Clinical trials: Cancer Colonic
Breast Cancer, Stage 0, Colorectal Cancer Stage I
Virtual Rehabilitation for Cancer Survivors
Pragmatic hybrid type 1 effectiveness-implementation (E-I) trial of a virtual cancer rehabilitation program: The study team will conduct a multi-center hybrid type I effectiveness-implementation study to examine the clinical…
- Conditions
- Breast Cancer, Stage 0, Colorectal Cancer Stage I, Head and Neck Cancer Stage I, Lymphoma
- Trial name
- NCT05898789
- Testing
- CaRE@Home intervention
- Where
- Canada
- Volunteers
- 388 people
- Sponsor
- University Health Network, Toronto
Colorectal Cancer
Effect of Stent Placement on Short Term Survival of Left Sided Obstructive Colorectal Cancers
The aim of this observational study is to determine effect of stent placement on survival results in first three years in a patient who applied to the emergency department with obstruction due to colorectal cancer.
- Trial name
- NCT06437691
- Testing
- Self-Expandable Metallic Stent Placement
- Volunteers
- 65 people
- Sponsor
- Yasir Musa Kesgin, MD
Cancer, Lung Cancer
tislelizUMaB in canceR Patients With molEcuLar residuaL Disease
Numerous studies have shown that even when imaging does not reveal the presence of cancer cells, traces of tumor DNA (i.e. originating from cancer cells) can be detected in the blood of certain patients: this is called molecular…
- Conditions
- Cancer, Lung Cancer, Colo-rectal Cancer, Pancreas Cancer
- Trial name
- UMBRELLA (NCT06332274)
- Testing
- Tislelizumab, Blood sampling
- Where
- France
- Volunteers
- 717 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Microsatellite Stable Metastatic Colorectal Cancer, Metastatic Colorectal Cancer
Immunotherapies in Combination With Stereotactic Body Radiation Radiotherapy in Microsatellite Stable (MSS) Metastatic Colorectal Cancer (mCRC)
Background: Metastatic colorectal cancer (mCRC) is cancer that has spread beyond the colon and rectum. Most people with mCRC die within 5 years. New immune-based treatments are making progress with some types of colon cancer.
- Conditions
- Microsatellite Stable Metastatic Colorectal Cancer, Metastatic Colorectal Cancer, Colorectal Cancer
- Trial name
- NCT06603818
- Testing
- Tiragolumab, Atezolizumab, Stereotactic Body Radiation Therapy (SBRT)
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer, Metastasis
Hepatic Artery Infusion With Oxaliplatin
Hepatic artery infusion (HAI) with oxaliplatin (OX), systemic 5 fluorouracil (5FU), and leucovorin (HAI/OX/FU) will be implemented using an interventional radiology technique to obviate the need for initial major surgery…
- Conditions
- Colorectal Cancer, Metastasis, Liver Cancer
- Trial name
- NCT00244348
- Testing
- Oxaliplatin (via HAI), 5 Fluorouracil (systemic)
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Colorectal Cancer Recurrent
Microbiome and Colorectal Cancer Recurrence
Anastomotic leak is associated with higher rates of tumor recurrence after colorectal cancer surgery. However, the mechanisms responsible remain unknown.
- Trial name
- NCT07057076
- Volunteers
- 51 people
- Sponsor
- Hospital del Mar
Colorectal Cancer
Study of CS-7017 in Colorectal Cancer Patients Who Have Achieved Disease Control Following First-Line Chemotherapy
Monotherapy treatment with CS-7017 to assess progression-free-survival (PFS) of subjects who achieved an objective response of Disease Control on first line therapy with Folinic acid (leucovorin), Fluorouracil (5-FU), Oxaliplatin…
- Trial name
- NCT00986440
- Testing
- CS-7017
- Where
- 39 sites in Czechia, France and 7 more
- Volunteers
- 84 people
- Sponsor
- Daiichi Sankyo
Advanced Colorectal Cancer, Metastatic Colorectal Cancer
Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)
Study CA239-0006 is an open-label, randomized Phase 3 clinical trial comparing the efficacy of MRTX849 administered in combination with cetuximab versus chemotherapy in the second-line treatment setting in patients with CRC with…
- Trial name
- NCT04793958
- Testing
- MRTX849, Cetuximab, mFOLFOX6 Regimen
- Where
- 419 sites in United States, Argentina and 30 more
- Volunteers
- 461 people
- Sponsor
- Mirati Therapeutics Inc.
Prostate Cancer Castration-resistant Prostate Cancer, Breast Cancer
Phase 1/2 Dose Finding, Safety and PK Study in Advanced Refractory Solid Tumors
This is a multicenter, open-label FIH, Phase 1a (dose escalation), Phase 1b (dose expansion) and Phase 2 study in patients with advanced metastatic solid tumors refractory to standard treatment.
- Conditions
- Prostate Cancer Castration-resistant Prostate Cancer, Breast Cancer, Colo-rectal Cancer, Lung Cancer (Non-Small Cell)
- Trial name
- NCT07145255
- Testing
- ADC
- Where
- 7 sites in United States
- Volunteers
- 150 people
- Sponsor
- MBrace Therapeutics
Metastatic Colorectal Cancer
Fruquintinib Sequential BEV+FOLFIRI vs. BEV+FOLFIRI Sequential Fruquintinib in Metastatic Colorectal Cancer
This is a prospective, open, multicenter, randomized controlled phase II study designed to observe the difference of efficacy, adverse events and quality of life between second-line and third-line application of Fruquintinib in…
- Trial name
- NCT05447715
- Testing
- Fruquintinib
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Weijian Guo
Rectal Cancer, Surgery
Impact of a Patient-Centered Program for Low Anterior Resection Syndrome a Multicenter Randomized Controlled Trial
After undergoing restorative proctectomy for rectal cancer, many patients are left with significant bowel dysfunction, known as Low Anterior Resection Syndrome (LARS).
- Conditions
- Rectal Cancer, Surgery, Patient Activation, Low Anterior Resection
- Trial name
- NCT03828318
- Testing
- Patient Activation Booklet and nursing support for patients with LARS
- Where
- 6 sites in United States, Canada
- Volunteers
- 160 people
- Sponsor
- Jewish General Hospital
Advanced Solid Tumors, Metastatic Colon Cancer
A Multi-Center, Open-Label Study of Fruquintinib in Solid Tumors and Colorectal, and Breast Cancers
An open-label, dose escalation and expansion clinical trial to evaluate the safety, tolerability, and PK of fruquintinib in patients with advanced solid tumors, metastatic colorectal cancer and metastatic breast cancer.
- Conditions
- Advanced Solid Tumors, Metastatic Colon Cancer, Metastatic Breast Cancer, Triple Negative Breast Cancer
- Trial name
- NCT03251378
- Testing
- Fruquintinib (HMPL-013)
- Where
- 9 sites in United States
- Volunteers
- 129 people
- Sponsor
- Hutchison Medipharma Limited
Adrenal Cortical Cancer, Brain Cancer
Spectroscopy With Surface Coils and Decoupling
The purpose of this study is to obtain chemical information from part of your body without a biopsy. This is done using a technique called magnetic resonance spectroscopy (MRS) which is similar to magnetic resonance imaging (MRI)…
- Conditions
- Adrenal Cortical Cancer, Brain Cancer, Breast Cancer, CNS Cancer
- Trial name
- NCT00581815
- Testing
- Proton-decoupled 31P MRS at 1.5T, 1H Spectroscopy at 1.5T and 3T
- Where
- United States
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colon Cancer, Splenic Flexure Mobilization
Surgical Outcomes in Splenic Flexure Cancers: A Multicenter Comparison of Segmental vs. Extended Hemicolectomy (SPARROW Study)
SPARROW Study: Surgical Outcomes in Splenic Flexure Cancer Colonic cancers located at the splenic flexure where the transverse colon turns into the descending colon are uncommon and represent less than 10% of all colorectal…
- Conditions
- Colon Cancer, Splenic Flexure Mobilization, Right Hemicolectomy, Left Hemicolectomy
- Trial name
- SPARROW (NCT07289568)
- Testing
- Colectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Acibadem University
Colorectal Cancer, Colon Adenoma
Cold Snare Polypectomy
During colonoscopy, the endoscopist will document prospectively all polyps detected and note the size, location and morphology. Polyps of 4-20 mm will be removed only in accordance with the method the cold snare.
- Trial name
- Cold-Snare (NCT03501849)
- Testing
- Polypectomy using a cold snare
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Metastatic Colorectal Cancer
A Study of ES104 in Patients With Metastatic Colorectal Cancer
The purpose of this open-label, Multicenter Phase I/II study is to evaluate the safety, tolerability, preliminary anti-tumor efficay, pharmacokinetics, anti-drug antibodies and biomarkers of ES104 in patients with unresectable…
- Trial name
- NCT05167448
- Testing
- ES104
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Elpiscience (Suzhou) Biopharma, Ltd.
Colorectal Cancer
Comparative Effectiveness of CTC & OC
The goal of this study is to compare the findings of virtual (CT-colonography) with findings of optical colonoscopies to determine if virtual colonoscopy is suitable for colorectal cancer surveillance.
- Trial name
- NCT02143115
- Testing
- Optical colonoscopy, CT-Colonography
- Where
- 5 sites in United States
- Volunteers
- 244 people
- Sponsor
- Fox Chase Cancer Center
Colorectal Cancer, Ovarian Cancer
An Audit of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Peritoneal carcinomatosis is a common event in the natural history of colorectal and other digestive tract cancers. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provides a promising…
- Conditions
- Colorectal Cancer, Ovarian Cancer, Peritoneal Disease
- Trial name
- NCT02754115
- Testing
- Hyperthermic intraperitoneal chemotherapy
- Where
- India
- Volunteers
- 400 people
- Sponsor
- Tata Memorial Centre
Right-sided Colon Cancer
RISE Ileocecal Valve Functional Reconstruction
The traditional surgical treatment for right-sided colon cancer involves the removal of an important structure, the ileocecal valve, which includes the ileocecal valve.
- Trial name
- NCT07167420
- Testing
- RISE (Revolute Insert Side-End ileocecal valve reconstruction)
- Volunteers
- 188 people
- Sponsor
- Army Medical University, China
Anatomic Stage IV Breast Cancer AJCC v8, Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors
This phase II trial studies the effect of avapritinib in treating malignant solid tumors that have a genetic change (mutation) in CKIT or PDGFRA and have spread to nearby tissue or lymph nodes (locally advanced) or other places…
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8, Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8, Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8
- Trial name
- NCT04771520
- Testing
- Avapritinib
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
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