Clinical trials: Cancer-Associated Pain
Gynecologycal Cancer, Cancer Related Pain
The Effectiveness of Battlefield Acupuncture (BFA) With Standard Therapy in Gynecological Cancer Pain
Pain is one of the most important symptoms of cancer patients, with nearly 40% of all cancer patients experiencing moderate to severe pain.
- Conditions
- Gynecologycal Cancer, Cancer Related Pain, Cancer Pain
- Trial name
- NCT06115330
- Testing
- Press Needle Acupuncture
- Where
- 3 sites in Indonesia
- Volunteers
- 58 people
- Sponsor
- Universitas Indonesia
Cancer, Pain
Study of Opioid Rotation Versus Opioid Escalation in Patients With Moderate to Severe Cancer Pain
Although opioid rotation is well known treatment modality in reducing pain and opioid-induced neurotoxicity, it is not established whether opioid rotation is more appropriate or opioid escalation is more effective in controlling…
- Trial name
- NCT02084355
- Testing
- oral oxycodone, oral hydromorphone, fentanyl patch
- Where
- South Korea
- Volunteers
- 136 people
- Sponsor
- Gyeongsang National University Hospital
Chronic Non-Cancer Pain
Preventive Interventions for Chronic Pain Worsening
This is an open label randomized controlled trial (RCT), which will be conducted with patients of the Copenhagen Wound Healing Center at Bispebjerg Hospital in Copenhagen (DK).
- Trial name
- NCT06351046
- Testing
- Virtual Reality-based Pain Self-management program
- Where
- Denmark
- Volunteers
- 44 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Early-stage Breast Cancer, Pain Syndrome
Comparing Tapering Low Dose Dexamethasone to Other Standard of Care Therapies for TAPS in Breast Cancer Patients
The REaCT TAPS clinical trial will compare a tapering dose of dexamethasone to other standards of care on the presence of taxane-associated pain syndrome (TAPS) in early stage breast cancer.
- Trial name
- REaCT-TAPS (NCT03348696)
- Testing
- Dexamethasone tapering dose, Dexamethasone physician choice
- Where
- 2 sites in Canada
- Volunteers
- 124 people
- Sponsor
- Ottawa Hospital Research Institute
Pain, Analgesics, Opioid
A Study of OROS Hydromorphone HCL vs Morphine in Cancer Pain Patients.
The purpose of this study was to demonstrate the clinical equivalence of hydromorphone and morphine (immediate-release [IR] and sustained-release [SR] formulations) using the "worst pain in the past 24 hours" item of the Brief…
- Trial name
- NCT00410540
- Testing
- OROS hydromorphone HCL ; Morphine sulfate
- Volunteers
- 202 people
- Sponsor
- Alza Corporation, DE, USA
Pain, Chronic
Dependence on Analgesics in Chronic Non-cancer Pain
The identification of an addiction to opioid analgesics has become strong recommendation for the purpose of improving the clinical management of the patients.
- Trial name
- DISCORDANCE (NCT03346408)
- Testing
- Questionnaire
- Where
- 7 sites in France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Toulouse
Cancer-related Problem/Condition
Combined Fluoroscopy and CT Guided Radiofrequency Ablation of Thoracic Dorsal Root Ganglia in Severe Thoracic Pain
In the current study, extra-guidance other than conventional fluoroscopy - will be integrated to improve the success of the transforaminal approach to the thoracic dorsal root ganglia (DRG).
- Trial name
- NCT03533413
- Testing
- combined CT-fluroscopy, standard fluroscopy
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- National Cancer Institute, Egypt
Pain, Intractable, Pain Cancer
Phase 3 Study to Assess Resiniferatoxin vs Standard of Care for the Treatment of Intractable Cancer Pain
This is a Phase 3 study to assess the safety and efficacy of a single epidural administration of Resiniferatoxin versus standard of care for the treatment of intractable pain associated with cancer.
- Trial name
- NCT04572776
- Testing
- Resiniferatoxin, Standard of Care
- Sponsor
- Sorrento Therapeutics, Inc.
Cancer, Pain
A Study Comparing Oxycodone to Oxycodone/Naloxone in Moderate to Severe, Chronic Cancer Pain
The purpose of this study is to test the oxycodone/naloxone combination compared to oxycodone alone in patient's specific type of "chronic cancer pain".
- Conditions
- Cancer, Pain, Constipation
- Trial name
- NCT00513656
- Testing
- Oxycodone, Oxycodone/Naloxone
- Where
- United Kingdom
- Volunteers
- 230 people
- Sponsor
- Mundipharma Research GmbH & Co KG
Opioid-Induced Constipation
The Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation
The purpose of this study is to evaluate the safety and efficacy of CB-5945 for the treatment of opioid-induced constipation (OIC) in adults taking opioid therapy for chronic non-cancer pain.
- Trial name
- NCT01901341
- Testing
- CB-5945
- Volunteers
- 44 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Opioid Withdrawal (Disorder)
Randomized, Double-Blind, Placebo-Controlled Pilot Study on the Safety and Effectiveness of LUCEMYRA During an Opioid Taper in Treatment of Withdrawal
Stopping prescription opioid pain medications can be difficult due to withdrawal symptoms. This study will test if LUCEMYRA helps reduce withdrawal symptoms and helps more people reduce their opioid dose compared to placebo.
- Trial name
- TAPER (NCT04070157)
- Testing
- Lofexidine
- Where
- 12 sites in United States
- Volunteers
- 4 people
- Sponsor
- USWM, LLC (dba US WorldMeds)
Cancer
E-MOSAIC Electronic Tool to Monitor Symptoms
RATIONALE: A hand held electronic tool used to monitor symptoms and assess quality of life may improve communication between patients and their doctors and improve the ability to plan treatment for patients with advanced cancer…
- Trial name
- NCT00477919
- Where
- 7 sites in Switzerland
- Volunteers
- 264 people
- Sponsor
- Swiss Cancer Institute
Opioid-induced Constipation
Safety and Efficacy of Tegaserod in Opioid-induced Constipation in Patients With Non-cancer Pain.
This study will evaluate the safety and efficacy of Tegaserod in opioid-induced constipation (OIC) in patients with non-cancer pain.
- Trial name
- NCT00399659
- Testing
- Tegaserod
- Where
- 57 sites in United States
- Volunteers
- 360 people
- Sponsor
- Novartis
Pain
An Open Label Study to Evaluate Safety, Tolerability and Clinical Utility of ULTRACET® (37.5mg Tramadol Hydrochloride/325mg Acetaminophen) for the Treatment of Breakthrough Pain in Cancer Patients
The purpose of this study is to evaluate the analgesic effectiveness and safety of 37.5mg Tramadol hydrochloride/325mg Acetaminophen in the treatment of breakthrough pain in cancer patients.
- Trial name
- NCT00576173
- Testing
- tramadol hydrochloride; acetaminophen
- Volunteers
- 60 people
- Sponsor
- Johnson & Johnson Taiwan Ltd
Cancer
Radiofrequency Splanchnic Denervation ,Neurolytic Retrocrural Celiac Plexus Block Chronic Upper Abdominal Cancer Pain
To compare between the efficacy of radiofrequency splanchnic denervation and neurolytic retrocrural celiac plexus block in chronic upper abdominal cancer pain
- Trial name
- NCT06678061
- Testing
- radiofrequency
- Where
- 2 sites in Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Pain
Evaluation of the Efficacy and Safety of Fentanyl Delivered by Adhesive Skin Patch in Out-Patients With Chronic Cancer Pain
The purpose of this study is to determine the safety and efficacy of pain control by fentanyl, administered via adhesive skin patches, at doses of 25 to 100 micrograms per hour in 80 out-patients with intense chronic cancer pain.
- Trial name
- NCT00236327
- Testing
- fentanyl
- Volunteers
- 34 people
- Sponsor
- Janssen Cilag S.A.S.
Breakthrough Cancer Pain
Instanyl® Non-Interventional Study
The aim of this study is to describe the use of Instanyl® (Intranasal fentanyl spray) in the treatment of breakthrough pain (BTP) in cancer patients by success of dose titration and distribution of dose strength.
- Trial name
- INIS (NCT01045603)
- Where
- 65 sites in Denmark, France and 5 more
- Volunteers
- 309 people
- Sponsor
- Takeda
Opioid-Induced Constipation
Safety and Preliminary Efficacy of BGP345A in Constipation Due to Opioid-based Medications
The purpose of this study is to assess safety and preliminary efficacy of BGP345A in patients with constipation due to the use of opioid-based medications for the management of chronic non cancer pain.
- Trial name
- OIC1 (NCT05133076)
- Testing
- Lactobacillus gasseri BGP345A
- Where
- 4 sites in France
- Volunteers
- 14 people
- Sponsor
- BioGaia Pharma AB
Intractable Cancer Pain
Study to Evaluate Safety and MTD of Epidural Resiniferatoxin Injection for Treatment of Intractable Cancer Pain
The study is a multicenter, open-label Phase 1b single dose escalation safety study for adult subjects with intractable pain associated with cancer in any area below the mid-thoracic level who meet all other eligibility criteria.
- Trial name
- NCT03226574
- Testing
- Resiniferatoxin
- Where
- 4 sites in United States
- Volunteers
- 17 people
- Sponsor
- Sorrento Therapeutics, Inc.
Cancer, Pain
An Efficacy and Safety Study of Hydromorphone Hydrochloride (HCl) Oral Osmotic System (OROS) in the Reduction of Breakthrough Pain Medication Frequency in Participants With Cancer
The purpose of this study is to evaluate the clinical efficacy of hydromorphone hydrochloride (HCl) Oral Osmotic System (OROS) by assessing the extent of reduction of medication frequency for the management of breakthrough pain…
- Trial name
- NCT01006356
- Testing
- Hydromorphone HCl OROS
- Volunteers
- 141 people
- Sponsor
- Janssen Korea, Ltd., Korea