Clinical trials: Cancer in Children/Adolescents
Osteosarcoma
A Study to Compare the Efficacy and Safety of Ifosfamide and Etoposide With or Without Lenvatinib in Children, Adolescents and Young Adults With Relapsed and Refractory Osteosarcoma
This Is a Multicenter, Randomized, Open-Label, Parallel-Group, Phase 2 Study to Compare the Efficacy and Safety of Lenvatinib in Combination with Ifosfamide and Etoposide Versus Ifosfamide and Etoposide in Children, Adolescents…
- Trial name
- NCT04154189
- Testing
- Lenvatinib, Ifosfamide, Etoposide
- Where
- 84 sites in United States, Australia and 19 more
- Volunteers
- 81 people
- Sponsor
- Eisai Inc.
Pediatric Cancer, Quality of Life
Outpatient Yoga Study for Adolescents Receiving Chemotherapy
LAY SUMMARY: The diagnosis and treatment of pediatric cancer is a significant stressor for adolescents and their families . Although most adolescents cope well with their cancer diagnosis, many experience emotional distress.
- Conditions
- Pediatric Cancer, Quality of Life, Cancer, Treatment-Related, Psychological Distress
- Trial name
- NCT03318068
- Testing
- Yoga Intervention
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- The Hospital for Sick Children
Unmet Fertility Information Needs
Investigating the Efficacy of a Paediatric Fertility Preservation Decision Aid in Parents and Adolescents and Young Adults (CAYA) Cancer Survivors
The current standard of care for paediatric patients with cancer regarding preservation of their fertility (FP) is to provide high-quality information during the clinical consultation process.
- Trial name
- FOCUS (NCT06894810)
- Testing
- Decision-aid
- Where
- Australia
- Volunteers
- 358 people
- Sponsor
- Murdoch Childrens Research Institute
Anaplastic Large-Cell Lymphoma
Denileukine Diftitox for Relapsed ALCL
The purpose of this study is to determine is Denileukin diftitox will be safe, well tolerated and induce a significant overall response alone and in combination with chemotherapy: ifosfamide, carboplatin and etoposide (ICE) and…
- Trial name
- NCT00801918
- Testing
- Denileukin Diftitox, Denileukin diftitox, ifosfamide, cyclophosphamide, etoposide
- Where
- United States
- Sponsor
- Columbia University
Sickle Cell Disease, Chronic Kidney Diseases
Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic Conditions
The purpose of this study is to test the efficacy of a peer support coaching intervention to improve activated chronic illness self-management versus an attention control group in 225 adolescents and young adults with childhood…
- Conditions
- Sickle Cell Disease, Chronic Kidney Diseases, Systemic Lupus Erythematosus, Childhood Cancer
- Trial name
- PiCASO (NCT03938324)
- Testing
- PiCASO Intervention Group
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Duke University
Adolescent Cancer Survivors, Pediatric Cancer Survivors
Adolescent Survivors of Cancer or Similar Illnesses
The purpose of this study is to examine the health behaviors of young adults who have been treated for cancer, leukemia, or similar illnesses.
- Trial name
- NCT00579631
- Testing
- Questionnaire or Interview
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Acute Myeloid Leukemia (AML)
Allogenic Stem Cell Transplantation for Children, Adolescents and Young Adults With Relapsed or Refractory AML
1. To evaluate whether stem cell transplantation from a matched sibling donor is equivalent to a matched unrelated donor in in a second complete remission of acute myeloid leukemia (AML). 2.
- Trial name
- NCT00606723
- Testing
- Hematopoietic stem cells from bone marrow or peripheral blood
- Where
- 24 sites in Austria, Czechia and 1 more
- Volunteers
- 154 people
- Sponsor
- Hannover Medical School
High Grade Glioma, Replication Repair Deficient
A Pilot Study Investigating Upfront Adaptive Immunotherapy Approach in Children, Adolescent and Young Adult (CAYA) Patients With Replication-Repair Deficient (RRD) High-Grade Gliomas (HGG)
This is open label, multicentre, single arm, pilot study of upfront nivolumab in patients with RRD-glioblastoma with favorable immune/genomic biomarkers.
- Trial name
- NCT06519682
- Testing
- Nivolumab, Radiation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Daniel Morgenstern
Childhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2008
QUESTIONS AND OBJECTIVES OF ALL-MB-2008 STUDY 1. Whether the early PEG-asparaginase in induction will lead to the earlier achievement of remission, improvement of days 8 and 15 responses leading to an earlier reconstitution of…
- Trial name
- ALL-MB 2008 (NCT01953770)
- Testing
- PEG-L-asparaginase ind, PEG-L-asparaginase cons, E.coli L-asparaginase
- Where
- 46 sites in Belarus, Russia and 1 more
- Volunteers
- 3,000 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Survivors of Childhood Cancer, Alopecia
A Study of Oral Minoxidil to Treat Hair Loss in Children, Teens, and Young Adults Who Are Cancer Survivors
This study will test whether minoxidil taken by mouth (oral minoxidil) can improve hair loss caused by cancer treatment in children and young adults.
- Trial name
- NCT05778825
- Testing
- Oral Minoxidil
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Glioma
Phase II Cisplatin + Temozolomide in Malignant Glial Tumours in Children and Adolescents
The purpose of this study is to determine whether the combination of Temozolomide and Cisplatinum is effective in the treatment of malignant glial tumours of children and adolescents
- Trial name
- NCT00147160
- Testing
- Temozolomide, Cisplatinum
- Where
- 2 sites in France, United Kingdom
- Volunteers
- 87 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Leukemia, Lymphoblastic, Leukemia, Myeloid, Acute
Oral Health Condition and Quality of Life in Children With Leukemia
Among the different types of cancer that most affect children, leukemia is the principal. One of the main treatments for leukemia is chemotherapy.
- Trial name
- NCT04968860
- Testing
- This study is observational
- Where
- Brazil
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Paulo Sergio da Silva Santos
Long-term Effects Secondary to Cancer Therapy in Adults, Pediatric Cancer
Exercise Intervention in Adolescent and Young Adult Cancer Survivors
Adolescent and young adult (AYA) survivors of cancer face a future of persistent medical issues across a wide spectrum of diseases One study examining health data from this cohort (ages 15-29) reported significantly higher rates…
- Trial name
- NCT04265638
- Testing
- Exercise
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- Indiana University
Medullary Thyroid Carcinoma, Multiple Endocrine Neoplasia Type 2A
Vandetanib to Treat Children and Adolescents With Medullary Thyroid Cancer
Background: Medullary thyroid carcinoma (MTC) is common in people with a genetic disorder called multiple endocrine neoplasia (MEN).
- Conditions
- Medullary Thyroid Carcinoma, Multiple Endocrine Neoplasia Type 2A, Multiple Endocrine Neoplasia Type 2B
- Trial name
- NCT00514046
- Testing
- Vandetanib
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Cancer Institute (NCI)
Childhood Cancer, Late Effects
Young Survivors at Kantonsspital Aarau, Switzerland
The Young Survivors at Kantonsspital Aarau project assesses the prevalence and severity of late effects in survivors of childhood and adolescent cancer according to the modified CTCAE criteria prospectively.
- Trial name
- NCT04811794
- Testing
- Physical examination, diagnostic tests, laboratory tests, Personal history
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- Kantonsspital Aarau
Acute Lymphoblastic Leukemia, Pediatric, Obesity, Pediatric
Low GI Diet in Children and Adolescents With ALL
The study aims to determine the feasibility of a 6-month low glycemic dietary intervention in children and adolescents undergoing treatment for acute lymphoblastic leukemia.
- Trial name
- NCT03157323
- Testing
- Low Glycemic Index Diet
- Where
- 5 sites in United States
- Volunteers
- 88 people
- Sponsor
- Columbia University
Pediatric Cancer, Pediatric Cancer Patients
Real World Pediatric Oncology Rehabilitation in Italy ( ReWori )
This observational study aims to describe changes in the functional abilities of children, adolescents and young adults with cancer who are undergoing physiotherapy or neuropsychomotor rehabilitation.
- Conditions
- Pediatric Cancer, Pediatric Cancer Patients, Pediatric Oncology, Rehabilitation
- Trial name
- REWORI (NCT07368582)
- Testing
- Rehabilitation intervention
- Where
- 13 sites in Italy
- Volunteers
- 249 people
- Sponsor
- Associazione Italiana Ematologia Oncologia Pediatrica
Liver Cancer
Combination Chemotherapy and Thalidomide in Treating Younger Patients Undergoing Surgery For Newly Diagnosed Liver Cancer
RATIONALE: Drugs used in chemotherapy, such as cisplatin and doxorubicin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00276705
- Testing
- cisplatin, cyclophosphamide, doxorubicin hydrochloride
- Where
- 21 sites in Ireland, United Kingdom
- Volunteers
- 47 people
- Sponsor
- Children's Cancer and Leukaemia Group
Soft Tissue Sarcoma of the Lower Extremity, Bone Sarcoma of the Lower Extremity
Functional and Structural Outcomes Following Childhood Bone or Soft Tissue Sarcomas of the Lower Extremity
Soft tissue and bone sarcomas of the lower extremity pose significant challenges for affected individuals, often associated with considerable burden.
- Conditions
- Soft Tissue Sarcoma of the Lower Extremity, Bone Sarcoma of the Lower Extremity, Childhood and Adolescent Cancer
- Trial name
- FOCUS (NCT06737172)
- Where
- 2 sites in Germany
- Volunteers
- 18 people
- Sponsor
- Technical University of Munich
Pineoblastoma
Prospective Pilot Trial to Assess a Multimodal Molecular Targeted Therapy in Children, Adolescent and Young Adults With Relapsed or Refractory High-grade Pineoblastoma
Children, adolescents and young adults with relapsed or treatment refractory pineoblastoma (rPB) represent a group of patients with dismal prognosis for whom a recommended standard salvage therapy is currently not available.
- Trial name
- NCT02596828
- Testing
- Temozolomide, Irinotecan, Dasatinib
- Where
- Germany
- Volunteers
- 4 people
- Sponsor
- University of Regensburg