Clinical trials: Cancer Pediatric
Neoplasms, Brain, Glioblastoma Multiforme
HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors
This study is a clinical trial to determine the safety of inoculating G207 (an experimental virus therapy) into a recurrent or refractory cerebellar brain tumor.
- Conditions
- Neoplasms, Brain, Glioblastoma Multiforme, Glioblastoma of Cerebellum, Neoplasms
- Trial name
- NCT03911388
- Testing
- G207
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- M.D. Anderson Cancer Center
Pediatric Cancer, Palliative Care
Integration of Palliative Care in Pediatric Onco-hematology
PALONCOPED is a multicentre, interregional, observational and qualitative study aiming to better understand the early integration of palliative care in children with cancer.
- Trial name
- PALONCOPED (NCT07838168)
- Testing
- PALONCOPED semi-structured interview
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Cardiovascular Diseases, Respiratory Disease
The Measurement of Vital Signs in Children by Lifelight® Software in Comparison to the Standard of Care
A prospective basic science study for collection of training and testing data for development of Lifelight® Junior
- Conditions
- Cardiovascular Diseases, Respiratory Disease, Febrile Illness, Pediatric ALL
- Trial name
- VISION-Jr (NCT05850013)
- Testing
- Lifelight Junior
- Where
- United Kingdom
- Volunteers
- 504 people
- Sponsor
- Xim Limited
Graft vs Host Disease
Activity, Safety and Pharmacokinetics in Pediatric Subjects With Moderate and Severe Chronic Graft vs. Host Disease After Allogeneic Stem Cell Transplant
This open-label, single-arm, Phase II multi-center study enrolled 46 participants and investigated the activity, pharmacokinetics and safety of ruxolitinib added to the subject's immunosuppressive regimen among infants, children…
- Trial name
- REACH 5 (NCT03774082)
- Testing
- INC424
- Where
- 21 sites in Brazil, Canada and 12 more
- Volunteers
- 46 people
- Sponsor
- Novartis Pharmaceuticals
Acute Lymphoid Leukemia Relapse, Acute Lymphoid Leukemia Relapse After Bone Marrow Transplant
Safety of Clofarabine With Multiagent Chemotherapy in Childhood Acute Lymphoblastic Leukemia
The purpose of this study is to determine Maximum Tolerated Dosage (MTD), Dosage Limited Toxicities (DLT), and the Rate Phase 2 Dosage of clofarabine when used in combination with etoposide, asparaginase, mitoxantrone and…
- Trial name
- Vandevol (NCT01279096)
- Testing
- Clofarabine
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Lille
Acute Lymphoblastic Leukemia ALL, Childhood Cancer Survivors
Online Physical Activity and Health Counseling for Survivors of Childhood Acute Lymphoblastic Leukemia
Advances in the medical treatment of childhood acute lymphoblastic leukemia (ALL) have resulted in 5-year survival rates above 90%- however, the success is not without consequences.
- Conditions
- Acute Lymphoblastic Leukemia ALL, Childhood Cancer Survivors, Exercise, Rehabilitation Exercise
- Trial name
- OPAC-ALL (NCT07042932)
- Testing
- Exercise
- Volunteers
- 82 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Recurrent Medulloblastoma, Recurrent Brain Tumor, Childhood
PEP-CMV in Recurrent MEdulloblastoma/Malignant Glioma
The primary goal of this prospective clinical trial is to evaluate the safety of PEP-CMV in patients with recurrent medulloblastoma and malignant glioma.
- Conditions
- Recurrent Medulloblastoma, Recurrent Brain Tumor, Childhood, Malignant Glioma
- Trial name
- PRiME (NCT03299309)
- Testing
- PEP-CMV
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Daniel Landi
Pediatric Cancer
LIFE Cancer Survivorship Database for Pediatric Cancer
The purpose of this study is to develop a mechanism for utilizing the comprehensive clinical database of childhood cancer survivors at Childrens Hospital Los Angeles (CHLA) for research purposes.
- Trial name
- NCT01518400
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Children's Hospital Los Angeles
Relapsed Pediatric ALL, Hematopoietic Cell Transplantation
CD45RA-depleted CD19-CAR T Cell Consolidation After TCRαβ+/CD19 B Cell-depleted Haploidentical Hematopoietic Cell Transplantation for Relapsed/Refractory CD19+ ALL and Lymphoma
The purpose of this study is to learn more about newer methods of transplanting blood cells donated by a partially matched family member to children with high-risk CD19 positive leukemia ALL.
- Conditions
- Relapsed Pediatric ALL, Hematopoietic Cell Transplantation, Hematologic Malignancy
- Trial name
- NCT07257419
- Testing
- Anti-Thymocyte Globulin (Rabbit), Cyclophosphamide, Fludarabine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- St. Jude Children's Research Hospital
Leukemia, Lymphoma
A Feasibility and Safety Study of Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy for CD19+CD22+ Leukemia
Patients with relapsed or refractory leukemia often develop resistance to chemotherapy and some patients who relapse following CD19 directed therapy relapse with CD19 negative leukemia.
- Trial name
- NCT03330691
- Testing
- Patient-derived CD19- and CD22 specific CAR
- Where
- 5 sites in United States, Canada
- Volunteers
- 78 people
- Sponsor
- Seattle Children's Hospital
Pediatric Cancer
Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells
The objective of this study is to utilize all donated pediatric tumor tissues and cells obtained from autopsy to prospectively develop novel patient derived orthotopic xenograft (PDOX) mouse models as well as in vitro cell…
- Trial name
- NCT05120518
- Testing
- Collection of post mortem tissue donation
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Central Nervous System Neoplasms, Pediatric Cancer
Pediatric Prospective Personalized Immune and Target Identification Trial
PPROSPERITIT is a prospective clinical study assessing the use of comprehensive molecular profiling to define the best matching targeted and immune treatment for relapsed, refractory or very high risk pediatric CNS tumors.
- Conditions
- Central Nervous System Neoplasms, Pediatric Cancer, GEN1 Gene Mutation, Tumor, Brain
- Trial name
- PPROSPERITIT (NCT04859543)
- Testing
- FoundationOneHeme
- Where
- 3 sites in Austria, Czechia
- Volunteers
- 80 people
- Sponsor
- Masaryk University
Paraganglioma/ Phaeochromocytoma, Melanoma and Other Malignant Neoplasms of Skin
An International Study on Pediatric Patients With Rare Tumors.
The PARTNER study is an international, prospective, observational study of paediatric patients with very rare tumours.
- Conditions
- Paraganglioma/ Phaeochromocytoma, Melanoma and Other Malignant Neoplasms of Skin, Gastrointestinal Stromal Tumor (GIST), Adrenocortical Tumor
- Trial name
- PARTNER (NCT07072143)
- Where
- Italy
- Volunteers
- 6,250 people
- Sponsor
- Azienda Ospedaliera di Padova
Late-effects of Childhood Cancer
SURfit - A Physical Activity Intervention for Childhood Cancer Survivors
Exercise can play a major role to mitigate or even prevent late effects in cancer survivors, such as cardiovascular disease, obesity, osteoporosis, fatigue, depression, reduced quality of life, mental health and physical…
- Trial name
- SURfit (NCT02730767)
- Testing
- partially supervised exercise intervention
- Where
- Switzerland
- Volunteers
- 151 people
- Sponsor
- University of Zurich
Neuroblastoma, High-risk Neuroblastoma
PediCARE Health Equity Intervention in High-Risk Neuroblastoma
This is a randomized Phase II trial evaluating the addition of the Pediatric Cancer Resource Equity (PediCARE) health equity intervention to usual supportive care for poverty-exposed children with newly diagnosed high-risk…
- Conditions
- Neuroblastoma, High-risk Neuroblastoma, Pediatric Cancer, Disparities
- Trial name
- NCT06335745
- Testing
- PediCARE Intervention
- Sponsor
- Dana-Farber Cancer Institute
PEComa, Hemangioma
Evaluation of New Biomarkers Predictive of Efficacy Betablockers in PEComa and Vascular Pediatric Tumors
PEComa is rare tumor affecting particularly patients with Tuberous Sclerosis. Biological similarities were seen between PEComa and infantile hemangioma.
- Trial name
- PEC-Hem (NCT02334930)
- Testing
- Biopsy
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Bordeaux
Hematologic Malignancy
Usability, Adherence and Diagnostic Performance of PointCheck in Pediatric Population
Single-site non-significant risk, open-label clinical investigation designed to validate the usability, adherence, and preliminary diagnostic performance of a novel technology to detect neutropenia.
- Trial name
- PC004 (NCT04889937)
- Testing
- PointCheck
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Leuko Labs, Inc.
Childhood Cancer
Neutrophil Extracellular Traps Formation Post-hematopoietic Stem Cell Transplantation
Identifying the post-transplantation phase wherein neutrophils recover their ability to release NETs could shed new light on the mechanism responsible for the increased susceptibility to infection among these patients and aid in…
- Trial name
- NETs post HSCT (NCT01491230)
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Brain Tumors, Central Nervous System Tumors
Electroacupuncture in Treating Delayed Nausea and Vomiting in Patients Receiving Chemotherapy For Newly Diagnosed Childhood Sarcoma, Neuroblastoma, Nasopharyngeal Cancer, Germ Cell Tumors, or Hodgkin Lymphoma
RATIONALE: Electroacupuncture may help to reduce or prevent delayed nausea and vomiting in patients treated with chemotherapy. PURPOSE: This randomized clinical trial is studying the effectiveness of electroacupuncture in…
- Conditions
- Brain Tumors, Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor
- Trial name
- NCT00040911
- Testing
- electroacupuncture therapy, quality-of-life assessment
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Children's Oncology Group
Leukemia, Lymphoma
Propofol Versus Propofol-Fentanyl as Sedation For Lumbar Puncture in Children With Acute Leukemia/Lymphoma
The hypothesis of the study is that propofol-fentanyl sedation for lumbar punctures in children with acute leukemia/lymphoma results in fewer adverse events than propofol sedation alone.
- Trial name
- NCT00214370
- Testing
- Propofol-Fentanyl, Propofol alone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Wisconsin, Madison
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