Clinical trials: Cancer Progression
Breast Cancer
DNA in Predicting Response After Systemic Therapy in Women With Metastatic Breast Cancer
RATIONALE: Studying samples of blood from patients with cancer and from healthy participants in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00899548
- Testing
- DNA methylation analysis, microarray analysis, polymerase chain reaction
- Where
- 4 sites in United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Type 1 Diabetes, Autoimmunity
Prospective Assessment in Newborns for Diabetes Autoimmunity
This is an observational study designed to help researchers understand the genetics and pathogenesis of type 1 diabetes, and to identify biomarkers for disease and disease complication prediction.
- Trial name
- PANDA (NCT00649246)
- Where
- 3 sites in United States
- Volunteers
- 25,055 people, healthy volunteers welcome
- Sponsor
- Augusta University
Myopia
Peripheral Optics in Myopia and Orthokeratology
The primary objective of the current study is to investigate changes in peripheral refraction and aberration in children wearing orthokeratology lenses and single-vision spectacles.
- Trial name
- NCT00978679
- Testing
- Orthokeratology lenses, Spectacles
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Acute Lung Injury, Pulmonary Injury
Electronic Nicotine Delivery Devices and Potential Progression to Acute Lung Injury
This is an observational - data and specimen collection study. There have been increasing reports of vaping-induced lung injury, including severe lung injury and rare cases of death.
- Conditions
- Acute Lung Injury, Pulmonary Injury, Electronic Cigarette Use, Electronic Cigarette Related Lung Injury
- Trial name
- ENDALI (NCT05316727)
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Chronic Kidney Disease, Sleep Loss
Sleep Disturbances as a Non-traditional Risk Factor in CKD-Actigraphy
To test if usual at home night time sleep duration as measured with activity monitors and questionnaires will predict changes in kidney function as measured by kidney filtration rate and of cardiovascular function as measured by…
- Trial name
- CRIC (NCT00817674)
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Colorectal Neoplasms, Colorectal Cancer
Bile Acids and Microbiome in Early Colorectal Carcinogenesis
Currently colorectal cancer pathogenesis is mainly explained by the adenoma-carcinoma sequence theory that was proposed more than half a century ago.
- Conditions
- Colorectal Neoplasms, Colorectal Cancer, Colorectal Polyp, Microbiome
- Trial name
- NCT06502704
- Where
- Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vilnius University
Parkinson Disease, Progression, Disease
Neuromelanin MRI: A Progression Marker in Early PD
Prospective observational study to qualify NM-MRI as progression marker in early Parkinson's.
- Trial name
- InsIghtPD (NCT05631158)
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Colorectal Cancer
The Roles of Exosomal Circ-LRBA and 451/CRTC2 Signaling Axis in Colorectal Cancer
Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Most of the patients with colorectal cancer were diagnosed in poor stage.
- Trial name
- NCT05579353
- Testing
- nothing
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Jingbo Chen
Cancer
Prevention of Cancer Development and Progression
The purpose of this study is to evaluate the efficacy and safety of arginine in preventing cancer development
- Trial name
- NCT03940053
- Testing
- Arginine hydrochloride
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Zujiang YU
HIV Exposure, HIV Infection
Early Versus Delayed BCG Vaccination of HIV-exposed Infants
In sub-Saharan Africa (SSA), more than 300,000 babies with HIV die each year. HIV-infected children develop AIDS and die faster in SSA than those in developed countries.
- Trial name
- NCT02062580
- Testing
- BCG
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Clinical Deterioration, Postoperative Complications
Evaluation of the Modified Early Warning Scoring System
In this study, it was aimed to determine the effect of HRU and HG on patient outcomes in the care process in surgical patients followed according to MEUSS.
- Conditions
- Clinical Deterioration, Postoperative Complications, Nurse's Role
- Trial name
- NCT05575531
- Testing
- MEWSS and Nursing Guide Application
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Myopia, Progressive
Stellest Lens Wear in Adult Progressing Myopes
It is expected that myopia progression stabilises in the late teenage years, however, some studies report that myopia progression continues through early adulthood in as many as one third of myopes.
- Trial name
- SWAP (NCT06520124)
- Testing
- Essilor® Stellest® spectacle lens, Single-vision spectacle lens
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Primary Open Angle Glaucoma
STudy to Assess Rapid Disease Progression by Clinical and Genetic Factors In Glaucoma patientS That Are High Risk
The purpose of this study is to perform exploratory analyses to evaluate rates of functional and structural change in glaucoma, to identify predictors of rapid progression in patients with glaucoma and to identify possible…
- Trial name
- STARFISH (NCT01442896)
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Dental Caries
Silver Diamine Fluoride Pilot Study (SDF)
This pilot trial is randomized, double-blind, and placebo-controlled trial with two parallel arms: an intervention group using silver diamine fluoride (SDF) and a placebo group (control).
- Trial name
- SDF (NCT02591147)
- Testing
- Silver Diamine Fluoride 38%
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Justine Kolker
Multiple Sclerosis
Predictors of Progression Independent of Relapse Activity in Relapsing Remitting Multiple Sclerosis
The goal of this prospective observational cohort study is to determine the frequency of progression independent of relapse activity (PIRA) and identify its clinical, radiological, neuroaxonal, and functional predictors in…
- Trial name
- RRMS (NCT07762040)
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Assiut University
Amyotrophic Lateral Sclerosis
PRE-Symptomatic Studies in Amyotrophic Lateral Sclerosis
The goal of PRESS-ALS is to study the earliest manifestations of disease in people with early ALS in whom some areas of the body are not yet affected.
- Trial name
- PRESS-ALS (NCT01508962)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Miami
Steatotic Liver Disease, Liver Fibrosis Progression in Chronic Liver Disease
Interventional AI-Human Collaboration for Steatotic Liver Disease Screening
Steatotic liver disease (SLD) is one of the most prevalent chronic liver diseases worldwide, affecting nearly 30% of the global population and projected to exceed 55% by 2040.
- Conditions
- Steatotic Liver Disease, Liver Fibrosis Progression in Chronic Liver Disease, Liver Steatosis, Liver Fibrosis
- Trial name
- NCT07613827
- Testing
- AI-human collaboration for SLD screening
- Where
- China
- Volunteers
- 7,969 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Colorectal Cancer
Evaluation of Serum Tumor Endothelial Marker1 as a Potential Biomarker for Colorectal Cancer Diagnosis and Cancer Progression
Aim of work 1. measurement level of serumTEM1 in CRC patients by ng/ml using ELISA kits . 2. find relation between serum TEM1 level and staging of CRC patients . 3.
- Trial name
- NCT05779553
- Testing
- Tumor Endothelial Marker 1 ( TEM1 ) by ELISA kits
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Interstitial Lung Disease
Best Clinical Endpoints That Likely Induce Worse Prognosis in Interstitial Lung Diseases
This prospective cohort study will investigate whether progression of the interstitial lung diseases is related to specific clinical endpoints and their changes over time.
- Trial name
- BELIEVE-ILD (NCT03400839)
- Testing
- Daily physical activity levels, 6-minute walk test, Cardiopulmonary exercise testing
- Where
- Brazil
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Myopia, Child Myopia Progression
Photolithography Microstructure Myopia Management Lenses in Preventing and Controlling Myopia in Children and Adolescents
Evaluate the effectiveness of different lithographic microstructured myopia management lenses in controlling the progression of myopia in children and adolescents, as well as the safety and comfort of wearing them.
- Trial name
- NCT07514039
- Testing
- Myopia management lens
- Where
- China
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center