Clinical trials: Cancer Colonic
Colorectal Cancer, Appendicitis
Appendectomy and Colorectal Cancer
Colorectal cancer (CRC) is one of the most common cancer worldwide. Initiation and progression of CRC involve complex interactions among genetic, epigenetic and environmental factors.
- Trial name
- NCT06091137
- Where
- Hong Kong
- Volunteers
- 180,000 people
- Sponsor
- Chinese University of Hong Kong
Colorectal Cancer
Accelerated Enhanced RECOVERy Following Minimally Invasive Colorectal Cancer Surgery (RecoverMI)
The goal of this clinical research study is to learn if RecoverMI care can help to shorten the time that patients are in the hospital after surgery and if it can help them recover sooner.
- Trial name
- NCT02613728
- Testing
- Accelerated Recovery Plan, Early Discharge, Telemedicine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer, Colorectal Cancer Metastatic
Possible Association of Intestinal Helminths and Protozoa With Colorectal Cancer Pathogenesis
Colorectal cancer (CRC) has the third highest cancer incidence in the world. There is mounting evidence that the intestinal microbiota plays an important role in colorectal carcinogenesis.
- Conditions
- Colorectal Cancer, Colorectal Cancer Metastatic, Intestinal Parasite, Protozoan Infections
- Trial name
- NCT03173001
- Testing
- Parasitological examination
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
Colorectal Cancer
Aspirin and/or Folic Acid in Preventing Recurrent Colorectal Polyps
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of aspirin and/or folic acid may be effective in preventing recurrent polyps in patients who have…
- Trial name
- NCT00033319
- Testing
- folic acid, acetylsalicylic acid
- Where
- 32 sites in United Kingdom
- Sponsor
- Queen's Medical Center
Colorectal Neoplasms, Ileus Postoperative
The ACURE Trial: Acupuncture for Colorectal Recovery
Purpose: The goal of this clinical trial is to evaluate whether electroacupuncture (EA) can accelerate the recovery of bowel function in patients undergoing minimally invasive surgery for colorectal cancer.
- Conditions
- Colorectal Neoplasms, Ileus Postoperative, Postoperative Complication, Gastrointestinal Motility
- Trial name
- ACURE (NCT07496528)
- Testing
- Electroacupuncture (EA), Enhanced Recovery After Surgery (ERAS) Protocol
- Volunteers
- 240 people
- Sponsor
- Chang Gung Memorial Hospital
Peripheral Neuropathy
Estimate the Efficacy of HD6610 Granule for Oxaliplatin-induced Peripheral Neuropathy
The purpose of this study is to estimate the usefulness and safety of HD6610 granule for oxaliplatin-induced peripheral neuropathy.
- Trial name
- NCT02590367
- Testing
- FOLFOX regimen, HD6610 Granule
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Jiangsu Province Hospital of Traditional Chinese Medicine
Colorectal Cancer
Virtual Colonoscopy Using Omnipaque as a Contrast Agent
CT colonography (CTC) is a validated screening exam for colorectal cancer. The diagnostic accuracy of CTC depends on the quality of the bowel cleansing and contrast tagging of residual stool and fluid.
- Trial name
- NCT04582500
- Testing
- Iohexol
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Stage I Colon Cancer, Stage II Colon Cancer
Phase II Open-label Trial of Neoadjuvant Immunochemotherapy for Resectable Non-metastatic Colon cancER: NICER
This is a Phase II open-label trial of neoadjuvant immunochemotherapy with Atezolizumab and CAPOX followed by surgery and potentially adjuvant chemotherapy for patients with localized resectable pMMR adenocarcinoma of the colon…
- Conditions
- Stage I Colon Cancer, Stage II Colon Cancer, Stage III Colon Cancer
- Trial name
- NICER (NCT05870800)
- Testing
- Tecentriq 1200 MG in 20 ML Injection + Capecitabine 1000 mg/m2 + Oxaliplatin 130 mg/m2, Oxaliplatin injection 85mg/m2 + Leucovorin 400mg/m2 + 5-Fluorouracil 2400mg/m2, Oxaliplatin 130mg/m2 + Capecitabine 1000mg/m2
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Baylor College of Medicine
Colorectal Cancer, Rectal Cancer
A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and Chemotherapy
The researchers are doing this study to find out whether the combination of botensilimab and balstilimab (BOT/BAL), followed by balstilimab alone, is an effective treatment for people with microsatellite stable (MSS) colorectal…
- Trial name
- NCT07227636
- Testing
- Botensilimab, Balstilimab
- Where
- 7 sites in United States
- Volunteers
- 284 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer, Constipation, Impaction, and Bowel Obstruction
Endoscopic Placement of Metal Stent in Patients With Cancer-Related Bowel Obstruction
RATIONALE: The use of endoscopy to place a metal stent in the large intestine is less invasive than surgery for treating cancer-related bowel obstruction and may have fewer side effects and improve recovery.
- Conditions
- Colorectal Cancer, Constipation, Impaction, and Bowel Obstruction, Gastric Cancer, Gastrointestinal Carcinoid Tumor
- Trial name
- NCT00004911
- Testing
- bowel obstruction management, quality-of-life assessment
- Where
- United States
- Sponsor
- Northwestern University
Low Anterior Resection Syndrome, Faecal Incontinence With Faecal Urgency
Understanding and Tailored Treatment of Low Anterior Resection Syndrome
The goal of this observational study is to learn why some patients develop low anterior resection syndrome (LARS) after colorectal cancer treatment.
- Conditions
- Low Anterior Resection Syndrome, Faecal Incontinence With Faecal Urgency, Faecal Incontinence, Colorectal (Colon or Rectal) Cancer Survivors
- Trial name
- PATO-LARS (NCT07573371)
- Where
- 3 sites in Denmark
- Volunteers
- 145 people
- Sponsor
- Aalborg University Hospital
Colorectal Anastomosis, Left-sided Colon Resection
Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections
The purpose of this study is to evaluate the safety and performance of the Signia™ power handle, Signia™ circular adapter, and Signia™ Tri-Staple™ 2.0 circular reloads (hereafter referred to as Signia™ circular stapler) in…
- Conditions
- Colorectal Anastomosis, Left-sided Colon Resection, Anastomotic Leak, Anastomotic Complication
- Trial name
- SECURE (NCT07351071)
- Testing
- Signia™ circular stapler with Tri-Staple™ Technology (Signia™ Circular Stapling system)
- Where
- 10 sites in United States
- Volunteers
- 137 people
- Sponsor
- Medtronic - MITG
Locally Advanced or Metastatic Epithelial Tumor
A Study of SI-B001, an EGFR/HER3 Bispecific Antibody, in Locally Advanced or Metastatic Epithelial Tumors
In phase Ia study, the safety and tolerability of SI-B001 in patients with locally advanced or metastatic epithelial malignancies will be investigated to determine the dose-limiting toxicity (DLT), maximum tolerated dose (MTD) of…
- Trial name
- NCT04603287
- Testing
- SI-B001
- Where
- 3 sites in China
- Volunteers
- 60 people
- Sponsor
- Sichuan Baili Pharmaceutical Co., Ltd.
Colon Cancer
Exploration of the Relationship Between Mismatch Repair Status of Colorectal Cancer and Lymph Node Metastasis Patterns and Pathological High-risk Factors
This study analyzed the differences in clinical baseline features and survival outcomes between pMMR and dMMR patients. The aim is to evaluate the impact of MMR status on overall survival and disease-free survival of colorectal…
- Trial name
- NCT06798857
- Volunteers
- 1,471 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Lynch Syndrome, Endometrial Cancer
Frequency of Endometrial Cancer Precursors Associated with Lynch Syndrome
Given that there is a significant prevalence of Lynch syndrome among patients with endometrial cancer (about 5% of patients with endometrial cancer), and given there is a known risk of endometrial cancer among patients with…
- Conditions
- Lynch Syndrome, Endometrial Cancer, Endometrial Hyperplasia, Mismatch Repair Deficiency
- Trial name
- NCT05257057
- Testing
- Immunohistochemical staining
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- WellSpan Health
Colorectal Cancer, Social Determinants of Health
Paired Promotion of Colorectal Cancer and Social Determinants of Health Screening
This work is an implementation science study that examines different aspects of implementing a single intervention. The intervention consists of asking community health centers to implement an outreach strategy to screen patients…
- Trial name
- NCT04585919
- Testing
- Paired Screening Intervention
- Where
- 4 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Colon Cancer
FOLFOX-4 3months Versus 6 Months and Bevacizumab as Adjuvant Therapy for Patients With Stage II/III Colon Cancer
This project consists of two independent, following specific eligibility criteria and different randomisation schemes studies, later on called DURATION study and BEV study.
- Trial name
- TOSCA (NCT00646607)
- Testing
- FOLFOX (Oxaliplatin, 5Fluorouracil, Lederfolin)
- Where
- 111 sites in Italy
- Volunteers
- 3,756 people
- Sponsor
- Gruppo Italiano per lo studio dei Carcinomi dell'Apparato Digerente
Anal Cancer, Colorectal Cancer
Quality of Life in Patients Undergoing Radiation Therapy for Primary Lung Cancer, Head and Neck Cancer, or Gastrointestinal Cancer
RATIONALE: Gathering information about patients' quality of life during radiation therapy for cancer may help doctors plan the best treatment.
- Conditions
- Anal Cancer, Colorectal Cancer, Esophageal Cancer, Extrahepatic Bile Duct Cancer
- Trial name
- NCT00836992
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Mayo Clinic
Metastatic Colorectal Cancer
Regorafenib and XELOX as 2nd Line Treatment in Metastatic Colorectal Cancer
This is an interventional, randomized open-label, parallel-group, multicenter, dose escalation phase Ib/II study, to investigate the combination of Regorafenib and XELOX as 2nd line treatment in mCRC patients.
- Trial name
- NCT04008511
- Testing
- Regorafenib, Capecitabine, Oxaliplatin
- Where
- China
- Volunteers
- 54 people
- Sponsor
- China Medical University, China
ctDNA, Chemotherapy
Randomized Study of Plasma ctDNA Methylation to Guide Adjuvant Chemotherapy Decisions in High-Risk T3N0 Colorectal Cancer
This study will utilize ctDNA methylation detection to evaluate patients with high-risk T3N0 stage II colorectal cancer who are ctDNA-positive one month after surgery.
- Conditions
- ctDNA, Chemotherapy, Colorectal Cancer
- Trial name
- CLEAR-02 (NCT07562711)
- Testing
- Capecitabine, FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin)
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Fudan University
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