Clinical trials: Cancer of the Thyroid
Medullary Thyroid Carcinoma
Efficacy and Safety Study of Sorafenib to Treat Advanced Medullary Thyroid Carcinoma
The purpose of his study is to evaluate the efficacy and safety of Sorafenib versus placebo in subjects with locally advanced medullary thyroid cancer (MTC).
- Trial name
- SUMMIT (NCT01736878)
- Testing
- Sorafenib
- Where
- Germany
- Sponsor
- Eanm Research Ltd
Thyroid Neoplasm, Goiter
Total Thyroidectomy With Harmonic Scalpel®
Harmonic scalpel is a new surgical instrument. Its use has been recommended in patients submitted to total thyroidectomy. Few randomized controlled trials has been published.
- Conditions
- Thyroid Neoplasm, Goiter, Thyroid Nodule
- Trial name
- NCT00385983
- Testing
- Harmonic Scalpel
- Where
- 9 sites in Brazil
- Volunteers
- 280 people
- Sponsor
- Brazilian Society of Head and Neck Surgery
Breast Cancer, Thyroid Cancer
3-D Super Resolution Ultrasound Microvascular Imaging
This is a 3-arm single center study of 45 patients. These cohorts will include 15 breast patients scheduled to undergo a biopsy, and 15 thyroid patients scheduled to undergo fine needle aspiration, biopsy, or thyroidectomy that…
- Trial name
- NCT04136912
- Testing
- Definity, Acoustic Angiography
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Thyroid Neoplasms
Study Of AG-013736 In Patients With 131I-Refractory Thyroid Cancer
The primary purpose is to determine how effective AG-013736 is in shrinking thyroid cancer that is resistant to radioactive iodine
- Trial name
- NCT00389441
- Testing
- AG-013736
- Where
- 26 sites in United States, Canada and 7 more
- Volunteers
- 52 people
- Sponsor
- Pfizer
Thyroid Nodule, Thyroid Neoplasms
Khon Kaen University's Thyroidectomy Registry
The endoscopic thyroidectomy approach is gaining popularity in the surgical field. This registry tries to collect the outcomes including quality of life and complication for both endoscopic and conventional thyroidectomy methods.
- Conditions
- Thyroid Nodule, Thyroid Neoplasms, Thyroid Cancer
- Trial name
- NCT03031639
- Testing
- Endoscopic approach thyroidectomy
- Where
- Thailand
- Volunteers
- 98 people
- Sponsor
- Khon Kaen University
Thyroid Cancer
Potential Role for Carbon Nanoparticles to Guide Central Neck Dissection in Patients With Papillary Thyroid Cancer
Papillary thyroid cancer (PTC) is the most common subtype of thyroid cancer. The most common site of PTC nodal metastases is the central neck, which has a reported rate of lymph node metastases as high as 50%~70%.
- Trial name
- NCT02724176
- Testing
- carbon nanoparticles
- Volunteers
- 140 people
- Sponsor
- Peking University Cancer Hospital & Institute
Patients Undergoing Thyroid Surgery for Neoplasm
Comparison of Quality of Recovery (QoR)-15 Scores Between Propofol and Remimazolam Anesthesia
Remimazolam is a ultra-short-acting benzodiazepine that is rapidly metabolized in the body by tissue esterase and not accumulates in the body for long periods of infusion.
- Trial name
- NCT05016518
- Testing
- Arm I (Propofol group), Arm II (Remimazolam group)
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- Gangnam Severance Hospital
Thyroid Cancer
Global Real World Data in Patients With Advanced Thyroid Cancer on Standard of Care and Specialized Interventions- Registry of Oncologic Outcomes With Testing and Treatment.
The goal of this clinical research study is to learn about the barriers in the real world to accessing treatments for ATC. And to learn about how patients with ATC tolerate and respond to the commercially available medications…
- Trial name
- GRASSROOT (NCT06507878)
- Where
- United States
- Volunteers
- 459 people
- Sponsor
- M.D. Anderson Cancer Center
Poorly Differentiated Thyroid Carcinoma
PLD Combined With Cisplatin in the Treatment of Advanced Poorly Differentiated Thyroid Carcinoma
This is a prospective, multicenter, open label Phase II Clinical Trial. 30 advanced poorly differentiated thyroid carcinoma patients who were histopathologically confirmed inoperable were enrolled in this study.
- Trial name
- NCT03387943
- Testing
- PLD, Cisplatin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Medullary Thyroid Cancer
Study in Healthy Volunteers to Assess Effect of Omeprazole and Ranitidine on the Pharmacokinetics of Vandetanib
Study in healthy volunteers to assess effect of omeprazole and ranitidine on the pharmacokinetics of vandetanib
- Trial name
- Vandetanib (NCT01539655)
- Testing
- vandetanib, omeprazole, ranitidine
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Sanofi
Hereditary Thyroid Gland Medullary Carcinoma, Locally Advanced Thyroid Gland Medullary Carcinoma
Sorafenib Tosylate in Treating Patients With Metastatic, Locally Advanced, or Recurrent Medullary Thyroid Cancer
This phase II trial studies how well sorafenib tosylate works in treating patients with medullary thyroid cancer that has spread to other parts of the body (metastatic), spread to the tissue surrounding the thyroid (locally…
- Conditions
- Hereditary Thyroid Gland Medullary Carcinoma, Locally Advanced Thyroid Gland Medullary Carcinoma, Multiple Endocrine Neoplasia Type 2A, Multiple Endocrine Neoplasia Type 2B
- Trial name
- NCT00390325
- Testing
- Sorafenib Tosylate
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Papillary Thyroid Cancer
Ultrasound-guided Thermal Ablation for Papillary Thyroid Carcinoma
To evaluate long-term outcomes of ultrasound-guided thermal ablation for the treatment of papillary thyroid carcinoma
- Trial name
- NCT06733740
- Testing
- ultrasound-guided thermal ablation
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Chinese PLA General Hospital
Parotid Neoplasm, Thyroid Neoplasms
Bevonescein to Highlight Nerves in Patients Undergoing Head & Neck Surgery
Bevonescein to Highlight Nerves in Patients Undergoing Head \& Neck Surgery
- Conditions
- Parotid Neoplasm, Thyroid Neoplasms, Head and Neck Neoplasms, Surgery
- Trial name
- NCT04420689
- Testing
- Bevonescein
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Alume Biosciences, Inc.
Papillary Thyroid Carcinoma
Multimodal Deep Learning for Lymph Node Metastasis in Thyroid Cancer
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy in clinical practice, accounting for approximately 85% of all thyroid malignancies.
- Trial name
- NCT07299318
- Testing
- not intervention
- Where
- China
- Volunteers
- 3,200 people
- Sponsor
- West China Hospital
Thyroid Neoplasms
Institut Paoli Calmettes Thyroid Cancer Database
Database of Institut Paoli-Calmettes patients diagnosed with thyroid cancer
- Trial name
- NCT02869620
- Testing
- Data collection
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- Institut Paoli-Calmettes
Thyroid Neoplasms
Assessment of Quality of Life After Adjunct Radioiodine Therapy in Patients With Differentiated Thyroid Cancer
The aim of this study was to assess the impact of adjuvant radioactive iodine therapy on the quality of life(QOL) in differentiated thyroid cancer patients and to identify independent factors affecting changes in the QOL.
- Trial name
- NCT02706743
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Southern Medical University, China
Thyroid Cancer Patients, Lymph Node Metastasis
Irreversible Electroporation for Recurrent or Metastatic Cervical Lymph Node Metastases From Thyroid Cancer: A Prospective Multicenter Single-Arm Study
This is a single-arm, open-label, multicenter, exploratory clinical trial designed to systematically evaluate the efficacy, safety, and patient benefit of ultrasound-guided irreversible electroporation (IRE) ablation for…
- Trial name
- IRE-TCLN (NCT07328243)
- Testing
- Irreversible Electroporation (IRE) Ablation
- Where
- 3 sites in China
- Volunteers
- 85 people
- Sponsor
- Tian'an Jiang
Anaplastic Thyroid Cancer, Thyroid Cancer
XL092 and Cemiplimab in BRAF WT Thyroid Cancer
This multicenter study examines the safety and feasibility of the combination of neoadjuvant XL092 and cemiplimab prior to surgical resection in participants with wild-type (WT) anaplastic thyroid cancer (ATC) that has a BRAF…
- Conditions
- Anaplastic Thyroid Cancer, Thyroid Cancer, BRAF Mutation-Related Tumors
- Trial name
- NEO-COMBATXL (NCT06902376)
- Testing
- Cemiplimab, XL092
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Anaplastic Thyroid Cancer
Zanzalintinib Plus Cemiplimab for the Treatment of BRAF Wild-Type Anaplastic Thyroid Cancer
The goal of the trial is to improve this OS by 4 months (to 9.9 months) using the zanzalintinib + cemiplimab treatment combination.
- Trial name
- NCT07470489
- Testing
- Cemiplimab, Zanzalintinib
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- M.D. Anderson Cancer Center
Thyroid Tumor
Effect of Dexmedetomidine After Thyroidectomy
The purpose of the present study was to compare the effect of dexmedetomidine which is administered during emergence in adult patients undergoing elective thyroidectomy on smooth emergence form general anesthesia (reducing…
- Trial name
- NCT02412150
- Testing
- Desflurane, Remifentanil, Thyroidectomy
- Where
- South Korea
- Volunteers
- 139 people
- Sponsor
- Chosun University Hospital
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