Clinical trials: Cancer of the Cervix
Cervical Cancer, Cervical Intraepithelial Neoplasia
The Correlations Between HPV L1-Specific Immunologic Responses in Cervical Cancer and Cervical Intraepithelial Neoplasia (CIN) Patients and Their Prognosis
A. To investigate the relationship between serum titer of anti-HPV16 antibody and clinicopathological factors of cervical cancer patients. B.
- Trial name
- NCT00728871
- Testing
- peripheral blood isolation
- Where
- China
- Volunteers
- 600 people
- Sponsor
- National Taiwan University Hospital
Cervical Cancer
Prophylactic Irradiation of the Para-Aortic Lymph Nodes and Supraclavicular Lymph Nodes in Locally Advanced Uterine Cervical Cancer
This study is an open-label, randomized study, which is designed to investigate the efficacy of Extended-field irradiation (EFI) on reducing recurrences at the para-aortic lymph node (PAN) and supraclavicular lymph nodes, and…
- Trial name
- NCT01063387
- Testing
- Prophylactic Irradiation of the Para-Aortic Lymph Nodes and supraclavicular lymph nodes in Locally Advanced Uterine Cervical Cancer
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Huazhong University of Science and Technology
Cervical Carcinoma, Endometrial Carcinoma
Comparison of Proton or Intensity Modulated Radiation Therapy After Surgery for Endometrial or Cervical Cancer
This early phase I trial compares the side effects between patients treated with proton radiation therapy versus intensity modulated radiation therapy after surgery for the treatment of endometrial or cervical cancer.
- Conditions
- Cervical Carcinoma, Endometrial Carcinoma, Endometriosis, Pelvic Inflammatory Disease
- Trial name
- NCT04567771
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Radiation Therapy
- Where
- 3 sites in United States
- Volunteers
- 121 people
- Sponsor
- Mayo Clinic
Infections, Papillomavirus, Papillomavirus Vaccines
Evaluation of Long-term Immunogenicity and Safety of a Human Papillomavirus (HPV) Vaccine in Healthy Female Subjects.
Infection with human papillomavirus (HPV) has been clearly established as the necessary cause of cervical cancer. This study is designed to evaluate the long-term immunogenicity and safety of the 580299 HPV vaccine up to 10 years…
- Trial name
- NCT00877877
- Testing
- Blood sampling
- Where
- 26 sites in Colombia, Germany and 3 more
- Volunteers
- 632 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Health Education
The Effects of Health Education About Human Papilloma Virus and Cervical Cancer Prevention on Knowledge, Attitudes, Beliefs and Behaviors
Aim: To determine the effects of health education about Human Papilloma Virus infection and cervical cancer prevention on knowledge, attitudes, beliefs and behaviors of adolescent girls and their mothers.
- Trial name
- NCT04113902
- Testing
- Health Education
- Where
- Turkey (Türkiye)
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
Quality of Life, Cervical Cancer
Comprehensive Study on the Quality of Life in Cervical Cancer Patients
This is prospective cohort study. All the patients with primary cervical cancer in the future three years in Peking Union Medical College Hospital will be included in this study.
- Conditions
- Quality of Life, Cervical Cancer, Urodynamics, Rectum Dynamics
- Trial name
- NCT03967457
- Testing
- questionnaires survey, Urodynamic testing, Rectum dynamics testing
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Lei Li
Cervical Cancer, Endometrial Cancer
A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Cervical and Endometrial Cancer
20 participants are expected to be enrolled for this open，Single-armed clinical trial to evaluate the safety and efficacy of the recombinant herpes simplex virus Ⅰ, R130 in patients with relapsed/refractory Cervical and…
- Conditions
- Cervical Cancer, Endometrial Cancer, Advanced Cancer
- Trial name
- NCT05812677
- Testing
- Recombinant oncolytic herpes simplex virus type Ⅰ (R130)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Yunying Medical Technology
Human Papillomavirus (HPV)-Related Cervical Cancer, HPV DNA
Clinical Trial Comparing the Self-test for Cervicovaginal Sample Versus Samples From Service Provider (Xyto-Ro)
Problem Description When cervical cancer screening is needed, the Pap test (or Pap smears) is still the most common, although there are challenges that continue to prevent effective screening services in many countries, poor…
- Trial name
- Xyto-Ro (NCT04520464)
- Testing
- Cervical samples for identification of HR-HPV DNA via real-time PCTR.
- Where
- Mexico
- Volunteers
- 444 people
- Sponsor
- Hospital General de México Dr. Eduardo Liceaga
Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
This trial will look at a drug called sigvotatug vedotin (SGN-B6A) alone and with pembrolizumab, with or without chemotherapy, to find out whether it is safe for people who have solid tumors.
- Conditions
- Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck, HER2 Negative Breast Neoplasms, Esophageal Squamous Cell Carcinoma
- Trial name
- NCT04389632
- Testing
- sigvotatug vedotin, pembrolizumab, cisplatin
- Where
- 158 sites in United States, France and 5 more
- Volunteers
- 1,006 people
- Sponsor
- Seagen, a wholly owned subsidiary of Pfizer
Cervical Carcinoma, Endometrioid Adenocarcinoma
Testing AZD1775 inC Combination With Radiotherapy and Chemotherapy in Cervical, Upper Vaginal and Uterine Cancers
This phase I trial studies the side effects and best dose of adavosertib when given together with external beam radiation therapy and cisplatin in treating patients with cervical, vaginal, or uterine cancer.
- Conditions
- Cervical Carcinoma, Endometrioid Adenocarcinoma, Malignant Female Reproductive System Neoplasm, Recurrent Cervical Carcinoma
- Trial name
- NCT03345784
- Testing
- Adavosertib, Cisplatin, External Beam Radiation Therapy
- Where
- 8 sites in United States, Canada
- Volunteers
- 10 people
- Sponsor
- National Cancer Institute (NCI)
Metastatic Solid Tumors, Stage 4 Cancer
The Sarah Nanotechnology System for Treatment of Advanced Metastatic Solid Tumors Using Hyperthermia.
This is a sequential, dose-escalation, non-randomized, prospective, early feasibility trial. The goal of this clinical trial is to gather information on the safety and the recommended dose of the Sarah Nanotechnology System.
- Trial name
- NCT07224464
- Testing
- The Sarah Nanotechnology System - intended to deliver thermal energy to malignant cells for the purpose of thermal destruction of these cells in patients with advanced metastatic solid tumors.
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- New Phase Ltd.
Cervical Cancer
Delivery, Uptake and Acceptability of HPV Vaccination in Tanzanian Girls
The aims of this study are: 1. To determine feasibility of a school-based human papillomavirus (HPV) vaccination programme in Tanzania. 2.
- Trial name
- NCT01173900
- Testing
- Gardasil® HPV vaccine
- Where
- Tanzania
- Volunteers
- 5,532 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Cervical Cancer
Phase 3 Trial of a Bivalent Human Papilloma Virus (HPV) Vaccine (Cecolin®) in Young Girls
This randomized controlled trial will evaluate a bivalent HPV vaccine, Cecolin®, in alternate 2-dose regimens, compared to an established HPV vaccine.
- Trial name
- NCT04508309
- Testing
- Cecolin®, Gardasil®
- Where
- 2 sites in Bangladesh, Ghana
- Volunteers
- 1,025 people, healthy volunteers welcome
- Sponsor
- PATH
Uterine Cervical Neoplasms
Tislelizumab Combined With Concurrent Chemoradiotherapy for Locally Advanced Cervical Cancer
This study aims to evaluate the efficacy and safety of Tislelizumab combined with concurrent chemoradiotherapy in the treatment of cervical cancer patients with cervical mass > 4cm and regional lymph node metastasis, paracervical…
- Trial name
- NCT05588219
- Testing
- Tislelizumab, DDP synchronous with radiotherapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Yong Zhang,MD
Cancer
External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Indinavir and ritonavir may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
- Trial name
- NCT00637637
- Testing
- indinavir sulfate, ritonavir, radiation therapy
- Where
- 3 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- Oncology Institute of Southern Switzerland
Cervical Cancer
System to Evaluate the Risk of Lymph Node Metastasis Preoperatively in Cervical Cancer
The lymph node status is difficult to be assessed preoperatively, this study aimed to develop a scoring system for predicting the risk of LNM in cervical cancer patients before operation.
- Trial name
- NCT06032481
- Testing
- surgery
- Volunteers
- 426 people
- Sponsor
- Fujian Maternity and Child Health Hospital
Cervical Squamous Cell Carcinoma, Cervical Adenocarcinoma
Complete Nerve-Sparing Radical Hysterectomy for Cervical Cancer
The purpose of this study is to evaluate the feasibility of complete nerve-sparing type C1 radical hysterectomy in cervical cancer.
- Conditions
- Cervical Squamous Cell Carcinoma, Cervical Adenocarcinoma, Malignant Neoplasm of Cervix Stage IB1, Stage IIA1 Cervical Cancer
- Trial name
- NCT02562729
- Testing
- Nerve-Sparing Radical Hysterectomy
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Shanghai Gynecologic Oncology Group
Cervical Cancer, Uterine Cancer
Gynecologic Brachytherapy-Specific Educational Video
Brachytherapy is a highly technical and integral component of the definitive treatment of gynecologic cancers [1]. To enhance provider communication and patient engagement, our study investigates a video consent on impact of…
- Trial name
- NCT04363957
- Testing
- Brachytherapy video, Standard Brachytherapy Consent Process
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, San Diego
HPV Infection
Global Burden Estimation of Human Papillomavirus (GLOBE-HPV)
This study is a multi-country and multi-site project to estimate the point-prevalence of high-risk (HR) HPV genotype infections among representative samples of girls and women aged 9-50 years, and among specific sub-populations…
- Trial name
- HPV (NCT06129253)
- Testing
- Urine Sample Collection, Self-collected Vaginal Swab, Blood Samples
- Where
- 8 sites in Bangladesh, Democratic Republic of the Congo and 6 more
- Volunteers
- 29,750 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Cervical Cancer
TMMR (Total Mesometrial Resection) Register Study
TMMR/tLNE was shown to result in very low locoregional recurrence rates and low morbidity in surgical treatment of cervical cancer stage IB-IIA without any adjuvant radiotherapy even in high risk situations.
- Trial name
- TMMR-RS (NCT01819077)
- Testing
- TMMR
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University Hospital, Essen