Clinical trials: Cancer-related Pain
Misuse, Opioid
Effect of Olanzapine on Opioid Craving and Misuse Among Patients Receiving Opioids for Cancer-related Pain: A Pilot Double-Blind, Randomized Control Trial
To learn about the effectiveness of taking the antipsychotic medication olanzapine to help lower opioid craving.
- Trial name
- NCT06200181
- Testing
- Olanzapine
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- M.D. Anderson Cancer Center
Pancreatic Cancer, Retroperitoneal Pain Syndrome
Simulation-Free Celiac Plexus Pain Ablation Using Stereotactic Body Radiotherapy (SBRT) in Participants With Cancer-Related Celiac Pain
Participants who are experiencing abdominal pain due to having cancer in their pancreas may be eligible for this research study. For this type of pain, doctors often recommend radiation therapy to help with the pain.
- Trial name
- NCT07117032
- Testing
- Simulation-free workflow, Celiac plexus SBRT
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Case Comprehensive Cancer Center
Bone Metastasis, Cancer Pain
Phase 3 Study on the Efficacy and Safety of Tanezumab in Patients With Cancer Pain Due to Bone Metastasis Who Are Taking Background Opioid Therapy
The purpose of this study is to determine whether tanezumab is effective in the treatment of cancer pain due to bone metastasis in patients already taking background opioid therapy.
- Trial name
- NCT02609828
- Testing
- Tanezumab
- Where
- 89 sites in Argentina, Australia and 14 more
- Volunteers
- 156 people
- Sponsor
- Pfizer
Oral Mucositis
Ozone Therapy for Cancer Therapy-Related Oral Mucositis
This retrospective observational study will evaluate clinical data already available from adult cancer patients who developed cancer therapy-related oral mucositis during radiotherapy and/or chemotherapy and who were managed in…
- Trial name
- OMUC-O3 (NCT07638904)
- Testing
- Combined Ozone-Based Oral Care Protocol
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- University of Pavia
Chronic Pain
Feasibility Study of an Online Self-management Program for Chronic Non-cancer Pain
Based on a mixed-methods design, the objective of this trial is to assess the feasibility and acceptability of the "Agir pour moi" program, an 8-week online self-management program for chronic non-cancer pain (CNCP).
- Trial name
- NCT05319652
- Testing
- Pain self-management program
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- CHU de Quebec-Universite Laval
Liver Cancer, Pancreas Cancer
A Clinical Trial to Evaluate Safety and Efficacy of Endovascualr Denervation in Treatment of Cancer Pain
A prospective, multicenter, self-control clinical trial aim to enroll 110 patients suffered from upper abdominal (liver, pancreas, stomach, etc.) cancers .
- Conditions
- Liver Cancer, Pancreas Cancer, Stomach Cancer, Bile Duct Cancer
- Trial name
- NCT04014478
- Testing
- Endovascular Denervation
- Volunteers
- 110 people
- Sponsor
- Shanghai Golden Leaf MedTec Co. Ltd
Painful Bone Metastases, Breast Carcinoma
MRI Guided High Intensity Focused Ultrasound (HIFU) and ThermoDox for Palliation of Painful Bone Metastases
This study will evaluate treatment with High Intensity Focused Ultrasound (HIFU)in combination with ThermoDox (liposomal doxorubicin) is safe and effective in reducing pain for patients with painful bone metastases.
- Conditions
- Painful Bone Metastases, Breast Carcinoma, Non-small Cell Lung Cancer, Small Cell Lung Cancer
- Trial name
- NCT01640847
- Testing
- High Intensity Focused Ultrasound (HIFU) in combination with ThermoDox
- Sponsor
- Imunon
Inappropriate Dose of Drug Administered, Pain, Chronic
Trial Applying Policy to Eliminate or Reduce Inappropriate Narcotics in the General-population
To assess the effectiveness of a government-led population-based opioid intervention on discontinuation of opioid medication in community-dwelling adults with chronic non-cancer pain.
- Conditions
- Inappropriate Dose of Drug Administered, Pain, Chronic, Health Behavior
- Trial name
- TAPERING (NCT03400384)
- Testing
- Direct-to-consumer educational brochure
- Where
- Canada
- Volunteers
- 4,255 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Chronic Pain
Morphine as First Drug for Cancer Pain
Background and Objectives: The drugs used as recommended by the WHO does not promote pain relief for all patients with cancer pain.
- Trial name
- NCT01541124
- Testing
- Opioid
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
Head and Neck Neoplasms, Squamous Cell Carcinoma of Head and Neck
Quad Shot Versus Split Course Radiotherapy in Incurable Head and Neck Cancer
Head and neck cancer in its advanced, incurable stage causes severe symptoms such as pain, trouble swallowing, and bleeding. Palliative radiation therapy is frequently used to relieve these symptoms and improve the patient's…
- Trial name
- QSSC-HN (NCT07823309)
- Testing
- Quad Shot Radiotherapy, Split Course Radiotherapy
- Volunteers
- 40 people
- Sponsor
- Instituto Nacional de Cancerologia, Columbia
Pain
Safety and Efficacy Study of Osmotic Release Oral System (OROS) Hydromorphone in Participants With Cancer Pain
The purpose of this study is to evaluate the effectiveness and safety of Osmotic Release Oral System (OROS) hydromorphone using standardized conversion from prior opioid therapy among participants with cancer pain.
- Trial name
- NCT01648699
- Testing
- Osmotic Release Oral System (OROS) hydromorphone
- Volunteers
- 20 people
- Sponsor
- Janssen Pharmaceutica
Cancer-Related Pain
Buprenorphine for Cancer Pain
This study will evaluate patients on both buprenorphine and full agonist opioids (FAO) to assess for withdrawal symptoms. Patients will be evaluated by clinicians and using validated tools to assess for pain and withdrawal.
- Trial name
- NCT05910190
- Testing
- Use of buprenorphine with FAO > 30 OME, CPM Rx application use
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Fox Chase Cancer Center
Pain, Pancreatic Cancer
Acupuncture and Acupressure in Treating Patients With Moderate or Severe Pain Related to Stage III or Stage IV Pancreatic Cancer
RATIONALE: Acupuncture and acupressure may help relieve moderate or severe pain associated with stage III or stage IV pancreatic cancer.
- Trial name
- NCT00040833
- Testing
- complementary or alternative medicine procedure, pain therapy
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer Pain, Tumor, Solid
Home Management of Simple Hydromorphone PCA Pump Mode
This prospective observational study will evaluate the efficacy and adverse effects of a "simple hydromorphone PCA pump model", which is a rapid titration followed by a convenient maintenance technique, to treat home cancer…
- Conditions
- Cancer Pain, Tumor, Solid, Carcinoma
- Trial name
- NCT05744089
- Testing
- PCA pump
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Cancer Pain
35kDa Hyaluronan Fragment Treatment of Colorectal and Rectal Cancer
HA35 (Bioactive HA or B-HA or HA35) have good tissue permeability (B-HA injection, Ministry of Health, Registration number L20200708MP07707).
- Trial name
- NCT06209970
- Testing
- HA35
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Nakhia Impex LLC
Cancer Pain
Unique Treatment of Oncology Pain in Advanced Cancer
This will be a proof-of-concept, single arm study with a maximum of 20 patients to evaluate preliminary analgesic efficacy and safety of Trichomylin® in patients with advanced cancer (male and female) who suffer from moderate to…
- Trial name
- UTOPIA-1 (NCT06533657)
- Testing
- Trichomylin® capsule (5 mg delta-9-tetrahydrocannabinol: 5 mg cannabidiol: 5 mg cannabichromene)
- Where
- 3 sites in Canada
- Volunteers
- 11 people
- Sponsor
- ZYUS Life Sciences Inc.
Pain, Unspecified Adult Solid Tumor, Protocol Specific
Valdecoxib in Treating Chronic Pain in Cancer Patients
RATIONALE: Valdecoxib may be effective in relieving chronic pain in cancer patients. It is not yet known if valdecoxib is effective in treating chronic pain.
- Trial name
- NCT00021996
- Testing
- valdecoxib
- Where
- 2 sites in United States
- Sponsor
- Dana-Farber Cancer Institute
Chronic Non Cancer Pain
Pharmacist for Detecting Opioid Misuse
Opioid use is increasing in Western countries and is associated with harms as hospitalization, addiction and deaths(1). Community pharmacists interact frequently with patients, giving them the opportunity to identify and prevent…
- Trial name
- NCT04544696
- Where
- France
- Volunteers
- 414 people
- Sponsor
- University Hospital, Montpellier
Cancer-related Problem/Condition
Combined Fluoroscopy and CT Guided Radiofrequency Ablation of Thoracic Dorsal Root Ganglia in Severe Thoracic Pain
In the current study, extra-guidance other than conventional fluoroscopy - will be integrated to improve the success of the transforaminal approach to the thoracic dorsal root ganglia (DRG).
- Trial name
- NCT03533413
- Testing
- combined CT-fluroscopy, standard fluroscopy
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- National Cancer Institute, Egypt
Cancer Patients, Cancer-related Pain
A Consensus on Opioid Prescription for Oncologic Patients in Latin America - A DELPHI Study.
As seen worldwide, cancer incidence is increasing in Latin America achieving an amount of 1.3 million new cases annually.1 In addition, it is expected that up to 70% of patients with cancer will experience pain2, one of the most…
- Trial name
- NCT04844788
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Instituto do Cancer do Estado de São Paulo