Trial name
- NCT04816045
- Testing
- Electrochemotheraoy
- Volunteers
- 24 people
- Sponsor
- Zealand University Hospital
Solid Tumours, Sarcoma
A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors
The purpose of this study is to investigate the study drug, OKN4395, administered alone and in combination with pembrolizumab. The overall objectives of this study are to determine the safety and tolerability (degree to which…
- Conditions
- Solid Tumours, Sarcoma, HNSCC, Non Small Cell Lung Cancer
- Trial name
- INVOKE (NCT06789172)
- Testing
- OKN4395, Pembrolizumab, Fasting
- Where
- 10 sites in United States, Australia and 1 more
- Volunteers
- 146 people
- Sponsor
- Epkin
Colorectal Neoplasms, Sedentary Behavior
An Intervention to Reduce Sedentary Behavior and Promote Physical Activity in Colorectal Cancer Chemotherapy
This single-group feasibility study develops and evaluates an intervention designed to reduce sedentary behavior and promote physical activity in patients with colorectal cancer undergoing chemotherapy.
- Trial name
- NCT07845877
- Testing
- Sedentary behavior reduction intervention for patients with colorectal cancer undergoing chemotherapy
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Colonic Polyps/Colonoscopy/Colorectal Neoplasms
Comparison of Cold and Hot Snare Resection for Colorectal Polyps Sized 10-19mm.
Patients who met the criteria for removal of 10-19mm colorectal polyps using cold snare or hot snare were included in the study, signed by endoscopic treatment written informed consent for surgery, patients with detailed tracking…
- Trial name
- NCT04451512
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Colorectal Cancer
Capecitabine and Radiation Therapy With or Without Panitumumab in Treating Patients With Advanced Rectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00814619
- Testing
- panitumumab, capecitabine, therapeutic conventional surgery
- Where
- 24 sites in Hungary, Switzerland
- Volunteers
- 68 people
- Sponsor
- Swiss Cancer Institute
Cancer
BCX-1777 in Treating Patients With Refractory Cancer
RATIONALE: BCX-1777 may stop the growth of cancer cells by blocking the enzymes necessary for their growth. PURPOSE: Phase I trial to study the effectiveness of BCX-1777 in treating patients who have refractory cancer.
- Trial name
- NCT00073944
- Testing
- forodesine hydrochloride
- Where
- United States
- Sponsor
- BioCryst Pharmaceuticals
Pancreatic Cancer, Gastrointestinal Neoplasms
Permission to Collect Blood Over Time for Research
To determine whether biomarkers assessed in blood samples can be used to detect individuals at risk for developing blood clots or worsening of their underlying disease.
- Conditions
- Pancreatic Cancer, Gastrointestinal Neoplasms, Colon Rectal Cancer Adenocarcinoma, Esophageal Cancer
- Trial name
- NCT00767234
- Testing
- Observation
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Stanford University
Rectal Cancer
Local Excision of Clinical T3 Rectal Adenocarcinoma Showing Major Response(ycT0-1) After Neoadjuvant Chemoradiotherapy
The purpose of this study is evaluation of the safety and the efficacy of transanal local excision in patients with cT3 rectal cancer which was downstaged into ycT0-1 after neoadjuvant chemoradiotherapy.
- Trial name
- NCT02490709
- Testing
- Local excision
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- National Cancer Center, Korea
Breast Cancer, Colorectal Cancer
Skin Biopsies and DNA Analysis in Patients Receiving Irinotecan or Gemcitabine For Advanced Solid Tumors
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
- Conditions
- Breast Cancer, Colorectal Cancer, Pancreatic Cancer
- Trial name
- NCT00369109
- Testing
- biologic sample preservation procedure, immunohistochemistry staining method, laboratory biomarker analysis
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 60 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Inflammatory Bowel Diseases, Colo-rectal Cancer
Collection of Gastrointestinal Malignant and Non-malignant Human Samples
To collect human tissue, blood, and fecal samples from patients suffering from Inflammatory Bowel Disease and Colorectal Cancer.
- Trial name
- NCT03415919
- Testing
- no intervention will be given to patients.
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas at Austin
Colorectal Cancer (CRC)
Low-Dose Radiotherapy to Sensitize Pucotenlimab Plus CAPEOX for pMMR Locally Advanced Rectal Cancer
This is a prospective, open-label, randomized, parallel-group phase II trial evaluating the efficacy and safety of a low-dose radiotherapy sensitization strategy combined with a PD-1 antibody (pucotenlimab) and CAPEOX as…
- Trial name
- NCT07448142
- Testing
- Low-dose radiotherapy, Pucotenlimab, CAPEOX/XELOX
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Colorectal Carcinoma
Smart Symptom Tracking ALEX Application for Tracking and Monitoring Gastrointestinal Health, Smart Horizons Pilot Trial
This clinical trial compares the impact of the Smart Symptom Tracking ALEX application (app) to standard symptom-tracking practices in tracking and monitoring gastrointestinal (GI) symptoms in young adults.
- Trial name
- NCT07618273
- Testing
- Artificial Intelligence-based Intervention, Best Practice, Communication Intervention
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
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