Clinical trials: Cancer-Related Condition
Breast Cancer
Association of SNPs in Long Intergenic Noncoding RNA 00511 (LINC00511) With Breast Cancer Among the Egyptian Population
Long non-coding RNAs (lncRNAs) play an important role in different types of cancer, including breast cancer, through regulation of gene expression and epigenetic signatures.
- Trial name
- NCT06357689
- Where
- 2 sites in Egypt
- Volunteers
- 417 people
- Sponsor
- Ain Shams University
Gynecological Malignancies, Cervical Cancer
Immunotherapy-related CRP Kinetics in Metastatic Gynecological Malignancies
ICK-Gyn is a prospective, multicentric, non-interventional investigator-initiated trial (IIT) that aims to investigate the prognostic value of CRP kinetics in advanced or metastatic gynecological malignancies under immune…
- Conditions
- Gynecological Malignancies, Cervical Cancer, Endometrial Cancer, Ovarian Cancer
- Trial name
- NCT05914974
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University Hospital Tuebingen
Rectal Cancer
Relationship Between Lymph Node Ratio and Survival Rate in Preoperative Chemoradiation Rectal Cancer Patients
Colorectal cancer is the most-common cancer of the gastrointestinal tract. The number of positive lymph nodes and total number of lymph nodes retrieved are important prognostic factors.
- Trial name
- NCT04096118
- Where
- Thailand
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Lymphedema, Breast Cancer, Mastectomy Related Lymphedema
Complete Decongestive Therapy Versus Non-pneumatic Compression Therapy in Post Mastectomy Lymphedema
The aim of the study is to compare the effectiveness of Complete Decongestive Therapy and Non-Pneumatic Compression Therapy, both combined with routine physical therapy, in reducing pain and edema volume, improving range of…
- Conditions
- Lymphedema, Breast Cancer, Mastectomy Related Lymphedema, Post Mastectomy Lymphedema
- Trial name
- CDT (NCT07217288)
- Testing
- Non Pneumatic compression device, Complete Decongestive therapy
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Persistent Cough, Pneumonectomy
Analysis of Factors and Treatment Related to Chronic Cough After Pulmonary Resection
Surgical resection is the primary treatment for pulmonary tumors. Surgeons has been frequently concerned about effectiveness, safety, and minimal invasive techniques.
- Conditions
- Persistent Cough, Pneumonectomy, Lung Neoplasms
- Trial name
- NCT05586035
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Dysphagia, Lung Cancer
Manuka Honey in Preventing Esophagitis-Related Pain in Patients Receiving Chemotherapy and Radiation Therapy For Lung Cancer
RATIONALE: Manuka honey may prevent or reduce esophagitis-related pain caused by chemotherapy and radiation therapy. It is not yet known whether Manuka honey is more effective than standard care in preventing pain.
- Conditions
- Dysphagia, Lung Cancer, Pain, Esophagitis
- Trial name
- NCT01262560
- Testing
- Manuka honey in liquid form, Manuka honey in lozenge form, Standard supportive care
- Where
- 59 sites in United States
- Volunteers
- 163 people
- Sponsor
- Radiation Therapy Oncology Group
Cancer-Related Condition
Quantifying Fatigue in Cancer Patients Using Smart Bracelet Devices
This project expects to enroll 60 cancer patients, 60 healthy people and their subjective-objective measurements on fatigue, stress, and total steps will be validated so that the information can be used in further care and…
- Trial name
- NCT04300842
- Testing
- smart bracelet
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Cancer, Fatigue
Modafinil to Reduce Persistent Fatigue in Patients Following Treatment for Cancer
The purpose of this study is to determine the efficacy of modafinil with regard to reducing cancer-related fatigue in cancer patients following chemotherapy or radiation therapy.
- Conditions
- Cancer, Fatigue, Chemotherapy
- Trial name
- NCT00178373
- Testing
- Modafinil, sugar pill
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Rochester
Solid Tumors, Adult, PIK3CA Mutation-Related Tumors
Alpelisib in Combination With Carboplatin in Patients With Solid Tumors and HPV-Positive Squamous Cell Carcinoma
This phase I/II trial tests the safety, side effects, and best dose of alpelisib and whether alpelisib and carboplatin work to shrink tumors in patients with solid tumors or human papillomavirus (HPV) positive squamous cell…
- Conditions
- Solid Tumors, Adult, PIK3CA Mutation-Related Tumors, PIK3CA Mutation, Human Papillomavirus-Related Carcinoma
- Trial name
- NCT05472220
- Testing
- Alpelisib, Carboplatin, Hyperpolarized Carbon-13 (13C) Pyruvate
- Sponsor
- Pamela Munster
Sleep Disorder, Polycystic Ovarian Syndrome (PCOS)
Association Between Polycystic Ovary Syndrome and Sleep Quality: A Questionnaire-Based Study
This cross-sectional study enrolled 310 women with PCOS (Rotterdam criteria) at a tertiary referral center between September 2025 and January 2026.
- Trial name
- PMOS (NCT07898423)
- Where
- Turkey (Türkiye)
- Volunteers
- 290 people
- Sponsor
- Tepecik Training and Research Hospital
Epilepsy, Cryptogenic, Epilepsy, Partial
IVIG Treatment for Refractory Immune-Related Adult Epilepsy
The purpose of the initial screening study is to find out if immune problems are an unrecognized cause of epilepsy in some patients.
- Conditions
- Epilepsy, Cryptogenic, Epilepsy, Partial, Seizure Disorder, Autoimmune Diseases, Nervous System
- Trial name
- NCT01545518
- Testing
- IVIG
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Breast Cancer
CHEmotherapy and Cognitive Deterioration in Patients With Operable Breast Cancer: Impact of Cognitive Rehabilitation (CHEMOFOG)
An interventional, non-pharmacological, monocentric study evaluating the effectiveness of cognitive rehabilitation in counteracting chemotherapy-induced cognitive impairment (CRCI) in women with operable breast cancer treated…
- Trial name
- CHEMOFOG (NCT06435559)
- Testing
- Neurotablet® and Neuropsychological evaluations, Neuropsychological evaluations
- Volunteers
- 128 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Genital Neoplasms, Female
Characterization of the Intestinal and Vaginal Microbiota in Long-term Survivors of Gynecological Cancer
The study proposes the characterization of the intestinal and vaginal microbiota in long-term radiated cervical and endometrial cancer survivors to study the association with long-term radiotherapy side effects.
- Trial name
- NCT05360459
- Testing
- Exposure to radiotherapy
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maria Bailen Andrino
Pancreas Adenocarcinoma, Cachexia
Assoc. of Genomic Polymorphisms With Cancer Cachexia in Subjects With Panc Adenocarcinoma
A major complication of pancreatic adenocarcinoma (PDAC) is cancer cachexia (CC) which is a complex syndrome characterized by skeletal muscle mass loss (with or without loss of fat mass) and progressive functional impairment not…
- Trial name
- NCT05376592
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Cancer, Immune-related Adverse Event
Extensive CArdioVAscular Characterization and Follow-up of Patients Receiving Immune Checkpoint Inhibitors
The goal of this prospective, multicentre study is to investigate short- and long-term cardiovascular effects in cancer patients treated with immune checkpoint inhibitors (ICIs).
- Conditions
- Cancer, Immune-related Adverse Event, Cardiac Abnormalities, Variable, Immune Checkpoint Inhibitor-Related Myocarditis
- Trial name
- CAVACI (NCT05699915)
- Testing
- Cardiology consultation, Chest Computed Tomography (CT) without contrast, Non-invasive endothelial function tests
- Where
- 4 sites in Belgium
- Volunteers
- 105 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Cognitive Remediation, Neuropsychology
Longitudinal Neurocognitive, Psychosocial and Health-related Quality of Life Assessment in Advanced Cancer Survivors Treated With Immunotherapy and the Efficacy of Integrative Neurocognitive Remediation Therapy
Since 2010, the field of immunotherapy has grown substantially, leading to a growing population of long-term cancer survivors treated with immunotherapy.
- Conditions
- Cognitive Remediation, Neuropsychology, Quality of Life, Psycho-Oncology
- Trial name
- CognIT (NCT05667857)
- Testing
- Integrative neurocognitive remediation therapy
- Where
- 2 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Breast Neoplasms, Cardiotoxicity
The Safety Management of Cardiac Toxicity in Breast Cancer Patients Under Multidiscipline Therapy.
This trial is to explore the optimal strategies for guaranteeing the cardiac safety of breast cancer patients following adjuvant radiotherapy in the modern era of multidisciplinary treatment.
- Trial name
- NCT02942615
- Testing
- limit heart dose
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Ruijin Hospital
Pancreatic Cancer
Circulating Cell-free Tumor DNA(ctDNA) in Pancreatic Cancer
The aim of the study is to evaluate whether peripheral circulating cell-free tumor DNA(ctDNA) can help early screening of pancreatic cancer recurrence or not.
- Trial name
- NCT02934984
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Breast Neoplasms, Anesthesia, General
Relationship Between Genetic Polymorphism and Postoperative Nausea and Vomiting in Chinese Han Population
Postoperative nausea and vomiting ( PONV ) is one of the common complications after general anesthesia while genetic factors may play an important role in Postoperative nausea and vomiting.
- Trial name
- NCT03705026
- Volunteers
- 568 people
- Sponsor
- Fujian Medical University Union Hospital
Breast Cancer, Drug-Related Side Effects
Gut Microbiota and Diarrhea in Breast Cancer Patients Receiving Pyrotinib
Background: Pyrotinib is an effective targeted drug for HER2-positive breast cancer, but it very frequently causes diarrhea, which can be severe enough to disrupt treatment and reduce patients' quality of life.
- Conditions
- Breast Cancer, Drug-Related Side Effects, Diarrhea
- Trial name
- NCT07264985
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hubei Cancer Hospital
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