Clinical trials: Cancer of Nasopharynx
Nasopharyngeal Cancer
A Study of Xeloda (Capecitabine) in Combination With XELOX (Oxaliplatin) in Patients With Metastatic Nasopharyngeal Cancer.
This single arm study will assess the efficacy and safety of Xeloda + oxaliplatin when given as first line treatment for patients with metastatic nasopharyngeal cancer.
- Trial name
- NCT00439426
- Testing
- Oxaliplatin, capecitabine [Xeloda]
- Where
- 5 sites in Morocco
- Volunteers
- 25 people
- Sponsor
- Hoffmann-La Roche
Nasopharyngeal Carcinoma
Efficacy and Safety of TPC+Apatinib+Camrelizumab vs GP+ Camrelizumab for High-Risk Nasopharyngeal Carcinoma: A Phase 3 Trial
This study aims to evaluate the efficacy and safety of the TPC regimen (nab-paclitaxel, cisplatin, and capecitabine) combined with apatinib and camrelizumab versus the GP regimen (gemcitabine and cisplatin) combined with…
- Trial name
- NCT06438627
- Testing
- TPC combined with Apatinib and Camrelizumab, GP Combined With Camrelizumab
- Where
- 2 sites in China
- Volunteers
- 164 people
- Sponsor
- XIANG YANQUN
Nasopharyngeal Carcinoma
PD-L1 and BRAF Expression in Nasopharyngeal Carcinoma
The prognostic value of programmed death-ligand 1 (PD-L1) and BRAF expression in nasopharyngeal carcinoma (NPC) is not well-defined.
- Trial name
- NCT03989297
- Testing
- Radiation
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Kiang Wu Hospital
Nasopharyngeal Carcinoma
Olfactory Change After Chemo-radiotherapy for Nasopharyngeal Carcinoma
This is an observational cohort study aimed to explore the changes of olfactory function at multiple time points from baseline to 1 year after radiotherapy among the local advanced nasopharyngeal carcinoma patients.
- Trial name
- NCT05146050
- Where
- China
- Volunteers
- 107 people
- Sponsor
- Sun Yat-sen University
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc
Hypothyroidism, Complications
Post-radiation Hypothyroidism After IMRT for Nasopharyngeal Carcinoma
The investigators evaluate if there are radiation dosimetric parameters for the prediction of biochemical and clinical hypothyroidism after intensity-modulated radiation therapy (IMRT) for non-metastatic nasopharyngeal carcinoma…
- Trial name
- NCT02689609
- Testing
- Intensity-modulated radiation therapy
- Volunteers
- 149 people
- Sponsor
- The University of Hong Kong
Nasopharyngeal Cancer, Dysphagia
Swallowing Exercises for Nasopharyngeal Cancer After Radiation Therapy
This study is designed to investigate the treatment efficacy of 8 weeks swallowing exercise programs for patients with NPC after radiation therapy.
- Trial name
- NCT01937793
- Testing
- effortful swallowing exercise, Mendelsohn swallowing exercise
- Where
- Taiwan
- Volunteers
- 16 people
- Sponsor
- National Taiwan University Hospital
Head and Neck Cancers - Nasopharyngeal
Photon Therapy Face Mask on Dermatitis Post Head and Neck Radiotherapy
A randomized controlled trial (RCT), 60 HNC patients who underwent radiotherapy (RT) with or without chemotherapy represented the sample of the study.
- Trial name
- dermatitis (NCT05855265)
- Testing
- photon therapy face mask
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Khadra Mohamed Ali
Nasopharyngeal Carcinoma
A Study of Anti-PD-1 AK105 in Patients With Metastatic Nasopharyngeal Carcinoma
This is a multicenter, single-arm open-label, phase II study to evaluate the anti-tumor activity, safety, PK and immunogenicity of AK105 (Anti-PD1 antibody) in patients with metastatic nasopharyngeal carcinoma who have progressed…
- Trial name
- NCT03866967
- Testing
- AK105
- Where
- 2 sites in China
- Volunteers
- 130 people
- Sponsor
- Akeso
Nasopharyngeal Carcinoma
EPstein-barr Virus DNA Response to Systemic Therapy for Treatment Adaptation in High Risk NPC (EP-STAR)
The investigators aim to investigate whether incorporating on-treatment EBV DNA surveillance for monitoring tumor responses to treatment and for guiding individuliased treatment adaptation can improve prognosis in nasopharyngeal…
- Trial name
- EP-STAR (NCT04072107)
- Testing
- sintilimab, Capecitabine
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Sun Yat-sen University
Head and Neck Cancer
Chemotherapy and Radiation Therapy in Treating Patients With Stage III or Stage IV Head and Neck Cancer
Phase I trial to study the effectiveness of docetaxel plus radiation therapy in treating patients who have stage III or stage IV head and neck cancer.
- Trial name
- NCT00006107
- Testing
- Taxotere, Surgery, radiation therapy
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Dana-Farber Cancer Institute
Nasopharyngeal Nonkeratinizing Carcinoma, Recurrent Nasopharynx Carcinoma
Nivolumab in Treating Patients With Recurrent and/or Metastatic Nasopharyngeal Cancer
This phase II trial studies how well nivolumab works in treating patients with nasopharyngeal cancer that has returned after a period of improvement (recurrent) and/or has spread to other parts of the body (metastatic).
- Conditions
- Nasopharyngeal Nonkeratinizing Carcinoma, Recurrent Nasopharynx Carcinoma, Stage III Nasopharyngeal Carcinoma AJCC v7, Stage IV Nasopharyngeal Carcinoma AJCC v7
- Trial name
- NCT02339558
- Testing
- Laboratory Biomarker Analysis, Nivolumab
- Where
- 19 sites in United States, China and 1 more
- Volunteers
- 45 people
- Sponsor
- National Cancer Institute (NCI)
Nasopharyngeal Carcinoma
Concurrent Chemoradiotherapy With Nedaplatin Versus Cisplatin in Nasopharyngeal Carcinoma
This is a Phase III trial to study the effectiveness of nedaplatin versus cisplatin with IMRT chemoradiotherapy in treating patients with locoregionally advanced nasopharyngeal carcinoma.
- Trial name
- NCT01540136
- Testing
- Nedaplatin, Cisplatin
- Where
- China
- Volunteers
- 402 people
- Sponsor
- Sun Yat-sen University
Recurrent Metastatic Nasopharyngeal Carcinoma
Clinical Study of Mitoxantrone Hydrochloride Liposome Injection Combined With Capecitabine Versus Capecitabine Monotherapy in Patients With Recurrent Metastatic Nasopharyngeal Carcinoma Who Failed Platinum-containing Treatment
This is a randomized, open-label, positive-controlled, multicenter Phase Ш study to evaluate the efficacy and safety of mitoxantrone hydrochloride liposome injection combined with capecitabine versus capecitabine monotherapy in…
- Trial name
- NCT05717764
- Testing
- Mitoxantrone hydrochloride liposome injection, Capecitabine
- Volunteers
- 500 people
- Sponsor
- CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd.
Chemotherapy-induced Nausea and Vomiting
Aprepitant for the Prevention of Chemotherapy-induced Nausea and Vomiting
To compare the antiemetic combination of palonosetron, dexamethasone, and aprepitant (PDA) with antiemetic combination of palonosetron and dexamethasone (PD) in nasopharyngeal carcinoma patients receiving docetaxel, cisplatin…
- Trial name
- CINV (NCT02933099)
- Testing
- Aprepitant+palonosetron+dexamethasone, palonosetron+dexamethasone
- Volunteers
- 300 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Nasopharyngeal Carcinoma, Radiation Therapy Complication
Atorvastatin in Preventing Nasopharyngeal Carcinoma Patients Receiving Radiotherapy From Carotid Stenosis
Patients with head and neck cancer who underwent irradiation have a higher risk of developing severe carotid stenosis, and eventually develop to transient ischemic attack or stroke.
- Trial name
- NCT02022293
- Testing
- Atorvastatin
- Where
- 6 sites in China
- Volunteers
- 324 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Nasopharyngeal Carcinoma
Phase IV Clinical Trial of Nimotuzumab in the Treatment of Nasopharyngeal Carcinoma
This clinical study is designed as an open, single group, multi-center, phase 4 clinical study to assess the safety of Nimotuzumab in the treatment of nasopharyngeal carcinoma and to provide a more reasonable basis for clinical…
- Trial name
- NCT02293356
- Testing
- Nimotuzumab Injection
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Biotech Pharmaceutical Co., Ltd.
Nasopharyngeal Carcinoma
Trail Evaluating Carbon Ion Radiotherapy (3 GyE Per Fraction) for Locally Recurrent Nasopharyngeal Carcinoma
The purpose of this study is to determine the maximal tolerated dose (MTD) of re-irradiation using carbon ion radiotherapy (CIRT) with the fraction size of 3 gray equivalent (GyE) in the treatment of locally recurrent…
- Trial name
- NCT02795195
- Testing
- Carbon ion radiotherapy (CIRT)
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Shanghai Proton and Heavy Ion Center
Nasopharyngeal Carcinoma (NPC), Cognitive Function
Treatment with Intensity Modulated Radiotherapy on the Change of Cognitive Function in Nasopharyngeal Carcinoma Patients: a Prospective Cohort Study
This is an observational cohort study aimed at investigating changes in hippocampal function and its impact on cognitive function in newly diagnosed nasopharyngeal carcinoma patients without metastasis, from baseline to a period…
- Trial name
- NCT06695936
- Volunteers
- 329 people
- Sponsor
- Sun Yat-sen University
Cancer of Oropharynx, Cancer of Nasopharynx
Dysphagia Assessment After Swallowing Sparing RadioTherapy
To prospectively assess post-radiation late dysphagia by using MDADI questionnaire (deglutition-related quality of life) and objective instrumental assessment by means of Fiberoptic Endoscopic Evaluation of Swallowing (FEES) and…
- Trial name
- DASRT (NCT03448341)
- Where
- Italy
- Volunteers
- 74 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
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