Clinical trials: Cancer-Related Condition
HER2-positive Breast Cancer, HER2 Low
ISPY-P1.01:Evaluating the Safety of Weekly Paclitaxel With Trastuzumab Duocarmazine (SYD985) in Patients With Metastatic Cancer
This is an open-label, single-arm, multi-site phase I/Ib trial with SYD985, an antibody-drug conjugate (ADC) targeting HER2 on the cell membrane, combined with paclitaxel.
- Conditions
- HER2-positive Breast Cancer, HER2 Low, SYD-985, SYD985
- Trial name
- NCT04602117
- Testing
- Vic-trastuzumab duocarmazine (SYD985) + paclitaxel
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- QuantumLeap Healthcare Collaborative
Colorectal Cancer
Emerging Role of NOTCH-related Long Non-coding RNA(s) as Biomarkers in Liquid Biopsy From Colorectal Cancer Patients
This work aims to Investigate the role of circulating notch associated lncRNAs SNHG3 and LUNAR1 as possible non invasive prognostic biomarkers for colorectal cancer (CRC) monitoring via measuring the gene expression level of…
- Trial name
- NCT06432413
- Where
- Egypt
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Breast Cancer, Xerostomia
Oral Health and Oral Health-Related Quality of Life in Early Stage Breast Cancer Survivors
The 3 Specific Aims are (1) To determine the prevalence, incidence and severity of oral conditions in postmenopausal early stage breast cancer survivors within the first 18 months of adjuvant Aromatase Inhibitor(AI) therapy, (2)…
- Trial name
- NCT01272570
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Colorectal Neoplasms
The Effects of Various Cooking Oils on Health Related Biomarkers in Healthy Subjects
Fats and oils play important roles in maintaining human nutrition and health through providing energy, essential fatty acids, and acting as modulators of many biological processes (signal transduction, immunity and inflammation).
- Trial name
- NCT02599103
- Testing
- Fat-free milkshake, Olive oil, Soybean oil
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Academia Sinica, Taiwan
HPV Infection, HPV-Related Cervical Carcinoma
A Randomized, Blinded, Placebo-controlled Phase I Clinical Trial Evaluating the Safety and Preliminary Immunogenicity of a 11-valent Recombinant Human Papillomavirus Vaccine (Hansenulapolymorpha) in Chinese Women Aged 9-45 Years
A total of 90 Chinese women aged 9-45 years old were divided into three age groups: 27-45 years old, 18-26 years old, and 9-17 years old. The experimental group and the placebo group were randomly assigned in a ratio of 2:1.
- Trial name
- NCT04083196
- Testing
- 11-valent recombinant human papilloma virus vaccine (Hansenula polymorpha)
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Vaccine and Serum Institute, China
HPV InfectioN, HPV-Related Carcinoma
A Study to Evaluate the Efficacy, Safety, and Immunogenicity of SCT1000 in Healthy Women Aged 18-45 Years
A total of 18000 healthy women aged 18-45 years old were divided into three age groups: 18-26 years old, 27-35 years old, and 36-45 years old. The experimental group and the placebo group were randomly assigned in a ratio of 1:1.
- Trial name
- NCT06041061
- Testing
- Recombinant 14-Valent Human Papillomavirus Vaccine（Insect Cell）
- Where
- 5 sites in China
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- Sinocelltech Ltd.
Esophageal Neoplasms, Adverse Drug Event
Effect of NST Whole-course Nutritional Management on Nutritional Status and Adverse Reactions in Esophageal Cancer
This study is a randomized, open, parallel controlled clinical trial. The main purpose of this study was to compare the changes in body weight/body mass index (BMI) before and after treatment between the two groups of patients…
- Trial name
- NCT05800054
- Testing
- Nutritional Support Team, Docetaxel, cisplatin
- Where
- China
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cancer, Nutrition Disorders
Co-designed Nutritional Training Program for Oncology Nurses in Vietnam
This study evaluates a co-designed nutritional training program for oncology nurses in Vietnam. The aim is to improve nurses' knowledge, confidence, and clinical practice in providing nutritional support for patients with cancer…
- Conditions
- Cancer, Nutrition Disorders, Chemotherapy-Related Symptoms
- Trial name
- NUTRI-NURSE-VN (NCT07566169)
- Testing
- Co-Designed Nutritional Training Program
- Where
- Vietnam
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- VinUniversity
Survivors of Childhood Cancer
Technological Gaming in Cancer Survivors (WINNERS)
HYPOTHESIS 1. Neurocognitive deficits in cancer survivors are underestimated. They represent a very limiting long-term side effect in this group of patients. 2.
- Trial name
- WINNERS (NCT06312969)
- Testing
- Video game based training
- Where
- Spain
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Antonio Pérez Martínez
Chronic Kidney Disease, Stage 4, Chronic Kidney Disease, Stage 5
BZLF1 Peptide Vaccine (OSU-2131) With QS-21 for the Prevention of Epstein-Barr Virus Related Cancer in Patients Awaiting Solid Organ Transplants
This phase 1B trial tests the safety, side effects and best dose of rh-Hsc70- BZLF1 peptide complex (OSU-2131) with Stimulon (Trademark) QS-21 and evaluates how well it works in preventing Epstein-Barr virus (EBV) infection and…
- Conditions
- Chronic Kidney Disease, Stage 4, Chronic Kidney Disease, Stage 5, EBV-Related Lymphoproliferative Disorder, EBV-Related Malignant Neoplasm
- Trial name
- NCT06741072
- Testing
- Biospecimen Collection, Dulbecco''s Phosphate-Buffered Saline, Peptide Vaccine
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Vitamin D Status
The Vitamin D Dose-Response Relationship
The purpose of the study is to determine the importance of the UV intensity and the UVB dose on the Vitamin D response after UVB.
- Trial name
- NCT01074541
- Testing
- UVB
- Where
- Denmark
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Polycystic Ovary Syndrome
AMH, Glucose Intolerance and Metabolic Syndrome in PCOS
Association between serum anti-Mullerian hormone (AMH) level and prevalence of glucose intolerance and metabolic syndrome in women with polycystic ovary syndrome (PCOS)
- Trial name
- NCT02676518
- Testing
- serum
- Where
- Thailand
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Human Papillomavirus Infection, Human Papillomavirus-Related Malignant Neoplasm
Extended Follow-up of Women Who Received One, Two, and Three Doses of the HPV Vaccine in the Costa Rica Vaccine Trial (CVT), ESCUDDO-CVT Study
This study is extending follow up of women who participated in the Costa Rica Vaccine Trial (CVT) and received one dose or two doses of the human papillomavirus (HPV) vaccine, along with a group of women who received three doses.
- Trial name
- NCT03309033
- Testing
- Biospecimen Collection, Questionnaire Administration
- Where
- Costa Rica
- Volunteers
- 946 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Prostate Infection, Prostate Disease
The Relationship Between Serum PSA Levels and WBC, Delta Neutrophil Index (DNI) and Other Hematological Parameters
Purpose: To find the correlation between hemogram parameters and Delta Neutrophil Index(DNI) and Serum PSA in patients presenting with the diagnosis of acute prostatitis.
- Conditions
- Prostate Infection, Prostate Disease, Prostate Cancer
- Trial name
- NCT05399940
- Testing
- Serum PSA,Delta Neutrophil Index(DNI),WBC
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Hisar Intercontinental Hospital
Hepatocellular Carcinoma
Searching for the Liver Cancer-Related Biomarkers
Hepatocellular carcinoma (HCC) has been the leading cause of cancer death in Taiwan. About 6000-8000 people died of this cancer every year in Taiwan.
- Trial name
- NCT00154544
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Tumor, Cardiovascular Diseases
Application of [68Ga]Ga-NI-FAPI-04 PET/CT Imaging in Fibroblast Activation Protein Related Diseases
The purpose of this study is to conduct clinical research on [68Ga] Ga-NI-FAPI-04 PET/CT imaging and further investigate its diagnostic value in fibroblast activation related diseases.
- Conditions
- Tumor, Cardiovascular Diseases, Pulmonary Fibrosis, Rheumatic Immune Diseases Involving Large Blood Vessels
- Trial name
- NCT07464132
- Testing
- Injection of 68Ga-NI-FAPI
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Adult ALL, Post-traumatic Stress Disorder
Effects of an EMDR Intervention on Traumatic and Obsessive Symptoms
The Eye Movement Desensitization and Reprocessing Protocol (EMDR) was first developed by Francine Shapiro in 1987 and can be adapted for online and in presence administration.
- Conditions
- Adult ALL, Post-traumatic Stress Disorder, Obsessive-Compulsive Disorder, Disgust
- Trial name
- MDL (NCT06110702)
- Testing
- EMDR
- Where
- Italy
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Healthy
Association Between Heat Pain Detection Threshold and Area of Secondary Hyperalgesia
The purpose of this prospective study is to investigate how close Heat Pain Detection Threshold is associated with the area of secondary hyperalgesia, elicited by the clinical pain model Brief Thermal Sensitization.
- Trial name
- NCT02527395
- Testing
- Brief thermal sensitization, Pain during 1 min. thermal stimulation, Heat pain detection threshold
- Where
- Denmark
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiotoxicity, Childhood Cancer
Prediction of Delayed Toxic Cardiomyopathy in Children
Longitudinal analysis of myocardial function using "Speckle Tracking Echocardiography" STE analysis and prediction of delayed toxic induced cardiomyopathy in young patients who received anthracycline therapy in childhood.
- Trial name
- SpeckleAnthra2 (NCT05781672)
- Testing
- cardiac ultrasound with speckle tracking analysis
- Where
- France
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Polycystic Ovary Syndrome, Insulin Resistance
Is There Association Between Vitamin D Levels And Insulin Resistance In Polycystic Ovary Syndrome?
The primary aim of the current study is to clarify whether serum vitamin D levels [25(OH)D3] have a temporal association with insulin resistance and/or insulin sensitivity in PCOS women versus healthy ones.
- Conditions
- Polycystic Ovary Syndrome, Insulin Resistance, Vitamin D Deficiency
- Trial name
- NCT02803476
- Where
- Egypt
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital