Clinical trials: Cancer-Associated Pain
Tumor, Pain
A Study to Evaluate Tapentadol (CG5503) in the Treatment of Chronic Tumor-Related Pain Compared With Placebo and Morphine
The purpose of this study will be to determine whether tapentadol (CG5503) is effective and safe in the treatment of chronic tumor related pain compared to placebo.
- Trial name
- NCT00472303
- Testing
- Tapentadol Extended Release, Morphine Sulphate Controlled Release
- Where
- 71 sites in Austria, Bulgaria and 14 more
- Volunteers
- 622 people
- Sponsor
- Grünenthal GmbH
Cachexia, Lymphoma
Celecoxib in Managing Pain, Weight Loss, and Weakness in Patients With Advanced Cancer
RATIONALE: Celecoxib may help relieve moderate or severe pain associated with cancer. It may also decrease weight loss and improve muscle strength in cancer patients.
- Conditions
- Cachexia, Lymphoma, Melanoma (Skin), Ovarian Cancer
- Trial name
- NCT00093678
- Testing
- celecoxib, anticachectic therapy, nutritional support
- Sponsor
- Eastern Cooperative Oncology Group
Misuse, Opioid
Effect of Olanzapine on Opioid Craving and Misuse Among Patients Receiving Opioids for Cancer-related Pain: A Pilot Double-Blind, Randomized Control Trial
To learn about the effectiveness of taking the antipsychotic medication olanzapine to help lower opioid craving.
- Trial name
- NCT06200181
- Testing
- Olanzapine
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- M.D. Anderson Cancer Center
Cancer
Pain Management in Cancer Patients Using a Mobile Application
The investigators have developed a mobile application (for use on smart phones) to help cancer patients better manage cancer pain.
- Trial name
- ePAL (NCT02069743)
- Testing
- ePAL Mobile Application
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Massachusetts General Hospital
Cancer Pain, Chronic Pain
Prospective Evaluation of Intrathecal Targeted Drug Delivery for Cancer Associated Pain
This Registry study will prospectively evaluate the differences in treatment outcomes in terms of pain intensity, pain interference, concomitant medication use, health-related quality of life, opioid adverse effects, and…
- Conditions
- Cancer Pain, Chronic Pain, Cancer Associated Pain, Neuropathic Pain
- Trial name
- NCT05674240
- Testing
- Intrathecal Targeted Drug Delivery, Conservative medical management
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wake Forest University Health Sciences
Neuroma, Neuroma Amputation
Targeted Reinnervation as a Means to Treat Neuromas Associated With Major Limb Amputation
Subjects are being asked to participate in this study because they have an arm or leg amputation and have developed pain related to a neuroma (an ongoing localized pain related to a cut nerve ending).
- Conditions
- Neuroma, Neuroma Amputation, Pain
- Trial name
- TMR (NCT02205385)
- Testing
- Targeted Muscle Reinnervation, Traction Neurectomy
- Where
- 6 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Pain, Cancer
Fentanyl Transdermal Matrix Patch ZR-02-01 to Treat Moderate to Severe Cancer Pain
The purpose of this study is to evaluate the safety of the matrix fentanyl patch ZR-02-01 in providing relief of cancer pain.
- Trial name
- NCT00126789
- Testing
- Fentanyl Transdermal Matrix Patch ZR-02-01
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- ZARS Pharma Inc.
Pancreatic Neoplasms, Pain
Acupuncture For Pancreatic Cancer Pain
Pain is a common problem in patients with pancreatic cancer. Some patients suffer from pain despite medication. We, the researchers at Memorial Sloan-Kettering Cancer Center, are conducting a Phase III study to determine the…
- Trial name
- NCT00136669
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer, Pain
Usefulness of Acupuncture in Cancer Pain and Quality of Life
The purpose of this study is to assess the effects of acupuncture on aspects of health including pain, energy level, sleep quality, activities of daily living and appetite.
- Trial name
- NCT00401063
- Testing
- Acupuncture
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Southern California University of Health Sciences
Breast Neoplasms, Musculoskeletal Pain
Hypnosis to Reduce Aromatase Inhibitor Pain and Improve Adherence
The purpose of this study is to determine whether hypnosis is efficacious in reducing musculoskeletal pain in breast cancer survivors taking aromatase inhibitors, and by doing so, whether hypnosis can help survivors to be more…
- Trial name
- NCT02657993
- Testing
- Hypnosis, Attention Control
- Where
- United States
- Volunteers
- 191 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pain, Pancreatic Cancer
Acupuncture and Acupressure in Treating Patients With Moderate or Severe Pain Related to Stage III or Stage IV Pancreatic Cancer
RATIONALE: Acupuncture and acupressure may help relieve moderate or severe pain associated with stage III or stage IV pancreatic cancer.
- Trial name
- NCT00040833
- Testing
- complementary or alternative medicine procedure, pain therapy
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
A Randomized Controlled Trial (RCT) to Determine the Efficacy of a Multidisciplinary CBT Based Pain Management Program for the Treatment of Aromatase Inhibitor Associated Musculoskeletal Symptoms (AIMSS) in Breast Cancer Survivors
The purpose of this research is to evaluate the effectiveness of a multidisciplinary pain management program for AIMSS in reducing pain, subjective cognitive complaints, psychological distress, and impaired functional status…
- Trial name
- NCT06831838
- Testing
- Cognitive Behavioral Therapy based Pain Management Program
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Mayo Clinic
Chronic Pain, Cancer Pain
Refining mUltiple Artificial intelliGence strateGies for Automatic Pain Assessment Investigations: RUGGI Study
This single-center, non-profit, observational-interventional study aims to develop artificial intelligence (AI) models for the automatic assessment of chronic pain (APA - Automatic Pain Assessment).
- Conditions
- Chronic Pain, Cancer Pain, Neuropathic Pain, Pain Assessment
- Trial name
- RUGGI (NCT07038434)
- Testing
- Multimodal AI-Based Pain Assessment
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Valentina Cerrone
Aromatase Inhibitor-Associated Musculoskeletal Syndrome, Arthralgia Syndrome
AKU Study - Acupuncture for Aromatase Inhibitor-Induced Musculoskeletal Syndrome
Third-generation aromatase inhibitors (AIs) represent a standard adjuvant endocrine treatment for postmenopausal and high-risk premenopausal women with hormone receptor-positive early breast cancer.
- Conditions
- Aromatase Inhibitor-Associated Musculoskeletal Syndrome, Arthralgia Syndrome, Early Breast Cancer (EBC)
- Trial name
- AKU (NCT07909785)
- Testing
- Manual Acupuncture
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Masaryk Memorial Cancer Institute
Head Neck Cancer, Squamous Cell Cancer of Head and Neck (SCCHN)
Stereotactic MRI-guided Focused Ultrasound Mesencephalotomy
This phase 1 multi-site study investigates the safety and initial effectiveness of focused ultrasound lesioning of the contralateral mesencephalon for severe, opioid-resistant pain associated with head and neck cancer and…
- Conditions
- Head Neck Cancer, Squamous Cell Cancer of Head and Neck (SCCHN), Cancer Pain
- Trial name
- MRg-FUS (NCT07405645)
- Testing
- ExAblate Neuro
- Where
- 6 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Cancer Pain
A Novel mHealth Approach to Assess and Manage Palliative Care Needs for Cancer Patients in Kigali
Palliative care is an approach that improves the quality of life of patients and their families facing the problem associated with life-threatening illness such as cancer, through the prevention and relief of suffering by means…
- Trial name
- NCT03367637
- Testing
- Standard palliative care, Smart Phone based symptom evaluation application
- Where
- Rwanda
- Sponsor
- Massachusetts General Hospital
Therapeutic Touch, Cancer
Reiki for Cancer: Pain, Anxiety, and Stress
The goal of this clinical trial is to investigate the effects of Reiki, Sham Reiki, and Progressive Relaxation Exercise on the levels of pain, anxiety, and stress in cancer patients.
- Trial name
- NCT06296680
- Testing
- Reiki, Progressive Relaxation Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Ege University
Cancer Pain
Phase I Study of sss40 Injection for Moderate-to-Severe Bone Metastatic Cancer Pain
This is a Phase Ib/IIa, multicenter, sequential clinical trial evaluating the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of SSS40 injection in patients with moderate-to-severe bone metastatic cancer…
- Trial name
- NCT07008703
- Testing
- Injection of humanized nerve growth factor (NGF) antibody
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Shenyang Sunshine Pharmaceutical Co., LTD.
Pancreatic Cancer Non-resectable, Tumor Pancreas
Upfront EUS CGN/CPN vs Conventional Step up Approach for Inoperable Painful Pancreatic Cancer
Patients with unresectable pancreatic cancer are often demoralized by intractable, persistent and incapacitating pain. It must be managed aggressively and strong opioids are recommended as the mainstay of treatment.
- Conditions
- Pancreatic Cancer Non-resectable, Tumor Pancreas, Pain Cancer
- Trial name
- NCT06160323
- Testing
- EUS-guided coeliac ganglion neurolysis / celiac plexus neurolysis
- Where
- Hong Kong
- Volunteers
- 94 people
- Sponsor
- Chinese University of Hong Kong
Cancer Pain
Development of a Cloud-Based PRO (Patient-Reported Outcome) Management Program for Home-Based Cancer Pain Care
This study aims to develop and pilot a cloud-based Patient-Reported Outcomes (PROs) management program for home-based cancer pain patients within a hospital setting.
- Trial name
- NCT07308223
- Testing
- Proactive monitoring and patient education
- Where
- China
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine