Clinical trials: Cancer Progression
Lens Opacity
Effects of Lycium Barbarum Supplements on the Progression of Senile Cataract in Hong Kong Chinese Population
With the rapid growing aging population, age-related eye diseases including cataract are becoming more prevalent. The demand for cataract surgery and post-surgical care posed enormous financial burdens to the government.
- Trial name
- NCT01142960
- Testing
- Starch, Lycium Barbarum
- Where
- Hong Kong
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Myopia Progressing
Myopia Control With a Innovative Spectacle Lens - A Cessation Study
The purpose of this study is to quantify myopic progression following cessation of a innovative spectacle lenses after 3 years' use.
- Trial name
- NCT06884527
- Testing
- Single Vision Lens to A innovative spectacle lens
- Where
- 5 sites in United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Essilor International
Non-small Cell Lung Cancer
Therapeutic Resistance Prediction of Tyrosine Kinase Inhibitors
The investigators propose a non-invasive prognostic tool for TKIs resistance in patients with stage IV EGFR-mutant non-small cell lung cancer (NSCLC) by computed tomography phenotypic features, which can be conveniently…
- Trial name
- NCT02851329
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Osteoarthritis, Knee
The Long-term Evaluation of Glucosamine Sulphate Study
The primary aim of this study is to determine if the dietary supplements, glucosamine sulphate and/or chondroitin can limit or reduce structural disease progression whilst providing symptomatic benefit in people with…
- Trial name
- LEGS (NCT00513422)
- Testing
- Glucosamine sulphate and chondroitin, Glucosamine sulphate, Chondroitin sulphate
- Where
- Australia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Frailty Syndrome
The CohorFES: a Prospective Study of Frailty and Dependence
Background Frailty has become a major problem for the health system, but also a window of opportunity to fight against disability through preventive strategies focused on the detection and treatment of frailty in all settings.
- Trial name
- COHORFES (NCT06965972)
- Where
- Spain
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Keratoconus
The Collagen Factors of Rapid Progression of Keratoconus in Children.
The purpose of this observational study was to understand the differences in clinical features and mechanisms of keratoconus between children and adults.
- Trial name
- KCLD (NCT06722937)
- Testing
- Observation
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Diabetic Nephropathy
Renal Resisitive Index as an Indicator of the Progression of Diabetic Nephropathy
diabetic nephropathy is one of the leading causes of end stage renal disease
- Trial name
- NCT03658317
- Testing
- renal arterial resistive index, uric acid level, serum urea and creatinine
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assiut University
Periodontitis, Surgery
Metronidazole vs Placebo as Adjuncts to Periodontal Surgery for Patients Positive to Porphyromonas Gingivalis
The objective of this study is to determine whether the use of a systemic antimicrobial (metronidazole) as an adjunct to periodontal surgery provides additional clinical and microbiological beneficial effects compared to…
- Trial name
- NCT03880448
- Testing
- Metronidazole, periodontal surgery
- Where
- Spain
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Mild Cognitive Impairment, Alzheimer Disease
Epilepsy in Alzheimer's Disease: Effect on Disease Progression
This is a long-term, prospective, interventional study to investigate the role and prevalence of subclinical epileptiform activity in the hippocampus in patients with mild cognitive impairment (MCI) due to Alzheimer's disease…
- Trial name
- EADP (NCT04131491)
- Testing
- Lumbar puncture
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Obesity, Insulin Resistance
Targeting the Gut Microbiome to Investigate the Pathways of Progression From Obesity to Metabolic Diseases in an At-risk Population.
Studies of the human gut microbiome have suggested that treatment or prevention aimed at the obese microbiome could influence the development of obesity-associated metabolic disturbances.
- Trial name
- NCT01433120
- Testing
- Lactobacillus paracasei ssp paracasei F19, Flax seed fibres
- Where
- Denmark
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Menopause, Arteriosclerosis
Kronos Early Estrogen Prevention Study (KEEPS)
The study will examine the effects of estrogen and progesterone on the development of atherosclerosis in menopausal women when hormone treatment is initiated within 3 years of the menopausal transition.
- Trial name
- NCT00154180
- Testing
- Conjugated equine estrogens 0.45 mg/day, Transdermal estradiol, 50 mcg/day, Micronized progesterone, 200 mg/day x 12 d/month
- Where
- 9 sites in United States
- Volunteers
- 728 people, healthy volunteers welcome
- Sponsor
- Kronos Longevity Research Institute
Myopia
Topical Application of Low-concentration (0.01%) Atropine on the Human Eye With Fast and Slow Myopia Progression Rate
Our project is a 24-month longitudinal randomized controlled trial that aims to investigate the myopia development after topical application of 0.01% atropine in children with either fast or slow myopia progression classified…
- Trial name
- NCT03374306
- Testing
- Atropine (0.01%), Artificial tear
- Where
- Hong Kong
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Lung Adenocarcinoma
Osimertinib to Suppress the Progression of Remaining GGN for EGFR Mutation-positive Stage IB-IIIA Lung Adenocarcinoma
This is an open label, phase II study to assess the efficacy of osimertinib (80 mg, orally, once daily) to suppress the progression of remaining GGN(s) in other lobes following surgical resection for actionable EGFR…
- Trial name
- NCT05528458
- Testing
- Osimertinib 80Mg Tab
- Where
- South Korea
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Alzheimers Disease, Dementia
A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
The purpose is to evaluate the biomarker effect, safety, and tolerability of investigational study drugs in participants who are known to have an Alzheimer's disease (AD)-causing mutation.
- Conditions
- Alzheimers Disease, Dementia, Alzheimers Disease, Familial
- Trial name
- DIAN-TU (NCT05552157)
- Testing
- Remternetug (SC)
- Where
- 37 sites in United States, Argentina and 13 more
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Cardiac Ageing, Exercise
Exercise to Slow Cardiovascular Ageing Progression
In ageing, deleterious alterations in cardiovascular (CV) structure and function increase risks of ageing-related cardiovascular disease (CVD).
- Conditions
- Cardiac Ageing, Exercise, Cardiovascular
- Trial name
- NCT05775484
- Where
- Singapore
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Myopia
Pilot Study to Assess the Efficacy of Short Exposure to Defocus to Slow the Progression of Myopia in Children
The objective of this pilot study is to establish whether brief periods of high levels of acutely imposed myopic defocus can be used to slow the progression of myopia in children, as measured by changes in spherical equivalent…
- Trial name
- NCT00400140
- Testing
- Hyperopic lens
- Where
- Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Myopia
SEED-LVPEI Myopia Study
This randomized clinical trial study aims to investigate the efficacy of novel SEED's EDOF based mid-lens design in controlling the myopia progression in Indian children with these specific objectives: 1.
- Trial name
- SLIMS (NCT04618510)
- Testing
- SEED 1-dayPure EDOF soft contact lens, Single Vision Spectacles
- Where
- India
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- L.V. Prasad Eye Institute
Multiple System Atrophy, Parkinson's Disease
Prospective Multicenter Registry Study of Multiple System Atrophy in China
Multiple system atrophy is a rare, rapidly progressive neurodegenerative disease characterized by variable combinations of parkinsonism, cerebellar ataxia, and autonomic dysfunction.
- Conditions
- Multiple System Atrophy, Parkinson's Disease, Atypical Parkinsonism
- Trial name
- MSA Registry S (NCT07644013)
- Where
- China
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Prevention of Subclinical Atherosclerosis Progression, Prevention of Cognitive Decline
Nattokinase Atherothrombotic Prevention Study
The potential for nattokinase to "thin" blood and to reduce blood clotting by positive antithrombotic and fibrinolytic effects presents a unique opportunity to safely study such effects on cardiovascular disease and cognition.
- Trial name
- NAPS (NCT02080520)
- Testing
- Nattokinase
- Where
- United States
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Parkinson's Disease
Imaging Biomarkers of Progression of Mobility Impairment in Parkinson Disease
The purpose of this research is to evaluate changes in cholinergic brain activity over time in subjects with Parkinson disease.
- Trial name
- NCT01106976
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development