Clinical trials: Cancer of the Esophagus
Metastatic Esophageal Adenocarcinoma, Metastatic Esophageal Squamous Cell Carcinoma
Paclitaxel With or Without Cixutumumab as Second-Line Therapy in Treating Patients With Metastatic Esophageal Cancer or Gastroesophageal Junction Cancer
This randomized phase II trial studies how well paclitaxel with or without cixutumumab works in treating patients with esophageal cancer or gastroesophageal junction cancer that has spread to other places in the body…
- Conditions
- Metastatic Esophageal Adenocarcinoma, Metastatic Esophageal Squamous Cell Carcinoma, Metastatic Gastroesophageal Junction Adenocarcinoma, Recurrent Esophageal Adenocarcinoma
- Trial name
- NCT01142388
- Testing
- Cixutumumab, Laboratory Biomarker Analysis, Paclitaxel
- Where
- 232 sites in United States
- Volunteers
- 94 people
- Sponsor
- National Cancer Institute (NCI)
Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma
Exploratory Clinical Trial of Oral Paclitaxel Plus Radiotherapy in Patients With Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma
This study aims to investigate the safety and efficacy of oral paclitaxel combined with radiotherapy in the treatment of locally advanced unresectable esophageal squamous cell carcinoma.
- Trial name
- NCT07435454
- Testing
- oral paclitaxel+radiotherapy
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Jiangsu Cancer Institute & Hospital
Esophageal Squamous Cell Carcinoma
Study To Investigate the Efficacy and Safety of Sitravatinib in Combination With Tislelizumab in Participants With Esophageal Squamous Cell Carcinoma
The study aimed to evaluate the efficacy and safety of sitravatinib in combination with tislelizumab as a second- or third-line treatment for participants with locally advanced, unresectable, or metastatic esophageal squamous…
- Trial name
- NCT05461794
- Testing
- Sitravatinib, Tislelizumab, Docetaxel
- Where
- 31 sites in China
- Volunteers
- 96 people
- Sponsor
- BeiGene
Oesophageal Cancer, Gastric Cancer
Modulated Mid-frequency Whole-body Electromyostimulation and Nutritional Therapy in Gastrointestinal Cancer Patients
The purpose of this study is to assess the efficacy of modulated mid-frequency whole-body electromyostimulation (WB-EMS) combined with nutritional therapy in patients with gastrointestinal cancer.
- Conditions
- Oesophageal Cancer, Gastric Cancer, Duodenal Cancer, Colorectal Cancer
- Trial name
- MOMENT (NCT06414122)
- Testing
- mid-frequency whole-body electromyostimulation (WB-EMS), conventional exercise training, nutritional therapy
- Where
- Germany
- Volunteers
- 88 people
- Sponsor
- University of Cologne
Esophageal Squamous Cell Carcinoma
Paclitaxel or S1 Plus Cisplatin in Concurrent Chemoradiotherapy for Squamous Cell Carcinoma of Esophagus
The purpose of this study is to determine which regimen is better for esophageal squamous carcinoma in concurrent chemoradiation(CCRT),paclitaxel or S1 plus cisplatin.
- Trial name
- NCT02586753
- Testing
- Paclitaxel plus Cisplatin with radiotherapy, S1 plus Cisplatin with radiotherapy
- Volunteers
- 2 people
- Sponsor
- Mianyang Central Hospital
Esophageal Cancer
Adjuvant Radiotherapy for Patients With Esophageal Squamous Cell Carcinoma After R0 Resection
This retrospective study is exploring the treatment effect and toxicity of adjuvant radiotherapy in patients diagnosed with esophageal squamous cell carcinoma after R0 resection.
- Trial name
- NCT05460403
- Testing
- Adjuvant Radiotherapy
- Where
- China
- Volunteers
- 3,591 people
- Sponsor
- Chinese Academy of Medical Sciences
Esophageal Cancer, Squamous Cell Esophagus Cancer
Pembrolizumab in Refractory Advanced Esophageal Cancer
This research study is studying a targeted therapy as a possible treatment for advanced esophageal cancer. The study intervention involved in this study is: -Pembrolizumab
- Conditions
- Esophageal Cancer, Squamous Cell Esophagus Cancer, Adenocarcinoma Esophagus
- Trial name
- NCT02971956
- Testing
- Pembrolizumab
- Where
- 3 sites in United States
- Volunteers
- 49 people
- Sponsor
- Dana-Farber Cancer Institute
Reflux, Esophagitis
The Effect of Nexium on Transmucosal Esophageal Leak
In a related study, the investigators have found evidence that patients with Barrett's esophagus have a leak for oral sucrose to leave their upper gastrointestinal tract, enter the blood, and be filtered into urine.
- Conditions
- Reflux, Esophagitis, Barrett's Esophagus
- Trial name
- NCT00216788
- Testing
- Esomeprazole (Nexium) 40 mg/day
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Main Line Health
Esophageal Neoplasms, Surgical Stomas
Hybrid-everted Versus Hand-sewn or Stapled Esophagogastrostomy in Prevention of Anastomotic Stricture
The investigators improved the hybrid everted esophagogastrostomy and expected to prevent the incidence of anastomotic stricture.
- Trial name
- NCT01139229
- Testing
- hybrid everted esophagogastric anastomosis, the conventional hand-sewn anastomosis, a stapled anastomosis
- Volunteers
- 144 people
- Sponsor
- Sichuan University
Esophagectomy, Pulmonary Wedge Resection
A Retrospective Analysis of Statin Use and Outcome After Thoracic Cancer Surgery
There is data to support an association between impaired preoperative endothelial function and adverse postoperative outcome. This study will investigate the potential association between perioperative statin use and improved…
- Conditions
- Esophagectomy, Pulmonary Wedge Resection, Pulmonary Lobectomy, Pulmonary Pneumonectomy
- Trial name
- NCT01169051
- Volunteers
- 569 people
- Sponsor
- Vanderbilt University Medical Center
Esophageal Cancer
Wnt, Notch and Hedgehog Activity in Chemo-Naive Tumors Collected During Staging of Esophageal Cancer Patients
Cancer results when undifferentiated cells grow in an uncontrolled manner, crowding out normal cells, causing morbidity and ultimately mortality.
- Trial name
- NCT02221245
- Testing
- Tumor Biopsy via Ultrasound Endoscopy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Miami
Esophageal Cancer
HPPH Photodynamic Therapy for Patients With Esophageal Cancer
Phase I study was to investigate the safety and tolerability of the photosensitizer (PS) 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) for injection in patients with Esophageal Cancer.
- Trial name
- HPPH (NCT03757754)
- Testing
- HPPH 2.5 mg/m2, HPPH 3 mg/m2, HPPH 3.5 mg/m2
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhejiang Hisun Pharmaceutical Co. Ltd.
Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M), Gastric/GEJ
CR-002 in Adult Participants With Locally Advanced or Metastatic Solid Tumors
The purpose of this study is to determine the safety and tolerability of monotherapy CR-002 and to identify the MTD and/or optimal biologic dose and RP2D(s) in participants with locally advanced or metastatic solid tumors.
- Conditions
- Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M), Gastric/GEJ, Biliary Tract Cancer (BTC), Esophageal Squamous Cell Carcinoma (ESCC)
- Trial name
- APOLLO (NCT07909031)
- Testing
- CR-002
- Where
- 3 sites in United States
- Volunteers
- 219 people
- Sponsor
- Crescent Biopharma, Inc.
Esophageal Squamous Cell Carcinoma
Precision Medicine for Immunotherapy-Resistant Advanced Esophageal Cancer
This study is an open-label, biomarker-integrated umbrella trial designed to evaluate the clinical efficacy of molecular subtype- and genomic biomarker-guided precision therapies in patients with advanced esophageal cancer…
- Trial name
- ESCC-PT (NCT07653451)
- Testing
- Afatinib + Toripalimab, Dalpiciclib + Pyrotinib, Camrelizumab + Apatinib
- Volunteers
- 90 people
- Sponsor
- Peking University Cancer Hospital & Institute
Microbial Colonization, Esophageal Cancer
Investigating the Association Between Microbiota and Esophageal/Oropharyngeal Cancer
Background: Esophageal cancer commonly occurs in middle-aged man. It is ranked to the 6th common cancer and 5th cancer-related death in Taiwanese male, and sometimes co-exist with oropharyngeal cancer, which impacts our national…
- Conditions
- Microbial Colonization, Esophageal Cancer, Oropharyngeal Neoplasms, Synchronous Neoplasm
- Trial name
- NCT05412628
- Testing
- Oral swab test
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
GERD, Barretts Esophagus
In Vivo Anatomy, Physiology, Mechanics and Function of the Lower Esophageal Sphincter
The purpose of this study is: To study the components of the gastroesophageal junction high-pressure zone individually and as a group, by pharmacologically eliminating or accentuating the pressure profile generated by the smooth…
- Trial name
- NCT00737802
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Esophageal Squamous Cell Carcinoma
A Study of Camrelizumab Combined With Chemotherapy as Neoadjuvant Therapy in Adcanced Esophageal Squamous Cell Carcinoma (ESCC)
To evaluate the efficacy and safety of camrelizumab combined with albumin paclitaxel and platinum chemotherapy in the preoperative treatment of locally advanced thoracic esophageal squamous cell carcinoma
- Trial name
- NCT04767295
- Testing
- Camrelizumab, Albumin Paclitaxel, Carboplatin
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Hunan Cancer Hospital
Esophageal Carcinoma in Situ AJCC V7
A Comparative Study of Endoscopic Submucosal Dissection and Photodynamic Therapy for Early Esophageal Cancer
The purpose of this study was to compare the efficacy and safety of Photodynamic therapy (PDT) and Endoscopic submucosal (ESD) dissection in the treatment of early esophageal cancer.
- Trial name
- NCT05208775
- Testing
- PDT, ESD
- Volunteers
- 46 people
- Sponsor
- The First Affiliated Hospital of Henan University of Science and Technology
ESCC, Gastric Adenocarcinoma
Sacituzumab Tirumotecan (Sac-TMT/SKB264) Plus Tagitanlimab (KL-A167) in Patients With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma and Gastric/Gastroesophageal Junction Adenocarcinoma
This is a single-arm, multi-center phase II study to evaluate the efficacy and safety of sacituzumab tirumotecan (Sac-TMT/SKB264) combined with tagitanlimab (KL-A167) as 2nd line therapy for recurrent or metastatic esophageal…
- Conditions
- ESCC, Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Esophageal Squamous Cell Carcinoma (ESCC)
- Trial name
- NCT07701681
- Testing
- Sacituzumab Tirumotecan + Tagitanlimab
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Sun Yat-sen University
Esophageal Cancer, Gastric Cancer
Surveillance After Resection of Oesophageal aNd Gastric Cancer (SARONG-II) Trial
Cancer of the food pipe (oesophagus) and stomach are increasingly common. Currently, most patients with cancer of the oesophagus and stomach are treated with surgery with or without additional chemotherapy or radiotherapy.
- Trial name
- SARONG-II (NCT06115629)
- Testing
- Surveillance protocol
- Where
- 13 sites in Germany, Ireland and 3 more
- Volunteers
- 952 people
- Sponsor
- University of Dublin, Trinity College
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