Clinical trials: Cancer of the Thyroid
Differentiated Thyroid Cancer
No Prognostic or Molecular Disparity Between Synchronous and Metachronous Metastases in Differentiated Thyroid Cancer: Insight From Middle Eastern Cohort
The goal of this observational study is to compare the clinical outcomes, molecular features, and immune profiles of patients with synchronous and metachronous distant metastases in Saudi cohort with well characterized…
- Trial name
- NCT07115810
- Testing
- No additional drugs(control Group)
- Volunteers
- 178 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Thyroid Neoplasms, Thyroid Diseases
Assessing Benefits of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Total Thyroidectomy
This study will see if the use of near infrared autofluorescence (NIRAF) detection with a 'Parathyroid Eye (PTeye)' for identifying parathyroid glands (PGs) during total thyroidectomy (TTx) is better than surgeon's detection…
- Conditions
- Thyroid Neoplasms, Thyroid Diseases, Hypoparathyroidism, Endocrine System Diseases
- Trial name
- NCT05022667
- Testing
- PTeye
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- University of Michigan
Radioactive Iodine-refractory, Differentiated Thyroid Cancer With NRAS Mutation, Advanced PDTC or ATC With NRAS Mutation
Phase II Trial of Tunlametinib in NRAS-Mutant Advanced Thyroid Cancer
This phase II trial evaluates Tunlametinib (MEK inhibitor) ± PD-1 in NRAS-mutant advanced thyroid cancer. Key Objectives: Assess efficacy (ORR by RECIST v1.1) Evaluate safety profiles Study Design: Single-arm, single-center 4…
- Trial name
- NCT06970353
- Testing
- Tunlametinib, Tunlametinib+PD-1 mAb
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fudan University
Papillary Thyroid Carcinoma
Microwave Ablation and Surgical Resection for Micropapillary Thyroid Carcinoma
The study aimed to compare the efficacy and safety of papillary thyroid microcarcinoma (PTMC) treated with microwave ablation(MWA) and surgery resection (SR), and to explore the tumor characteristics suitable for each treatment…
- Trial name
- NCT04197960
- Testing
- Microwave ablation, Surgical resection
- Where
- China
- Volunteers
- 973 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Thyroid Cancer
Impact of Conventional Treatments and Clinical Variables on Thyroid Cancer
DTC has a generally favorable prognosis. The possibility to discriminate between patients with aggressive tumors and those with a more indolent behavior may reduce the need for unnecessary treatments.
- Trial name
- THY-CANC (NCT05752604)
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- Istituto Auxologico Italiano
Advanced Solid Tumor, Lung Cancer
Carbon Nanoparticle-Loaded Iron [CNSI-Fe(II)] in the Treatment of Advanced Solid Tumor
This Phase I clinical trial aims to evaluate the safety, tolerability, pharmacokinetics (PK) profile and preliminary efficacy of intratumoral injection of Carbon Nanoparticle-Loaded Iron [CNSI-Fe(II)] in patients with advanced…
- Conditions
- Advanced Solid Tumor, Lung Cancer, Pancreas Cancer, Breast Cancer
- Trial name
- CNSI-Fe(II) (NCT06048367)
- Testing
- CNSI-Fe(II) 30 mg, CNSI-Fe(II) 60 mg, CNSI-Fe(II) 90 mg
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Sichuan Enray Pharmaceutical Sciences Company
Postoperative Hypoparathyroidism, Thyroid Disease
Assessing Benefits of NIRAF Detection for Identifying Parathyroid Glands During Total Thyroidectomy
This study describes a single center, randomized, single-blinded clinical trial to assess the clinical benefits of the use of near infrared autofluorescence (NIRAF) detection with an FDA-cleared device 'Parathyroid Eye (PTeye)'…
- Conditions
- Postoperative Hypoparathyroidism, Thyroid Disease, Thyroid Neoplasms, Thyroid Cancer
- Trial name
- NCT05579782
- Testing
- NIRAF Detection Technology
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Salivary Gland Cancer, Thyroid Cancer
Sacituzumab Govitecan in Metastatic Salivary Gland and Thyroid Cancers (SG-SGTC)
The goal of this clinical trial is to learn if the drug, sacituzumab govitecan, works to treat: 1. Salivary gland cancers that have spread to other parts of the body or come back after previous treatment, and cannot be removed by…
- Trial name
- TROP2 (NCT06923826)
- Testing
- Sacituzumab govitecan
- Where
- Singapore
- Volunteers
- 32 people
- Sponsor
- National University Hospital, Singapore
Thyroid Cancer
Multiple Target Kinase Inhibitor and Anti-Programmed Death-1 Antibody in Patients With Advanced Thyroid Cancer
The study is being conducted to evaluate the safety and efficacy of Multiple Target Kinase Inhibitor(mTKI) Combined with Anti-Programmed Death-1(PD-1) Antibody in subjects with advanced thyroid cancer.
- Trial name
- NCT04521348
- Testing
- multiple tyrosine kinase inhibitor(mTKI) Combined with anti-PD-1 antibody
- Where
- China
- Volunteers
- 103 people
- Sponsor
- Fudan University
Thyroid Cancer, Papillary
Intraoperative Pathologic Evaluation of Central Lymph Nodes in Papillary Thyroid Carcinoma
Efficacy of Intraoperative pathologic evaluation of central lymph nodes
- Trial name
- NCT07066644
- Testing
- central node dissection
- Where
- South Korea
- Volunteers
- 509 people
- Sponsor
- Seoul National University Hospital
Paraganglioma/ Phaeochromocytoma, Melanoma and Other Malignant Neoplasms of Skin
An International Study on Pediatric Patients With Rare Tumors.
The PARTNER study is an international, prospective, observational study of paediatric patients with very rare tumours.
- Conditions
- Paraganglioma/ Phaeochromocytoma, Melanoma and Other Malignant Neoplasms of Skin, Gastrointestinal Stromal Tumor (GIST), Adrenocortical Tumor
- Trial name
- PARTNER (NCT07072143)
- Where
- Italy
- Volunteers
- 6,250 people
- Sponsor
- Azienda Ospedaliera di Padova
Papillary Thyroid Carcinoma
Diagnostic Accuracy of Fluorodeoxyglucose-18 PET in the Evaluation of RPTC With Patient's Raised Thyroglobulin Level
This research will employ cross-sectional analytical to determine diagnostic accuracy of Flourodeoxyglucose-18 Positron Emission Computed Tomography in the evaluation of Recurrent Papillary Thyroid Carcinoma with patient's raised…
- Trial name
- NCT07062211
- Where
- Pakistan
- Volunteers
- 39 people
- Sponsor
- Superior University
Carcinoma of Head/Neck
Observational Study on Thyroid Tumors and EvaLuation of the roLe of New pOntential Predictive/Prognostic Factors
The OTELLO Study is a monocentric, ambispective observational study that systematically analyzes the clinical, laboratory, anatomopathological, and molecular characteristics of patients with thyroid neoplasms treated at the…
- Trial name
- OTELLO (NCT07064369)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Radioactive Iodine-refractory Differentiated Thyroid Cancer
Camrelizumab in Combination With Apatinib in Patients With Radioactive Iodine-refractory Differentiated Thyroid Cancer
This is a single arm, open-label, non-randomized and single-center phase II clinical study, to evaluate the safety, tolerance, and efficacy of Camrelizumab in combination with Apatinib in patients with Radioactive…
- Trial name
- NCT04560127
- Testing
- Camrelizumab combination with Apatinib
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking Union Medical College Hospital
Iodine-resistant Thyroid Cancer, Meningioma
A Dual-targeting Tracer TATE-RGD for the Diagnosis of SSTR- and RGD- Positive Tumors
The US FDA approved a targeted somatostatin receptor 2 imaging agent, 68Ga-DOTATATE, in 2016. It has higher uptake in small cell lung cancer, pulmonary carcinoid, and medullary thyroid cancer.
- Conditions
- Iodine-resistant Thyroid Cancer, Meningioma, NETs
- Trial name
- NCT06632860
- Testing
- 68Ga-TATE-RGD, 18-FDG
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Thyroid Cancer
Outcome of RAI131 Therapy in Patients With Differentiated Thyroid Cancer (Low and Intermediate Risk)
Thyroid cancer is a universally relatively rare neoplasm, accounting for nearly 1-5% of all female cancers and less than 2% of male cancers.
- Trial name
- NCT07056218
- Testing
- neck ultrasound, thyroglobulin
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Thyroid Neoplasms, Carcinoma, Papillary
Hybrid Endoscopic Hemithyroidectomy and Targeted Ablation for Bilateral Papillary Thyroid Carcinoma
This study evaluates a thyroid-function-preserving alternative to routine total thyroidectomy for bilateral papillary thyroid carcinoma (PTC).
- Trial name
- NCT07033572
- Testing
- Endoscopic Hemithyroidectomy with Central-Neck Dissection, Ultrasound-Guided Radiofrequency Ablation of Contralateral Nodule
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fujian Medical University
Medullary Thyroid Cancer (MTC)
A Prospective Cohort Study of Pralsetinib or Anlotinib in the Treatment of Locally Advanced and/or Metastatic Medullary Thyroid Carcinoma With RET Gene Mutations
This trial is a prospective, observational Phase II clinical study. For patients with locally advanced and/or metastatic medullary thyroid carcinoma with RET gene mutations who require systemic treatment, they are randomly…
- Trial name
- NCT07048964
- Volunteers
- 40 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Vocal Cord Paralysis, Bilateral, Airway Obstruction, Postoperative
Peri-operative BiPAP to Prevent Tracheostomy in High-Risk Bilateral Vocal-Cord Paralysis (BVCP)
Why: After thyroid or neck surgery, some patients can lose movement of both vocal cords (bilateral vocal-cord paralysis, BVCP). This can make breathing difficult and often leads to an emergency or preventive tracheostomy…
- Conditions
- Vocal Cord Paralysis, Bilateral, Airway Obstruction, Postoperative, Thyroid Neoplasms, Sleep Apnea, Obstructive
- Trial name
- BVCP-BiPAP (NCT07042971)
- Testing
- Pre-operative BiPAP Training, Post-extubation BiPAP Support, Standard Peri-operative Care
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Fujian Medical University
Papillary Thyroid Carcinoma, Thyroid Neoplasms
RET-US Study - Ultrasound-Based Prediction of RET Alterations and Lateral-Neck Metastasis in Thyroid Cancer
Why is this study being done? RET gene alterations occur in only 5-10 % of papillary thyroid cancers, but they can change how surgeons treat the disease.
- Conditions
- Papillary Thyroid Carcinoma, Thyroid Neoplasms, RET Proto-Oncogene Mutation, Lymphatic Metastasis
- Trial name
- RET-US (NCT07042984)
- Testing
- AI-Ultrasound RET Prediction
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Fujian Medical University