Clinical trials: Cancer Esophagus
Esophageal Carcinoma
Botulinum Toxin Type A in Preventing Complications After Surgery in Patients With Esophageal Cancer
This randomized phase II trial studies how well botulinum toxin type A works in preventing complication after surgery in patients with esophageal cancer.
- Trial name
- NCT02965976
- Testing
- Botulinum Toxin Type A, Esophagectomy, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Roswell Park Cancer Institute
Gastric Adenocarcinoma, Esophageal Adenocarcinoma
Pilot Study of Perioperative Docetaxel, Oxaliplatin, and 5-Fluorouracil (FLOT) in Gastroesophageal Adenocarcinoma
Gastric or gastroesophageal junction adenocarcinoma is commonly treated with chemotherapy before and after surgery. The chemotherapy regimen used in our institution, called DCF (docetaxel,cisplatic, 5-fluorouracil) is active…
- Trial name
- NCT01932580
- Testing
- FLOT (5-fluorouracil, oxaliplatin, docetaxel)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McGill University
Irresectable Squamous Cell or Adenocarcinoma of the Oesophagus
Radio-chemotherapy With or Without Panitumumab (Vectibix®) in Irresectable Squamous Cell Carcinoma or Adenocarcinoma of the Oesophagus
For esophageal cancer that can not be removed by surgery, the choice of treatment is a combination of chemotherapy and radiotherapy. We call this combination- (or concurrent) chemoradiotherapy.
- Trial name
- PANORAMIC (NCT01262183)
- Testing
- CRT + Panitumumab, Concurrent chemoradiation therapy without panitumumab
- Where
- Netherlands
- Volunteers
- 4 people
- Sponsor
- Radboud University Medical Center
Esophageal Cancer, Gastric Cancer
Vinorelbine in Unresectable or Metastatic Esophageal and Gastric Adenocarcinoma
The purpose of this study is to collect anti-tumor activity of vinorelbine when given to patients with esophageal or gastric tumors. We will also collect information on the toxicities of vinorelbine in these patients.
- Conditions
- Esophageal Cancer, Gastric Cancer, Stomach Cancer
- Trial name
- NCT00215462
- Testing
- Vinorelbine
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Dana-Farber Cancer Institute
HER2-expressing Gastrointestinal Cancers, Including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer, and Colorectal Cancer
A Safety and Efficacy Study of ZW25 (Zanidatamab) Plus Combination Chemotherapy in HER2-expressing Gastrointestinal Cancers, Including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer, and Colorectal Cancer
This is a multicenter, global, Phase 2, open-label, 2-part, first-line study to investigate the safety, tolerability, and anti-tumor activity of ZW25 (zanidatamab) plus standard first-line combination chemotherapy regimens for…
- Trial name
- NCT03929666
- Testing
- ZW25 (Zanidatamab), Capecitabine, Cisplatin
- Where
- 23 sites in United States, Canada and 2 more
- Volunteers
- 74 people
- Sponsor
- Jazz Pharmaceuticals
Carcinoma, Squamous Cell, Oesophageal Cancer
TGF-β And PDL-1 Inhibition in Esophageal Squamous Cell Carcinoma Combined With Chemoradiation TheRapY
The primary objective of this study is to assess the feasibility of treatment with bintrafusp alfa combined with definitive chemoradiation (carboplatin, paclitaxel and radiation) in patients with squamous cell carcinoma of the…
- Trial name
- TAPESTRY (NCT04481256)
- Testing
- External beam radiotherapy, Bintrafusp alfa, Paclitaxel
- Where
- Netherlands
- Volunteers
- 49 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Esophageal Cancer
A PILOT STUDY OF DIFFUSION WEIGHTED MRI TO ASSESS ESOPHAGEAL TUMOR RESONSE TO NEOADJUVANT CHEMORADIATION
The purpose of this research study will be to determine the sensitivity and specificity of dwMRI metrics to assess tumor response following neoadjuvant chemoradiation in esophageal cancer.
- Trial name
- NCT03151642
- Testing
- Chemotherapy, Radiation Therapy, Surgery
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Lung, Prostate, Breast, Colon, Pancreatic, Renal, Bladder,Thyroid, Ovarian, Head and Neck,GI (Foregut - Esophagus),GI (Midgut) Cancer, Cancer of the Ovarian, Head and Neck,GI (Foregut - Esophagus),GI (Midgut), Sarcoma Cancer
Optional Sub-study to Intraoperative Imaging With ICG Registry
The primary goal of this optional sub-study is to record what tissues fluoresce in the operating room, and then to identify if these lesions are cancer when the histopathology is performed.
- Conditions
- Lung, Prostate, Breast, Colon, Pancreatic, Renal, Bladder,Thyroid, Ovarian, Head and Neck,GI (Foregut - Esophagus),GI (Midgut) Cancer, Cancer of the Ovarian, Head and Neck,GI (Foregut - Esophagus),GI (Midgut), Sarcoma Cancer, Cancer of Neuro-onc, Parathyroid, Desmoid Tumors, Melanoma Cancer
- Trial name
- NCT02651246
- Testing
- data collection
- Where
- United States
- Volunteers
- 291 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Neoplasms
Induction Chemotherapy Followed by Chemoradiotherapy in Esophageal Cancer
The contribution of induction chemotherapy before definitive chemoradiotherapy is unknown. The purpose of this study was to compare the efficacy and toxicity of induction chemotherapy followed by definitive chemoradiotherapy…
- Trial name
- NCT02403531
- Testing
- Docetaxel, Cisplatin, Radiotherapy
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Mian XI
Esophageal Cancer
QL1706 Plus Chemotherapy for Borderline Resectable Esophageal Cancer
China bears a disproportionately high burden of esophageal cancer, accounting for approximately 50% of newly diagnosed cases worldwide, with an average 5-year survival rate of only 30%.
- Trial name
- BRICES (NCT07283991)
- Testing
- chemotherapy combined with Aparolitolovureli immunotherapy
- Volunteers
- 24 people
- Sponsor
- Ruijin Hospital
Esophageal Cancer
Palliative Radiotherapy and Brachytherapy for Oesophageal Cancer Dysphagia
Hypothesis: In the management of advanced oesophageal cancer, to determine if a shorter regime of external beam radiotherapy (using higher daily doses, and combined with intraluminal high dose rate brachytherapy) is not inferior…
- Trial name
- NCT00665197
- Testing
- Protracted Course Radiotherapy, Short Course Radiotherapy
- Where
- 7 sites in Canada, China and 5 more
- Volunteers
- 200 people
- Sponsor
- International Atomic Energy Agency
Barrett's Esophagus, Intestinal Dysplasia
Endoscopic Sub-mucosal Dissection With the Nestis® Jet Injector System With a Bi-functional Catheter: First Prospective Trial
ESD (Endoscopic Sub-mucosal Dissection)is the first-intent method to treat superficial neoplasms of the digestive tract at it allows an en-bloc R0 resection.
- Conditions
- Barrett's Esophagus, Intestinal Dysplasia, Esophageal Dysplasia, Colorectal Neoplasms
- Trial name
- NESTIS (NCT01913223)
- Testing
- Nestis® jet injector system with a bi-functional catheter
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Hospices Civils de Lyon
Esophagus Cancer, Adenocarcinoma
Preoperative Marking of the Oral Resection Margin in Esophageal Cancer With a Surgical Fiducial Marker - First Experiences
This study aims to evaluate if BioXmark™, a surgical marker, may efficiently and safely be used to preoperatively mark the proximal and distal resection line 5 cm proximal and distal to the tumor margin of…
- Trial name
- NCT05069766
- Testing
- BioXmark™
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Anemia, Multiple Myeloma
The Effect of Epoetin Alfa on the Anemia of Patients With Selected Cancers Receiving Chemotherapy
The purpose of this study is to evaluate the safety and effectiveness of epoetin alfa versus placebo in reducing or preventing the need for transfusions in anemic patients with cancer receiving chemotherapy, and to investigate…
- Conditions
- Anemia, Multiple Myeloma, Lymphoma, Breast Cancer
- Trial name
- NCT00270166
- Testing
- epoetin alfa
- Volunteers
- 201 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Esophageal Neoplasms
PET-CT Based Radiotherapy in Esophageal Cancer Patients
The purpose of this study is to determine the locoregional control in PET/CT based radiotherapy treatment planning in the treatment of esophageal cancer patients.
- Trial name
- NCT01156831
- Where
- 5 sites in Netherlands
- Volunteers
- 115 people
- Sponsor
- Maastricht Radiation Oncology
Esophageal Cancer (EC)
A Phase II Study of Anlotinib + PD-1 Inhibitor vs. PD-1 Inhibitor Maintenance After First-Line Chemoimmunotherapy in Advanced ESCC (Esophageal Squamous Cell Carcinoma)
Chemotherapy combined with PD-1 inhibitor immunotherapy is the standard treatment for advanced esophageal squamous cell carcinoma (ESCC), yet patient prognosis remains unsatisfactory, with a median PFS of only about 6 months and…
- Trial name
- NCT07863141
- Testing
- anlotinib + PD-1 inhibitor, PD-1 inhibitor
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Sun Yat-sen University
Oesophageal Cancer
Esophageal Self-expandable Metal Stent for Malignant Strictures: a Safety and Efficacy Study
A single center prospective observational non-randomized clinical study to assess the safety and efficacy of placement of a new esophageal self-expandable metal stent (SEMS) for palliation of patients with malignant dysphagia.
- Trial name
- ENTRANCE (NCT06364553)
- Testing
- Esophageal self-expandable metal stent
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Erasmus Medical Center
Anemia, Esophageal Cancer
Iron Replacement in Oesophagogastric Neoplasia
40 eligible patients with confirmed esophageal or gastric adenocarcinoma and anemia will be randomized to a control or intervention group for management of this anemia.
- Conditions
- Anemia, Esophageal Cancer, Gastric Cancer
- Trial name
- IRON (NCT01927328)
- Testing
- Iron isomaltoside 1000
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Esophagus Cancer, Chemoradiotherapy
Study of PD-1 Antibody Combined With Chemoradiotherapy in Oligometastatic Esophageal Cancer
Chemoradiotherapy（CRT） is the main treatment for esophageal cancer patients with recurrent desease，and checkpoint blockade (PD-1) have been shown to be effective in advanced esophageal cancer.
- Conditions
- Esophagus Cancer, Chemoradiotherapy, Oligometastatic Disease, Immunotherapy
- Trial name
- NCT04821765
- Testing
- PD-1 antibody, Chemoradiation, Albumin-Bound Paclitaxel
- Where
- 2 sites in China
- Volunteers
- 35 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Esophageal Cancer, Chemoradiation
Phase II Study of Neo-adjuvant Chemoradiotherapy for Squamous Cell Esophageal Cancer
The investigators designed a new preoperative chemoradiotherapy regimen to focus on the most important radiation area and hope to reduce the radiation volume and try to reduce the postoperative mortality and treatment-related…
- Conditions
- Esophageal Cancer, Chemoradiation, Surgery
- Trial name
- NCT02938195
- Testing
- radiotherapy, Surgery
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Chest Hospital
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