Clinical trials: Cancer-Associated Pain
Cancer Pain
Phase I Study of sss40 Injection for Moderate-to-Severe Bone Metastatic Cancer Pain
This is a Phase Ib/IIa, multicenter, sequential clinical trial evaluating the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of SSS40 injection in patients with moderate-to-severe bone metastatic cancer…
- Trial name
- NCT07008703
- Testing
- Injection of humanized nerve growth factor (NGF) antibody
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Shenyang Sunshine Pharmaceutical Co., LTD.
Breast Cancer, Musculoskeletal Complications
S1202: Duloxetine Hydrochloride for Muscle/Joint Pain in Early-Stage Breast Cancer Receiving Hormone Therapy
RATIONALE: Duloxetine hydrochloride may lessen muscle, bone, and joint pain caused by hormone therapy. It is not yet known whether duloxetine hydrochloride is more effective than a placebo in treating patients with muscle, bone…
- Conditions
- Breast Cancer, Musculoskeletal Complications, Pain
- Trial name
- NCT01598298
- Testing
- duloxetine hydrochloride
- Where
- 714 sites in United States
- Volunteers
- 299 people
- Sponsor
- SWOG Cancer Research Network
Head Neck Cancer, Squamous Cell Cancer of Head and Neck (SCCHN)
Stereotactic MRI-guided Focused Ultrasound Mesencephalotomy
This phase 1 multi-site study investigates the safety and initial effectiveness of focused ultrasound lesioning of the contralateral mesencephalon for severe, opioid-resistant pain associated with head and neck cancer and…
- Conditions
- Head Neck Cancer, Squamous Cell Cancer of Head and Neck (SCCHN), Cancer Pain
- Trial name
- MRg-FUS (NCT07405645)
- Testing
- ExAblate Neuro
- Where
- 6 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Wounds and Injuries, Cancer Pain
Benefits of Morphine Gel for Pain Reduction in Patients With Cancer Wounds
The goal of this clinical trial is to compare in compare pain reduction in patients with malignant wounds using morphine gel or lidocaine gel.
- Conditions
- Wounds and Injuries, Cancer Pain, Cancer, Breast, Cancer Head Neck
- Trial name
- MorphineGEL (NCT05800834)
- Testing
- Morphine Sulfate, Lidocaine Hcl 2% Jelly
- Where
- Brazil
- Volunteers
- 106 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Malignancy, Pain
Real-time Cancer Pain Assessment and Intervention
This study aim at the advanced malignant tumor patients who suffer from cancer pain, investigate the current status of cancer pain treatment, and study the effects in pain control and quality of life improvement using the method…
- Trial name
- NCT01914107
- Testing
- real-time monitoring and instruction of cancer pain, standard cancer pain care
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sun Yat-sen University
Pain, Chronic Pain
Decreasing Long-term Opioid Use in Cancer Survivors
This is a feasibility pilot trial assessing a behavioral intervention for chronic pain among disease-free cancer survivors to decrease long-term opioid dependence.
- Conditions
- Pain, Chronic Pain, Cancer Pain, Survivorship
- Trial name
- NCT05067556
- Testing
- Acceptance and Commitment Therapy for chronic pain (ACT-CP)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Virginia Commonwealth University
Constipation, Pain
Efficacy of Oxycodone/Naloxone(OXN), Versus Oxycodone (OXY), for the Reduction of Intensity of Opioid-induced Constipation in Pain Patients
The primary objective of this trial is to study the efficacy of oxycodone/naloxone prolonged release tablets (OXN PR), compared to oxycodone prolonged release tablets (Oxy PR), for the reduction of the intensity of opioid-induced…
- Trial name
- OXN3505 (NCT01014559)
- Testing
- Oxycodone Naloxone, Oxycodone PR Tablets
- Where
- France
- Volunteers
- 225 people
- Sponsor
- Mundipharma SAS
Chronic Cancer-related Pain
An N-of-1 Trial of an Internet-delivered CBT Program Based on the Psychological Flexibility Model of Chronic Pain for Cancer-related Difficulties
Chronic pain is a commonly occurring complication of cancer and can have negatively impact day-to-day functioning and well-being. The recommended treatment for all forms of chronic pain is cognitive behavioral therapy (CBT).
- Trial name
- NCT06749964
- Testing
- Internet-delivered, therapist-assisted, pain-focused CBT based on the psychological flexibility model for chronic pain
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Lund University
Pancreatic Cancer Pain, Intrathecal Analgesic
Evaluating the Effectiveness of AIT in the Treatment of Pain Related to Pancreatic Cancer
The aim of this clinical trial is to assess the effectiveness of intratracheal analgesia on pain intensity in cancer patients, from the start of treatment up to 3 months. It will also investigate the safety of this technique.
- Conditions
- Pancreatic Cancer Pain, Intrathecal Analgesic, Intrathecal Administration of the Drug, Pancreatic Carcinoma
- Trial name
- PIT (NCT07733427)
- Testing
- Intrathecal catheter connected to an implantable pump, Administration of medication, including analgesics, via an intrathecal catheter connected to an implantable pump or via periodic injections
- Where
- 3 sites in France
- Volunteers
- 40 people
- Sponsor
- Clinique Bizet
Pain; Cancer
An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Cancer Participants With Inadequately Controlled Pain by Non-Narcotic Analgesics
The purpose of this study is to evaluate the efficacy and safety of Transdermal Therapeutic System (TTS)-fentanyl D-Trans (transdermal patch containing a drug that is put on the skin so the drug will enter the body through the…
- Trial name
- NCT01060124
- Testing
- Fentanyl D-trans
- Volunteers
- 103 people
- Sponsor
- Janssen Korea, Ltd., Korea
Neoplasms, Bone Metastases
Open Label Extension In Cancer Patients
To evaluate the safety and efficacy of anti-NGF AB in cancer patients with pain due to bone metastases who participated in the double-blind Study A4091003 and who wish to receive open-label therapy.
- Trial name
- NCT00830180
- Testing
- Anti-NGF AB
- Where
- 23 sites in United States, Austria and 8 more
- Volunteers
- 41 people
- Sponsor
- Pfizer
Cannabis Use, Cannabis Use, Unspecified
Cannabis and Cancer, an Online Training for Oncology Nurses
The purpose of this study is to evaluate the preliminary effects and impacts of a digital educational intervention to support nurses' professional practice regarding safe cannabis use by young adults (18-39 years) diagnosed with…
- Conditions
- Cannabis Use, Cannabis Use, Unspecified, Nurse's Role, Oncology Pain
- Trial name
- NCT05663346
- Testing
- Cannabis & Cancer digital educational intervention, Standard information regarding cannabis use in oncology
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Chronic Pain, Cancer
Cancer Chronic Pain Predicted by Emotional and Cognitive Status
The aim of this study is to investigate the predictive dimension of cognitive-emotional status of cancer patients on the chronic pain development 6 months after different cancer treatment protocol (surgery, chemotherapy…
- Trial name
- CanoPEe (NCT02777697)
- Testing
- chronic pain
- Where
- France
- Volunteers
- 89 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cancer Pain
Effects of Mobile Medicine on Cancer Patients
With the existing medical system and insufficient medical resources in China, we developed a mini program. a pain management mini app can be useful and appreciated by patients and health care professionals, making it a good…
- Trial name
- NCT05049811
- Testing
- mini program, conventional pharmaceutical care
- Volunteers
- 200 people
- Sponsor
- Fujian Cancer Hospital
Chronic Pain, Chronic Non-cancer Pain
Personalized Care Management Model (GAP-421) for Chronic Pain in Primary Care Physiotherapy
This multicenter pilot study evaluates the feasibility, implementation fidelity, and preliminary effects of the GAP-421 (Personalized Care Management) model for chronic pain management in primary care physiotherapy.
- Conditions
- Chronic Pain, Chronic Non-cancer Pain, Care Coordination, Primary Health Care
- Trial name
- GAP-421 (NCT07451587)
- Testing
- GAP-421 Personalized Care Management Model
- Where
- 2 sites in Spain
- Volunteers
- 66 people
- Sponsor
- Universidad Autonoma de Madrid
Chronic Pain
Feasibility Study of an Online Self-management Program for Chronic Non-cancer Pain
Based on a mixed-methods design, the objective of this trial is to assess the feasibility and acceptability of the "Agir pour moi" program, an 8-week online self-management program for chronic non-cancer pain (CNCP).
- Trial name
- NCT05319652
- Testing
- Pain self-management program
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- CHU de Quebec-Universite Laval
Cancer, Breakthrough Cancer Pain
Inhaled Cannabinoids Versus Immediate-release Oral Opioids for the Management of Breakthrough Cancer Pain
Breakthrough cancer pain (BTcP) is a rapid onset, high intensity and short duration pain episode, which takes place within stable background pain control.
- Trial name
- REBORN (NCT03564548)
- Testing
- PPP001, Morphine sulfate or Hydromorphone or Oxycodone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Tetra Bio-Pharma
Cancer, Pain
Oral Ketamine as an Adjuvant to Opioids for Pain Treatment in Cancer Patients
In the current research the investigators would like to examine the effect of a well acquainted drug, Ketamine, which is used by anesthesiologists to induce sleep in operations.
- Conditions
- Cancer, Pain, Tolerance
- Trial name
- NCT01207206
- Testing
- oral ketamine
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Cancer-related Problem/Condition
Magnesium Associated With Morphine for Cancer Pain Relief
This study is an evaluation of the analgesic effect of magnesium associated with morphine in patients with cancer pain.
- Trial name
- NCT01541111
- Testing
- Magnesiun
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo