Clinical trials: Cancer of the Head and Neck
Thyroid Neoplasms
Nexavar® Versus Placebo in Locally Advanced/Metastatic RAI-Refractory Differentiated Thyroid Cancer
Trial of sorafenib versus placebo in the treatment of locally advanced or metastatic differentiated thyroid cancer refractory to radioiodine
- Trial name
- NCT00984282
- Testing
- Sorafenib (Nexavar, BAY43-9006)
- Where
- 81 sites in United States, Austria and 16 more
- Volunteers
- 417 people
- Sponsor
- Bayer
Radiation Therapy Complication, Tumor Neck
Grid Therapy for Tumors of the Head, Neck, Thorax, Abdomen, Pelvis and Extremities.
This study is an observational registry study evaluating the clinical outcomes of grid therapy. Subjects will be screened at outpatient clinic visit appointments and interested qualified subjects will be consented and offered…
- Conditions
- Radiation Therapy Complication, Tumor Neck, Tumor Abdomen
- Trial name
- NCT04549246
- Testing
- Spatially Fractionated Radiation (GRID) Therapy
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Mayo Clinic
Squamous Cell Carcinoma of Oropharynx
Treatment De-Intensification for Squamous Cell Carcinoma of the Oropharynx
This research is being done to try to reduce radiation side effects that happen with the standard radiation methods. Generally surgery, radiation therapy, and sometimes chemotherapy are standard treatment for people with squamous…
- Trial name
- NCT01088802
- Testing
- IMRT, Cisplatin, Carboplatin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Head & Neck Cancer, Head & Neck Squamous Cell Carcinoma
Longitudinal Oral Health Changes After Head and Neck Radiotherapy
This prospective observational study evaluates how head and neck radiotherapy affects oral health over time. Patients with head and neck cancer undergoing standard radiotherapy are followed from before treatment through multiple…
- Conditions
- Head & Neck Cancer, Head & Neck Squamous Cell Carcinoma, Periodontal Disease, Xerostomia
- Trial name
- HN-ORAL-RT (NCT07394842)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Head and Neck Neoplasms
S-Frame CT Immobilization Masks For Patients Undergoing Radiation Therapy For Head and Neck Cancer
Immobilization devices such as thermoplastic masks are used routinely in the radiation treatment of head and neck cancer patients.
- Trial name
- NCT00252473
- Testing
- MedTec S-frame Immobilization Masks
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Cervical Intraepithelial Neoplasia, Cervical Cancer
Impact of HPV Vaccine On The Prevalence Of HPV In Norway
The overall aim of the study is to assess the effect of school-based Human Papillomavirus (HPV) vaccination by comparing type-specific HPV prevalence between vaccinated and non-vaccinated women born in 1997.
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Oropharyngeal Cancer
- Trial name
- NCT02934724
- Testing
- Self sample from vagina, Self sample from the oral cavity, Questionnaire
- Where
- Norway
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Head and Neck Squamous Cell Carcinoma, Cancer
Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer
The purpose of this study is to compare any good or bad effects of using pembrolizumab (an experimental drug) and radiation therapy (RT), compared to using cisplatin chemotherapy and radiation therapy (RT) in the treatment of…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Cancer, Cancer of Head and Neck, Cancer, Advanced
- Trial name
- NCT03383094
- Testing
- Pembrolizumab, Radiation therapy, Cisplatin
- Where
- 6 sites in United States
- Volunteers
- 126 people
- Sponsor
- Loren Mell, MD
Liver Cancer, Esophageal Squamous Cell Carcinoma, Gastric Adenocarcinoma, Cervical Cancer, MSI-H Colorectal Cancer
A Phase I Clinical Study of Recombinant Humanized Anti-BTLA Monoclonal Antibody (JS004) Injection Combined With Toripalimab Injection in Patients With Advanced Solid Tumors
This is an open-label phase I study to evaluate the safety, tolerability, and initial efficacy of JS004 injection combined with Toripalimab Injection in patients with advanced solid tumors who have failed standard therapy.
- Trial name
- NCT05427396
- Testing
- JS004, Toripalimab Injection
- Where
- 2 sites in China
- Volunteers
- 31 people
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Carcinoma of the Oesophagus
Radiotherapy & Olaparib in COmbination for Carcinoma of the Oesophagus
The purpose of this study is to determine the Maximum Tolerated Dose (MTD) of olaparib in combination with radical radiotherapy in patients with oesophageal cancer who are unsuitable for platinum containing chemotherapy.
- Trial name
- ROCOCO (NCT01460888)
- Testing
- Olaparib, Radical external beam radiotherapy, 50Gy in 25 fractions
- Where
- 2 sites in United Kingdom
- Volunteers
- 36 people
- Sponsor
- The Christie NHS Foundation Trust
Oral Mucositis, Head and Neck Cancer
Dose Ranging Study to Assess the Safety and Efficacy of SCV-07 for the Delay to Onset of Severe Oral Mucositis in Patients Receiving Chemoradiation Therapy for Head and Neck Cancer
Oral Mucositis (OM) is a painful and debilitating side effect of many of the drug or radiation regiments used to treat cancer. This study examines the investigational drug SCV-07 and it's possible application in treating Oral…
- Trial name
- SCV-07 OM (NCT00756951)
- Testing
- SCV-07
- Where
- 19 sites in United States
- Volunteers
- 59 people
- Sponsor
- SciClone Pharmaceuticals
Cancer of the Head and Neck
Dermaprazole Cream for Radiation Dermatitis in Head and Neck Cancer
In this study, the study team seek to conduct a pilot clinical study to evaluate the safety and efficacy of a reformulated proton pump inhibitor (PPI) cream (Dermaprazole) in definitive head and neck cancer (HNC) patients.
- Trial name
- NCT04865731
- Testing
- Dermaprazole, Aquaphor
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Breast Cancer, Colorectal Cancer
Pain in Cancer Survivors
The purpose of this study is to find out about the pain and quality of life of individuals who are adult cancer survivors. By quality of life, we mean how you are feeling about different aspects of your life, including your…
- Conditions
- Breast Cancer, Colorectal Cancer, Prostate Cancer, Head and Neck Cancer
- Trial name
- NCT00581724
- Testing
- Telephone interview or self report survey.
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Head and Neck Cancer
Finding Predictors of Side Effects to Chemoradiation Treatment in Elderly Patients With Head and Neck Cancer
To look at what types of measures can be used to predict how an older person will tolerate chemoradiation treatment for head and neck cancer. This study uses surveys and a blood draw to look at the different measures.
- Trial name
- NCT01688323
- Testing
- Collect Blood and Survey Instruments
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cachexia, Squamous Cell Carcinoma
Role of Myostatin, Activin A and Follistatin Cachexia of ENT Cancers
The main objective of our study was to determine the modifications of blood myostatin and activin A concentrations associated with head and neck cancers.
- Conditions
- Cachexia, Squamous Cell Carcinoma, Head and Neck Cancer
- Trial name
- MYOCACH (NCT03162042)
- Testing
- Tumor removal
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Oropharynx Cancer, Squamous Cell Carcinoma of the Oral Cavity
TPF-Induction Chemotherapy of Oropharyngeal and Cavity of the Mouth Cancer
A combination therapy of Docetaxel, Cisplatin und 5-Fluorouracil (= TPF) will be used in patients with resectable oropharyngeal and cavity of the mouth cancer.
- Trial name
- NCT01108042
- Testing
- Taxotere, Cisplatin, 5-Fluorouracil (5-FU)
- Where
- 4 sites in Germany
- Volunteers
- 71 people
- Sponsor
- Orlando Guntinas-Lichius, Prof. Dr. med.
Solid Tumors, Lymphoma
Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas
This is an open-label, dose-escalation Phase 1/2 study to assess the safety of ASTX660, determine the maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D), and recommended dosing regimen, and to obtain preliminary…
- Trial name
- NCT02503423
- Testing
- ASTX660
- Where
- 68 sites in United States, Belgium and 6 more
- Volunteers
- 253 people
- Sponsor
- Taiho Oncology, Inc.
Squamous Cell Carcinoma, Head And Neck, Squamous Cell Carcinoma Mouth
Pre-operative Mocetinostat (MGCD0103) and Durvalumab (MEDI4736) (PRIMED) for Squamous Cell Carcinoma of the Oral Cavity
This is a Phase 1 Window of Opportunity study to evaluate the pharmacodynamic and immune effects of pre-operative therapy with Mocetinostat and Durvalumab on patients with squamous cell carcinoma of the oral cavity.
- Conditions
- Squamous Cell Carcinoma, Head And Neck, Squamous Cell Carcinoma Mouth, Resectable Squamous Cell Carcinoma of Oral Cavity
- Trial name
- PRIMED-001 (NCT02993991)
- Testing
- Mocetinostat, Durvalumab
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Head & Neck Cancer
Nimotuzumab Combined With Toripalimab and Chemotherapy for Locally Advanced Tonsillar Cancer
This is a prospective,single-arm,Phase II clinical study to designed to evaluate the efficancy and safety of nimotuzumab Combined with Toripalimab and Chemotherapy for Locally Advanced Tonsillar Cancer
- Trial name
- NCT07353723
- Testing
- Nimotuzumab, Toripalimab, Nab-paclitaxel
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Tang-Du Hospital
Head and Neck Cancer, Dental Disease
Observational Study of Dental Outcomes in Head and Neck Cancer Patients
The purpose of this study is to measure the two-year rate of tooth loss in patients who have received external beam radiation therapy with curative intent for head and neck cancer.
- Conditions
- Head and Neck Cancer, Dental Disease, Xerostomia, Osteoradionecrosis
- Trial name
- ORARAD (NCT02057510)
- Where
- 6 sites in United States
- Volunteers
- 613 people
- Sponsor
- Wake Forest University Health Sciences
Human Papilloma Virus Infection, Stage III Squamous Cell Carcinoma of the Oropharynx
Nab-paclitaxel and Carboplatin Followed by Response-Based Local Therapy in Treating Patients With Stage III or IV HPV-Related Oropharyngeal Cancer
This phase II trial studies nab-paclitaxel (paclitaxel albumin-stabilized nanoparticle formulation) and carboplatin followed by response-based local therapy in treating patients with stage III or IV human papillomavirus…
- Conditions
- Human Papilloma Virus Infection, Stage III Squamous Cell Carcinoma of the Oropharynx, Stage IVA Squamous Cell Carcinoma of the Oropharynx, Stage IVB Squamous Cell Carcinoma of the Oropharynx
- Trial name
- OPTIMA (NCT02258659)
- Testing
- paclitaxel albumin-stabilized nanoparticle formulation, carboplatin, radiation therapy
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Chicago
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.