Clinical trials: Cancer Colon
Colorectal Cancer
DC-CIK Immunotherapy Plus Chemotherapy vs Chemotherapy Alone in the Adjuvant Treatment of Stage III Colorectal Cancer
Stage III colorectal cancer constitutes more than half of the colorectal patients, and the prognosis does not improve much recently although varies of adjuvant drugs have been tried.
- Trial name
- NCT02415699
- Testing
- Fluorouracil, Oxaliplatin, Leucovorin
- Volunteers
- 100 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Colorectal Cancer
Nivolumab Plus FOLFOXIRI/Bevacizumab in First Line Chemotherapy of Advanced Colorectal Cancer RASm/BRAFm Patients
This is a multicentric single arm, open label trial. In this study patients candidated to a first line of chemotherapy for metastatic colorectal cancer will be treated with 8 cycles of folfoxiri plus bevacizumab plus nivolumab…
- Trial name
- NIVACOR (NCT04072198)
- Testing
- Nivolumab, Bevacizumab, Irinotecan
- Where
- 8 sites in Italy
- Volunteers
- 73 people
- Sponsor
- Gruppo Oncologico Italiano di Ricerca Clinica
Colorectal Cancer, Liver Metastases
Treatment Strategies in Colorectal Cancer Patients With Initially Unresectable Liver-only Metastases
Colorectal cancer patients with initially unresectable liver-only metastases may be cured after downsizing of metastases by neoadjuvant systemic therapy.
- Trial name
- CAIRO5 (NCT02162563)
- Testing
- FOLFOX/ FOLFIRI with bevacizumab, FOLFOXIRI with bevacizumab, FOLFOX/ FOLFIRI with panitumumab
- Where
- 56 sites in Belgium, Netherlands
- Volunteers
- 530 people
- Sponsor
- Dutch Colorectal Cancer Group
Adenocarcinoma of the Rectum, Adenocarcinoma
Optimum Timing for Surgery After Pre-operative Radiotherapy 6 vs 12 Weeks
The aim of this study is to determine whether greater rectal cancer downstaging and regression occurs when surgery is delayed to 12 weeks after completion of radiotherapy/chemotherapy compared to 6 weeks.
- Conditions
- Adenocarcinoma of the Rectum, Adenocarcinoma, Adenocarcinoma, Mucinous, Carcinoma
- Trial name
- NCT01037049
- Testing
- Patients who have surgery at 12 weeks after radiotherapy/chemoradiotherapy
- Where
- 23 sites in Brazil, Canada and 2 more
- Volunteers
- 237 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Colorectal Cancer
Uncovering the Barriers of Colorectal Cancer Screening Amongst Siblings of Colorectal Cancer Patients.
To determine amongst siblings of colorectal cancer patients:1. The knowledge, perception and barriers towards screening colonoscopy. 2. The current screening colonoscopy adoption rate. 3.
- Trial name
- NCT03395938
- Testing
- Proactive engagement, Current practice
- Where
- Singapore
- Volunteers
- 223 people
- Sponsor
- National University Health System, Singapore
Stage II Breast Cancer, Stage III Breast Cancer
Ask Questions (ASQ):Implementation of a Communication Intervention
This clinical trial implements a communication intervention to improve patient-oncologist communication in the outpatient medical oncology setting.
- Conditions
- Stage II Breast Cancer, Stage III Breast Cancer, Stage IV Breast Cancer, Stage II Colorectal Cancer
- Trial name
- NCT05025748
- Testing
- Behavioral Intervention
- Where
- 8 sites in United States
- Volunteers
- 81 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Metastatic Colorectal Cancer
Trial in Metastatic Colorectal Cancer With FOLFIRI Plus Aflibercept as First Line Treatment
Investigators propose to study the combination of m FOLFIRI plus Aflibercept in a Phase II trial of patients with metastatic colorectal cancer.
- Trial name
- MINOAS (NCT02624726)
- Testing
- 5 Fluorouracil, Leucovorin, Irinotecan
- Where
- 10 sites in Greece
- Volunteers
- 31 people
- Sponsor
- Hellenic Oncology Research Group
Colorectal Cancer (CRC)
Fruquintinib vs Bevacizumab Combined With Irinotecan Liposome and Capecitabine as Second-Line Therapy for Advanced Metastatic Colorectal Cancer
This study is divided into two phases. The first phase aims to preliminarily evaluate the efficacy and safety of fruquintinib in combination with irinotecan liposome and capecitabine as second-line therapy for advanced metastatic…
- Trial name
- ARK (NCT07051785)
- Testing
- Fruquintinib+Irinotecan Liposome+Capecitabine, Bevacizumab+Irinotecan Liposome+Capecitabine
- Volunteers
- 68 people
- Sponsor
- Liu Huang
Metastatic Colorectal Cancer
Combination Chemotherapy and Cetuximab or Bevacizumab in Treating Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, leucovorin calcium, oxaliplatin, capecitabine, and irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by…
- Trial name
- NCT01280643
- Testing
- fluorouracil, leucovorin calcium, oxaliplatin
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Fox Chase Cancer Center
Screening for Colon Cancer, Blood Samples
Evaluation of PreveCol's Efficiency As a Second Line Method for the Early Colorectal Cancer Detection
The objective of this low-risk interventional study is to evaluate whether the PreveCol® test has sufficient efficiency to be considered as a second-line method for the detection of both colorectal cancer and advanced adenomas…
- Conditions
- Screening for Colon Cancer, Blood Samples, Survey and Questionnaire, Colorectal Carcinoma
- Trial name
- MS-Prevecol (NCT06703632)
- Testing
- blood sampling, Survey using a questionnaire.
- Where
- 2 sites in Portugal, Spain
- Volunteers
- 4,538 people, healthy volunteers welcome
- Sponsor
- ADVANCED MARKER DISCOVERY S.L.
Adenomatous Polyposis Coli
Post-Trial Access for Guselkumab in Participants With Familial Adenomatous Polyposis
The purpose of this post-trial access (PTA) program is to provide guselkumab to participants with Familial Adenomatous Polyposis (FAP) who are experiencing clinical benefit after completing 48 weeks of treatment in Study…
- Trial name
- NCT04948398
- Testing
- Guselkumab
- Sponsor
- Janssen Research & Development, LLC
Solid Tumor, Hepatocellular Carcinoma
NKG2D CAR-T(KD-025) in the Treatment of Relapsed or Refractory NKG2DL+ Tumors
This is a Phase 1, single-arm, single-center, open-label study to evaluate the safety and effectiveness of NKG2D-based CAR-T cells infusion in the treatment of relapsed/refractory NKG2DL+ solid tumors.
- Conditions
- Solid Tumor, Hepatocellular Carcinoma, Colorectal Cancer, Glioma
- Trial name
- NCT04550663
- Testing
- KD-025 CAR-T cells
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Colorectal Carcinoma, Familial Adenomatous Polyposis
An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis
This open-label phase II trial tests how well TPST-1495 works in reducing the number of polyps in the small bowel and colon in patients with familial adenomatous polyposis (FAP).
- Trial name
- NCT06557733
- Testing
- Biopsy Procedure, Biospecimen Collection, EP2/EP4 Antagonist TPST-1495
- Where
- 4 sites in United States
- Volunteers
- 38 people
- Sponsor
- National Cancer Institute (NCI)
Cancer of Colon
Implementation of Enhanced Recovery After Surgery Program (ERAS) in Colorectal Cancer Surgery, a Randomized Controlled Trial
The aim of our study is to determine the effect of implementation of the ERAS (enhanced recovery after surgery) protocol in our institute and its impact on hospital length of stay and outcome of surgery.
- Trial name
- NCT03928678
- Testing
- enhanced recovery after surgery program in colorectal cancer surgery
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Metastatic Colorectal Cancer, Metastatic Head and Neck Cancer
Prophylaxis of Magnesium-rich Mineral Water to Prevent Hypomagnesemia Induced by an Anti-EGFR (OPTIMAG)
Anti-EGFR (Epidermal Growth Factor Receptor) therapies, namely cetuximab and panitumumab, have become standards in the management of metastatic colorectal and head and neck cancers.
- Trial name
- OPTIMAG (NCT03146338)
- Testing
- Magnesium-rich mineral water (Rozana)
- Where
- 12 sites in France
- Volunteers
- 106 people
- Sponsor
- Weprom
Non-small Cell Lung Cancer, Gastric Cancer
Clinical Efficacy and Safety of NKT Cell Infusion in Patients With Advanced Solid Tumor
Natural killer T (NKT) cells are a unique subset of lymphocytes that present a mixed T-NK phenotype. Our hypothesis is that Natural killer T cells may decrease the tumor burden and improve overall survival.
- Conditions
- Non-small Cell Lung Cancer, Gastric Cancer, Hepatocellular Carcinoma, Colorectal Cancer
- Trial name
- NCT02562963
- Testing
- natural killer T cell
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Minghui Zhang
Liver Metastasis, Colorectal Neoplasms
Study of the Litx™ System Combined With Chemotherapy in Patients With Colorectal Liver Metastases
The purpose of this study is to determine whether the Litx™ system is safe and effective in combination with chemotherapy in the treatment of liver metastasis arising from colorectal cancer.
- Conditions
- Liver Metastasis, Colorectal Neoplasms, Liver Neoplasms, Neoplasm Metastasis
- Trial name
- NCT00083785
- Testing
- Talaporfin sodium (LS11), LED-based light infusion device, Light emitting diodes (LED)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Light Sciences LLC
Physical Activity, Breast Neoplasm
The Impact of Physical Activity on the Outcome of Surgery
Over the last decades different life style factors have been established as risk factors for various diseases. The obesity pandemic displays a good example of a disease where great effort is undertaken to characterize risk…
- Conditions
- Physical Activity, Breast Neoplasm, Colorectal Neoplasm, Gall Stones
- Trial name
- NCT01707121
- Where
- 2 sites in Sweden
- Volunteers
- 450 people
- Sponsor
- Sahlgrenska University Hospital
Psychological Stress
Effectiveness of Telephone Intervention for Colorectal Cancer Caregivers
The purpose of this study is to assess the effectiveness of the telephone intervention program for caregivers of colorectal cancer.
- Trial name
- NCT01519895
- Testing
- Telephone intervention
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Hospital Authority, Hong Kong
Advanced Malignant Neoplasm, Colorectal Cancer
The Real Clinical Background of Advanced Colorectal Cancer Treatment Situation Survey
Collect the real clinical background of advanced colorectal cancer c of China.
- Trial name
- Sprit (NCT01549067)
- Where
- 2 sites in China
- Volunteers
- 3,700 people
- Sponsor
- Chinese Medical Doctor Association
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