Clinical trials: Cancer Progression
Parkinson Disease
Neuro-immune Interactome in Parkinson's Disease
This study will be observational and have a prospective case-control longitudinal design. Eligible subjects with idiopathic REM behavior disorder (RBD), Parkinson's disease with RBD, and healthy controls will be recruited.
- Trial name
- NCT07026929
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Yale University
Chronic Hepatitis b
IL-35+Breg/Il-35 Effect on T Cell Immune in Patients With CHB
The investigators observed the level of IL-35 secreting B regulatory (IL-35+Bregs) cells in peripheral blood cells in patients with chronic hepatitis B, and analysed the relationship between the IL-35+Bregs level and disease…
- Trial name
- NCT03734783
- Where
- China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Pregnancy, Labor
Determination of Labor Progression Patterns Using Non-invasive, Ultrasound Based, Multiple Parameters
The purpose of this study is to establish normograms of parameters measured by the LaborPro system. To test the prediction of these parameters on labor progress and mode of delivery.
- Trial name
- NCT00827125
- Testing
- LaborPro device
- Where
- 2 sites in United States, Israel
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Trig Medical Inc
Neoplasm, Breast, Congenital, Familial and Genetic Disorders
SEQUence of Endocrine Therapy in Advanced Luminal Breast Cancer (SEQUEL-Breast)
The study is a nationwide, multicenter single-arm phase 2 study. The current phase 2 study investigates the efficacy of the combination of fulvestrant and alpelisib directly after progression on fulvestrant (either in first or…
- Trial name
- SEQUEL-Breast (NCT05392608)
- Testing
- Alpelisib 150 MG Oral Tablet [Piqray], Fulvestrant
- Where
- 25 sites in Netherlands
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Borstkanker Onderzoek Groep
Knee Osteoarthritis
Quantitative MRI For Detection and Tracking of Knee Osteoarthritis
The goal of this observational study is to develop whole-joint quantitative MRI techniques that aid in the detection and tracking of osteoarthritis disease progression at 3T and 7T MRI scanners. The research objectives are: 1.
- Trial name
- NCT06063304
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Alzheimer Disease (AD), Cognitive Dysfunction, Cognitive Disorder
Aβ PET and Tau PET Imaging in the Diagnosis and Progression Assessment of Alzheimer's Disease
This prospective study recruited 20 healthy volunteers and 50 patients diagnosed with Alzheimer's disease (AD) and mild cognitive impairment (MCI) according to clinical guidelines.
- Conditions
- Alzheimer Disease (AD), Cognitive Dysfunction, Cognitive Disorder, PET Imaging
- Trial name
- NCT07114224
- Testing
- AV45/AV-1、AV1451 PET
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Hypertension
Progression Evaluation and Genetic Determinants of Hypertension in Chinese - A Follow-up Study of Taiwan SAPPHIRe
The purpose of this study is to determine the progression evaluation and genetic determinations of hypertension in Chinese
- Trial name
- NCT00260910
- Where
- Taiwan
- Volunteers
- 1,246 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Myopia
Wearability of and Myopia Progression With ZEISS MyoCare Spectacle Lenses
This is a clinical trial evaluating the wearability and effectiveness of three types of ZEISS spectacle lenses in controlling myopia progression.
- Trial name
- NCT07021560
- Testing
- ZEISS MyoCare spectacle lenses, ZEISS SV RX SPH 1.5, ZEISS Clearview
- Where
- Vietnam
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- ZEISS Vision Care
Kidney Disease, Chronic
Diuretic Testing in Chronic Kidney Disease
The goal of this clinical trial is to predict the progression of chronic kidney disease by diuretic testing in patients with chronic kidney disease.
- Trial name
- U-TUBE 2 (NCT06841692)
- Testing
- Diuretic Testing
- Where
- Netherlands
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Parkinson's, Parkinson Disease
Longitudinal Investigation of I2BS in PD
In this study, the researchers aim to find a biomarker of PD. Using imaging scans called Positron Emission tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic Resonance Imaging (MRI).
- Conditions
- Parkinson's, Parkinson Disease, Parkinson's Disease, Neurodegenerative Diseases
- Trial name
- FOX_2 (NCT05516719)
- Testing
- Positron Emission Tomography (PET) scan using BU99008 tracer, FP-CIT Single-photon Emission Computed Tomography (SPECT) scan, Magnetic Resonance Imaging (MRI) Scan
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Aortic Stenosis, Cardiac Death
Endothelial Progenitors in Aortic Stenosis: Association With Aortic Stenosis Progression and Severity
There is a correlation between endothelial progenitor cells (stem cells) and stenosis of the aortic valve.
- Trial name
- NCT02060071
- Testing
- Blood test
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
Periodontal Disease
Biomarkers of Periodontal Disease Progression
The primary purpose of the study will be to look for biological biomarkers to determine which people with gum disease will have a worsening of the disease.
- Trial name
- NCT01489839
- Testing
- Periodontal therapy
- Where
- 5 sites in United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- The Forsyth Institute
Caries, Salivary Function
Lesion Progression After Icon Treatment in Young Adults
This is a three year single site clinical evaluation of a FDA approved (510(k):K100062) lesion penetrating resin used to infiltrate and hamper progression of proximal carious lesions.
- Conditions
- Caries, Salivary Function, Tooth Sensitivity
- Trial name
- NCT01988337
- Testing
- Resin infiltration, Mock treatment
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- DMG Dental Material Gesellschaft mbH
Parkinson's Disease
The Effects of Mindfulness-based Cognitive Therapy in People With Parkinson's Disease
Parkinson's disease (PD) is a debilitating neurodegenerative disorder occurring in 7 million patients worldwide. PD is caused by progressive loss of nigro-striatal dopamine cells, which causes motor symptoms such as slowness of…
- Trial name
- MIND-PD (NCT05779137)
- Testing
- MBCT
- Where
- Netherlands
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Adverse Events
Effectiveness of a Proficiency-based Progression Communication Training Programme
Breakdown in communication between healthcare workers leads to significant patient harm on a daily basis, worldwide. The "safety huddle" is being introduced internationally as a means of overcoming this problem.
- Trial name
- PROTECT (NCT05390125)
- Testing
- A team, proficiency based progression, simulation training programme
- Where
- 2 sites in Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dorothy Breen
Nutrition, Metabolic Syndrome
Impact of Genetic Polymorphisms And DASH Diet On Weight Loss Progression In Climacteric Women With Metabolic Syndrome
Metabolic syndrome is a multifactorial inflammatory condition that is very prevalent in overweight women with type 2 diabetes. However, there seems to be great benefit in changing lifestyle and dietary patterns in the treatment…
- Conditions
- Nutrition, Metabolic Syndrome, Obesity, Weight Loss
- Trial name
- NCT06978504
- Testing
- DASH diet
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nutrindo Ideais Research Center
Crohn Disease (CD), Ulcerative Colitis (UC)
IBD Biomarker Discovery and Validation Platform
The goal of this observational study is to establish a multicenter prospective clinical and biospecimen platform for biomarker discovery and validation in inflammatory bowel disease, including Crohn's disease and ulcerative…
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), Inflammatory Bowel Diseases (IBD)
- Trial name
- IBD-BIOP (NCT07686406)
- Where
- 2 sites in China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema
Longitudinal Follow up to Assess Biomarkers Predictive of Emphysema Progression in Patients With COPD (Chronic Obstructive Pulmonary Disease)
The study will include 60 healthy subjects (ex-smoker without any airflow limitation), 125 COPD GOLD (global initiative for chronic obstructive lung disease) I , 125 COPD GOLD II, 125 COPD GOLD III and up to 20 patients with COPD…
- Trial name
- NCT02719184
- Where
- 51 sites in United States, Belgium and 10 more
- Volunteers
- 463 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Cardiac Ageing, Exercise
Exercise to Slow Cardiovascular Ageing Progression
In ageing, deleterious alterations in cardiovascular (CV) structure and function increase risks of ageing-related cardiovascular disease (CVD).
- Conditions
- Cardiac Ageing, Exercise, Cardiovascular
- Trial name
- NCT05775484
- Where
- Singapore
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Lymphedema, Breast Cancer
Lymphedema Progression Screening Using MRI
This study will apply novel, noninvasive structural and functional magnetic resonance imaging (MRI) methods to patients with mild and moderate breast cancer-related lymphedema (BCRL) for the first time to test fundamental…
- Trial name
- INFORM (NCT02611557)
- Testing
- Manual lymphatic drainage therapy
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University