Clinical trials: Cancer Esophagus
Esophageal Cancer
Study of TNFerade™ Gene Therapy, Radiation, 5-FU and Cisplatin in Esophageal Cancer
The primary purpose of this study is to assess the safety and feasibility of giving TNFerade™ with 5-FU, Cisplatin and radiation therapy to patients with locally advanced, esophageal cancer prior to surgical resection.
- Trial name
- NCT00051480
- Testing
- TNFerade
- Where
- 12 sites in United States
- Sponsor
- GenVec
Esophageal Cancer
Esophagectomy in Middle and Lower Thoracic Esophageal Cancer Patients Through Left Versus Right Transthoracic Approach
Esophageal carcinoma is an aggressive malignant disease with poor prognosis. Surgical resection remains the most effective method for this malignancy.
- Trial name
- NCT02448979
- Testing
- Left thoracotomy, Right thoracotomy
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Chinese Academy of Medical Sciences
Esophageal Cancer, Advanced Solid Tumor
Pharmacokinetics Study of Larotinib in Subjects With Impaired Hepatic Function
To evaluate the pharmacokinetics and safety of Larotinib in subjects with mild and moderate hepatic function impairment and healthy subjects in a single-center, non-randomized, open, single-dose administration
- Trial name
- NCT05048368
- Testing
- Larotinib
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Esophageal Squamous Cell Carcinoma
PPIO-004 Clinical Application of Efficacy Prediction Model Based on Epigenomics Sequencing Technology in Neoadjuvant Immunotherapy for Esophageal Cancer
The goal of this observational study is to learn about in potential operable esophageal cancer patients (cT1-2N + M0 and cT3NanyM0) receiving neoadjuvant therapy.
- Trial name
- PPIO-004-EC001 (NCT05880082)
- Testing
- Tislelizumab
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Carcinoma, Squamous Cell, Adenocarcinoma of the Esophagus and Gastric Cardia
Neoadjuvant Chemotherapy Versus Radiochemotherapy for Cancer of the Esophagus or Cardia
The purpose of this randomized study is to clarify if neoadjuvant radiochemotherapy gives a higher degree of complete histological response than neoadjuvant chemotherapy before surgery in patients undergoing treatment for cancer…
- Trial name
- NeoRes (NCT01362127)
- Testing
- Chemotherapy, Radiochemotherapy
- Where
- Sweden
- Volunteers
- 181 people
- Sponsor
- Karolinska University Hospital
GERD, Barrett Esophagus
The Evaluation of Patients With Esophageal and Foregut Disorders With WATS (Wide Area Transepithelial Sample With 3-Dimensional Computer-Assisted Analysis) vs. 4-Quadrant Forceps Biopsy
Patients scheduled to undergo routine upper endoscopy for foregut or esophageal symptoms or undergoing surveillance for Barrett's esophagus with no dysplasia or low-grade dysplasia are candidates for participation, but patients…
- Conditions
- GERD, Barrett Esophagus, Low Grade Esophageal Glandular Dysplasia, Esophageal Diseases
- Trial name
- NCT03859557
- Where
- United States
- Volunteers
- 1,032 people
- Sponsor
- CDx Diagnostics
Esophageal Cancer
Oxaliplatin and Fluorouracil Plus Radiation Therapy in Treating Patients With Primary Esophageal or Stomach Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00004257
- Testing
- fluorouracil, oxaliplatin, conventional surgery
- Where
- United States
- Sponsor
- Albany Medical College
Stage IIB Esophageal Cancer AJCC v7, Stage III Esophageal Cancer AJCC v7
Ferumoxytol-Enhanced MRI in Imaging Lymph Nodes in Patients With Stage IIB-IIIC Esophageal Cancer
This pilot clinical trial studies how well ferumoxytol-enhanced magnetic resonance imaging (MRI) works in imaging lymph nodes in patients with stage IIB-IIIC esophageal cancer.
- Conditions
- Stage IIB Esophageal Cancer AJCC v7, Stage III Esophageal Cancer AJCC v7, Stage IIIA Esophageal Cancer AJCC v7, Stage IIIB Esophageal Cancer AJCC v7
- Trial name
- NCT02857218
- Testing
- Ferumoxytol, Magnetic Resonance Imaging
- Sponsor
- OHSU Knight Cancer Institute
Esophagus Cancer, Esophageal Cancer
Proton Beam Therapy in the Treatment of Esophageal Cancer
The investigators plan to include both operable and inoperable patients with esophagus cancer in this prospective trial. Since both proton and photon treatments are biologically equivalent, the investigators do not expect a…
- Conditions
- Esophagus Cancer, Esophageal Cancer, Cancer of the Esophagus
- Trial name
- NCT03482791
- Testing
- Proton beam therapy, Patient-Reported Outcome Measures
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Washington University School of Medicine
Oral and Esophageal Cancer, Metabolic Syndrome.
The Association Between Areca-nut Chewing Habit and Metabolic Syndrome
The purpose of this study is going to determine the odds ratio of metabolic syndrome (MS), the habit of areca nut chewing, antioxidant, and inflammatory status in oral and esophageal patients.
- Trial name
- NCT02175524
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taichung Veterans General Hospital
Epiphora Due to Insufficient Drainage, Left Side, Epiphora Due to Insufficient Drainage, Right Side
Minimally Invasive Intrathoracic Esophagogastric Side to Side Anastomosis vs. End to Side Anastomosis
On the basis of minimally invasive Ivor Lewis operation for the treatment of lower thoracic esophageal cancer or esophageal gastric junction cancer, the purpose of this study is to compare the probability of anastomotic leakage…
- Trial name
- NCT05812495
- Testing
- Esophagogastric Side to Side Anastomosis, Esophagogastric End to Side Anastomosis
- Where
- China
- Volunteers
- 402 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Barrett's Mucosa With High Grade Intraepithelial Neoplasia (HGIEN)
Confocal Laser Endomicroscopy and Endoscopic Mucosal Resection
The accurate detection and therapy of adenocarcinoma originating from Barrett's oesophagus is challenging as current endoscopic techniques are unreliable for both the detection of high grade intraepithelial neoplasia (HGIN)…
- Trial name
- NCT01124994
- Testing
- Endoscopic mucosal resection
- Where
- Austria
- Volunteers
- 38 people
- Sponsor
- Medical University of Vienna
Barrett Esophagus
Coordinating Center: Natural History of Barrett's Esophagus Using Tethered Capsule Endomicroscopy
The goal of this research is to follow Barrett's Esophagus participants for 3 years using the tethered capsule endomicroscopy device with distal scanning and a compact imaging system in a multi-site clinical study.
- Trial name
- NCT03459339
- Testing
- Tethered Capsule Endomicroscopy (TCE)
- Where
- 5 sites in United States
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
Esophageal Cancer
DCE-MRI Based on 4D Free Breathing for Predicting Preoperative Neoadjuvant Chemoradiotherapy for Esophageal Cancer
To prospectively collect medical images and clinical data related to esophageal cancer using 4D Free Breathing DCE-MRI technology, to evaluate the image quality in the diagnosis of esophageal cancer, and to predict the efficacy…
- Trial name
- NCT06755866
- Testing
- The application value of MRI 4D Free Breathing DCE-MRI in the treatment of esophageal cancer
- Where
- China
- Volunteers
- 135 people
- Sponsor
- Yunnan Cancer Hospital
Rectal Cancer, Head and Neck Cancer
Feasibility of Online MR-guided Radiotherapy on a 1.5T MR-Linac
This study investigates the feasibility of imaging and treatment on a novel 1.5 T MR-Linac radiotherapy hybrid device.
- Conditions
- Rectal Cancer, Head and Neck Cancer, Liver Cancer, Breast Cancer
- Trial name
- NCT04172753
- Testing
- Radiotherapy on the MR-Linac, Imaging on the MR Linac
- Where
- Germany
- Volunteers
- 472 people
- Sponsor
- University Hospital Tuebingen
Esophageal Cancer, Neoplasms, Esophageal
Trial of XELOX Followed by Radiation Combined With Carboplatin and RAD001 for Esophageal Cancer
The purpose of this study is to test the drug RAD001 in combination with another chemotherapy drug, Carboplatin, as well as radiation therapy in the treatment of esophageal cancer.
- Trial name
- NCT01490749
- Testing
- RAD001, XELOX, Carboplatin
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- Emory University
Barrett Esophagus, Barrett Metaplasia
Aceto-whitening in the Assessment of Gastrointestinal Neoplasia
Acetic acid chromoendoscopy is an established standard technique used to detect dysplasia within the gastrointestinal tract. Acetic acid spray helps to identify neoplasia by highlighting the surface pattern, highlighting the…
- Conditions
- Barrett Esophagus, Barrett Metaplasia, Barrett Oesophagitis With Dysplasia, Barrett Adenocarcinoma
- Trial name
- NCT01618643
- Testing
- Acetic acid chromoendoscopy
- Where
- United Kingdom
- Volunteers
- 197 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Esophageal Cancer
Study of Apatinib in Metastatic Esophageal Cancer
The purpose of this study is to assess the efficacy and safety of apatinib in Metastatic Esophageal Cancer.
- Trial name
- NCT02683655
- Testing
- Apatinib
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Huai'an First People's Hospital
Cancer
A Study of Docetaxel in Combination With Capecitabine in Stomach and Esophagus Cancers
This is a phase II study that will investigate weekly dosing of docetaxel in combination with capecitabine in advanced gastric and gastro-esophageal adenocarcinomas.
- Trial name
- NCT00177255
- Testing
- Docetaxel, Capecitabine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pittsburgh
Esophageal Cancer, Metastatic Disease
The Role of Surgery for Esophageal Cancer With Metastatic Disease (M1)
Treatment of stage IV esophageal cancer is traditionally palliative, but treatment response is usually poor. The role of surgery in the treatment of advanced esophageal cancer remains controversial.
- Trial name
- NCT06424210
- Where
- Taiwan
- Volunteers
- 163 people
- Sponsor
- National Taiwan University Hospital
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