Clinical trials: Cannabis
Driving Behavior, Driving Under the Influence
Validation of the Drug Impaired Driving Scenario (DIDS) on the CRCDS-miniSim
Subjects will participate in a 4-visit study protocol at the National Advanced Driving Simulator, part of the University of Iowa, in which they will be asked to complete assorted questionnaires, computerized cognitive tasks, and…
- Trial name
- PDID (NCT04970342)
- Testing
- 0.75 mg Alprazolam Capsule, Cannabis (6.18% THC / <0.025% CBD), Cannabis (0%/ THC / 0% CBD)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Timothy L. Brown
Marijuana Abuse, Attention Deficit Disorder With Hyperactivity
Atomoxetine Treatment for ADHD and Marijuana Dependence
The aim of the study is to determine if atomoxetine treatment combined with motivational enhancement therapy is effective in reducing marijuana use in adult individuals with attention-deficit hyperactivity disorder and marijuana…
- Trial name
- NCT00360269
- Testing
- Atomoxetine, Motivational enhancement therapy
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Medical University of South Carolina
Cannabis Use Disorder
N-Acetylcysteine for Youth Cannabis Use Disorder
This is a 12-week randomized, placebo-controlled trial of N-acetylcysteine for cannabis use disorder (CUD) in youth (N=192). Participants will be randomized to double-blind NAC or PBO, yielding two equally-allocated treatment…
- Trial name
- NCT03055377
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Medical University of South Carolina
Cannabis Dependence
Study of Long-Acting Injectable Naltrexone to Treat Cannabis Dependence
This is an 8 week, outpatient research study testing the use of long-acting naltrexone (Vivitrol) as a treatment for marijuana dependence.
- Trial name
- NCT02088177
- Testing
- Long-acting injectable naltrexone
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- New York State Psychiatric Institute
Cannabis Use
Effect of Lorcaserin on Cannabis Withdrawal and Self-administration
In this study, the investigators are interested in testing how lorcaserin influences the effects of cannabis in a human laboratory model of cannabis use.
- Trial name
- NCT03253926
- Testing
- Lorcaserin, Marijuana
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Persian Gulf Syndrome, Chronic Sinusitis
Gulf War Illness Nasal Irrigation Study
The purpose of this study is to determine whether nasal irrigation with Xylitol or saline are effective in the treatment of chronic rhinosinusitis and fatigue symptoms associated with Gulf War Illness.
- Conditions
- Persian Gulf Syndrome, Chronic Sinusitis, Fatigue, Acute Sinusitis
- Trial name
- GWINIS (NCT01700725)
- Testing
- Nasal Irrigation - Saline, Nasal Irrigation - Xylitol
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Wisconsin, Madison
Marijuana Abuse
The Effect of Food on the Oral Bioavailability of AEF0117 in Healthy Volunteers
Cannabis use is increasing and will only further escalate with legalization of recreational and medical cannabis use in western countries , with a prevalence greater than 30 % in the US and most European countries for individuals…
- Trial name
- NCT05451017
- Testing
- 3ß-(4-methoxybenzyloxy)pregn-5-en-20-one in fed condition, 3ß-(4-methoxybenzyloxy)pregn-5-en-20-one in fasting condition
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Aelis Farma
Schizophrenia, Dual Diagnosis
Cannabis and Schizophrenia: Self-Medication and Agonist Treatment
The first aim of this study is to determine whether a brain reward center (BRC) deficiency in patients with schizophrenia (SCZ) and cannabis use disorder (CUD) will be normalized when patients are given cannabis or dronabinol.
- Conditions
- Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder
- Trial name
- NCT00946348
- Testing
- Dronabinol, Cannabis
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cannabis, Cannabis Use
Impact of Reduced Cannabis Use on Functional Outcomes (R33 Phase)
Nearly 20 million Americans report use of cannabis in the past month, and heavy cannabis use has increased by nearly 60% in the U.S. since 2007.
- Trial name
- FOCUS (NCT04567238)
- Testing
- Mobile contingency management
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Smoking, Marijuana
Laboratory Study of Cannabidiol on the Effects of Smoked Marijuana
The objective of this study is to assess the effects of oral cannabidiol (CBD; 0, 200, 400, 800 mg) on smoked marijuana's (0, 5.6% THC) subjective, reinforcing, cognitive, and cardiovascular effects.
- Trial name
- NCT01844687
- Testing
- CBD
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Marijuana Abuse
Treatment for Adolescent Marijuana Abuse
Marijuana remains the most prevalent illicit substance used by adolescents and the number of adolescents receiving treatment for marijuana abuse more than tripled during the last decade.
- Trial name
- NCT00580671
- Testing
- MET/CBT, CM, BPT
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Marijuana Smoking
Effect of Quetiapine on Marijuana Withdrawal and Relapse
The objective of this study is to investigate the interaction between marijuana and quetiapine, with the goal of using this information to improve marijuana treatment outcome.
- Trial name
- NCT00743366
- Testing
- Marijuana, Quetiapine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cannabis, Marijuana Abuse
Dronabinol Interactions With Cognitive Enhancing Drug in Humans
Marijuana use is a major problem among veterans and non-veterans. A patient's use of marijuana while engaged in psychotherapy treatment may affect their memory and, therefore, limit their ability to benefit from treatment.
- Trial name
- NCT00842985
- Testing
- drug condition
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Yale University
Psychosis, Substance Use
Families With Substance Use and Psychosis: A Pilot Study
The purpose of this study is to develop and evaluate an intervention that adapts Community Reinforcement and Family Training (CRAFT) for families experiencing first episode psychosis and substance use delivered via telemedicine…
- Conditions
- Psychosis, Substance Use, Substance Use Disorders, Family
- Trial name
- NCT04284813
- Testing
- CRAFT-FT
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Risk Reduction Behavior, Health Behavior
Alcohol, Marijuana, and Risky Sex: Group Interventions With Detained Adolescents
This research is studying behaviors that young people engage in that may place them at risk for contracting a sexually transmitted disease like HIV/AIDS, and what kind of educational program works best to reduce these risky…
- Conditions
- Risk Reduction Behavior, Health Behavior, Sexual Behavior, Adolescent Behavior
- Trial name
- MARS (NCT01170260)
- Testing
- INFORMATION-ONLY SEXUAL RISK REDUCTION (INFO-ONLY), SEXUAL PLUS ALCOHOL RISK REDUCTION (SRRI+ETOH), SEXUAL + ALCOHOL + MARIJUANA RISK REDUCTION
- Where
- United States
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Pain, Peripheral Neuropathy
A Study of Sativex® for Pain Relief of Peripheral Neuropathic Pain, Associated With Allodynia
The purpose of this study is to evaluate the efficacy of Sativex® compared with placebo in relieving peripheral neuropathic pain associated with allodynia.
- Trial name
- NCT00710554
- Testing
- Sativex
- Where
- United Kingdom
- Volunteers
- 246 people
- Sponsor
- Jazz Pharmaceuticals
Marijuana Dependence
Vilazodone Treatment for Marijuana Dependence
Marijuana is the most commonly used illicit drug, yet few clinical trials have evaluated pharmacotherapy treatments for marijuana dependence.
- Trial name
- NCT01574183
- Testing
- Vilazodone
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Medical University of South Carolina
Medical Abortion, Pain
Cannabinoids for Pain Control During Medical Abortion
The objective of this study is to determine if a synthetic cannabis derivative, dronabinol, in addition to ibuprofen, decreases maximum pain scores compared to ibuprofen and placebo in women undergoing medical abortion.
- Trial name
- NCT03604341
- Testing
- Dronabinol 5mg Cap
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Oregon Health and Science University
Marijuana Dependence
Vaping THC From Electronic Cigarettes
This study aims to understand THC pharmacology and the safety of cannabis vaping, including the pharmacology and safety of co-administration of nicotine and THC.
- Trial name
- V-PAX (NCT02955329)
- Testing
- Nicotine, Cannabis, PAX Loose Leaf Vaporizer
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cannabis, Pain
Repeated Cannabis Administration on Experimental Pain and Abuse Liability
Chronic pain is a significant public health concern in the U.S., for which prescription opioids have historically been the standard treatment. This has resulted in striking rates of opioid use disorders and fatal overdoses.
- Conditions
- Cannabis, Pain, Tolerance, Hyperalgesia
- Trial name
- NCT04576507
- Testing
- Active Cannabis
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute