Clinical trials: Cancer Esophagus
Post-operative Pneumonia, Lung Cancer
Prevention of Post-operative Pneumonia (POPP)
Postoperative pneumonia is a major complication in patients undergoing thoracic surgery. It leads to considerable morbidity and contributes to perioperative morbidity.
- Conditions
- Post-operative Pneumonia, Lung Cancer, Esophageal Cancer
- Trial name
- POPP (NCT01446874)
- Testing
- 0.12% chlorhexidine solution
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Washington University School of Medicine
Non-Small Cell Lung Cancer, Malignant Melanoma
Phase Ib of L-NMMA and Pembrolizumab
The purpose of this Phase Ib study is to test the safety of NG-monomethyl-L-arginine (L-NMMA) and pembrolizumab when used together in participants with melanoma, non-small cell lung cancer (NSCLC), head and neck squamous cell…
- Conditions
- Non-Small Cell Lung Cancer, Malignant Melanoma, Head and Neck Squamous Cell Carcinoma, Classical Hodgkin Lymphoma
- Trial name
- NCT03236935
- Testing
- L-NMMA, Pembrolizumab
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The Methodist Hospital Research Institute
Esophageal Cancer
Cetuximab and Radiation Therapy for Surgically Resectable Esophageal and Gastroesophageal (GE) Junction Carcinomas
The interaction of epidermal growth factor receptor (EGFR) inhibitory agents such as cetuximab combined with radiation shows promising results.
- Trial name
- NCT00319735
- Testing
- Radiation Therapy, Surgery, Tissue Sample
- Where
- 7 sites in United States
- Volunteers
- 41 people
- Sponsor
- Nasser Hanna, M.D.
Gastric-Esophageal Cancer
Signatera-Guided De-escalation of Adjuvant Therapy in Resectable Stage II-IVa Gastric/Gastric-Esophageal Cancer
The goal of this clinical trial is to assess if circulating tumor DNA, as assessed by Signatera tumor-informed MRD assay, can guide de-escalation of adjuvant therapy in patients with resectable Stage II-IVa…
- Trial name
- SIGNAL GEC-101 (NCT07565857)
- Testing
- Signatera Genome ultra-sensitive ctDNA blood test
- Volunteers
- 1,000 people
- Sponsor
- Natera, Inc.
Cancer of Esophagus
Impedance Spectroscopy in Esophageal Cancer
Detection of early esophageal cancer in surrounding normal tissue can be challenging even for experienced examiners. The early detection is essential to determine the following treatment.
- Trial name
- NCT04046601
- Testing
- impedance
- Where
- Germany
- Volunteers
- 67 people
- Sponsor
- Sana Klinikum Offenbach
Advanced Solid Tumor, Esophageal Cancer
A Study of PRT3789 in Combination With Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors With a SMARCA4 Mutation
This is a Phase 2 an open-label, multi-center study to determine the safety, tolerability, efficacy, pharmacokinetics, pharmacodynamics, and anti-tumor activity of PRT3789 in combination with pembrolizumab in patients with…
- Conditions
- Advanced Solid Tumor, Esophageal Cancer, Metastatic Solid Tumor, Non-small Cell Lung Cancers
- Trial name
- NCT06682806
- Testing
- PRT3789, pembrolizumab
- Where
- 9 sites in United States, Spain
- Volunteers
- 6 people
- Sponsor
- Prelude Therapeutics Incorporated
Cancer of Esophagus, Cancer of the Esophagus
Study of Inspiratory Muscle Training for Patients Undergoing Esophageal Surgery
To obtain definitive evidence for the effectiveness of a short preoperative inspiratory muscle training (IMT) protocol on the morbidity and recovery from an esophageal surgical resection.
- Conditions
- Cancer of Esophagus, Cancer of the Esophagus, Esophageal Cancer, Esophagus Cancer
- Trial name
- NCT02843750
- Testing
- Inspiratory Muscle Training-Rehabilitation, Questionnaires
- Where
- United States
- Sponsor
- Mayo Clinic
Esophageal Cancer, Gastric Cancer (Diagnosis)
Exercise Training After Upper Gastrointestinal Cancer Surgery
This randomized controlled trial aims to determine the optimal exercise intensity for improving postoperative recovery in patients with upper gastrointestinal cancer.
- Conditions
- Esophageal Cancer, Gastric Cancer (Diagnosis), Upper Gastrointestinal Cancer
- Trial name
- NCT07561840
- Testing
- High-Intensity Interval Training (HIIT), Low-Intensity Continuous Training (LICT)
- Where
- 2 sites in Japan
- Volunteers
- 171 people
- Sponsor
- Kansai Medical University
Esophageal Cancer
a Multicentric Randomized Controlled Trial of Self-Expandable Esophageal Radiation Stent
Esophageal cancer is common in some areas , ranking as the fourth leading cause of death from cancer in China and sixth worldwide.
- Trial name
- NCT01054274
- Testing
- novel stent, conventional covered stent
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Southeast University, China
Gastric Cancer, Gastrointestinal Cancer
Neratinib and Fam-Trastuzumab Deruxtecan in Advanced Gastro-esophageal Cancer Patients
This is Phase 1 dose finding trial with potential dose expansion to evaluate the safety, toxicity, recommended phase 2 dose (RP2D), and maximum tolerated dose (MTD) of Neratinib plus TDxD using a standard 3+3 dose escalation…
- Conditions
- Gastric Cancer, Gastrointestinal Cancer, HER2 Gene Mutation
- Trial name
- NCT05274048
- Testing
- Neratinib Pill, Fam-Trastuzumab Deruxtecan-Nxki (TDxD)
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Fox Chase Cancer Center
Esophageal Carcinoma
Induction Chemotherapy for Locally Advanced Esophageal Cancer
Evaluate mFOLFOX6 (5-Fluorouracil, Leucovorin and Oxaliplatin) chemotherapy as induction treatment prior to standard neoadjuvant chemoradiation to decrease the rate of distant recurrence among patients with locally advanced…
- Trial name
- NCT03110926
- Testing
- mFOLFOX6, Chemoradiation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Rochester
Metastatic Solid Tumor, Recurrent Solid Tumor
A Study of LY4101174 in Participants With Recurrent, Advanced or Metastatic Solid Tumors
The purpose of this study is to find out whether the study drug, LY4101174, is safe, tolerable and effective in participants with select advanced or metastatic solid tumors.
- Conditions
- Metastatic Solid Tumor, Recurrent Solid Tumor, Advanced Solid Tumor, Urinary Bladder Neoplasm
- Trial name
- EXCEED (NCT06238479)
- Testing
- LY4101174
- Where
- 28 sites in United States, Australia and 5 more
- Volunteers
- 490 people
- Sponsor
- Eli Lilly and Company
Colorectal Cancer, Esophageal Cancer
Nutritional Status and Nutrient Supply in Hospitalised Surgical Patients
Prospective single arm, single center observational study to assess the nutritional status and the nutrient supply during hospitalization for elective gastrointestinal surgery.
- Conditions
- Colorectal Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT03787537
- Where
- Germany
- Volunteers
- 128 people
- Sponsor
- Charite University, Berlin, Germany
Esophageal Cancer
High-dose Intensity Modulated Radiotherapy and Concurrent Chemotherapy in Esophageal Cancer
To assess the efficacy and feasibility of high-dose intensity-modulated radiotherapy with concurrent weekly paclitaxel and cisplatin for patients with locoregionally advanced esophageal cancer
- Trial name
- NCT03535207
- Testing
- high dose chemoradiotherapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Cachexia, Oesophageal Cancer
REVOLUTION Surgery (REVOLUTION Surgery)
Some people with cancer suffer from muscle wasting, lose weight and feel tired. This process, termed cachexia, is a significant problem and can lead to a reduction in both quality and quantity of life.
- Conditions
- Cachexia, Oesophageal Cancer, Gastric Cancer, Pancreatic Cancer
- Trial name
- NCT05642819
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Edinburgh
Hypoxemia, Esophageal Cancer
High-flow Nasal Cannula Oxygenation in Sedated Endoscopy for High-risk Obstructive Sleep Apnea Patients
Hypoxia is the most common adverse event during propofol sedation for gastrointestinal endoscopy. The STOP-BANG questionnaire is a widely used, simple assessment tool for screening obstructive sleep apnea (OSA) risk.
- Conditions
- Hypoxemia, Esophageal Cancer, Gastric Cancer (Diagnosis), Colon Cancer
- Trial name
- NCT07155330
- Testing
- High-flow nasal cannula
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhejiang University
Esophageal Cancer, Squamous Cell Carcinoma
Low-Dose Nedaplatin (CDGP:Cis-Diammine-Glycolatoplatinum)/5-FU Combined With Radiation for Esophageal Cancer
The purpose of this study is to clarify efficacy and toxicity of daily low-dose Nedaplatin (CDGP) and continuous infusion of 5-FU combined with radiation in patients with esophageal squamous cell carcinoma.
- Trial name
- NCT00197444
- Testing
- CDGP/5-FU combined with radiation, Radiotherapy
- Where
- Japan
- Volunteers
- 33 people
- Sponsor
- Hamamatsu University
Esophageal Cancer
Celecoxib, Paclitaxel, and Carboplatin in Treating Patients With Cancer of the Esophagus
RATIONALE: Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00066716
- Testing
- carboplatin, celecoxib, paclitaxel
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Weill Medical College of Cornell University
Bladder Cancer, Brain and Central Nervous System Tumors
Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors
RATIONALE: Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Bladder Cancer, Brain and Central Nervous System Tumors, Breast Cancer, Esophageal Cancer
- Trial name
- NCT00313599
- Testing
- lapatinib, paclitaxel
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, San Francisco
Esophageal Cancer, Gastroesophageal Cancer
Oxaliplatin-Based Chemotherapy and Chemoradiotherapy or Chemoradiotherapy in Esophageal or Gastroesophageal Carcinoma
The goal of this clinical research study is to learn if a combination of the investigational drug oxaliplatin with 5-Fluorouracil (5-FU) (given at the same time as radiation therapy) is as effective as a combination of these two…
- Trial name
- NCT00525915
- Testing
- 5-Fluorouracil, Oxaliplatin, Radiation Therapy
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- M.D. Anderson Cancer Center
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