Clinical trials: Cancer Patient
Healthy Volunteers, Breast Cancer
Study to Evaluate the Safety, Biodistribution, Radiation Dosimetry and Tumor Imaging Potential of [131I]-SGMIB Anti-HER2 VHH1 in Healthy Volunteers and Breast Cancer Patients
Primary purpose of the clinical study is to evaluate the safety, biodistribution and radiation dosimetry of [131I]-SGMIB Anti-HER2 VHH1 in healthy volunteers and patients with HER2+ breast cancer.
- Trial name
- CAM-VHH1 (NCT02683083)
- Testing
- [131I]-SGMIB Anti-HER2 VHH1
- Where
- Belgium
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Precirix
Malignant Digestive System Neoplasm, Malignant Female Reproductive System Neoplasm
Surgical Thromboprophylaxis Practices in Oncology Patients Within the NCORP Network, STOP-VTE Study
This study evaluates the use of extended venous thromboembolism prophylaxis (ePPx) following abdominopelvic cancer surgery within the NCI Community Oncology Research Program (NCORP) network, targeting surgeons and surgical…
- Conditions
- Malignant Digestive System Neoplasm, Malignant Female Reproductive System Neoplasm, Malignant Genitourinary System Neoplasm
- Trial name
- STOP-VTE (NCT07215624)
- Testing
- Non-Interventional Study
- Where
- 104 sites in United States, Puerto Rico
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Myelodysplastic Syndromes, Acute Myeloid Leukemia
Constitution of a Biological Cohort Following Bone Marrow Sampling From MDS or AML Patients and Age-matched Healthy Donors
It is of clinical significance to better characterize the intrinsic defects harbored by mesenchymal stromal cells (MSC) in Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) context, as compared to physiological…
- Conditions
- Myelodysplastic Syndromes, Acute Myeloid Leukemia, Cardio-vascular Surgery
- Trial name
- COSMOS (NCT03233074)
- Testing
- Bone marrow analyses
- Where
- 2 sites in France
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cancer
Laboratory Assay in Determining Cancer Resistance in Patients With Metastatic Cancer and in Healthy Participants
RATIONALE: Studying samples of blood and tissue in the laboratory from patients with cancer and from healthy participants may help doctors learn more about cancer.
- Trial name
- NCT00899496
- Testing
- immunological diagnostic method, physiologic testing
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Covid19, Cancer
Evaluation of the Effect and Side Effect Profile of Covid-19 Vaccine in Cancer Patients
The aim of the study is to evaluate the effects and side effects of inactive COVID-19 vaccine in patients with cancer and compare them with the healthy control group.
- Trial name
- NCT04771559
- Testing
- COVID-19 antibody test
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Colorectal Cancer, Health Status Unknown
Blood and Tissue Sample Collection for Future Colon Cancer Biomarker Studies in Patients Undergoing Colonoscopy
RATIONALE: Collecting and storing samples of blood and tissue from patients undergoing colonoscopy to study in the laboratory may help doctors learn more about colon cancer and identify biomarkers related to colon cancer in the…
- Trial name
- NCT00897403
- Testing
- biologic sample preservation procedure, diagnostic colonoscopy
- Where
- 4 sites in United States
- Volunteers
- 6,446 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Prostatic Neoplasms
Shared Decision Making for Prostate Cancer Screening: a Practice-Based Randomized Controlled Trial
The purpose of this study is to determine whether an intervention designed to help men share decisions about prostate cancer screening with their physician results in better decision making, more shared decisions, and changes in…
- Trial name
- NCT00630188
- Testing
- You Decide, Reducing Your Risks in the Crash
- Where
- 4 sites in United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of North Carolina
Breast Cancer
Decision Aids for Tamoxifen Treatment in Breast Cancer Patients
This is an educational intervention study for breast cancer patients who undergo tamoxifen treatment. The purpose of the study is to assess the impact of decision aids (DA) on the patients' decision-making process, compliance on…
- Trial name
- NCT02488603
- Testing
- Decision aids (tamoxifen-related educational materials in brochure or mobile app), tamoxifen
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Lung Cancer, Nonsmall Cell
[18F]F-AraG/Total Body PET Imaging and Healthy Subjects and Lung Cancer Patients
In this pilot study, healthy volunteers and patients with Non-Small Cell Lung Cancer will undergo [18F]F-AraG dynamic imaging on the uEXPLORER total body Positron Emission Tomography/Computerized Tomography scanner to obtain…
- Trial name
- NCT04678440
- Testing
- [18F]F-AraG Imaging
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Hematopoietic Cell Transplantation Recipient, Recurrent Diffuse Large B-Cell Lymphoma
Venetoclax, Carmustine, Etoposide, Cytarabine, and Melphalan Before Stem Cell Transplant in Treating Participants With Relapsed or Refractory Non-Hodgkin Lymphoma
This phase I/II trial studies the side effects and best dose of venetoclax when given together with carmustine, etoposide, cytarabine, and melphalan before stem cell transplant in treating participants with non-Hodgkin lymphoma…
- Conditions
- Hematopoietic Cell Transplantation Recipient, Recurrent Diffuse Large B-Cell Lymphoma, Recurrent Grade 1 Follicular Lymphoma, Recurrent Grade 2 Follicular Lymphoma
- Trial name
- NCT03583424
- Testing
- Carmustine, Cytarabine, Etoposide
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Distress, Anxiety
Mobilized Psychoeducation and Skills Based Intervention (Pep-Pal) for Caregivers of Patients With Advanced Illness
The proposed project is a pilot study of the Pep-Pal (Psychoeducation and Skills Based Intervention) versus a treatment as usual control group.
- Conditions
- Distress, Anxiety, Depression
- Trial name
- NCT03002896
- Testing
- Pep-Pal, Treatment as Usual
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Critical Illness, Chronic Obstructive Lung Disease
Advance Care Planning Evaluation in Hospitalized Elderly Patients
The purpose of the study is to inform decision-makers of the best strategies to implement advanced care planning (ACP). An advanced care plan (ACP) is a verbal or written instruction describing what kind of care an individual…
- Conditions
- Critical Illness, Chronic Obstructive Lung Disease, Congestive Heart Failure, Cirrhosis
- Trial name
- ACCEPT (NCT01362855)
- Where
- 9 sites in Canada
- Volunteers
- 503 people, healthy volunteers welcome
- Sponsor
- Daren K. Heyland
Acceptance and Commitment Therapy, Mental Health, Cognitive Impairment,Colorectal Cancer
Effect of Acceptance and Commitment Therapy Based Interventions on Mental Health and Cognitive Impairment for Patients With Advanced Colorectal Cancer
The present study aims to: Determine the effect of acceptance and commitment therapy-based interventions on mental health and cognitive impairment for patients with advanced colorectal cancer.
- Trial name
- NCT05741255
- Testing
- Acceptance and Commitment Therapy
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Cervical Cancer
Cisplatin Based Chemoradiation v.s Radiotherapy for Cervical Cancer and With Clinically Defined Good Prognosis
This phase III study is designed to examine if low-risk, as defined by clinical and radiological parameters, stage IB-IIB cervical cancer patients treated by cisplatin-based chemoradiation, which is a recommended method by…
- Trial name
- NCT00846508
- Testing
- Cisplatin
- Where
- 2 sites in Taiwan
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Colorectal Cancer
Scaling CRC Screening Through Outreach, Referral, and Engagement (SCORE)
This study will test the effectiveness of mailing fecal immunochemical tests (FITs) in increasing colorectal cancer (CRC) screening rates in U.S. adults ages 45-75.
- Trial name
- SCORE (NCT04406714)
- Testing
- Trial Mailed FIT Intervention - Age Group 50-75, Sub-Study Mailed FIT Intervention Enhanced Envelope - Age Group 45-49, Sub-Study Mailed FIT Active Comparator Plain Envelope - Age Group 45-49
- Where
- 2 sites in United States
- Volunteers
- 4,318 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Liver Diseases, Hepatocellular Cancer
A2ALL-Patients Safety System Improvements in Living Donor Liver Transplantation
Living donor liver transplantation (LDLT), involves complex systems and processes of care that are particularly vulnerable to medical errors and preventable complications.
- Conditions
- Liver Diseases, Hepatocellular Cancer, Endstage Liver Disease, Liver Cirrhosis
- Trial name
- NCT02073435
- Testing
- Donor pain management
- Where
- 4 sites in United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Acute Myeloid Leukemia, Multiple Myeloma
The Value of a Tailored-based, Exercise Program for Improving Quality of Life of Patients With Hematologic Malignancies: a Pilot Randomized Trial
This multicenter, prospective, pilot randomized controlled trial aims to evaluate the feasibility and preliminary efficacy of a 16-week structured exercise program (SEP) in patients with hematologic malignancies, including acute…
- Conditions
- Acute Myeloid Leukemia, Multiple Myeloma, Lymphoma
- Trial name
- Hematowellness (NCT07912684)
- Testing
- Structured Exercise Program (SEP)
- Where
- 3 sites in Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Refractory Multiple Myeloma
A Phase I Study of Lintuzumab-Ac225 in Patients With Refractory Multiple Myeloma
1. Establish the MTD of Lintuzumab-Ac225 as monotherapy 2. Establish overall response rate (ORR) where ORR = CR + sCR+ VGPR+PR) 3. Confirm the safety profile of the treatment regimen 4.
- Trial name
- NCT02998047
- Testing
- Lintuzumab AC 225
- Where
- 5 sites in United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Actinium Pharmaceuticals
Stage IV Gastrointestinal Cancer, Advanced Gynecological Cancer
The Mediating Effects of Decentering on Self-Management of Stress and End of Life Planning
Caregivers of persons with cancer may face many challenges as they support and care for a person receiving treatment. Sometimes having to help make treatment decisions for a patient can cause distress for caregivers.
- Trial name
- NCT02842047
- Testing
- Stop, Breathe & Think™, End of Life Planning Videos, Caregiver wellness videos
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer, Post Operative Pain
Dexmedetomidine Versus Dexamethasone as Adjuncts in Erector Spinae Plane Block in Modified Radical Mastectomy
The aim of this study is to evaluate the analgesic efficacy and safety of adding dexmedetomidine versus dexamethasone to levobupivacaine in ultrasound guided ESPB for patients undergoing modified radical mastectomy
- Trial name
- NCT05447949
- Testing
- Adjuncts to levobupivacaine in Erector Spinae Plane Block
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute, Egypt
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