Clinical trials: Cancer Patient
Advanced Metastatic Castration Resistant Prostate Cancer
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of INV-9956 in Adult Patients With Advanced Metastatic Castration Resistant Prostate Cancer
This is a Phase 1 and Phase 2 study to evaluate the safety and antitumor activity of INV-9956 in adult patients with advanced metastatic Castration Resistant Prostate Cancer.
- Trial name
- NCT06609005
- Testing
- INV-9956
- Where
- 22 sites in United States, China
- Volunteers
- 84 people
- Sponsor
- Shenzhen Ionova Life Sciences Co., Ltd.
Chronic Lymphocytic Leukemia
A Prospective Observational Trial to Assess Treatment Sequences and Factors That Impact Overall Sur-vival in Patients With Chronic Lymphocytic Leukaemia (CLL) Treated Within First-line Studies of the GCLLSG
This observational trial is designed to investigate long-term survival with regard to the primary endpoint overall survival (OS) after start of first-line treatment.
- Trial name
- CLL2000 (NCT06792994)
- Testing
- Observational
- Where
- 2 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- German CLL Study Group
Tuberous Sclerosis, Angiolipoma
Long Term Follow Up for RAD001 Therapy of Angiomyolipomata in Patients With Tuberous Sclerosis (TSC) and Sporadic Lymphangioleiomyomatosis (LAM)
This is an open label long term follow up study, open to those subjects who were previously enrolled in"RAD001 Therapy of Angiomyolipomata in Patients with Tuberous Sclerosis Complex and Sporadic Lymphangioleiomyomatosis", CCHMC…
- Trial name
- NCT00792766
- Testing
- everolimus (RAD001)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Advanced Cancer, Older Adults (65 Years and Older)
A Pilot Randomized Controlled Trial of a Social Network Intervention
This is a pilot randomized controlled trial to assess the feasibility, acceptability, appropriateness, and structure of the SONATA intervention.
- Conditions
- Advanced Cancer, Older Adults (65 Years and Older), Social Networks
- Trial name
- SONATA 2 (NCT07393529)
- Testing
- SONATA
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Rochester
Metastatic Breast Cancer
Multi-peptide Vaccine With Basilixumab for Breast Cancer
Eligible patients will receive subcutaneous vaccinations of the hTERT/survivin/CMV multipeptide vaccine and GM-CSF over a 24 month period. All patients will receive basiliximab 20 mg 1 day prior to the start of vaccinations.
- Trial name
- NCT01660529
- Testing
- hTERT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Telemedicine, eHealth
Efficacy of the "Consilium" Smartphone App for Detecting Symptoms and Treatment Side Effects in Cancer Patients
The study investigates the influence of the use of a Smartphone App, on changes in general well-being and the occurrence of symptoms during a tumor therapy.
- Trial name
- APP-2 (NCT03578731)
- Testing
- app
- Where
- 18 sites in Austria, Germany and 1 more
- Volunteers
- 224 people
- Sponsor
- OnkoZentrum Zürich AG
Solid Tumors
An Investigational Immuno-therapy Study of Experimental Medication BMS-986156, Given by Itself or in Combination With Nivolumab in Patients With Solid Cancers or Cancers That Have Spread.
The purpose of this study is to evaluate the safety and tumor-shrinking ability of experimental medication BMS-986156, when given by itself or in combination with nivolumab in patients with solid cancers that are advanced or…
- Trial name
- NCT02598960
- Testing
- BMS-986156, Nivolumab
- Where
- 27 sites in United States, Australia and 8 more
- Volunteers
- 295 people
- Sponsor
- Bristol-Myers Squibb
Neoplasms
Safety Study of PT-523 in Cancer Patients to Treat Solid Tumors Including a Preliminary Assessment of Effectiveness
The purpose of this study is to determine the safety of a short intravenous infusion of PT-523 to patients with solid tumors who have failed curative or survival prolonging therapy or for whom no such therapies exist.
- Trial name
- NCT00088023
- Testing
- PT-523 for Injection
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Spectrum Pharmaceuticals, Inc
Neuroblastoma, Sarcoma
Monoclonal Antibody A1G4 Plus BCG in Treating Patients With Cancer
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Combining monoclonal antibody A1G4 with BCG may kill more tumor cells.
- Trial name
- NCT00003023
- Testing
- BCG vaccine, monoclonal antibody A1G4 anti-idiotype vaccine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Neoplasms, Therapy-Associated
Icotinib as the Adjunctive Treatment After Surgery in Stage I-IIIB Lung Adenocarcinoma Patients With EGFR Gene Mutation
This is a randomized ,opened, prospective controlled trial of clinical effectiveness for Icotinib as the adjunctive treatment after surgery in stage I-IIIB lung adenocarcinoma patients with epidermal growth factor receptor gene…
- Trial name
- NCT02283424
- Testing
- Icotinib, chemotherapy (Carboplatin and Docetaxel)
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Chinese PLA General Hospital
Precancerous Condition, Stage 0 Melanoma
Lovastatin in Treating Patients At High Risk of Melanoma
The use of lovastatin may slow disease progression in patients at high risk of melanoma. It is not yet known whether lovastatin is more effective than a placebo in treating patients at high risk of melanoma.
- Conditions
- Precancerous Condition, Stage 0 Melanoma, Stage I Melanoma, Stage II Melanoma
- Trial name
- NCT00462280
- Testing
- lovastatin, biopsy, laboratory biomarker analysis
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute (NCI)
Extensive Stage Small Cell Lung Cancer (ES-SCLC)
ARTEMIS-007: HS-20093 in Patients With Extensive Stage Small Cell Lung Cancer
This is a phase 2,open-label, multi-center study to evaluate the efficacy, safety, pharmacokinetics (PK) and immunogenicity of HS-20093 as a monotherapy in patients with small cell lung cancer(SCLC).
- Trial name
- NCT06052423
- Testing
- HS-20093
- Sponsor
- Hansoh BioMedical R&D Company
Non Small Cell Lung Cancer
A Clinical Study of TQB2450 Injection Combined With Anlotinib Hydrochloride Capsules Versus K Drug in the Treatment of First-line Non-small Cell Lung Cancer(NSCLC)
A clinical study to evaluate the efficacy and safety of TQB2450 injection combined with Anlotinib Hydrochloride capsules versus K drug as a first-line treatment of advanced non-small cell lung cancer.A total of 375 subjects will…
- Trial name
- NCT04964479
- Testing
- TQB2450 injection, Anlotinib Hydrochloride Capsules, Pembrolizumab injection
- Where
- 17 sites in China
- Volunteers
- 375 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL)
Pharmacokinetic and Pharmacodynamic Assessment of Treatment With CPX-351 (Cytarabine: Daunorubicin) Liposome for Injection in Acute Leukemias and MDS Patients With Moderate Hepatic Impairment
To assess the impact of moderate hepatic impairment on cytarabine and daunorubicin pharmacokinetics and their metabolites following administration of CPX-351.
- Conditions
- Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Myelodysplastic Syndrome (MDS)
- Trial name
- NCT02269579
- Testing
- CPX-351
- Where
- 5 sites in United States
- Sponsor
- Jazz Pharmaceuticals
Non-Hodgkin's Lymphoma, Lymphoma
Effect of Zoledronic Acid on Chemotherapy Induced Bone Loss
Primary Objective: Evaluate the effect of zoledronate on change in bone mineral density (BMD) at the total lumbar spine and femoral neck.
- Trial name
- NCT00352846
- Testing
- Zoledronic Acid, Vitamin D, Calcium Carbonate
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- M.D. Anderson Cancer Center
Glioblastoma, IDH-wildtype, MGMT-Methylated Glioblastoma
Lomustine in Addition to Standard of Care in Patients With MGMT Methylated Glioblastoma
Background: Glioblastoma (GBM) is notoriously difficult to treat, with current therapies often extending life by only a few months.
- Trial name
- NCT06419946
- Testing
- Temozolomide, Lomustine
- Where
- 20 sites in Austria, Denmark and 2 more
- Volunteers
- 200 people
- Sponsor
- Vastra Gotaland Region
Neoplasms, Endometrial
A Study to Evaluate the Safety of Dostarlimab in Adult Participants in India With Recurrent or Advanced Endometrial Cancer (EC)
The goal of this study is to evaluate the safety profile of dostarlimab in Indian adults with recurrent or advanced endometrial cancer.
- Trial name
- NCT06897527
- Testing
- Dostarlimab
- Volunteers
- 100 people
- Sponsor
- GlaxoSmithKline
Liposarcoma, Myxoid, Sarcoma, Soft Tissue
Trabectedin Plus Radiotherapy in Soft Tissue Sarcoma Patients
Phase I-II trial that combines trabectedin plus radiotherapy for tumor reduction response measure in four cohorts of patients: Cohort A: Patients with diagnosis of non-operable or unresectable or not oncologically recommended…
- Conditions
- Liposarcoma, Myxoid, Sarcoma, Soft Tissue, Leiomyosarcoma, Liposarcoma
- Trial name
- TRASTS (NCT02275286)
- Testing
- Trabectedin, Radiotherapy
- Where
- 17 sites in France, Italy and 1 more
- Volunteers
- 199 people
- Sponsor
- Grupo Espanol de Investigacion en Sarcomas
Solid Tumors, Chemotherapy-induced Neutropenia
G-CSF-Related Bone Pain and Supportive Care Strategies in Patients With Solid Tumors
This prospective two-center observational cohort study evaluated G-CSF-related bone pain and multidimensional symptom burden in adults with solid tumors receiving chemotherapy and filgrastim prophylaxis.
- Trial name
- GCSF-PAIN (NCT07192770)
- Testing
- Filgrastim (G-CSF), Naproxen, Loratadine
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 190 people
- Sponsor
- Ankara Etlik City Hospital
High Grade B-Cell Lymphoma, Not Otherwise Specified, High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements
Study of Zanubrutinib, Rituximab and Combination Chemotherapy in Newly-diagnosed Aggressive B-cell Non-Hodgkin Lymphoma
Non-Hodgkin lymphoma (NHL), with high aggressiveness and mortality, is one of the top ten high-incidence tumors in the world and is among the ten most prevalent cancers worldwide with the fastest growing incidence.
- Conditions
- High Grade B-Cell Lymphoma, Not Otherwise Specified, High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements, Diffuse Large B Cell Lymphoma, B-cell Non Hodgkin Lymphoma
- Trial name
- NCT05164770
- Testing
- Zanubrutinib+R-CHOP; Zanubrutinib+R-DA-EPOCH; Zanubrutinib+R-HD MTX, R-CHOP; R-DA-EPOCH; R-HD MTX
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shandong Provincial Hospital
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