Clinical trials: Cancer Patients and Physical Activity
Lung Cancer
Lung Cancer, Exercise and Force Development
This study evaluates the effectiveness of a supervised one-leg resistance training program in patients with inoperable lung cancer with the primary outcome being rate of force development.
- Trial name
- NCT05778136
- Testing
- Resistance training
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Breast Cancer
Dietary Habits, Nutritional Knowledge and Physical Activity Assessment in Early Stage Breast Cancer Patients
The advances in early detection coupled with improvements in treatments have led to an ever increasing number of breast cancer survivors.
- Trial name
- DEMETRA (NCT06073418)
- Where
- Italy
- Volunteers
- 1,098 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Breast Neoplasm Female, Symptom Cluster
Effects of a Traditional Chinese Exercise Program on Symptom Cluster in Breast Cancer Patients
The Medical Research Council Framework for Developing and Evaluating Complex Interventions (MRC Framework) will be utilized to develop and evaluate an evidence-based tai chi intervention for managing the symptom cluster of…
- Conditions
- Breast Neoplasm Female, Symptom Cluster, Tai ji
- Trial name
- NCT04190342
- Testing
- control group, tai chi group
- Where
- 2 sites in China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Charles Darwin University
Non-small Cell Lung Cancer, Head and Neck Cancer
A First in Human, Dose Escalation Study of JAB-3068 （SHP2 Inhibitor） in Adult Patients With Advanced Solid Tumors
This is a phase 1, multi-center, dose escalation, open-label study to evaluate the safety, tolerability, pharmacokinetics, and preliminary evidence of antitumor activity of JAB-3068 in adult patients with advanced solid.
- Conditions
- Non-small Cell Lung Cancer, Head and Neck Cancer, Esophageal Cancer, Other Metastatic Solid Tumors
- Trial name
- NCT03518554
- Testing
- JAB-3068
- Where
- 4 sites in United States
- Volunteers
- 38 people
- Sponsor
- Jacobio Pharmaceuticals Co., Ltd.
Melanoma
A Phase 1b Trial to Evaluate Safety of MB097 in Combination With Pembrolizumab in Melanoma Patients
A Phase 1b study to evaluate the safety and tolerability of MB097 given in combination with pembrolizumab in patients with melanoma who demonstrate primary resistance to anti-PD1 therapy.
- Trial name
- MELODY-1 (NCT06540391)
- Testing
- MB097, Pembrolizumab, Vancomycin
- Where
- 19 sites in France, Italy and 2 more
- Volunteers
- 41 people
- Sponsor
- Microbiotica Ltd
Polycystic Ovary Syndrome, Anovulation
Structured Exercise Training Program Versus Hypocaloric Hyperproteic Diet in Obese Anovulatory Infertile Patients With PCOS
Lifestyle modifications are successfully employed in polycystic ovarian syndrome (PCOS) improving menstrual cycles and fertility. Unfortunately, the compliance over the time is very low.
- Conditions
- Polycystic Ovary Syndrome, Anovulation, Infertility
- Trial name
- NCT00473538
- Testing
- Structured exercise training, Hypocaloric hyperproteic diet
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University Magna Graecia
Physical Activity, Mobile Application
HopeMove App in Pediatric Cancer Patients
This pilot feasibility study aims to assess the acceptability, usability, safety, and initial effects of the HopeMove mobile health app on fatigue in adolescents aged 13 to 18 years undergoing hematology-oncology treatment.
- Trial name
- NCT07274358
- Testing
- HopeMove Mobile Application
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Koç University
Solid Tumors
Evaluation of Thymidine Kinase Activity in the Serum of Patients With Solid Tumors
This study aimed to evaluate serum thymidine kinase 1 (TK1) activity as a marker for solid tumors and more specifically in: preoperative testing for prediction of disease recurrence and survival; follow-up after surgical removal…
- Trial name
- NCT01050413
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Hadassah Medical Organization
Lung Cancer (NSCLC), Physiotherapy
THE EFFECT OF CALISTHENIC EXERCISES ON FATIGUE AND EXERCISE ATTITUDES IN PATIENTS WITH LUNG CANCER
Purpose: This study was carried out to investigate fatigue and exercise barriers of calisthenic exercises in patients with lung cancer.
- Conditions
- Lung Cancer (NSCLC), Physiotherapy, Fatigue in Cancer Survivors, Exercise
- Trial name
- NCT07237503
- Testing
- Exercise, Home based exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Hasan Kalyoncu University
Advanced Solid Tumors
QTX3544 in Patients With Advanced Solid Tumors With KRAS G12V Mutations
Phase 1 study to determine the safety, tolerability, and anti-tumor activity of QTX3544 as a single agent or in combination with cetuximab.
- Trial name
- NCT06715124
- Testing
- QTX3544, Cetuximab
- Where
- 10 sites in United States
- Volunteers
- 237 people
- Sponsor
- Quanta Therapeutics
NSCLC
Phase 1/2 Study of BBT-176 in Advanced NSCLC With Progression After EGFR TKI Treatment
This clinical trial is the first-in-human study of BBT-176. The purpose of this trial is to investigate the safety and tolerability of BBT-176 (Part 1) and to evaluate the anti-tumor activity of BBT-176 (Part 2).
- Trial name
- NCT04820023
- Testing
- BBT-176, QD, BBT-176, BID
- Where
- 4 sites in South Korea
- Volunteers
- 45 people
- Sponsor
- Bridge Biotherapeutics, Inc.
Prostate Cancer
High Impact Training to Patients with Prostate Cancer and Bone Metastases
HIP is a randomized controlled trial. The aim is investigate the effect, safety and feasibility of brief, high-impact exercise targeting bones in patients with prostate cancer and bone metastases.
- Trial name
- HIP (NCT06259279)
- Testing
- High intensity high impact exercise intervention
- Where
- Denmark
- Volunteers
- 102 people
- Sponsor
- Copenhagen University Hospital at Herlev
Tumor
Exercise and Tumor Blood Flow in Lymphoma And Breast Cancer Patients (EXETUMOR 3)
Recent pre-clinical studies strongly suggest that due to dysfunctional vasculature and blunted sympathetic constriction in the tumor, tumor blood flow is increased even by 200% compared to resting values.
- Trial name
- EXETUMOR3 (NCT04990856)
- Testing
- Exercise
- Where
- Finland
- Volunteers
- 28 people
- Sponsor
- Turku University Hospital
Advanced Cancer, Metastatic Cancer
FS222 First in Human Study in Patients With Advanced Malignancies
This study will be conducted in adult participants diagnosed with advanced tumours to characterize the safety, tolerability, pharmacokinetics (PK), and activity of FS222.
- Trial name
- NCT04740424
- Testing
- FS222
- Where
- 21 sites in Australia, Georgia and 5 more
- Volunteers
- 260 people
- Sponsor
- invoX Pharma Limited
Unresectable Melanoma, Metastatic Melanoma
A Clinical Study of the Safety and Activity of the Investigational Cell Therapy NEO-PTC-01 in Patients With Advanced Melanoma
This study will investigate the safety and activity of NEO-PTC-01 in patients with unresectable or metastatic melanoma. NEO-PTC-01 is an autologous personalized T cell (PTC) product for adoptive cell therapy that is manufactured…
- Trial name
- NCT04625205
- Testing
- NEO-PTC-01, IL-2, PD-1 Inhibitors
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 22 people
- Sponsor
- BioNTech US Inc.
Solid Tumors (Phase 1)
First-in-Human Study of ADCE-B05 in Patients With Advanced Solid Tumors
The main purpose of the study is to determine the Maximum Tolerated Dose (MTD), the Recommended Expansion Dose and the safety and tolerability of ADCE-B05 when given as a single therapy over a range of different dose levels.
- Trial name
- NCT07362888
- Testing
- ADCE-B05
- Where
- 7 sites in United States, Australia
- Volunteers
- 180 people
- Sponsor
- Adcendo ApS
Advanced Solid Tumors With MAPK Signal Pathway Mutations
GH55 for Advanced Cancers With MAPK Mutations: A Study on Safety and Early Results
This is a multi-center, open-label, dose escalation phase I and dose expansion phase II study aimed to evaluate the safety, tolerability, PK and PD profiles as well as to observe the efficacy of GH55 in patients with MAPK mutant…
- Trial name
- NCT06310382
- Testing
- GH55
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Suzhou Genhouse Bio Co., Ltd.
Solid Tumor
Safety, Pharmacokinetics, and Antitumor Activity of BGB-B167 Alone and in Combination With Tislelizumab (BGB-A317) in Participants With Advanced Solid Tumors
This study will evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of BGB-B167 monotherapy and in combination with tislelizumab (BGB-A317) in participants with select advanced solid…
- Trial name
- NCT05494762
- Testing
- BGB-B167, Tislelizumab
- Where
- 8 sites in United States, Australia
- Volunteers
- 55 people
- Sponsor
- BeiGene
Breast Neoplasms, Physical Fitness
Feasibility and Effects of Home-based Physical Activity Intervention in Patients With Breast Cancer in Indonesia
The goal of this clinical trial is to learn the impact and implementation of home-based aerobic and resistance training for patients with breast cancer in Indonesia.
- Trial name
- NCT07338903
- Testing
- 12weeks of home-based aerobic (pedometer-driven walking) and resistance training using therapeutic bands
- Where
- Indonesia
- Volunteers
- 36 people
- Sponsor
- Gadjah Mada University
Metastatic Cancer, Solid Tumor
Sym022 (Anti-LAG-3) in Patients With Advanced Solid Tumor Malignancies or Lymphomas
This is the first study to test Sym022 in humans. The primary purpose of this study is to see if Sym022 is safe and tolerable for patients with locally advanced/unresectable or metastatic solid tumor malignancies or lymphomas…
- Conditions
- Metastatic Cancer, Solid Tumor, Lymphoma
- Trial name
- NCT03489369
- Testing
- Sym022
- Where
- 3 sites in United States, Canada
- Volunteers
- 15 people
- Sponsor
- Symphogen A/S
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