Clinical trials: Canker Sore
Photobiomodulation, Stomatitis, Aphthous
Efficacy of Photobiomodulation in the Treatment and Relief of Pain in Recurrent Aphthous Stomatitis
Photobiomodulation (PBM) is a therapy that stimulates repair, pain relief, and reduces inflammation. The aim of this study is to evaluate the effectiveness of a new PBM protocol in the treatment and pain relief of RAS lesions.
- Trial name
- NCT06416046
- Testing
- Gemini laser
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Recurrent Aphthous Stomatitis, Mouth Ulcer
The Preventive and Therapeutic Effects of Spirulina Preparations on Ulcers of Oral Mucosa
This is a prospective, randomized, double-blind, placebo-controlled clinical trial designed to evaluate the efficacy and safety of spirulina supplementation in patients with radiation-induced oral mucositis (RIOM) receiving…
- Trial name
- NCT07723612
- Testing
- Spirulina Tablets
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Stomatitis, Aphthous
Comparison of Hypericum Perforatum, Topical Corticosteroids, and Hyaluronic Acid for Recurrent Aphthous Stomatitis
Recurrent aphthous stomatitis (RAS) is one of the most common ulcerative diseases of the oral mucosa and is characterized by recurrent painful ulcers that adversely affect eating, speaking, and overall quality of life.
- Trial name
- NCT06839313
- Testing
- Kenacort A Orabase® pomad , Bristol-Myers Squibb İlaçları Inc. İstanbul , Türkiye, Hyaluronic acid, Aftamed ® Oral jel , AktiFarma . İstanbul, Türkiye, Hypericum perforatum (St. John's wort oil, Zade Vital; Health&Fitness, Developed With Ege Üniversiesi Argefar)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Batman University
Recurrent Aphthous Stomatitis, Aphthous Ulcer
Salivary E-cadherin, Calprotectin, and Matrix Metalloproteinase-9 Levels in Recurrent Aphthous Stomatitis
The goal of this observational cross-sectional study is to determine the salivary levels of E-cadherin, Calprotectin, and Matrix Metalloproteinase-9 (MMP-9) in patients with Recurrent Aphthous Stomatitis (RAS) and to compare them…
- Trial name
- NCT07141758
- Testing
- ELISA
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Selin Yeşiltepe
Trisomy 8 Mosaicism, Trisomy 8 Associated Autoinflammatory Disease
Natural History of Trisomy 8-Associated Autoinflammatory Disease (TRIAD) and Related Disorders
Background: Trisomy 8 mosaicism is a genetic disorder that can increase inflammation in the body. Symptoms include fevers; sores or ulcers in the mouth, digestive tract, or genital area; skin rashes; problems in organs or…
- Conditions
- Trisomy 8 Mosaicism, Trisomy 8 Associated Autoinflammatory Disease, Mucosal Ulcerations
- Trial name
- NCT07683104
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Recurrent Aphthous Stomatitis
Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Recurrent Aphthous Stomatitis
Bromelain, a natural product, exhibits anti-inflammatory, immunomodulatory, and wound-healing properties. However, its efficacy in treating oral mucosal ulcers remains unexplored.
- Trial name
- NCT06993337
- Testing
- 35% Topical Bromelain in Orabase, 50% Topical Bromelain in Orabase, 0.1% Topical Triamcinolone Acetonide in Orabase
- Volunteers
- 63 people
- Sponsor
- Cairo University
Recurrent Aphthous Ulcer
Devintec OR-AT0222 Oral Gel for the Treatment of Canker Sores: A Double Blind, Randomized, Placebo Controlled Clinical Investigation
Canker sore, also known as aphthous stomatitis or ulcers and aphthae, is a common ailment, idiopathic in nature, with recurrent painful aphthous ulcers on the non-keratinized oral mucous membranes.
- Trial name
- NCT05959824
- Testing
- OR-AT0222
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- Devintec Sagl
Oral Aphthous Ulcers
Evaluation of Topical Rebamipide Versus Topical Betamethasone for Treatment of Oral Aphthous Ulcers
The goal of this randomized clinical trial is to to compare the effect of topical rebamipide to topical betamethasone on pain intensity in patients having recurrent oral aphthous ulcers.
- Trial name
- NCT06084624
- Testing
- Rebamipide mouthwash, Betamethasone mouthwash
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Cairo University
Oral Ulcer
Clinical Efficiency of Natural Herbal Based Gel.
This clinical trial was conducted in School of Dentistry, Islamabad from 15th June 2023 to 16th January 2024. A total 202 participants took part in study and were divided equally into two groups i.e Control group and Experimental…
- Trial name
- NCT06490289
- Testing
- Denpro oral gel
- Where
- Pakistan
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Recurrent Aphthous Stomatitis
Effect of Zinc Oxide Ointment on Recurrent Aphthous Stomatitis
This randomized placebo-controlled trial evaluated the effectiveness of zinc oxide ointment in the treatment of recurrent aphthous stomatitis (RAS).
- Trial name
- ZO-RAS (NCT07565181)
- Testing
- zinc oxide, Placabo
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Faculty of Dental Medicine for Girls
Oral Aphthous Ulcer
Clinical Evaluation of Topical Coenzyme Q10 in Management of Oral Aphthous Ulcer
Recurrent oral aphthous ulcer is the most common oral lesion in occurrence and one of cause is oxidative stress so investigators need to use antioxidant drugs like topical coenzyme Q10 gel to treat the lesion and more safe for…
- Trial name
- NCT03213769
- Testing
- topical coenzyme Q10 gel, Carpabol gel
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Cairo University
Recurrent Aphthous Ulcers
The Salivary and Faecal Microbiome of Recurrent Aphthous Stomatitis Patients Before and After Treatment With Probiotics
Recurrent aphthous stomatitis (RAS) is one of the most common ulcerative diseases affecting the oral mucosa. The aetiology remains unknown, but several local, systemic, immunologic, genetic, allergic, nutritional, and microbial…
- Trial name
- NCT02976922
- Testing
- Probiotic lozenge
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Oral Aphthae
Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae
The purpose of this study is to determine whether low doses of prednisolone, or colchicine are effective in the treatment of oral aphthae.
- Trial name
- NCT00723268
- Testing
- Prednisolone, Colchicine
- Where
- Iran
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Cutaneous Manifestations, Skin Manifestations
Cutaneous Manifestations of Coronavirus Disease 2019(COVID-19).
An outbreak of Corona virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-coV-2) occurred in Wuhan city, Hubei province, China in December 2019.
- Conditions
- Cutaneous Manifestations, Skin Manifestations, COVID-19, COVID-19 Pneumonia
- Trial name
- NCT05094687
- Where
- Pakistan
- Volunteers
- 1,206 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
Oral Lichen Planus, Recurrent Aphthous Stomatitis
Improving Prescribing Quality for Oral Mucosal Disorders Using a Pharmacist-Led Model
This study aims to improve how oral mucosal disorders-such as oral lichen planus, recurrent aphthous stomatitis, burning mouth syndrome, herpes viral infection and oral candidiasis-are treated in dental settings.
- Conditions
- Oral Lichen Planus, Recurrent Aphthous Stomatitis, Burning Mouth Syndrome, Oral Candidiasis
- Trial name
- NCT07721090
- Testing
- Pharmacist-Led Prescribing Optimization and Patient Counselling
- Volunteers
- 336 people
- Sponsor
- University of Fujairah
Canker Sore
Salivary Catecholamines in Aphthous Stomatitis (Canker Sores)
The purpose of this study is to examine how compounds produced in patients with canker sores affect wound healing.
- Trial name
- NCT00556686
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Davis
Recurrent Aphthous Ulcer, Recurrent Aphthous Stomatitis
Curcumin and Nanocurcumin in Oral Aphthous Ulcer
Recurrent aphthous ulcer is a painful inflammatory lesion with a high prevalence. Since the etiology is not clear, several strategies have been proposed to reduce pain and severity of its symptoms.
- Trial name
- NCT04385979
- Testing
- Gel
- Where
- Iran
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Behçet Disease
Dusquetide for the Treatment of Behcet's Disease
This is a clinical study to see if dusquetide can treat flares of oral and genital ulcers caused by Behcet's Disease. Study participants will receive an infusion of dusquetide twice a week for 4 weeks (8 treatments total), with…
- Trial name
- NCT06386744
- Testing
- Dusquetide
- Where
- Turkey (Türkiye)
- Volunteers
- 8 people
- Sponsor
- Soligenix
Intense-exuberant Stomach Fire Syndrom, Acute Pericoronitis
Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome
This clinical research focus on evaluating the effectiveness of Huanglian-Jiedu Decoction in patients with intense-exuberant stomach fire syndrome (one of the common TCM syndrome)of acute pericoronitis,minor recurrent aphthous…
- Conditions
- Intense-exuberant Stomach Fire Syndrom, Acute Pericoronitis, Recurrent Aphthous Stomatitis, Recurrent Herpes Simplex Labialis
- Trial name
- NCT03469232
- Testing
- Huanglian-Jiedu Decoction
- Where
- 3 sites in China
- Volunteers
- 240 people
- Sponsor
- China Academy of Chinese Medical Sciences
Aphthous Stomatitis
Systemic Zinc Sulphate in Treatment of Recurrent Aphthous Ulcerations:A Doubleblind, Placebo Controled Study
Recurrent aphthous stomatitis (RAS) is one of the most common of oral mucosa diseases that affects approximately 20% of the general population.
- Trial name
- NCT01210014
- Testing
- zinc sulphate 220mg/day in one dosage
- Where
- Iran
- Volunteers
- 14 people
- Sponsor
- Qazvin University Of Medical Sciences