Clinical trials: Cancer-Associated Pain
Pain, Intractable
Effectiveness of Ketamine in Malignant Neuropathic Pain Relief
To see whether the addition of low-dose ketamine to a subcutaneous morphine infusion improves analgesia in patients with neuropathic cancer pain.
- Trial name
- KETA-1 (NCT01951911)
- Testing
- Ketamine
- Where
- Norway
- Sponsor
- Haukeland University Hospital
Head and Neck Cancer, Cancer Pain
Effect of Transcutaneous Electrical Nerve Stimulation or Acupressure on Pain in Patients With Head and Neck Cancer
This clinical trial aims to evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS), acupressure intervention, or standard care (control group) for pain management in participants hospitalized with head…
- Trial name
- NCT07051265
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS), Acupressure
- Where
- Taiwan
- Volunteers
- 240 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Locally Advanced Cancer, Metastatic Cancer
Evaluating Interventional Radiology for Cancer Pain Management
Each year, the number of new cancer cases increases globally and the associated pain remains a major concern. The scientific literature shows that the prevalence and severity of cancer-related pain have decreased thanks to new…
- Trial name
- RI-LieF (NCT07529314)
- Testing
- Self-reported questionnaires
- Volunteers
- 125 people
- Sponsor
- Hospices Civils de Lyon
Pain, Advanced Cancer
A Two-Part Study of Sativex® Oromucosal Spray for Relieving Uncontrolled Persistent Pain in Patients With Advanced Cancer
The primary objective of this study was to evaluate the efficacy of nabiximols (Sativex®), compared with placebo, when used as an adjunctive measure in relieving uncontrolled persistent chronic pain (not breakthrough pain) in…
- Trial name
- NCT01424566
- Testing
- Nabiximols
- Where
- 65 sites in Australia, Bulgaria and 11 more
- Volunteers
- 406 people
- Sponsor
- Jazz Pharmaceuticals
Screening Tool for Depresion in Cancer Pain Patients
The Edmonton Symptom Assessment System (ESAS) as a Screening Tool for Depression in Cancer Pain Patients
Compare Thai versions of the Edmonton Symptom Assessment System (ESAS) and the Hospiral Anxiety and Depression Scale (HADS) with Diagnostic and Statistical Manual (DSM-5), as a screening tool for depression in cancer pain patients
- Trial name
- NCT03686605
- Testing
- Thai version of the Edmontom Symptom Assessment System (ESAS)
- Where
- Thailand
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Cancer Pain, Quality of Life
Meditation With Virtual Reality for Cancer Pain Relief in the Pain Therapy and Palliative Care Service
Cancer is a disabling, challenging and growing global disease. Although early diagnosis and adequate treatment of oncological disease have been developing rapidly, a large part of the population remains without access to…
- Conditions
- Cancer Pain, Quality of Life, Palliative Medicine
- Trial name
- NCT06328751
- Testing
- Case group, Active control group, Passive control group
- Where
- Brazil
- Volunteers
- 129 people
- Sponsor
- Emily Santos Montarroyos
Bladder Cancer, LUTS
Protoves M1® Syrup in Controlling Adverse Event During HIVEC® Instillations
100 patients with bladder cancer whose underwent Hyperthermic Intravesical Chemotherapy (HIVEC®) will be randomized in two groups (Group A: PROTOVES M1 SYRUP, Group B: NO TREATMENT).
- Conditions
- Bladder Cancer, LUTS, Pain
- Trial name
- NCT04148677
- Testing
- Protoves M1®
- Volunteers
- 100 people
- Sponsor
- Cardarelli Hospital
Neoplasms, Pain
The Pain Pen for Breakthrough Cancer Pain
The purpose of this study is to see whether injection of hydromorphone through a subcutaneous injection device is more effective in treating breakthrough cancer pain than oral morphine.
- Trial name
- NCT00125801
- Testing
- Subcutaneous hydromorphone delivered by pain pen
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Erasmus Medical Center
Pain
Ketamine Associated With Opioids in Refractory Cancer Pain Treatment
Long-term opioid therapy is commonly administered for the management of severe cancer pain. Increasing doses of opioids are titrated against effects until analgesia is achieved or intolerable adverse effects occur.
- Trial name
- KETADOL (NCT00484484)
- Testing
- Ketamine
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Arthritis, Pain
Non-cancer Pain and Cognitive Impairment: A Disabling Relationship
To compare the efficacy of long-acting oxycodone to extended-release acetaminophen in older persons with no and mild to moderate cognitive impairment and persistent moderate or higher intensity non-cancer lower extremity…
- Conditions
- Arthritis, Pain, Cognitive Impairment
- Trial name
- NCT01264965
- Testing
- long acting oxycodone, extra strength acetaminophen
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Chicago
Pain
Conversion From Parenteral to Oral Methadone.
The majority of current studies regarding the use of methadone (MTD) in the treatment of cancer pain are focused in its administration via the oral route (PO). The ratio considered from VO to parenteral route (BP) is 2:1.
- Trial name
- RATIOMTD (NCT01836328)
- Testing
- Parenteral /oral methadone ratio 1:2, Parenteral /oral methadone ratio 1:1.2
- Where
- 3 sites in Spain
- Volunteers
- 44 people
- Sponsor
- L'Hospitalet de Llobregat
Cancer
Oxcarbazepine Plus Morphine in Patients With Refractory Cancer Pain
This is an open-label, single arm, Phase Ib dose escalation study of Oxcarbazepine with morphine in patients with refractory cancer pain.
- Trial name
- NCT02078089
- Testing
- Morphine, Oxcarbazepine
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Costantine Albany
Cancer, Pain With Neuropathic Component
Efficacy of Lidocaine Versus Placebo in Palliative Care Patients With Opioid-refractory Cancer Pain With Neuropathic Component: a Multicenter, Prospective, Double-blind Randomized Placebo-controlled Study.
This is a multicenter, prospective, randomized, placebo-controlled, double-blind, two-parallel groups study comparing lidocaine (experimental group) to placebo (control group).
- Trial name
- LIDOSP (NCT02137954)
- Testing
- Lidocaine
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Bowel Dysfunction, Constipation
Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain
Adults who are taking opioid therapy for persistent non-cancer pain and have resulting opioid-induced bowel dysfunction (OBD) will be randomized (1:1:1) to one 2 alvimopan arms, or to placebo.
- Trial name
- NCT00256932
- Testing
- alvimopan
- Where
- 200 sites in United States, Austria and 8 more
- Volunteers
- 518 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Oral Cancer, Oral Cavity Cancer
Effectiveness of Opioid vs Pregabalin Plus Naproxen Sodium in Pain Management of Oral Cancer Patients
This randomized clinical study was designed to compare two pain treatment approaches for adults with oral cancer who had moderate to severe pain.
- Conditions
- Oral Cancer, Oral Cavity Cancer, Oral Squamous Cell Carcinoma (OSCC)
- Trial name
- NCT07606638
- Testing
- Tramadol, Pregabalin + Naproxen Sodium
- Where
- Pakistan
- Volunteers
- 98 people
- Sponsor
- Mayo Hospital Lahore
Pain, Cancer
A Phase III Clinical Study of KW-2246
This study is designed to assess the safety and efficacy of long-term KW-2246 treatment as rescue medication for breakthrough pain.
- Trial name
- NCT00683995
- Testing
- KW-2246 (fentanyl citrate)
- Where
- 20 sites in Japan
- Volunteers
- 43 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Opioid-Induced Constipation
Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation
The purpose of this study is to evaluate the safety and efficacy of CB-5945 for the treatment of opioid-induced constipation (OIC)in adults taking opioid therapy for chronic non-cancer pain.
- Trial name
- NCT01901328
- Testing
- CB-5945
- Volunteers
- 49 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Pain
Analgesic Treatment for Cancer Pain in South East Asia
This study is planned to investigate the pain control status in cancer patients in 6 South East Asian countries through evaluation of prescription pattern of analgesics, satisfaction of pain control, quality of life and…
- Trial name
- ACE (NCT02664987)
- Testing
- Patients receiving cancer pain treatment
- Volunteers
- 462 people
- Sponsor
- Mundipharma Pte Ltd.
Arthralgia, Breast Cancer
Cannabidiol (CBD) for Treatment of Aromatase Inhibitor-Associated Arthralgias
Study of Cannabidol to examine the safety and efficacy of 15 weeks of CBD in postmenopausal women with aromatase inhibitor-associated musculoskeletal symptoms (AIMSS).
- Trial name
- NCT04754399
- Testing
- Cannabidiol (CBD)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan Rogel Cancer Center
Intractable Pelvic Cancer Pain
Fluoroscopic &Ultrasonographic Guidance of Superior Hypogastric Plexus Neurolysis in Intractable Pelvic Pain
fluoroscopic group \& includes 30 patients where SHPB will be done Fluoroscopic-guided (the posterior oblique trajectory technique.the double modality group \& includes 30 patients where SHPB will be done using our described new…
- Trial name
- NCT03606811
- Testing
- fluroscopic guided block, double modality (ultrasound and fluroscopic) guided block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University