Clinical trials: Cancer Progression
Age-Related Macular Degeneration
Effect of Omega-3 Fatty Acid Supplementation on Dry-AMD Progression
This randomized, double-blind, placebo-controlled study aims to evaluate the effect of krill oil supplementation in patients with dry age-related macular degeneration (AMD).
- Trial name
- OMEGA-AMD (NCT05465252)
- Testing
- Krill Oil, Olive Oil
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Chronic Kidney Diseases, Acute Kidney Injury
Use of New Drug QRX-3 for Prevention and Treatment of Chronic Kidney Disease Progression
Chronic kidney disease CKD is estimated to affect nearly over 800 million people globally today (with roughly 125,000 people ending up annually on dialysis in the United States alone.
- Conditions
- Chronic Kidney Diseases, Acute Kidney Injury, Kidney Failure
- Trial name
- NAD agent (NCT06866236)
- Testing
- QRX-3
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Ebima Clifford Okundaye
High Grade Glioma
Predicting Sites of Tumour Progression in the Invasive Margin of Glioblastomas (PRaM-GBM Study)
Brain tumours are the leading cause of cancer deaths in children, men under the age of 45 and women under the age of 25. Glioblastoma is the most common and most malignant primary tumour.
- Trial name
- PRaM-GBM (NCT03294434)
- Testing
- Diffusion tensor Imaging (DTI)
- Where
- United Kingdom
- Volunteers
- 147 people
- Sponsor
- CCTU- Cancer Theme
Physical Activity
Sit-to-Stand Progression Using Movi Chair vs Traditional Practices
Prior to discharging admitted patients, current UAB Hospital policy recommends physical therapy intervention for patients with impaired functional mobility.
- Trial name
- NCT03103464
- Testing
- Standard-of-Care Therapy + Sit-to-Stand Therapy, Standard-of-Care Therapy
- Where
- United States
- Sponsor
- University of Alabama at Birmingham
Breast Cancer
Aggressive Local Therapy for Limited Bone-Only Metastasis to Improve Progression-Free Survival in Breast Cancer Patients
The goal of this clinical research study is to find out if adding local therapy (surgery and/or radiation) to standard therapy (chemotherapy or endocrine therapy) in the treatment of patients with metastatic breast cancer can…
- Trial name
- NCT00929214
- Testing
- Standard Therapy, Local Therapy
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- M.D. Anderson Cancer Center
Mild Cognitive Impairment, Dementia
Train the Brain - Cognitive and Physical Training for Slowing Dementia
Train The Brain is aimed at assessing the efficacy of cognitive and physical training in slowing progression to dementia in patients diagnosed with mild cognitive impairment (MCI).
- Conditions
- Mild Cognitive Impairment, Dementia, Memory Disorders
- Trial name
- TTB (NCT01725178)
- Testing
- Cognitive and Physical training
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy
Deterioration, Clinical
The Orientation Intervention to Rapid Response Teams (ORIENT-RRT) Study: A Quasi-Experimental Study
This study will measure knowledge, confidence, and nursing practice outcomes related to the effectiveness and feasibility of a 12-hour educational clinical intervention for NGNs during orientation.
- Trial name
- The ORIENT-RRT (NCT07897851)
- Testing
- Orientation day with rapid response nurse
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Prostate Adenocarcinoma, PSA Failure
White Button Mushroom Sup for the Reduction of PSA in Pts With Biochemically Rec or Therapy Naive Fav Risk Prostate CA
This phase II trial studies how well white button mushroom supplement works in reducing prostate-specific antigen (PSA) levels in patients with prostate cancer that has come back (recurrent) or has favorable risk and has not…
- Conditions
- Prostate Adenocarcinoma, PSA Failure, PSA Progression, Recurrent Prostate Carcinoma
- Trial name
- NCT04519879
- Testing
- Clinical Observation, Patient Observation, Questionnaire Administration
- Where
- 7 sites in United States
- Volunteers
- 133 people
- Sponsor
- City of Hope Medical Center
High Altitude Pulmonary Hypertension
Right Ventricular Function at Rest in Highlanders/Lowlanders
The purpose of the current study is to evaluate the progression of right ventricular function and dimension in Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a cross sectional case-control study.
- Trial name
- NCT03165656
- Where
- Kyrgyzstan
- Volunteers
- 173 people
- Sponsor
- University of Zurich
Hypertriglyceridemia
Effect of Vascepa on Improving Coronary Atherosclerosis in People With High Triglycerides Taking Statin Therapy
Effect of Vascepa on Progression of Coronary Atherosclerosis in Persons with Elevated Triglycerides (200-499) on Statin Therapy.
- Trial name
- EVAPORATE (NCT02926027)
- Testing
- Vascepa
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Unresectable/Metastatic Colorectal Cancer
Fruquintinib Plus Camrelizumab and Capecitabine as Salvage Therapy After Progression on FOLFOXIRI-based First-line Treatment in Patients With Unresectable/Metastatic Colorectal Cancer
FOLFOXIRI-based regimen is more used as a first-line therapeutic approach for patients diagnosed with unresectable or metastatic colorectal cancer for its superior efficacy.
- Trial name
- NCT06148402
- Testing
- Fruquintinib plus camrelizumab and capecitabine
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Rectal Cancer
Influence of Lengthening the Interval Between Radiochemotherapy and Surgery on Complete Pathological Response in Rectal Cancer
At the end of the neoadjuvant radiochemotherapy, patients are seen by their surgeon to planify the surgery. During this visit, the study will be explained them and their consent obtained.
- Trial name
- GRECCAR6 (NCT01648894)
- Testing
- Surgery after 11 weeks of delay after chemoradiotherapy., Surgery after 7 weeks of delay after chemoradiotherapy
- Where
- France
- Volunteers
- 265 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson Disease
Bee Venom for the Treatment of Parkinson Disease
The purpose of this study is to evaluate the efficacy of repeated (monthly) injections of bee venom on motor symptoms of Parkinson's disease over a period of one year, also the potential effects of this treatment on disease…
- Trial name
- MIREILLE (NCT01341431)
- Testing
- bee venom
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myeloproliferative Neoplasm, Primary Myelofibrosis
Sympathicomimetic Agonist in Patients With Myeloproliferative Neoplasms With JAK2-mutation
The aim of this phase II study is to test a novel concept in the treatment of patients with myeloproliferative neoplasms (MPN), a disease of the bone marrow.
- Conditions
- Myeloproliferative Neoplasm, Primary Myelofibrosis, Essential Thrombocythemia, Polycythemia Vera
- Trial name
- NCT02311569
- Testing
- Mirabegron
- Where
- 11 sites in Switzerland
- Volunteers
- 39 people
- Sponsor
- Swiss Cancer Institute
Progression Free Survival of the Treatment
IPO-NEC Trial:Study on the Efficacy and Safety Using Sequential IP Therapy and Oct Lar in the Treatment of Advanced GI NEC
This is a prospective, single-armed, open label study on the efficacy and safety of sequential IP therapy(Irinotecan plus cisplatin) and octreotide lar in the treatment of GI poorly diffrentiated Neuroendocrine carcinoma.
- Trial name
- NCT01480986
- Testing
- Irinotecan combined with cisplatin, octreotide lar
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University
Lower Urinary Tract Symptoms
Prostatic Obstruction Investigation Team Multicenter Study
The present is a multicenter, observational study organized by the Prostatic Obstruction Investigation Team (POInT), with a main purpose of looking into the current status and symptom progression of male lower urinary tract…
- Trial name
- POInT (NCT03394651)
- Testing
- Oral medications to treat lower urinary tract symptoms, Minimal invasive transurethral prostate procedures
- Where
- China
- Volunteers
- 11,500 people
- Sponsor
- Changhai Hospital
Chronic Obstructive Pulmonary Disease
Imaging Progression of Chronic Obstructive Pulmonary Disease Using MRI and CT (MR-COPDII)
In this follow-up trial, MRI and CT images of the lung will be acquired prospectively in a subcohort of 370 patients, three years after they successfully participated in the first COSYCONET subtrial with CT and MRI ("MR-COPD I"…
- Trial name
- MR-COPDII (NCT03591562)
- Where
- 10 sites in Germany
- Volunteers
- 252 people
- Sponsor
- University Hospital Heidelberg
Scoliosis
Prospective Multicenter Evaluation of a New Predictive Model for the Progression of Adolescent Idiopathic Scoliosis
Scoliosis is a three-dimensional deformity affecting the orientation and position of the spine. Locally, the shape of the vertebra is also affected.
- Trial name
- NCT02434003
- Where
- 9 sites in United States, Canada and 4 more
- Volunteers
- 1,200 people
- Sponsor
- St. Justine's Hospital
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Study of Lanreotide to Treat Polycystic Kidney Disease
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst formation in both kidneys, in most patients leading to end stage renal disease.
- Trial name
- DIPAK1 (NCT01616927)
- Testing
- Lanreotide
- Where
- 4 sites in Netherlands
- Volunteers
- 300 people
- Sponsor
- University Medical Center Groningen
Alzheimer's Disease
Study of MK0677 for the Treatment of Alzheimer's Disease (0677-030)(COMPLETED)
An investigational drug (MK0677) will be studied to determine whether it helps the memory and cognition of patients with Alzheimer's Disease.
- Trial name
- NCT00074529
- Testing
- MK0677
- Volunteers
- 512 people
- Sponsor
- Merck Sharp & Dohme LLC
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