Clinical trials: Cancer-related Cognitive Dysfunction
Chemo Brain, Chemotherapy-related Cognitive Impairment
Nicotinic Treatment of Post-Chemotherapy Subjective Cognitive Impairment: A Pilot Study
The purpose of this study is to evaluate the use of a nicotine patch as a treatment for problems with attention, learning and memory in breast cancer patients who are 1-5 years post chemotherapy.
- Conditions
- Chemo Brain, Chemotherapy-related Cognitive Impairment, Chemo Fog, Breast Cancer
- Trial name
- NCT02312934
- Testing
- Transdermal nicotine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Vanderbilt University Medical Center
Cancer-related Cognitive Impairment
Testosterone, Cognition, Ageing, and Cancer
The primary aim of the study is - in a prospective controlled design - to examine whether treatment-induced decreases in testosterone acts as a mechanism of cancer-related cognitive impairment (CRCI) in testicular and prostate…
- Trial name
- NCT03452436
- Where
- Denmark
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cancer-related Fatigue, Cancer-related Cognitive Impairment
Reducing Cancer Side-effects With Systematic Light Exposure
The main purpose of this interdisciplinary proposal is to conduct two randomized controlled trial (RCT) of the efficacy of self-administered systematic light exposure (Bright White Light (BWL)), an innovative, low cost, and low…
- Trial name
- LYS (NCT02661308)
- Testing
- Litebook
- Where
- Denmark
- Volunteers
- 108 people
- Sponsor
- Aarhus University Hospital
Breast Cancer
The Effect of Acupuncture on Cancer-Related Cognitive Difficulties
The purpose of this study is to test whether acupuncture can improve cognitive difficulties and insomnia in survivors of breast cancer.
- Trial name
- NCT04837820
- Testing
- Acupuncture, Wait-List Control (WLC), Questionnaires
- Where
- 7 sites in United States
- Volunteers
- 270 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer, Sarcopenia
JUMP Prevalence of Sarcopenia and Chemobrain in Post-cancer Patients
Therapeutic advances in oncology have transformed the prognosis of cancer patients, placing a significant number of them either in a context of recovery or in prolonged remission close to a chronic disease.
- Trial name
- JUMP (NCT05800535)
- Testing
- Study of the adverse effects of long-term oncological treatments, Study of the long-term side effects of oncological treatments on the anxiety-depressive and cognitive state of patients
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Chemotherapy-Related Cognitive Impairment, Healthy
Telerehabilitation Cognitive Impairments Following Chemotherapy Usability Study
Develop a game-based upper-extremity motor and cognitive rehabilitation system using custom and adaptable virtual reality simulations.
- Trial name
- TCIFCU (NCT04839588)
- Testing
- Usability study
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Bright Cloud International Corp
Breast Cancer, Peripheral Neuropathy
Role of Silymarin in Chemotherapy Toxicity and Cognition Improvement in Breast Cancer Patients
Aim of the work This study aims to evaluate the possible beneficial role of silymarin in attenuating both doxorubicin related cardiac and hepatic toxicities and paclitaxel associated peripheral neuropathy and improving cognitive…
- Conditions
- Breast Cancer, Peripheral Neuropathy, Cardiac Toxicities, Hepatic Toxicity
- Trial name
- NCT05595109
- Testing
- Silymarin
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Tanta University
Breast Cancer
Cognitive Training and Exercise for Women With Breast Cancer and Cognitive Impairment
Chemotherapy-related cognitive impairment is a prevalent and distressing condition among breast cancer survivors, adversely affecting memory, attention, and overall cognitive function, thereby diminishing quality of life.
- Trial name
- CHEMO-CogEx (NCT07017530)
- Testing
- Cognitive training, Psychoeducational therapy
- Where
- Spain
- Volunteers
- 220 people
- Sponsor
- Universidad de Extremadura
Patients Treated for Cancer
Cancer Related Cognitive Impairment
Various recent scientific data testify to the cognitive deficiencies of cancer patients, called Cancer-Related Cognitive Impairments (CRCI) (Noal, Daireaux \& Joly, 2010).
- Trial name
- APACO (NCT03949322)
- Testing
- Adapted Physical Activity Program
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Institut Cancerologie de l'Ouest
Cancer-related Cognitive Impairment, Cancer-related Cognitive Dysfunction
CanCOG®: Pilot Trial of Cognitive Rehabilitation for Cancer Survivors
Cancer-related cognitive impairment (CRCI) affects a large proportion of non-central nervous system cancer survivors and can negatively impact cognitive functioning and daily life.
- Conditions
- Cancer-related Cognitive Impairment, Cancer-related Cognitive Dysfunction, Cancer-related Cognitive Difficulties, Depression and Anxiety Symptoms
- Trial name
- CanCOG® (NCT07755839)
- Testing
- CanCOG® - Cogntive Rehabilitation in Cancer
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Aveiro University
Non-Metastatic Prostate Carcinoma, Stage I Prostate Cancer AJCC v8
An Investigational Scan (7 Tesla MRI) in Diagnosing Cognitive Impairment in Patients With Non-Metastatic Prostate Cancer
This trial studies 7 Tesla magnetic resonance imaging (MRI) in diagnosing cognitive impairment in patients with prostate cancer that has not spread to other places in the body (non-metastatic) and who have or have not received…
- Conditions
- Non-Metastatic Prostate Carcinoma, Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage IIA Prostate Cancer AJCC v8
- Trial name
- NCT04318028
- Testing
- 7 Tesla Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
Cancer, Hearing Loss Ototoxic
The Effect of Cancer Treatments on Speech Perception in Noise, Cognition, and Hearing-Related Quality of Life
The study will assess the effect of cancer treatments on speech perception in noise, cognition, and hearing-related quality of life by monitoring 200 cancer patients receiving standard care for their underlying malignancy.
- Conditions
- Cancer, Hearing Loss Ototoxic, Cognitive Decline, Quality of Life
- Trial name
- CaSPiN (NCT06551857)
- Testing
- Chemotherapy, chemoradiation, radiation therapy
- Where
- Finland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Cancer
MAAT For Young Adult Cancer Survivors
The goal of this clinical trial is to pilot-test a modified version of telehealth-delivered Memory and Attention Adaption Training (MAAT) that is tailored to young adult childhood cancer survivors (ages 18-39; MAAT-YS) with…
- Trial name
- MAAT-YACCS (NCT06150976)
- Testing
- MAAT-YS
- Where
- 3 sites in United States
- Volunteers
- 7 people
- Sponsor
- University of Pittsburgh
Cancer, Chemotherapy
The Activity Intervention for Chemobrain
Cognitive dysfunction following chemotherapy is an adverse treatment effect that impacts the quality of life for many cancer survivors receiving this adjuvant therapy.
- Conditions
- Cancer, Chemotherapy, Cognitive Impairment
- Trial name
- TACTIC (NCT00495703)
- Testing
- Exercise, Usual Care
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Chemotherapy-induced Cognitive Impairment
Chemotherapy-Induced Cognitive Impairment in Ovarian Cancer Patients
Chemotherapy-induced cognitive impairment (CICI), also known as "chemobrain," is a spectrum of neurocognitive deficits experienced during and after the administration of chemotherapy for cancer.
- Trial name
- NCT03324945
- Testing
- Neurocognitive assessments
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Rachel Miller
Age-related Cognitive Decline, Cognitive Deterioration
Decoding the Cognitive Trajectory of Hong Kong SuperAgers: a Longitudinal Follow-up Study
This is a prospective follow-up study conducted at the Department of Psychiatry, The Chinese University of Hong Kong. The participants, including high-performing elderly (SuperAgers), normal ageing elderly and neurocognitive…
- Conditions
- Age-related Cognitive Decline, Cognitive Deterioration, Dementia, Mild
- Trial name
- NCT05728801
- Testing
- Ageing
- Where
- Hong Kong
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Breast Cancer Survivorship, Cancer-related Cognitive Impairment
An Attention-Restorative Therapy (ART)-Based Virtual Reality Intervention to Address Cancer-Related Cognitive Impairments Among Breast Cancer Survivors
This study is to assess the feasibility of using a Virtual Reality (VR) headset to provide nature-based Attention-Restorative Therapy (ART) as treatment for cognitive impairment in post-treatment cancer survivors.
- Trial name
- NCT05030792
- Testing
- Attention-restorative therapy (ART)-based virtual reality (VR)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan Rogel Cancer Center
Breast Cancer
Creatine and Cognitive Health in Patients With Early-stage Breast Cancer During and After Chemotherapy Treatment
The goal of this clinical trial is to evaluate whether oral creatine supplementation can prevent chemotherapy-related cognitive impairment in patients with early-stage breast cancer undergoing neoadjuvant or adjuvant…
- Trial name
- IARA (NCT07372144)
- Testing
- Creatine
- Where
- Brazil
- Volunteers
- 227 people
- Sponsor
- D'Or Institute for Research and Education
Chemo-brain, Drug-Related Side Effects and Adverse Reactions
Acupuncture Prevents Chemobrain in Breast Cancer Patients
Chemobrain is an expression used to describe a cluster of chemotherapy-induced cognitive impairment symptoms, including problems with visual and verbal memory, forgetfulness, difficulty in learning, attention, concentration and…
- Conditions
- Chemo-brain, Drug-Related Side Effects and Adverse Reactions, Mild Cognitive Impairment, Breast Cancer
- Trial name
- NCT02457039
- Testing
- Dense cranial electroacupuncture stimulation, Body acupuncture, Least acupuncture stimulation
- Where
- 6 sites in China, Hong Kong
- Volunteers
- 93 people
- Sponsor
- The University of Hong Kong
Cancer-related Cognitive Difficulties, Cancer-related Problem/Condition
Modafinil to Improve Fatiguability
Cancer-related fatigue (CRF) and cancer-related cognitive impairment (CRCI) are among the most commonly reported disabling symptoms experienced by patients with advanced cancer.
- Conditions
- Cancer-related Cognitive Difficulties, Cancer-related Problem/Condition, Fatigue
- Trial name
- MODIFY (NCT05333250)
- Testing
- Modafinil
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Ottawa Hospital Research Institute