Clinical trials: Cancer of the Esophagus
Esophageal Cancer
SLND Versus Non-Dissection Following ESD for T1a Stage Esophageal Squamous Cell Carcinoma
This is a study from Fujian Cancer Hospital Thoracic of Surgery Project, numbered as FJCHTOSP-1. Systematically mediastinal Lymph Node Dissection (SLD) Versus Non-Dissection Following Endoscopic Submucosal Dissection (ESD) for…
- Trial name
- NCT06979986
- Testing
- Endoscopic Submucosal Dissection with Systematically mediastinal Lymph Node Dissection, Endoscopic Submucosal Dissection without SLND
- Volunteers
- 102 people
- Sponsor
- Fujian Cancer Hospital
Esophageal Neoplasms, Carcinoma, Squamous Cell
Phase I Dose Escalation of Stereotactic Radiosurgical Boost for Locally Advanced Esophageal Cancer
To study the safety and feasibility of stereotactic radiation dose escalation following neoadjuvant chemotherapy with concurrent conventionally fractionated radiation, by evaluating the acute and late toxicity of treatment.
- Conditions
- Esophageal Neoplasms, Carcinoma, Squamous Cell, Adenocarcinoma, Esophageal Cancer
- Trial name
- NCT00368329
- Testing
- Capecitabine (Xeloda), [18-F] Fluorodeoxyglucose (FDG), 5-Fluorouracil (5-FU)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Stanford University
Esophageal Cancer
Effect of Cervical Paraesophageal Lymph Node Metastasis Versus Supraclavicular Lymph Node Metastasis on the Overall Survival of Patients With Thoracic Esophageal Squamous Cell Carcinoma: An Observational Study
The goal of this observational study is to learn about in health conditions of ESCC. The main question[s] it aims to answer are: •Lymph node metastasis(LNM) in cervical paraesophageal or supraclavicular which influence OS more.
- Trial name
- ECPLNMvsSLNM (NCT06165094)
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Barrett Esophagus
Evaluation of Safety and Dose Response Using C2 CryoBalloon™ Swipe Ablation System for Barrett's Esophagus
The primary objective is to determine the safety and efficacy of the C2 CryoBalloon™ Swipe Ablation System ("CryoBalloon Swipe") used at increasing doses.
- Trial name
- NCT03097666
- Testing
- C2 CRYOBALLOON SWIPE ABLATION SYSTEM
- Where
- 3 sites in Netherlands
- Volunteers
- 24 people
- Sponsor
- Pentax Medical
Oesophageal Squamous Cell Carcinoma
A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F)
The purpose of this trial is to assess if ifinatamab deruxtecan (I-DXd) can treat esophageal squamous cell carcinoma (ESCC). I-DXd is an antibody-drug conjugate (ADC).
- Trial name
- NCT07405151
- Testing
- I-DXd, Rescue Medication
- Where
- 32 sites in United States, Brazil and 9 more
- Volunteers
- 60 people
- Sponsor
- Merck Sharp & Dohme LLC
Perforation Esophagus, Esophageal Cancer
Feasibility and Efficacy of a Combination of a SEMS and Vacuum Wound Treatment (VACStent)
Open, prospective, one-arm feasibility and efficacy study of a European conformity (CE) certified Combination product of two CE certified medical devices in the intended indication.
- Conditions
- Perforation Esophagus, Esophageal Cancer, Esophageal Achalasia, Esophageal Diseases
- Trial name
- VACStent (NCT03962179)
- Testing
- VACStent
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital of Cologne
CNS Brain Metastasis, Head and Neck Cancer
Pilot Study of 18F-FLT PET
Fractionated radiotherapy induces an observable change in the proliferative activity as assessed by pre-treatment and early-treatment 18F-FLT PET imaging.
- Conditions
- CNS Brain Metastasis, Head and Neck Cancer, Lung Cancer, Prostate Cancer
- Trial name
- NCT00585741
- Testing
- Imaging with 18F-FLT PET
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Wisconsin, Madison
Esophageal Cancer
Study of Anti-PD-L1 in Combination With Chemo(Radio)Therapy for Oesophageal Cancer
This is an open-label, Phase 1/2 study to evaluate the safety of durvalumab (MEDI4736) in combination with oxaliplatin/capecitabine chemotherapy in metastatic/locally advanced oesophageal cancer (OC) and with neoadjuvant…
- Trial name
- NCT02735239
- Testing
- Durvalumab, Tremelimumab, Oxaliplatin
- Where
- 4 sites in United Kingdom
- Volunteers
- 73 people
- Sponsor
- Ludwig Institute for Cancer Research
Esophageal Cancer
Safety Study of Multiple Peptide Vaccine to Esophageal Cancer
This is a phase 1 study of multiple peptide vaccine therapy and GM-CSF in treating patients with esophageal cancer.
- Trial name
- NCT00561275
- Testing
- LY6K, VEGFR1, VEGFR2
- Where
- Japan
- Volunteers
- 6 people
- Sponsor
- Japanese Foundation for Cancer Research
Cancer
E-MOSAIC Electronic Tool to Monitor Symptoms
RATIONALE: A hand held electronic tool used to monitor symptoms and assess quality of life may improve communication between patients and their doctors and improve the ability to plan treatment for patients with advanced cancer…
- Trial name
- NCT00477919
- Where
- 7 sites in Switzerland
- Volunteers
- 264 people
- Sponsor
- Swiss Cancer Institute
Appendix Carcinoma, Colon Carcinoma
Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients With Gastrointestinal Cancer
This phase II trial investigates how well oral cryotherapy plus acupressure and acupuncture compared with oral cryotherapy alone work in decreasing chemotherapy-induced peripheral neuropathy in patients with gastrointestinal…
- Conditions
- Appendix Carcinoma, Colon Carcinoma, Esophageal Carcinoma, Gastric Carcinoma
- Trial name
- NCT04505553
- Testing
- Acupuncture Therapy, Acupressure Therapy, Oral Cryotherapy
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Washington
Advanced Esophageal Cancer
A Phase II Study of HR070803 in the Treatment of Advanced Esophageal Cancer
To evaluate the efficacy, safety and pharmacokinetic characteristics of HR070803 in the treatment of advanced esophageal cancer.
- Trial name
- NCT05425472
- Testing
- HR070803
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Barrett Esophagus
Detection of Early Esophageal Cancer by NIR-FME.
To improve detection of esophageal (pre)malignant lesions during surveillance endoscopy of patients at risk of developing malignancies, for example in Barrett's Esophagus (BE), there is a need for better endoscopic visualization…
- Trial name
- ESCEND (NCT03877601)
- Testing
- Bevacizumab-IRDye800CW, Fluorescence endoscopy
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
Esophageal Cancer
FLT PET/CT for Staging, Target Definition and Assessment of Response to Therapy in Patients With Esophageal Cancer
The purpose of this pilot study is to develop a more advanced software program that will collect, compare and analyze tumor images for evaluation.
- Trial name
- NCT01243619
- Testing
- 3'-deoxy-3'-(18) F-fluorothymidine
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Dana-Farber Cancer Institute
Gastrointestinal Neoplasms, Gastrointestinal Disease
Endoscopic Resection Multicenter Registry
This is a retrospective and prospective multicenter registry to collect long-term data (1 year) on patients who have or will undergo Endoscopic resection such as EMR, ESD, EFTR, STER, etc.
- Conditions
- Gastrointestinal Neoplasms, Gastrointestinal Disease, Gastric Cancer, Gastric Neoplasm
- Trial name
- NCT03065257
- Testing
- Endoscopic Resection
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Colorectal Cancer, Esophagus Cancer
A Clinical Trial Targeting CEA Chimeric Antigen Receptor T (CAR-T) for CEA Positive Advanced Malignant Solid Tumors
This is a single-arm, open, dose-increasing phase I clinical study to explore the safety, tolerability and pharmacokinetic characteristics of the drug C-13-60 cells, and preliminarily observe the efficacy of the drug in CEA…
- Conditions
- Colorectal Cancer, Esophagus Cancer, Gastric Cancer, Pancreas Cancer
- Trial name
- NCT06043466
- Testing
- CEA-targeted CAR-T cells
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Chongqing Precision Biotech Co., Ltd
Barretts Esophagus, Esophageal High-Grade Intraepithelial Neoplasia
Barrett&Apos;s Intervention for Dysplasia by Endoscopy
LAY SUMMARY A type of gullet cancer (oesophageal adenocarcinoma) has become the 5th commonest UK cause of cancer death. Unfortunately, by the time patients have symptoms, the cancer is often incurable.
- Conditions
- Barretts Esophagus, Esophageal High-Grade Intraepithelial Neoplasia, Esophageal Cancer Stage I
- Trial name
- BRIDE (NCT01733719)
- Testing
- ER plus RFA, ER plus APC
- Where
- 5 sites in United Kingdom
- Volunteers
- 76 people
- Sponsor
- University Hospitals, Leicester
Barrett Esophagus, Esophageal Adenocarcinoma
Nitrates and IL-8 in Barrett's Esophagus
The purpose of this study is to determine if nitrates and IL-8 (which are found in food and throughout the body regulating stomach acidity) play a role in Barrett's Esophagus and/or Esophageal Adenocarcinoma severity and if…
- Trial name
- NCT04642690
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Esophageal Cancer
Neoadjuvant Immunochemotherapy for Adenocarcinoma of the Esophagogastric Junction
The investigators will conduct a prospective phase 2 study to evaluate the efficacy and safety of a modified neoadjuvant immunotherapy plus chemotherapy (one cycle of Tislelizumab monotherapy followed by four cycles of…
- Trial name
- TRACE (NCT06469060)
- Testing
- neoadjuvant anti-PD-1 with DOC chemotherapy
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Shanghai Chest Hospital
Esophageal Cancer, Gastric Cancer
Spanish Registry of Esophagogastric Cancer
This study aims to development of a database through a web page for epidemiological and clinical research purposes that is accessible to members of the AGAMENON - SEOM group that guarantees a rigorous collection, exploitation and…
- Trial name
- AGAMENON (NCT04958720)
- Testing
- Surgery, Chemotherapy, anti-targeted agents and immunotherapy, Radiotherapy
- Where
- 38 sites in Spain
- Volunteers
- 10,000 people
- Sponsor
- Fundación Sociedad Española de Oncologia Médica
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