Clinical trials: Cancer-Associated Pain
Gynaecomastia, Prostate Cancer
Casodex - Nolvadex Combination
This study looks at the relationship in the dose of nolvadex and the incidence of gynaecomastia and also Prostate Specific Antigen (PSA) inhibition when co-administered with Casodex.
- Trial name
- NCT00637871
- Testing
- Casodex, Tamoxifen
- Sponsor
- AstraZeneca
Neoplasms
Educational Intervention Targeting Nurses Attitudes and Knowledge About Cancer-related Pain Management
The purpose of this study is to investigate whether an intervention consisting of the implementation of guidelines about daily systematic pain assessment following a theory based education, targeting cancer-related pain and pain…
- Trial name
- NCT01313234
- Testing
- Education
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Blekinge Institute of Technology
Breast Cancer
A mHealth Behavioral Cancer Pain Protocol for Medically Underserved Communities
The purpose of this study is two-fold. First, the investigator will develop a low-literacy Mobile Pain Coping Skills Training (mPCST) protocol for cancer patients with pain (i.e., therapist manual, patient manual including…
- Trial name
- NCT02783755
- Testing
- Device: smartphone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Cancer, Pain
Two Step Versus the Standard Three Step Approach of the WHO Analgesic Ladder for Cancer Pain Relief.
The World Health Organization analgesic ladder for cancer pain relief is an internationally used approach to managing cancer pain. Patients generally start on Step 1 of the ladder (paracetamol).
- Trial name
- TVT (NCT01493635)
- Testing
- analgesic ladder
- Where
- United Kingdom
- Volunteers
- 152 people
- Sponsor
- University of Edinburgh
Cancer Pain
Opioid Titration in the Hospice Setting: Barriers Assessment and Modification of the Model Order Sheet and Protocol
The purpose of this study is to modify the opioid titration order sheet to meet the needs of the outpatient hospice population and to conduct a pilot trial to assess feasibility, utility, and derive preliminary efficacy data.
- Trial name
- NCT01230515
- Testing
- Individual patient interview, focus group and structured survey, interview, focus group and structured survey
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Vanderbilt-Ingram Cancer Center
Chronic Pain
Prospective Study About Clinical and Pharmacogenetic Safety of Opioid Use for Chronic Pain
Aim of this project is to customize the choice of the strong opioid in the treatment of cancer chronic pain through the identification of patient clinical history and pain characteristics, moreover in the analysis the…
- Trial name
- NCT00916890
- Testing
- Morphine, Oxycodone, Fentanyl
- Where
- 6 sites in Italy
- Volunteers
- 320 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm
A Collaborative Intervention for Improving Cancer Pain Management in Cancer Survivors
This clinical trial tests a collaborative pain management intervention (ASCENT) for improving cancer pain in cancer survivors. Cancer pain is prevalent, under-treated, and remains a major cause of suffering, impairment, and…
- Conditions
- Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm, Hematopoietic and Lymphatic System Neoplasm
- Trial name
- ASCENT (NCT06198010)
- Testing
- Best Practice, Educational Intervention, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 680 people
- Sponsor
- Mayo Clinic
Cancer-associated Pain
Pilot Study on the Effect of Intrathecal Opioids on Immune Function in Humans With Cancer Pain
The purpose of this study is to examine the changes in immune function, as measured by biomarkers in the blood, that happen with intrathecal (spinal) delivery of opioid medications for the treatment of moderate to severe cancer…
- Trial name
- NCT02151513
- Testing
- Intrathecal Pump Placement
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Utah
Cancer, Terminal Disease
Occupational Therapy Modulates the Pain in Cancer Patient Under Palliative Care
Pain is one of the most incapacitating symptoms because it is a complex experience that includes sensory and emotional perceptions, in which sensory, affective, cognitive, behavioral, cultural and social characteristics interact.
- Conditions
- Cancer, Terminal Disease, Pain
- Trial name
- NCT02102178
- Testing
- Tapestry, Regular occupation therapy, Weaving a scarf on a nail frame
- Volunteers
- 58 people
- Sponsor
- Barretos Cancer Hospital
Opioid Use, Auriculotherapy
Auriculo-Nerve Stimulation on Post-Operative Opioid Requirement
The NSS-2 BRIDGE® device (NSS stands for Neuro-Stimulation System) is a disposable device that stimulates the branches of cranial nerves and of the superficial cervical plexus innervating the ear.
- Conditions
- Opioid Use, Auriculotherapy, Pain, Abdominal, Cancer Pain
- Trial name
- NCT05506878
- Testing
- NSS-2 BRIDGE
- Where
- 4 sites in United States
- Volunteers
- 286 people
- Sponsor
- Jacques E. Chelly
Oncology Pain, Chemotherapy-induced Peripheral Neuropathy
The Potential Protective Role of Venlafaxine Versus Memantine in Paclitaxel Induced Peripheral Neuropathy
This is a double blinded two-arm randomized case-only interventional trial. A total of 60 patients who are to receive Paclitaxel to be included and allocated in two groups.
- Trial name
- NCT04737967
- Testing
- Venlafaxine, Memantine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mendel AI
Cancer, Pain
Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain
The purpose of this study is to determine whether oral methadone plus acetaminophen can substitute morphine in the treatment of cancer pain.
- Conditions
- Cancer, Pain, Palliative Care
- Trial name
- NCT00525967
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Faculdade de Medicina do ABC
Breakthrough Pain
Quality of Life Study in Patients With Cancer Breakthrough Pain Treated in Palliative Care Units
Patients treated in Palliative Care Units are potentially fragile patients, especially in our case, which are cancer patients. The management of these patients is usually done from experience, because these patients rarely meet…
- Trial name
- CAVIDIOPAL (NCT02840500)
- Testing
- No intervention
- Where
- 10 sites in Spain
- Volunteers
- 101 people
- Sponsor
- Angelini Farmacéutica
Opioid-Induced Constipation
Assessment of Efficacy and Safety in Relieving Opioid-induced Constipation in Patients With Cancer-related Pain
The purpose of this study is to compare the effect of NKTR-118 with placebo in the treatment of opioid-induced constipation (OIC) in patients with cancer-related pain, including those patients that have inadequate response to…
- Trial name
- NCT01384292
- Testing
- NKTR-118
- Where
- 140 sites in United States, Australia and 12 more
- Volunteers
- 14 people
- Sponsor
- AstraZeneca
Palliative Care, Pain
A Study of Sativex® for Pain Relief in Patients With Advanced Malignancy
The purpose of this study is to determine whether Sativex® and GW-2000-02 are effective in the management of subjects with intractable cancer-related pain.
- Conditions
- Palliative Care, Pain, Cancer
- Trial name
- SPRAY (NCT00674609)
- Testing
- Sativex®, THC Alone
- Where
- United Kingdom
- Volunteers
- 177 people
- Sponsor
- Jazz Pharmaceuticals
Cancer: Breakthrough Pain, Cancer: Extreme Pain on Movement
Comparison of Oral Morphine Versus Nasal Ketamine Spray With Chitosan in Cancer Pain Outpatients
34 adult (>18 years) cancer pain outpatients with Opioid base therapy because of pain and breakthrough pain or extreme pain on movement will be included in this prospective, randomized, double-blind crossover study.
- Trial name
- ONKEMI (NCT02591017)
- Testing
- Morphine, Ketamine, Chitosan
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- University Hospital, Basel, Switzerland
Breakthrough Pain
Quality of Life Study Breakthrough Cancer Pain Treated in Medical Oncology Services (CAVIDIOM)
In cancer patients, pain is one of the most common symptoms. The range of reported prevalence of pain varies from 33% to 64% including different stages of cancer, during or after anticancer treatment.
- Trial name
- CAVIDIOM (NCT03435120)
- Testing
- No intervention
- Where
- 14 sites in Spain
- Volunteers
- 118 people
- Sponsor
- Angelini Farmacéutica
Breakthrough Cancer Pain
Patient Satisfaction and Quality of Life Impact - PecFent®
National multicenter, prospective, observational study in cancer patients with chronic background pain and breakthrough pain to whom PecFent® has been prescribed under pragmatic condition by a specialist in the treatment of…
- Trial name
- Qualipec (NCT01693328)
- Testing
- PecFent® (fentanyl) nasal spray
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Archimedes Development Ltd
Opioid-induced Constipation
Risk of Major Adverse Cardiovascular Events for Naldemedine & Other Medications for Opioid Induced Constipation
The research objective is to characterize the risk of a major adverse cardiovascular event (MACE) among new users of naldemedine versus new users of lubiprostone and new users of naloxegol as comparator opioid induced…
- Trial name
- NCT03720613
- Testing
- Naldemedine, Lubiprostone, Naloxegol
- Where
- United States
- Volunteers
- 34,532 people
- Sponsor
- BioDelivery Sciences International
Pain
Long-term Opioid Therapy, Misuse and Mortality in Patients With Chronic Non-cancer Pain in Germany
Among patients receiving opioids for noncancer pain, recent research in North America showed a strong association between doses and opioid-related mortality, especially at dosages exceeding thresholds recommended in recent…
- Trial name
- NCT03778450
- Testing
- Analgesics, Opioid, Non-Opioid Analgesic
- Where
- Germany
- Volunteers
- 3,232 people
- Sponsor
- LinkCare GmbH