Clinical trials: Cancer of the Thyroid
Thyroid Cancer
Molecular Markers in Thyroid Cancer
The purpose of this study is to evaluate how common gene mutations are in benign and malignant thyroid lesions.
- Trial name
- NCT00598364
- Where
- United States
- Volunteers
- 847 people
- Sponsor
- OHSU Knight Cancer Institute
Follicular Thyroid Cancer, Insular Thyroid Cancer
Dabrafenib With or Without Trametinib in Treating Patients With Advanced Differentiated Thyroid Cancer
This randomized phase II trial studies how well dabrafenib works with or without trametinib in treating patients with recurrent thyroid cancer.
- Conditions
- Follicular Thyroid Cancer, Insular Thyroid Cancer, Papillary Thyroid Cancer, Recurrent Thyroid Cancer
- Trial name
- NCT01723202
- Testing
- dabrafenib, trametinib
- Where
- 5 sites in United States
- Volunteers
- 53 people
- Sponsor
- Bhavana Konda
Thyroid Abnormalities
Thyroid Abnormalities Associated With Exposure to Atmospheric Emissions of Radioactive Iodine
Background: An inadequate filtering system at the Mayak nuclear weapons production facility in Ozyorsk, Russia, allowed the release of various radioactive materials, particularly I-131 (radioactive iodine) into the city's…
- Trial name
- NCT00342693
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- National Cancer Institute (NCI)
Neoadjuvant Treatment, Thyroid Cancer
Zanzalintinib for the Treatment of Advanced Thyroid Cancer Before Surgery
To look at the effectiveness of zanzalintinib, followed by surgery, in treating advanced thyroid cancer. The safety of this treatment will also be studied.
- Trial name
- NCT06959511
- Testing
- Zanzalintinib
- Where
- 4 sites in United States
- Volunteers
- 45 people
- Sponsor
- M.D. Anderson Cancer Center
Medullary Thyroid Cancer (MTC)
A Prospective Cohort Study of Pralsetinib or Anlotinib in the Treatment of Locally Advanced and/or Metastatic Medullary Thyroid Carcinoma With RET Gene Mutations
This trial is a prospective, observational Phase II clinical study. For patients with locally advanced and/or metastatic medullary thyroid carcinoma with RET gene mutations who require systemic treatment, they are randomly…
- Trial name
- NCT07048964
- Volunteers
- 40 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Whey Protein, Thyroid Neoplasms
Whey Protein and Carbohydrates in ERAS for Recovery After Thyroidectomy: A Cohort Study
Exploring the effects of whey protein combined with carbohydrates in an Enhanced Recovery After Surgery (ERAS) protocol on the postoperative recovery of thyroid cancer patients undergoing lateral neck dissection, aiming to…
- Conditions
- Whey Protein, Thyroid Neoplasms, Neck Dislocation, Enhanced Recovery After Surgery
- Trial name
- NCT06607965
- Testing
- Whey Protein and Carbohydrates
- Where
- China
- Volunteers
- 127 people
- Sponsor
- Chongqing General Hospital
Head and Neck Cancer
Irinotecan in Treating Patients With Metastatic or Inoperable Thyroid Cancer
RATIONALE: Drugs used in chemotherapy, such as irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00100828
- Testing
- irinotecan hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Thyroid Carcinoma, Nonmedullary
Effects of Radioactive Iodine on the Immune System in Thyroid Cancer
Blood will be drawn 1 month before and 2 month after regular radioactive iodine treatment. Monocytes will be isolated. The three main outcomes are whole blood counts, cytokine production upon in vitro stimulation of monocytes and…
- Trial name
- SCIMITAR (NCT05989555)
- Testing
- Blood drawing
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Thyroid Gland Medullary Carcinoma
STAGE-MTC Trial Thyroid Lobectomy With Ipsilateral Central Neck Dissection
This clinical trial studies how well thyroid lobectomy with ipsilateral central neck dissection works to treat medullary thyroid cancer (MTC) in patients without a germline RET mutation (sporadic).
- Trial name
- NCT07612293
- Testing
- Biospecimen Collection, FDG-Positron Emission Tomography and Computed Tomography Scan, Ga-68 PET/CT Scan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Pancreatic Cancer, Small Bowel Cancer
Expanded Access to Ulixertinib (BVD-523) in Patients With Advanced MAPK Pathway-Altered Malignancies
The objective of this expanded access program is to provide ulixertinib (BVD-523) for compassionate use in advanced cancer patients with MAPK pathway-altered solid tumor(s), including but not limited to KRAS, NRAS, HRAS, BRAF…
- Conditions
- Pancreatic Cancer, Small Bowel Cancer, Colorectal Cancer, Melanoma
- Trial name
- NCT04566393
- Testing
- Ulixertinib (BVD-523)
- Where
- 26 sites in United States
- Sponsor
- xCures
Papillary Thyroid Cancer
Overdiagnosis of Thyroid Cancer in the Marne and Ardennes Departments of France From 1975 to 2014
Introduction - Incidence of thyroid cancer has increased considerably in France in recent years, but the mortality rate has declined only slightly. Part of this increased incidence could be attributable to overdiagnosis.
- Trial name
- OTCancer (NCT03623516)
- Where
- France
- Volunteers
- 2,008 people
- Sponsor
- CHU de Reims
Thyroid Neoplasms
Phase II Two-step Radioimmunotherapy Clinical Study in Medullary Thyroid Carcinoma
Phase II clinical trial assessing efficacy and toxicity of pretargeted radioimmunotherapy using anti-CEAxanti-DTPA bispecific antibody and di-DTPA-131I peptide in patients with reccurrence of medullary thyroid carcinoma (abnormal…
- Trial name
- RIT in MTC (NCT00467506)
- Testing
- bispecific antibody and di-DTPA-131I
- Where
- 11 sites in France
- Sponsor
- Nantes University Hospital
Papillary Thyroid Carcinoma, Thermal Ablation
A Study of Factors Influencing Recurrence After Thermal Ablation of Papillary Thyroid Carcinoma
A prospective cohort of papillary thyroid carcinoma(PTC), patients who received thermal ablation in our hospital since February 2023 was established as the study object.
- Trial name
- NCT05962892
- Testing
- No Intervention
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Beijing Friendship Hospital
Thyroidectomy, Thyroid Cancer
Evaluation of Central Compartment Dissection Without Thyroidectomy
In accordance with the current guidelines,papillary thyroid microcarcinoma such as turmo invasive nerve or trachea, requires total thyroidectomy for follow-up iodine-131 treatment.In the course of clinical work, if the patient…
- Conditions
- Thyroidectomy, Thyroid Cancer, Central Compartment Neck Dissction
- Trial name
- NCT03454464
- Testing
- Conventional, central neck dissection first
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fujian Medical University
Thyroid Papillary Carcinoma
Prospective Study on the Clinical Prognosis of Bilateral Central Lymph Node Dissection in the Patients With Unilateral Thyroid Papillary Carcinoma
This study recruit the patients with unilateral papillary thyroid cancer before operation,the patients agree to enter the test,and divided into experimental and control group.experimental group patients receive the surgery…
- Trial name
- NCT02648399
- Testing
- surgery：BCND（bilateral central lymph node dissection）, surgery：UCND（unilateral central lymph node dissection）
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Fujian Medical University
Differentiated Thyroid Cancer
Investigating National Solutions for Personalised Iodine-131 Radiation Exposure
This is a single-arm non-interventional prospective observational study to perform quantitative I-131 imaging and patient-specific dosimetry for patients undergoing radioiodine treatment.
- Trial name
- INSPIRE (NCT04391244)
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Thyroid Nodules
Radiofrequency Ablation in Thyroid Nodules
Thyroid nodules are common problems and although > 95% are stated to be benign, they may cause some problems like hyperthyroidism, compression symptoms, and cosmesis associated with their function, size and localization.
- Trial name
- NCT01750593
- Testing
- Radiofrequency ablation of the thyroid nodule
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bezmialem Vakif University
Thyroid
IMRT Followed by Pembrolizumab in the Adjuvant Setting in Anaplastic Cancer of the Thyroid (IMPAACT): Phase II Trial Adjuvant Pembrolizumab After IMRT in ATC
This is an open label, single center, phase 2 trial of adjuvant pembrolizumab after external beam radiation to the primary tumor in patients with stage IVB (disease localized to the neck) ATC.
- Trial name
- NCT05059470
- Testing
- Pembrolizumab
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- M.D. Anderson Cancer Center
Malignant Neoplasm of Thyroid Stage I, Malignant Neoplasm of Thyroid Stage II
Effect of Metformin on Decrement in Levothyroxin Dose Required for Thyroid Stimulating Hormone (TSH) Suppression in Patients With Differentiated Thyroid Cancer
Differentiated thyroid cancer is the most common neoplasm of endocrine system. After surgery and radioiodine treatment, thyroid stimulating hormone (TSH) suppression is the main goal which is achieved with levothyroxine…
- Trial name
- NCT01341886
- Testing
- Metformin
- Where
- Iran
- Volunteers
- 51 people
- Sponsor
- Mashhad University of Medical Sciences
Cancer, Breast Cancer
The Unmet Needs of Cancer Survivors in Ausl IRCCS Reggio Emilia
This qualitative study seeks to explore the unmet needs of individuals who have recently undergone a cancer diagnosis and completed the acute phase of treatment.
- Conditions
- Cancer, Breast Cancer, Prostate Cancer, Thyroid Cancer
- Trial name
- Survivorship (NCT06236373)
- Testing
- Focus Groups or Interviews
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Modena and Reggio Emilia
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