Clinical trials: Cancer Progression
Myopia
Echothiophate Iodide for the Prevention of Progression of Myopia
The purpose of this study is to test the hypothesis that myopia progression can be slowed or prevented by low dose Echothiophate Iodide.
- Trial name
- NCT02544529
- Testing
- Echothiophate Iodide 0.03% Ophthalmic Solution, Carboxymethylcellulose Sodium (0.5%)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Danbury Eye Physicians & Surgeons, PC
HIV-1, AIDS
HLA-B35 Alleles and AIDS
This study will identify variations in the genome of the human immunodeficiency virus (HIV) early after infection and following the development of AIDS.
- Trial name
- NCT00340223
- Where
- 7 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Age-Related Macular Degeneration
Alpha Lipoic Acid in Geographic Atrophy
Because of its iron-chelating and antioxidant properties, alpha lipoic acid may be a treatment for geographic atrophy (GA) secondary to age-related macular degeneration.
- Trial name
- ALA (NCT02613572)
- Testing
- alpha lipoic acid
- Where
- 5 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Osteoarthritis
A Longitudinal Study of Osteoarthritis (OA) Disease Progression Measured by MRI, dGEMRIC, and Radiography
In order to design future disease modifying osteoarthritis drug (DMOAD) proof of concept studies, this study is being conducted to assess magnetic resonance imaging (MRI) measurements of cartilage morphology and glycosaminoglycan…
- Trial name
- NCT00505297
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Caesarean Sections, Augmentation With Oxytocin
The Labour Progression Study, a Cluster Randomised Trial on Labour Progression for First Time Mothers
The purpose of this study is to evaluate if the rate of emergency caesarean section can be reduced if adhering to a dynamic labour progression curve compared to a static progression curve for first time mothers without…
- Conditions
- Caesarean Sections, Augmentation With Oxytocin, Labour Dystocia
- Trial name
- LAPS (NCT02221427)
- Testing
- Dynamic progression curve, Static labour progression curve (F)
- Where
- Norway
- Volunteers
- 6,582 people, healthy volunteers welcome
- Sponsor
- Ostfold Hospital Trust
Chronic Obstructive Pulmonary Disease
Characteristics of Intestinal Microbiome in the Progression of Early COPD
This study is aiming at explore the characteristics of intestinal microbiome during the early progression of COPD, the correlation between the changes of intestinal microbiome and the severity and risk of acute exacerbation of…
- Trial name
- NCT04876833
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Cardiovascular Diseases, Heart Diseases
Aortic Calcium: Epidemiology and Progression -- Ancillary to MESA
To study the epidemiology of aortic calcium.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Coronary Arteriosclerosis
- Trial name
- NCT00059124
- Volunteers
- 1,980 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Atherosclerotic Disease, Plaque, Atherosclerotic
Natural History of Carotid Plaque as Determined by 3D Ultrasound
This proposed follow-up study aims to recruit participants from the original BioImage cohort for a one-time follow-up examination.
- Conditions
- Atherosclerotic Disease, Plaque, Atherosclerotic, Heart Diseases, Stroke
- Trial name
- BioImage2 (NCT03314818)
- Testing
- Ultrasound 3D Imaging
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Pieter Muntendam
Vitamin D Deficiency
Vitamin D in Periodontal and Cardiovascular Disease Progression
Vitamin D has been considered to possess anti-inflammatory and antimicrobial activity which may be a link for the known interaction of periodontitis (CP) and coronary heart disease (CHD).
- Trial name
- NCT03873935
- Testing
- Evaluation of periodontal status
- Where
- Italy
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- University of Messina
Parkinson's Disease
Compensatory Mechanisms in Parkinson Disease (PD)
Parkinson's disease is characterized by a large number of non motor, especially neuropsychiatric, signs. Their pathophysiology is complex but the role of dopaminergic and serotoninergic systems dysfunction is suggested by several…
- Trial name
- CompensationPD (NCT02038608)
- Testing
- PET
- Where
- France
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Multiple Sclerosis, Neuroinflammatory Diseases
REtinal Markers In Neuroinflammatory Diseases ("REMIND")
The goal of this observational study, including patients with Multiple Sclerosis, patients with other neuroinflammatory diseases and healthy controls, is to determine the predictive value of retinal markers in predicting disease…
- Trial name
- NCT06369766
- Testing
- Optical coherence tomography (OCT), Static retinal vessel analyzer, Dynamic retinal vessel analyzer
- Where
- Switzerland
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Tooth Erosion, Tooth Wear
Association Between Erosive Tooth Wear Progression and Dietary Risk Factors.
Study to determine if whether or not exist an association between the tissue loss (ETW progression) and the frequency of an acidic diet.
- Conditions
- Tooth Erosion, Tooth Wear, Erosion, Dental Erosion
- Trial name
- NCT04586322
- Testing
- No intervention, (observational study).
- Where
- Belgium
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University Ghent
Covid19
Cough Sound Recordings to Understand COVID-19-like Symptom Progression to Understand COVID-19-like Symptom Progression
Decentralized clinical study designed to collect further cough sounds, self-reported symptoms, and medical treatment questionnaires from participants enrolled on the COVID-Cough Study ("Study 1").
- Trial name
- NCT04989452
- Testing
- Recordings of cough sounds from adults
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- ResApp Health Limited
Dementia With Lewy Bodies (DLB), Mild Cognitive Impairment (MCI)
Dementia With Lewy Bodies: Clinical Symptoms, Biomarkers and Progression
The goal of this observational study is to improve the detection of dementia with Lewy bodies (DLB) and its prodromal phases, as well as advancing our current understanding of biological mechanisms and therapeutic options.
- Conditions
- Dementia With Lewy Bodies (DLB), Mild Cognitive Impairment (MCI), Cognitively Unimpaired, Other Dementias
- Trial name
- Find-DLB (NCT07629349)
- Where
- Sweden
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Duchenne Muscular Dystrophy, Muscular Dystrophies
Non-invasive Imaging of Muscle Structure in Duchenne Muscular Dystrophy Using Multispectral Optoacoustic Tomography
This pilot study aims to assess subcellular muscle structure in patients with Duchenne X-linked progressive Duchenne muscular dystrophy (DMD) in comparison to healthy volunteers using multispectral optoacoustic tomography (MSOT).
- Conditions
- Duchenne Muscular Dystrophy, Muscular Dystrophies, Muscular Dystrophy, Duchenne
- Trial name
- MSOT_DMD (NCT03490214)
- Testing
- Multispectral Optoacoustic Tomography
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Cystic Fibrosis
Microbiome Acquisition and Progression of Inflammation and Airway Disease in Infants and Children With Cystic Fibrosis
Cystic Fibrosis (CF) is a fatal, recessive genetic disorder characterized by progressive inflammation and lung damage. It is unclear whether current treatment strategies, which focus on detection and eradication of pathogenic…
- Trial name
- NCT01661491
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yale University
Alzheimers Disease, Mild Cognitive Impairment
Non-expensive and Widely Available Tests as Diagnostic Tools in Dementia and Their Ability to Predict Disease Progression
Alzheimers disease (AD) is the most common course of cognitive decline and thereby the course of more than half of all cases of dementia.
- Trial name
- DEMPROG (NCT01642420)
- Where
- Denmark
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Respiratory Insufficiency, Clinical Deterioration
Wearable Wireless Respiratory Monitoring System That Detects and Predicts Opioid Induced Respiratory Depression
An observational study will be conducted in approximately 14 participants to evaluate the ability of a wearable, wireless acoustic Respiratory Monitoring System (RMS) to accurately measure a participant's respiratory rate, tidal…
- Trial name
- NCT06442488
- Testing
- Respiratory Monitoring System
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Jeffrey Joseph
Sarcopenia, Frailty
Effectiveness of Individual Physical Activity Programs to Prevent Sarcopenia and Frailty Among Older Adults
Sarcopenia and frailty could be prevented and rehabilitated through individual physical activities in the form of combined exercise that could be practiced at home in daily life.
- Trial name
- NCT06149871
- Testing
- Physical activity
- Where
- Thailand
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Thailand
Alzheimer s Disease, Mild Cognitive Impairment (MCI)
Crownlands Observing Progression With Neurons Study
The CROWN-I Study is an observational study to learn about molecular features of Alzheimer's disease (AD) and mild cognitive impairment (MCI).
- Trial name
- CROWN-I (NCT07611396)
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Crownlands