Clinical trials: Cancer of the Head and Neck
Recurrent and Metastatic Nasopharyngeal Carcinoma
Nedaplatin Combined With Gemcitabine in the Treatment of Recurrent and/or Metastatic Nasopharyngeal Carcinoma : a Single Arm and Phase Ⅱ Clinical Trail
The purpose of this single arm,phase Ⅱ clinical trail is to determine the safety and efficacy of nedaplatin combined with gemcitabine in the treatment of recurrent and metastatic nasopharyngeal carcinoma
- Trial name
- NCT02789189
- Testing
- nedaplatin and gemcitabine
- Volunteers
- 60 people
- Sponsor
- Sun Yat-sen University
Hypoxemia, Gastric Cancer (Diagnosis)
Effect of High-flow Nasal Cannula Oxygenation on the Incidence of Hypoxemia During Painless Gastrointestinal Endoscopy in Patients at High Risk for Obstructive Sleep Apnea Syndrome in High-altitude Regions
Patients living in high-altitude areas naturally have lower blood oxygen levels. Those at high risk for Obstructive Sleep Apnea (OSA) face an even greater risk of low oxygen during painless gastrointestinal endoscopy.
- Conditions
- Hypoxemia, Gastric Cancer (Diagnosis), Esophageal Cancer, High-altitude Illness
- Trial name
- NCT07904260
- Testing
- High-flow nasal cannula Group, Regular Nasal Cannula Group
- Where
- 3 sites in China
- Volunteers
- 430 people
- Sponsor
- Diansan Su
Melanoma
Neurotropic Melanoma of the Head and Neck
This is a 2-armed randomised controlled trial comparing surgery alone with surgery plus post-operative radiation therapy for patients with completely resected primary melanoma showing histological features of neurotropism.
- Trial name
- RTN2 (NCT00975520)
- Testing
- Observation, Radiation Therapy
- Where
- 16 sites in United States, Australia and 1 more
- Volunteers
- 50 people
- Sponsor
- Melanoma and Skin Cancer Trials Limited
Squamous Cell Carcinoma of Head and Neck
Optimised Early Management of Squamous Cell Carcinoma of the Head and Neck Cancer
Post-operative concomitant radiochemotherapy is a treatment that is difficult to achieve for several reasons. First of all, and by definition, these patients have had recent surgery, most often accompanied by several weeks of…
- Trial name
- OPTINECK (NCT04528420)
- Testing
- optimised management
- Where
- 7 sites in France
- Volunteers
- 138 people
- Sponsor
- Centre Henri Becquerel
Thoracic Cancers, Malignant Pleural Mesotheliomas NOS
Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining
Background: Chromatin is is the structural building block of a chromosome. It is found inside the nucleus of the cell and consists of a complex of DNA and protein.
- Conditions
- Thoracic Cancers, Malignant Pleural Mesotheliomas NOS, Lung Cancer NOS, Esophageal Cancers NOS
- Trial name
- NCT00242723
- Where
- United States
- Volunteers
- 1,559 people
- Sponsor
- National Cancer Institute (NCI)
Esophageal Cancer
Radiochemotherapy With and Without Dose Escalation in Patients Presenting Locally Advanced or Inoperable Carcinoma of the Oesophagus
Exclusive concomitant radiochemotherapy (RCT) at a dose of 50 Gy delivered over 5 weeks, according to the RTOG 85-01 protocol, has led to improved 5-year survival in 25% of patients, whereas no patients survived for 5 years using…
- Trial name
- CONCORDE (NCT01348217)
- Testing
- Conformal 3D Radiotherapy with " ENI "-type prophylactic irradiation of the lymph node, Boost, chemotherapy: FOLFOX 4
- Where
- France
- Volunteers
- 196 people
- Sponsor
- Centre Georges Francois Leclerc
Major Salivary Gland Carcinoma, Minor Salivary Gland Carcinoma
Nivolumab and Ipilimumab in Treating Patients With Metastatic/Recurrent ACC of All Sites and Non-ACC Salivary Gland Cancer
This phase II trial studies the efficacy (the effect on the tumor) and the safety (the effect on the body) of the study drugs when given as a combination in participants with this type of cancer.
- Conditions
- Major Salivary Gland Carcinoma, Minor Salivary Gland Carcinoma, Recurrent Salivary Gland Carcinoma, Stage IV Major Salivary Gland Carcinoma
- Trial name
- NCT03146650
- Testing
- Ipilimumab, Laboratory Biomarker Analysis, Nivolumab
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwestern University
Head and Neck Squamous Cell Carcinoma
Paclitaxel, Carboplatin and Cetuximab (PCC) With Cetuximab, Docetaxel, Cisplatin and Fluorouracil (C-TPF) in Previously Untreated Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma
The goal of this clinical research study is to learn which chemotherapy combination is more effective in treating locally advanced head and neck squamous cell carcinoma. The side effects of these combinations will also be studied.
- Trial name
- NCT01154920
- Testing
- Paclitaxel, Carboplatin, Cetuximab
- Where
- 2 sites in United States
- Volunteers
- 128 people
- Sponsor
- M.D. Anderson Cancer Center
Head and Neck Cancer
Functional Imaging in HNC Undergoing Chemoradiation
The purpose of the study is to generate a library of functional imaging and anatomical imaging for patients with head and neck cancers for evaluation of new radiotherapy strategies and planning techniques including IMRT.
- Trial name
- NCT00837980
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Thyroid Cancer
Investigating Utility of ctDNA and Tumour Evolution in Advanced Thyroid Cancer
Although most thyroid cancers are treated and cured successfully there are still 30% who recur after many years. This will eventually progress and at this point may become incurable with treatment options including complex and…
- Trial name
- NOMINATE (NCT05837260)
- Testing
- Sample collection only
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Locally Advanced Squamous Cell Carcinoma of the Head and Neck Region
Combined FDG PET/CT Imaging in Response Evaluation After Radiochemotherapy in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)
To determine if combined [18F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) is performant enough with respect to detecting residual lymph node involvement after chemoradiation in order…
- Trial name
- ECLYPS (NCT01179360)
- Testing
- Integrated FDG PET/CT
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 152 people
- Sponsor
- University Hospital, Antwerp
Head and Neck Cancer, Xerostomia
Xerostomia Pilot Fudan: Acupuncture for Prevention of Radiation-Induced Xerostomia
PRIMARY AIM 1. Determine the feasibility of providing true and sham acupuncture treatment to patients at Fudan University Cancer Hospital (Cancer Hospital) who are receiving radiation treatment for cancer of the head and/or neck…
- Trial name
- NCT00862550
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 23 people
- Sponsor
- M.D. Anderson Cancer Center
Head and Neck Cancer
Phase 1b Safety Study of Xevinapant, Weekly Cisplatin, and RT in Participants With Unresected LA SCCHN (HyperlynX)
The purpose of this study is to evaluate the tolerability and safety of Xevinapant when added to weekly cisplatin-based concurrent chemoradiotherapy (CRT) in the treatment of participants with unresectable locally advanced…
- Trial name
- NCT06056310
- Testing
- Xevinapant, Cisplatin, intensity-modulated radiation therapy (IMRT)
- Where
- 23 sites in United States, Belgium and 4 more
- Volunteers
- 18 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Oropharyngeal Neoplasms
Human Papillomavirus and Oropharynx Carcinoma
High risk papillomavirus (HR-HPV) have an oncogenic role in Oropharyngeal squamous cell carcinomas (OP-SCC) in at least 25% of the cases and the prevalence is increasing.
- Trial name
- Papillophar (NCT00918710)
- Where
- France
- Volunteers
- 362 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Head and Neck Neoplasms
Afatinib and Pembrolizumab for Head and Neck Squamous Cell Carcinoma (ALPHA Study)
The primary objectives of the trial is to examine the toxicities and efficacies of afatinib and pembrolizumab for recurrent and/or metastatic head and neck squamous cell carcinoma.
- Trial name
- ALPHA (NCT03695510)
- Testing
- Afatinib Oral Tablet, Pembrolizumab Injection
- Where
- Taiwan
- Volunteers
- 29 people
- Sponsor
- National Taiwan University Hospital
Small Cell Lung Cancer, Pancreatic Cancer
Doxil Topotecan Doublet Cancer Study
The primary objective is to determine the nature and degree of the toxicity of weekly dosing of topotecan in escalating dose levels by cohorts of 3-6 patients in combination with a fixed dose of pegylated liposomal doxorubicin…
- Conditions
- Small Cell Lung Cancer, Pancreatic Cancer, Head and Neck Cancer, Gastric Cancer
- Trial name
- NCT00252889
- Testing
- Topotecan and pegylated doxorubicin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Christiana Care Health Services
Locally Advanced Adrenal Gland Pheochromocytoma, Locally Advanced Paraganglioma
Radioactive Drug (177Lu-DOTATATE) for the Treatment of Locally Advanced, Metastatic, or Unresectable Rare Endocrine Cancers
This phase II trial studies how well 177Lu-DOTATATE works in treating patients with rare endocrine cancers that have spread from where they started to nearby tissue or lymph nodes (locally advanced), spread to other places in the…
- Conditions
- Locally Advanced Adrenal Gland Pheochromocytoma, Locally Advanced Paraganglioma, Metastatic Adrenal Gland Pheochromocytoma, Metastatic Paraganglioma
- Trial name
- NCT04106843
- Testing
- Lutetium Lu 177 Dotatate
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Oral Squamous, Cell Carcinoma
Radio/Pathological Evaluation of Tongue Cancer Infiltration
The aim of the study is to assess the good correlation and prediction of the DOI for the post-operative pathological results and prognosis.
- Trial name
- RaP E ToC (NCT04821128)
- Testing
- Radiologic and pathological review.
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Esophageal Cancer
Clinical Study on the Efficacy of Single-port Inflatable Mediastinoscopy Combined With Laparoscopic-assisted Small Incision Surgery and Thoracoscopy Combined With Laparoscopic Surgery for Radical Esophagectomy
We previously developed a novel non-trans thoracic esophagectomy, the single-port inflatable mediastinoscopy combined with laparoscopy for the radical esophagectomy of esophageal cancer.This study is evaluating the feasibility…
- Trial name
- NCT05105945
- Testing
- Single-Port Inflatable Mediastinoscopy Combined With Laparoscopic-Assisted Small Incision Surgery, Thoracoscopy Combined With Laparoscopic Surgery
- Where
- China
- Volunteers
- 1,164 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Head and Neck Cancer
Free Skin Grafting to Reconstruct Donor Sites After Radial Forearm Flap Harvesting
Reconstruction of the donor site after radial forearm flap harvesting is a common procedure in maxillofacial plastic surgery. Unfortunately, free skin graft transplantation faces wound healing impairments such as necrosis…
- Trial name
- NCT05137639
- Testing
- Platelet-rich fibrin (PRF)
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
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