Clinical trials: Cancer-Associated Pain, open to volunteers
Opioid-induced Constipation
Risk of Major Adverse Cardiovascular Events for Naldemedine & Other Medications for Opioid Induced Constipation
The research objective is to characterize the risk of a major adverse cardiovascular event (MACE) among new users of naldemedine versus new users of lubiprostone and new users of naloxegol as comparator opioid induced…
- Trial name
- NCT03720613
- Testing
- Naldemedine, Lubiprostone, Naloxegol
- Where
- United States
- Volunteers
- 34,532 people
- Sponsor
- BioDelivery Sciences International
Cancer Patients, Survivor Patients
A Study Testing Topical Pain-Relieving Herbal Plasters in People Who Are Using Opioids for Their Pain
The are doing this study to find out whether using topical (on the skin) herbal plasters, Tibetree pain- relieving plasters (PRPs), can be an effective addition to standard opioid therapy for pain management.
- Conditions
- Cancer Patients, Survivor Patients, Cancer Pain
- Trial name
- NCT07447856
- Testing
- Topical herbal plaster
- Where
- 7 sites in United States
- Volunteers
- 150 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pain, Chronic Pain
Evaluation of an Opioid Stewardship Program in Non-Cancer Patients
The objective of this prospective, non-randomized clinical trial is to evaluate the effectiveness of a pharmacist-led Opioid Stewardship Program (OSP) in outpatient adults with chronic non-cancer pain.
- Conditions
- Pain, Chronic Pain, Opioid Analgesia, Opioid Use
- Trial name
- NCT07102446
- Testing
- Opioid Stewardship Program
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Korea University Guro Hospital
Intrathecal Drug Delivery, Refractory Cancer Pain
Intrathecal Therapy Versus Standard Care for Severe Cancer Pain
Approximately 66% of patients with advanced cancer experience pain, which is often inadequately controlled and associated with a decline in health-related quality of life (HRQoL).
- Conditions
- Intrathecal Drug Delivery, Refractory Cancer Pain, Conventional Medical Management
- Trial name
- CAREGIVER (NCT07691840)
- Testing
- Intrathecal Drug Delivery, Comprehensive Medical Management
- Where
- Belgium
- Volunteers
- 72 people
- Sponsor
- Universitair Ziekenhuis Brussel
Cancer, Pain
Cancer Pain 101: A Digital, Asynchronous Intervention of Pain Management in Advanced Cancer
This is a Stage 1 study of a behavioral intervention, which means that a new intervention is being pilot tested to understand whether it is acceptable and feasible for people with advanced cancer to use.
- Conditions
- Cancer, Pain, Advanced Cancer
- Trial name
- COPES Aim 3 (NCT07852468)
- Testing
- Cancer Pain 101
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Alabama at Birmingham
Cancer Pain
3D1002 in Combination With Oxycodone Hydrochloride Sustained-release Tablets in Patients With Moderate to Severe Cancer Pain
This study aims to evaluate the safety and efficacy of 3D1002 alone or in combination with oxycodone hydrochloride sustained-release tablets (OxyContin) for the management of moderate or severe cancer pain.
- Trial name
- NCT05265052
- Testing
- 3D1002 (50 mg)(Phase IIa), 3D1002 (100 mg)(Phase IIa), 3D1002 (150 mg)(Phase IIa)
- Volunteers
- 177 people
- Sponsor
- 3D Medicines
Cancer Pain
RAD ONC FREEDOM Oncology Pain
The investigators propose to conduct a study in medically refractory cancer pain patients utilizing radiosurgery to ablate the pituitary hypophysis, as well as neuromodulate the centromedian and parafascicular complexes within…
- Trial name
- FREEDOM (NCT07605546)
- Testing
- Radiosurgery
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Aromatase Inhibitor Associated Musculoskeletal Symptoms (AIMSS), Breast Cancer
Clinical Application of Vagus Nerve Stimulation Combined With Immunoregulatory T Cells in Alleviating Aromatase Inhibitor-Induced Pain
The goal of this clinical trial is to learn whether transcutaneous auricular vagus nerve stimulation, also called taVNS, can help relieve aromatase inhibitor-related joint and muscle pain in adult women with hormone…
- Conditions
- Aromatase Inhibitor Associated Musculoskeletal Symptoms (AIMSS), Breast Cancer, Pain Alleviation
- Trial name
- NCT07593365
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Peking University People's Hospital
Upper Abdominal Malignancies
Coeliac Plexus vs Splanchnic Nerve Neurolysis for Upper Abdominal Cancer Pain
The goal of this clinical trial is to determine whether Neurolytic Splanchnic Nerve Block (NSNB) reduces pain in adults with upper abdominal malignancies.
- Trial name
- NCT07653906
- Testing
- Neurolytic Coeliac Plexus Block (NCPB), Neurolytic Splanchnic Nerve Block (NSNB)
- Where
- Bangladesh
- Volunteers
- 44 people
- Sponsor
- Bangladesh Medical University
Chronic Non-Cancer Pain
Preventive Interventions for Chronic Pain Worsening
This is an open label randomized controlled trial (RCT), which will be conducted with patients of the Copenhagen Wound Healing Center at Bispebjerg Hospital in Copenhagen (DK).
- Trial name
- NCT06351046
- Testing
- Virtual Reality-based Pain Self-management program
- Where
- Denmark
- Volunteers
- 44 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cancer Pain
Real-world Study of the Effectiveness and Tolerability of Outpatient Titration of OxyContin for the Moderate and Severe Pain in Cancer Patients
The purpose of this observational study is to evaluate the effectiveness and tolerability of outpatient titration regimen with OxyContin as background for moderate and severe pain in cancer patients in adult patients with…
- Trial name
- NCT07869797
- Where
- 20 sites in China
- Volunteers
- 378 people
- Sponsor
- Mundipharma (China) Pharmaceutical Co. Ltd
Cervical Cancer, Endometrial Cancer
Hypogastric Plexus Block and Ganglion Impar Block for Cervical and Endometrial Cancer Pain Management
This study compared the efficacy and safety of superior hypogastric plexus block and ganglion impar block procedures on the management of pelvic and perineal cancer pain in patients with cervical and endometrial cancer
- Trial name
- NCT05427058
- Testing
- Superior Hypogastric Plexus Block, Ganglion Impar Block
- Where
- Indonesia
- Volunteers
- 36 people
- Sponsor
- University of Brawijaya
Opioid-Induced Constipation, Pain Cancer
Real World Study of Oxycodone/Naloxone Sustained-Release Tablets (Mimeixin) for Patients With Severe Cancer Pain
This study is a prospective, single-arm, multicenter, real-world study to evaluate effect of bowel function, analgesic effect, quality of life, and safety of Mimeixin® in Chinese patients with severe cancer pain.
- Trial name
- NCT06897917
- Testing
- Oxycodone Hydrochloride and Naloxone Hydrochloride Sustained-release Tablets
- Where
- China
- Volunteers
- 203 people
- Sponsor
- Henan Cancer Hospital
Cancer Pain
Phase I Study of sss40 Injection for Moderate-to-Severe Bone Metastatic Cancer Pain
This is a Phase Ib/IIa, multicenter, sequential clinical trial evaluating the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of SSS40 injection in patients with moderate-to-severe bone metastatic cancer…
- Trial name
- NCT07008703
- Testing
- Injection of humanized nerve growth factor (NGF) antibody
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Shenyang Sunshine Pharmaceutical Co., LTD.
Breast Cancer
A Randomized Controlled Trial (RCT) to Determine the Efficacy of a Multidisciplinary CBT Based Pain Management Program for the Treatment of Aromatase Inhibitor Associated Musculoskeletal Symptoms (AIMSS) in Breast Cancer Survivors
The purpose of this research is to evaluate the effectiveness of a multidisciplinary pain management program for AIMSS in reducing pain, subjective cognitive complaints, psychological distress, and impaired functional status…
- Trial name
- NCT06831838
- Testing
- Cognitive Behavioral Therapy based Pain Management Program
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Mayo Clinic
Cancer
Digital Intervention for Symptom Management in Cancer and Opioid Sparing Using Virtual Reality (DISCOVR) Study
Patients living with cancer commonly have chronic pain due to the disease or to cancer treatments. Virtual reality, a new technology that immerses the user in pleasant, diverting, and exciting virtual environments, may lower…
- Trial name
- DISCOVR (NCT07228377)
- Testing
- virtual reality pain therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Medstar Health Research Institute
Breast Cancer, Aromatase Inhibitor Associated Musculoskeletal Symptoms (AIMSS)
Tart Cherry and Omega-3's for Aromatase Inhibitor Musculoskeletal Symptoms
Both Tart Cherry and Omega 3 FAs have better side effect profiles compared to other commonly used medications for AIMSS, such as nonsteroidal anti-inflammatories, steroids, and serotonin norepinephrine reuptake inhibitors.
- Conditions
- Breast Cancer, Aromatase Inhibitor Associated Musculoskeletal Symptoms (AIMSS), Joint Pain
- Trial name
- NCT06123286
- Testing
- Tart Cherry, Omega 3 FA (Fish Oil)
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Philip Chang
Cancer Pain
The Effect of Patient-Controlled TEAS vs Sham TEAS for Improve Quality of Life in Patients With Cancer Pain
The conduct of a pilot trial is of great significance as a means of assessing the feasibility and harmonization of the research and is a very necessary precursor to the better conduct of formal trials.
- Trial name
- NCT06188286
- Testing
- Transcutaneous electrical acupoint stimulation
- Volunteers
- 94 people
- Sponsor
- Yi Liang
Breast Cancer Survivor
Enhanced Pain Coping in Cancer (EPIC): A Study of Managing Treatment-Related Joint Pain in Breast Cancer Survivors
The researchers are doing this study to compare two different types of group therapy and find out whether they are effective approaches for helping breast cancer survivors manage joint pain caused by aromatase inhibitors (AI).
- Trial name
- NCT06728579
- Testing
- Mindfulness Oriented Recovery Enhancement (MORE), Questionnaires, Supportive Psychotherapy (SG)
- Where
- 9 sites in United States
- Volunteers
- 200 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Chronic Cancer-related Pain
An N-of-1 Trial of an Internet-delivered CBT Program Based on the Psychological Flexibility Model of Chronic Pain for Cancer-related Difficulties
Chronic pain is a commonly occurring complication of cancer and can have negatively impact day-to-day functioning and well-being. The recommended treatment for all forms of chronic pain is cognitive behavioral therapy (CBT).
- Trial name
- NCT06749964
- Testing
- Internet-delivered, therapist-assisted, pain-focused CBT based on the psychological flexibility model for chronic pain
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Lund University