Clinical trials: Cancer Progression
Hypoparathyroidism, Pseudohypoparathyroidism
German Hypoparathyroidism Registry
Chronic hypoparathyroidism is a rare condition in which the parathyroid glands do not make enough parathyroid hormone (PTH). PTH helps control the levels of calcium and phosphate in the blood.
- Trial name
- HyPaReg (NCT07857460)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital Augsburg
Parkinson Disease
A Study of the Efficacy of IAMT as an Assessment Tool for Prediction of Progression of Parkinson's Disease
The primary objective of this proposal is to examine the efficacy of Improvised Active Music Therapy (IAMT) sessions as an early novel tool for cognitive and motor assessment for individuals with Parkinson's Disease (PD) in…
- Trial name
- Music Therapy (NCT05971459)
- Testing
- Improvised Active Music Therapy
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Wilfrid Laurier University
Myopia
Myopia Control With Novel Eye Drops
Myopia currently affects 30% of the world and by 2050, almost 50% of the world will be myopic based on conservative estimates.1 In 2050, this will equate to almost 5 billion people with myopia, and those with high myopia will…
- Trial name
- NCT04301323
- Testing
- BHVI1 eye drops, BHVI2 eye drops, BHVI3 eye drops
- Where
- Vietnam
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Hai Yen Eye Care
Small-cell Lung Cancer
a Study of QL1706 or QL1604 in Patients With Limited-stage Small Cell Lung Cancer After Chemoradiotherapy.
The study is being conducted to evaluate the efficacy and safety of QL1706 versus QL1604 monotherapy as consolidation treatment in patients with limited-stage small cell lung cancer (LS-SCLC) who have not experienced disease…
- Trial name
- NCT06789796
- Testing
- Iparomlimab and Tuvonralimab (QL1706), QL1604
- Volunteers
- 636 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Rheumatoid Arthritis
An Open-Label Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Active Rheumatoid Arthritis
This open-label, single-arm study will evaluate the efficacy and safety of tocilizumab in patients with active moderate to severe rheumatoid arthritis.
- Trial name
- NCT01951170
- Testing
- Tocilizumab
- Where
- 10 sites in Australia
- Volunteers
- 52 people
- Sponsor
- Hoffmann-La Roche
Multiple Myeloma in Relapse, Multiple Myeloma Progression
Rivaroxaban or Aspirin As Thromboprophylaxis in Multiple Myeloma
The intended study is designed as a a phase IV pragmatic multicenter randomized controlled clinical trial, comparing the impact of two different therapies including ASA vs.
- Conditions
- Multiple Myeloma in Relapse, Multiple Myeloma Progression, Multiple Myeloma Stage II, Multiple Myeloma Stage I
- Trial name
- RithMM (NCT03428373)
- Testing
- Rivaroxaban, ASA
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Kidney Disease
A Study of AST-120 for Evaluating Prevention of Progression In Chronic Kidney Disease Including Assessment of Quality of Life (EPPIC-2)
1) To evaluate the effectiveness of AST-120 (spherical carbon adsorbent) added to standard-of-care therapy in moderate to severe Chronic Kidney Disease (CKD), on time to first occurrence of any event of the triple composite…
- Trial name
- NCT00501046
- Testing
- AST-120
- Where
- 106 sites in United States, Argentina and 10 more
- Volunteers
- 1,015 people
- Sponsor
- Tanabe Pharma Corporation
Colorectal Cancer, Metastatic Colorectal Cancer
Safety and Effectiveness Study of Chemotherapy and Ziv-aflibercept to Treat Metastatic Colorectal Cancer
FC-8 is a Phase II, multi-center randomized study of a continuation regimen of 5-FU/LV with ziv-aflibercept or 5-FU/LV alone (control arm) following the induction regimen of mFOLFOX6 and ziv-aflibercept as first-line therapy for…
- Trial name
- NCT01889680
- Testing
- 5-FU, LV, ziv-aflibercept
- Sponsor
- NSABP Foundation Inc
Lymphoma, Large B-Cell, Diffuse
Genomic Evaluation in Patients With Diffuse Large B Cell Lymphoma After First Relapse/Progression
DLBCL has the highest frequency out of all lymphoid malignancies. With the recent development of antitumor agents targeting intracellular/extracellular cell signaling pathways, patients have access to various treatment options…
- Trial name
- COGET-B (NCT03977623)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Lung Cancers, Lung Cancer, Non-Small Cell
Quality of Life as a Predictor of OS and PFS in Patients With Lung Cancer
By 2020, lung cancer continues leading the first cause of cancer mortality and the second most common type of cancer in the world.
- Trial name
- FACT-L_Pred (NCT06900283)
- Where
- Colombia
- Volunteers
- 320 people
- Sponsor
- Instituto Nacional de Cancerologia, Columbia
Age-related Macular Degeneration
A Study to Evaluate the Safety and Efficacy of RQC for AMD
To evaluate the safety and efficacy of resveratrol, quercetin, and curcumin in combination (RQC) over 2 years in patients with age-related macular degeneration (AMD).
- Trial name
- NCT05062486
- Testing
- Resveratrol, Quercetin, Curcumin (RQC), Curcumin
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Paul A Knepper, MD PhD
Cancer Disease Progression
PET Enhanced CT Scan Performance in Cancer
Hypothesis: The investigators would like to demonstrate that diagnosis performance of PET/CT scan without and with contrast agent (COMBI TEP), are equivalent or better than those of PET/ non enhanced CT scan (PET scan) associated…
- Trial name
- COMBITEP (NCT01881620)
- Testing
- COMBI TEP : PET / enhanced CT scan
- Volunteers
- 109 people
- Sponsor
- Institut Bergonié
Rectal Cancer, Feasibility
Feasibility of the Maastro Applicator in Rectal Cancer
The goal of this interventional pilot trial is to confirm that Maastro endoluminal HDR ( High Dose Radiation) contact brachytherapy boosting is feasible and may increase the chance of functional organ sparing of the rectum in…
- Conditions
- Rectal Cancer, Feasibility, Toxicity, Quality of Life
- Trial name
- NCT06087718
- Testing
- Maastro applicator
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht Radiation Oncology
Calciphylaxis, Calcific Uremic Arteriolopathy
Double-blind Trial of Sodium Thiosulfate for the Treatment of Pain Associated With Calcific Uremic Arteriolopathy
To evaluate the efficacy of Sodium Thiosulfate (STS) compared to placebo, in reducing analgesic requirement in subjects with calcific uremic arteriolopathy (CUA) during an initial 28-day treatment phase.
- Trial name
- NCT02527213
- Testing
- Sodium thiosulfate
- Where
- 3 sites in United States
- Sponsor
- American Regent, Inc.
HELLP Syndrome, Preeclampsia
Analysis of Biological Progression and Regression of HELLP Syndrome in Time
Prospective observational study about progression and regression of biological parameters of HELLP syndrome
- Trial name
- NCT06758960
- Where
- Morocco
- Volunteers
- 72 people
- Sponsor
- CHU Mohammed VI Marrakech
Myopia
A Study of the Efficacy and Safety of Two Low-concentration Atropine Sulfate Eye Drops
A randomized, double-blind, placebo-controlled, multicenter, phase III clinical study of the efficacy and safety of two low-concentration atropine sulfate eye drops in slowing the progression of myopia in children
- Trial name
- China-CHAMP (NCT06209320)
- Testing
- Lower dose atropine sulfate eye drops, Low dose atropine sulfate eye drops
- Where
- China
- Volunteers
- 777 people
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Cirrhosis, Hepatocellular Carcinoma
Simvastatin in Preventing Liver Cancer in Patients With Liver Cirrhosis
This phase II trial studies how well simvastatin works in preventing liver cancer in patients with liver cirrhosis. Simvastatin may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
- Trial name
- NCT02968810
- Testing
- Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging
- Where
- 5 sites in United States, Puerto Rico
- Volunteers
- 52 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer
An Open-Label, Bayesian Adaptive Phase II Clinical Study in HR+/HER2- Advanced Breast Cancer After Progression on Standard Therapy
This is a prospective, Phase II, open-label, two-arm parallel study evaluating the efficacy and safety of combined treatment (L-Ornithine L-Aspartate, N-Acetylcysteine) with CDK4/6 inhibitors and Fulvestrant in patients with…
- Trial name
- NCT07117630
- Testing
- L-Ornithine L-Aspartate, CDK4/6 inhibitor, Fulvestrant
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fudan University
Parkinson's Disease, Dysarthria
Dysarthria in Parkinson's Disease: Lusophony vs. Francophony Comparison
Parkinson's disease (PD) affects between 1% and 2% of the world's population aged 60 and older; in Europe the prevalence is around 150 PD patients per 100,000 individuals.
- Conditions
- Parkinson's Disease, Dysarthria, Speech, Cross-language
- Trial name
- FraLusoPark (NCT02753192)
- Testing
- Patients
- Where
- 3 sites in France, Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre National de la Recherche Scientifique, France
Diabetic Retinopathy
A Study That Uses Data From Routine Eye Examinations of Patients Participating in Studies FIDELIO-DKD and FIGARO-DKD to Explore Whether Finerenone Can Delay the Progression of a Diabetes Complication That Affects the Eyes (Diabetic Retinopathy ,DR)
Diabetic retinopathy (DR) is a diabetes complication caused by damage to the small blood vessels inside the retina at the back of the eye. Diabetic retinopathy may cause mild vision problems or eventually blindness.
- Trial name
- ReFineDR (NCT04477707)
- Testing
- Finerenone (BAY94-8862)
- Where
- 62 sites in United States, Argentina and 13 more
- Volunteers
- 206 people
- Sponsor
- Bayer
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