Clinical trials: Cancer Related Cognitive Decline
Gynecologic Cancer, Chemotherapy Effect
Improve Cancer-related Cognitive Impairment
Cancer-related cognitive impairment (CRCI), also known as "chemobrain," is the cognitive decline that negatively impacts the majority of cancer patients undergoing chemotherapy, radiation, and/or hormonal treatments.
- Conditions
- Gynecologic Cancer, Chemotherapy Effect, Chemo-brain, Cancer-related Cognitive Difficulties
- Trial name
- NCT05864274
- Testing
- Cognitive training application
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Patients Treated for Cancer
Cancer Related Cognitive Impairment
Various recent scientific data testify to the cognitive deficiencies of cancer patients, called Cancer-Related Cognitive Impairments (CRCI) (Noal, Daireaux \& Joly, 2010).
- Trial name
- APACO (NCT03949322)
- Testing
- Adapted Physical Activity Program
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Institut Cancerologie de l'Ouest
Breast Cancer, Cancer of the Breast
Prehabilitation to Revolutionize Oncology: Telehealth Exercise for Cognitive Triumphs (The PROTECT Trial)
The investigators propose to deliver a pilot randomized controlled trial to 40 women newly diagnosed with breast cancer and scheduled to undergo chemotherapy.
- Trial name
- NCT05716542
- Testing
- Physical Activity Intervention
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Washington University School of Medicine
Cancer, Sarcopenia
JUMP Prevalence of Sarcopenia and Chemobrain in Post-cancer Patients
Therapeutic advances in oncology have transformed the prognosis of cancer patients, placing a significant number of them either in a context of recovery or in prolonged remission close to a chronic disease.
- Trial name
- JUMP (NCT05800535)
- Testing
- Study of the adverse effects of long-term oncological treatments, Study of the long-term side effects of oncological treatments on the anxiety-depressive and cognitive state of patients
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Breast Cancer, Fatigue
The Role of Circadian Rhythms in Cancer-Related Symptoms
Emerging evidence indicates that circadian rhythms may be disrupted following cancer and its treatment, and that circadian rhythm disruption may be an underlying pathophysiological mechanism of cancer- and cancer…
- Conditions
- Breast Cancer, Fatigue, Cognitive Impairment, Sleep
- Trial name
- CHRONO (NCT04401189)
- Where
- Denmark
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Disease/Condition Name Cancer-related Cognitive Dysfunction, Chronic Lymphocytic Leukemia (CLL)
Impact of Targeted Therapy on Cancer-Related Cognitive Impairment
This study examines whether there are differences in brain health or well-being in patients receiving TKI therapy for leukemia compared to individuals who do not receive TKI therapy.
- Conditions
- Disease/Condition Name Cancer-related Cognitive Dysfunction, Chronic Lymphocytic Leukemia (CLL), Chronic Myeloid Leukemia, BCR-ABL1 Positive
- Trial name
- TKI (NCT07638007)
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Rochester NCORP Research Base
Cancer-related Cognitive Impairment
Electroacupuncture for Cognitive Toxicity in Cancer Survivors: Assessing Implementation, Cost, and Effectiveness for Integration
The goal of this clinical trial is to evaluate the clinical effectiveness and understand the biological mechanisms of electroacupuncture (EA) in reducing cognitive toxicity among cancer survivors.
- Trial name
- EAST-ALIGN (NCT07583979)
- Testing
- True electroacupuncture
- Where
- Singapore
- Volunteers
- 168 people
- Sponsor
- National Cancer Centre, Singapore
Cancer, Cognitive Impairment
Digital Intervention Targeting Cancer-related Cognitive Impairments
Cognitive deficits are frequently reported following cancer treatment and can significantly impact daily functioning. These cognitive impairments often persist for years after cancer treatment.
- Trial name
- NCT06693102
- Testing
- Digital intervention targeting cancer-related cognitive impairments, Crossword and sudoku taks
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Haukeland University Hospital
Breast Cancer, Cognitive Dysfunction
Reducing Breast Cancer-related Fatigue and Improving Cognition With Non-Invasive Brain Stimulation
This study will test the preliminary efficacy of transcranial direct current stimulation (tDCS) to improve fatigue and cognition in women with a history of breast cancer and persistent fatigue.
- Conditions
- Breast Cancer, Cognitive Dysfunction, Fatigue
- Trial name
- NCT03143894
- Testing
- tDCS
- Where
- 3 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cancer-related Cognitive Impairment
Photobiomodulation for Cancer-Related Cognitive Impairment
This is a single site, pilot randomized, double blinded control trial designed to assess changes in cognitive symptoms in cancer survivors with cancer-related cognitive impairment.
- Trial name
- NCT05855694
- Testing
- THOR LED Photobiomodulation Helmet - Therapeutic, THOR LED Photobiomodulation Helmet - Control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Arash Asher, MD
Postoperative Cognitive Dysfunction, Postoperative Delirium
Postoperative Cognitive Dysfunction in Elderly Urologic Oncology Patients (POCD)
Postoperative cognitive changes are more common in elderly patients, which can result in poor quality of life, loss of workforce, disability, early retirement, physical-social dependence, increased health care cost and premature…
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Frailty
- Trial name
- POCD (NCT04837391)
- Testing
- Near Infrared Spectroscopy (NIRS), Blood sample, Addenbrooke Cognitive Examination III (ACE-III)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Istanbul University
Cancer
MAAT For Young Adult Cancer Survivors
The goal of this clinical trial is to pilot-test a modified version of telehealth-delivered Memory and Attention Adaption Training (MAAT) that is tailored to young adult childhood cancer survivors (ages 18-39; MAAT-YS) with…
- Trial name
- MAAT-YACCS (NCT06150976)
- Testing
- MAAT-YS
- Where
- 3 sites in United States
- Volunteers
- 7 people
- Sponsor
- University of Pittsburgh
Chemotherapy-Related Cognitive Impairment
Electroacupuncture for Chemotherapy-Related Cognitive Impairment
The objective of this trial is to evaluate the effect of electroacupuncture compared to sham acupuncture in preventing CRCI among breast cancer patients scheduled to undergo chemotherapy.
- Trial name
- NCT05941598
- Testing
- Electroacupuncture
- Volunteers
- 100 people
- Sponsor
- Beijing University of Chinese Medicine
Patients With Cancer
Cognition Assessment and REhabilitation in Virtual Reality for Patients With Cancer
1. To assess the cognitive function of patients with cancer by leveraging a validated virtual reality (VR)-based cognitive assessment tool. 2.
- Trial name
- CARE-VR4PC (NCT07335393)
- Testing
- VR-based cognitive rehabilitation therapy (VR-CRT)
- Volunteers
- 64 people
- Sponsor
- JING MINGXUE
Cancer Patients Eligible for a Treatment With Curative Intent, Cognitive Impairment
Predictive Value of the Distress Thermometer as a Predictive Screening Instrument to Detect Cancer-related Cognitive Impairment in Cancer Patients
Cognitive impairment associated with chemotherapy is an important reported post-treatment side-effect among breast and other cancer survivors.
- Trial name
- CONCEPT (NCT01846260)
- Where
- Belgium
- Volunteers
- 125 people
- Sponsor
- General Hospital Groeninge
Breast Cancer, Cancer-related Problem/Condition
Making Activity Time for Cognitive Health
Approximately 75% of cancer survivors experience some degree of cognitive deficit throughout their cancer experience, with upwards of one third of breast cancer survivors reporting impairments up to a decade after treatment.
- Conditions
- Breast Cancer, Cancer-related Problem/Condition, Cognitive Impairment, Physical Activity
- Trial name
- MATCH (NCT04255225)
- Testing
- Walking for 10 minutes, Walking for 20 minutes, Walking for 30 minutes
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Fatigue, Neoplasms
D-MPH in the Treatment of Fatigue and Neurobehavioral Function Related to Chemotherapy in Adult Cancer Patients
To evaluate the efficacy of dexmethylphenidate (d-MPH) in the treatment of chemotherapy-related fatigue in adult cancer subjects.
- Trial name
- NCT00047476
- Testing
- dexmethylphenidate(d-mph)
- Where
- 21 sites in United States
- Volunteers
- 160 people
- Sponsor
- Celgene Corporation
Cancer, Fatigue
Health-related Quality of Life-intervention in Survivors of Breast and Other Cancers Experiencing Cancer-related Fatigue Using Traditional Chinese Medicine: The HERBAL Trial
This study is a phase 2, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy and safety of a Traditional Chinese Medicine decoction, the modified Xiang Bei Yang Rong Tang, in alleviating cancer related…
- Conditions
- Cancer, Fatigue, Cognitive Impairment
- Trial name
- HERBAL (NCT04104113)
- Testing
- Modified Xiang Bei Yang Rong Tang
- Where
- Singapore
- Volunteers
- 80 people
- Sponsor
- National University of Singapore
Breast Cancer Female
Metacognitive Strategy Training in Cancer-related Cognitive Impairment
The first aim of this study is to determine the feasibility of delivering CO-OP remotely to breast cancer survivors, who self-report cancer-related cognitive impairment (CRCI), in preparation for a future R01 trial.
- Trial name
- NCT05505045
- Testing
- CO-OP Procedures, Attention Control Procedures
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Missouri-Columbia
Brain Metastases, Radiotherapy Side Effect
GM1 Prophylaxis for WBRT Related Cognitive Dysfunction
To evaluate the efficacy and safety of GM1 for preventing cognitive impairment related to whole brain radiotherapy in breast cancer patients with brain metastases.
- Conditions
- Brain Metastases, Radiotherapy Side Effect, Cognitive Impairment, Gangliosidosis, GM1
- Trial name
- GLORY (NCT04395339)
- Testing
- Monosialotetrahexosyl ganglioside (GM1), Control
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Sun Yat-sen University