Clinical trials: Cancer of the Thyroid
Cancer
Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer
Phase I trial to study the effectiveness of trastuzumab plus R115777 in treating patients who have advanced or metastatic cancer.
- Trial name
- NCT00005842
- Testing
- trastuzumab, tipifarnib
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Papillary Thyroid Cancer, Pediatric Cancer
Targeted Therapy to Increase RAI Uptake in Metastatic DTC
Papillary thyroid cancer (PTC) is a common type of differentiated thyroid cancer (DTC) in children and represents the second most common cancer in adolescent females.
- Conditions
- Papillary Thyroid Cancer, Pediatric Cancer, Differentiated Thyroid Cancer
- Trial name
- NCT05024929
- Testing
- Whole body scan
- Where
- 9 sites in United States, Australia
- Volunteers
- 32 people
- Sponsor
- Children's Hospital of Philadelphia
Papillary Thyroid Cancer, Lymph Node Metastases
Evaluation of Accuracy of One-Step Nucleic Acid Amplification (OSNA) in Diagnosis of Lymph Node Metastases of Papillary Thyroid Carcinoma
The incidence of node metastases in papillary thyroid carcinoma (PTC) is high, ranging from 20% to 90%. Prophylactic central lymph node compartment dissection (CLND), suggested from the latest guidelines for high-risk tumors…
- Trial name
- NCT03889769
- Testing
- OSNA test
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Cagliari
Differentiated Thyroid Gland Carcinoma, Thyroid Gland Follicular Carcinoma
Lenvatinib and Iodine Therapy in Treating Patients With Radioactive Iodine-Sensitive Differentiated Thyroid Cancer
This phase II trial studies how well lenvatinib works when given together with standard of care iodine I-131 in treating patients with radioactive iodine-sensitive differentiated thyroid cancer.
- Conditions
- Differentiated Thyroid Gland Carcinoma, Thyroid Gland Follicular Carcinoma, Thyroid Gland Papillary Carcinoma
- Trial name
- NCT03506048
- Testing
- Lenvatinib
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Emory University
Papillary Carcinoma of Thyroid Gland, Metastatic Medullary Thyroid Cancer
Pre-Operative Nodal Staging of Thyroid Cancer Using USPIO MRI: Preliminary Study
The purpose of this research study is to see if a specific kind of MRI can identify small and otherwise undetected abnormal lymph nodes in patients with thyroid cancer who are undergoing surgery.
- Conditions
- Papillary Carcinoma of Thyroid Gland, Metastatic Medullary Thyroid Cancer, Follicular Thyroid Cancer Lymph Node Metastasis
- Trial name
- NCT01927887
- Testing
- Ferumoxytol, Nanoparticle MRI
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
Thyroid Cancer
Predictive Factors of Clinical, Laboratory and Imaging Findings Routinely Used in Diagnosing Thyroid Cancer
The purpose of this study is to describe the correlation between the cytohistology exam of patients undergoing thyroid surgery, and the predictive values of: suspicious clinical findings, preoperative thyroid imaging, and the…
- Trial name
- TIR-2009-01 (NCT01074684)
- Where
- 8 sites in Italy
- Volunteers
- 959 people
- Sponsor
- National Cancer Institute, Naples
Surgical Wound Infection, Thyroid Nodule
Comparing Efficacy of Postoperative Oral Antibiotic Use in Trans-Oral Thyroidectomy
Transoral endoscopic thyroid surgery is a emerging surgical technique for thyroid surgery. This study to investigate the need for postoperative antibiotics in transoral endoscopic thyroid surgery.
- Trial name
- POTO (NCT03295955)
- Testing
- Amoxicillin Clavulanate
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Thyroid Nodule, Thyroid Neoplasms
The Role of Elastography in the Diagnosis of Thyroid Nodules
The primary objective of this study is to evaluate the role of elastography (along with echographic and cytological data) as a diagnostic tool for thyroid cancer
- Trial name
- NCT01292044
- Testing
- Elastography
- Where
- France
- Volunteers
- 188 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Thyroid Cancer
Pemetrexed + Paclitaxel in Patients With Recurrent/Advanced Thyroid Cancer
The aims of this trial are to evaluate the efficacy and tolerability of pemetrexed + paclitaxel in patients with recurrent/advanced follicular, papillary or anaplastic thyroid cancer.
- Trial name
- Panthera (NCT00786552)
- Testing
- pemetrexed + paclitaxel
- Where
- Germany
- Volunteers
- 47 people
- Sponsor
- University Hospital Schleswig-Holstein
Goiter
Subtotal Versus Total Thyroidectomy for Benign Goiter
The extent of thyroid resection in benign goiter is controversial. Potential advantages of TT over BST may include: one-stage removal of incidental thyroid cancer reported in up to 10% of operatively treated benign thyroid…
- Trial name
- NCT01273714
- Testing
- thyroid resection
- Where
- Poland
- Volunteers
- 8,006 people
- Sponsor
- Jagiellonian University
Cancer, Thyroid
Use of an In Vivo Optical Probe to Discriminate Benign From Malignant Thyroid Nodules
This study will investigate the usefulness of an optical probe in the differentiation of thyroid cancer from normal thyroid tissue in a thyroidectomy specimen.
- Trial name
- NCT01401855
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Thyroid Cancer
Impact of Conventional Treatments and Clinical Variables on Thyroid Cancer
DTC has a generally favorable prognosis. The possibility to discriminate between patients with aggressive tumors and those with a more indolent behavior may reduce the need for unnecessary treatments.
- Trial name
- THY-CANC (NCT05752604)
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- Istituto Auxologico Italiano
Thyroid Nodule, Thyroid Cancer
Genomic Profiling of Nodular Thyroid Disease and Thyroid Cancer
The purpose of this registry is to collect uniform genomics-centered data on patients with nodular thyroid disease and cancer in a prospective fashion.
- Conditions
- Thyroid Nodule, Thyroid Cancer, Thyroid Diseases, Thymic Carcinoma
- Trial name
- NCT03170804
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Aventura Hospital and Medical Center
Thyroid Cancer Stage IV
Stereotactic Body Radiotherapy for the Treatment of Distant Metastases in Thyroid Cancer: A Phase II Prospective Clinical Study
The goal of this observational study is to evaluate the efficacy and safety of Stereotactic Body Radiotherapy in the treatment of distant metastatic thyroid cancer.
- Trial name
- NCT07755423
- Testing
- SBRT
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Fudan University
Thyroid Cancer
The Role of tHyroid cAncer Specific Patient Concerns iNventory (PCI-TC) in Enhancing Shared decisiOn Making
Multiple clinical equipoises exist for the management of thyroid cancers. Shared decision-making (SDM) process where patients are supported to consider options, to achieve informed preferences with their clinicians have been…
- Trial name
- HANSOM (NCT06322160)
- Testing
- Interview
- Where
- 2 sites in United Kingdom
- Volunteers
- 19 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Solid Tumor, Thyroid Cancer
Imatinib in Combination With Dacarbazine and Capecitabine in Medullary Thyroid Carcinoma
Objectives: Primary objectives: To determine the maximum tolerated doses (MTD) for the combination of imatinib mesylate, capecitabine, and dacarbazine in patients with solid tumors.
- Trial name
- NCT00354523
- Testing
- Capecitabine (Xeloda), DTIC-Dome (Dacarbazine), Gleevec (Imatinib Mesylate)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- M.D. Anderson Cancer Center
Childhood Hepatocellular Carcinoma, Papillary Thyroid Cancer
Sorafenib Tosylate in Treating Younger Patients With Relapsed or Refractory Rhabdomyosarcoma, Wilms Tumor, Liver Cancer, or Thyroid Cancer
This phase II trial studies how well sorafenib tosylate works in treating younger patients with relapsed or refractory rhabdomyosarcoma, Wilms tumor, liver cancer, or thyroid cancer.
- Conditions
- Childhood Hepatocellular Carcinoma, Papillary Thyroid Cancer, Previously Treated Childhood Rhabdomyosarcoma, Recurrent Childhood Liver Cancer
- Trial name
- NCT01502410
- Testing
- sorafenib tosylate, pharmacological study, laboratory biomarker analysis
- Where
- 92 sites in United States, Australia and 1 more
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
Thyroid Cancer
Study of PET Imaging With 18F-TFB in Patients With Thyroid Cancer
The goal of the study is to evaluate a new imaging test that may allows the investigators to predict the uptake of radioactive iodine by thyroid cancer faster than the current standard and that does not interfere with the uptake…
- Trial name
- NCT03196518
- Testing
- PET Imaging, 18F-tetrafluoroborate (18F-TFB)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Thyroid Nodule, Thyroid Goiter
Prospective Evaluation of the Pulse Biosciences nPulse™ Vybrance™ Percutaneous Electrode System
The primary objective of this study is to reproduce in a multi-center study results obtained during the feasibility First-In-Human (FIH) study with Prof.
- Conditions
- Thyroid Nodule, Thyroid Goiter, Ablation
- Trial name
- PRECISE-BTN (NCT07287176)
- Testing
- nPulse Vybrance Percutaneous Electrode System
- Where
- 3 sites in United States
- Volunteers
- 103 people
- Sponsor
- Pulse Biosciences, Inc.
Radioactive Iodine-refractory Differentiated Thyroid Cancer
Camrelizumab in Combination With Apatinib in Patients With Radioactive Iodine-refractory Differentiated Thyroid Cancer
This is a single arm, open-label, non-randomized and single-center phase II clinical study, to evaluate the safety, tolerance, and efficacy of Camrelizumab in combination with Apatinib in patients with Radioactive…
- Trial name
- NCT04560127
- Testing
- Camrelizumab combination with Apatinib
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking Union Medical College Hospital
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