Clinical trials: Cannabis Abuse
Cannabis Use, Cannabis
Investigating Real-world Stress-related Mechanisms in Heavy Cannabis Users
This research project proposes a novel approach to elucidate the biological adaptations associated with heavy cannabis use and to assess whether such adaptations are predictive of higher cannabis craving in response to both…
- Conditions
- Cannabis Use, Cannabis, Cannabis Abuse
- Trial name
- CLR2 (NCT05833230)
- Testing
- Intensive Day Monitoring
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Yale University
Cannabis Use, Cancer
Cannabis Use Registry to Improve Overall Understanding of Symptoms (CURIOUS)
Through partnership with Ontracka, the HealthPartners Institute Cancer Research Center created a secure and compliant app-based technology with the ability to seamlessly collect patient-level data on symptoms, cannabis use…
- Trial name
- CURIOUS (NCT07227324)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Substance Abuse, Depression
CONNECT for Depressed Cannabis Users Trial
The purpose of this study is to test the usefulness of a computer-assisted intervention for depressed cannabis users by combining peer and therapist social network support via Facebook that uses the techniques of cognitive…
- Trial name
- CONNECT (NCT03727659)
- Testing
- SHADE therapy + CONNECT FaceBook support
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of California, Los Angeles
Cannabis Dependence
Study of Long-Acting Injectable Naltrexone to Treat Cannabis Dependence
This is an 8 week, outpatient research study testing the use of long-acting naltrexone (Vivitrol) as a treatment for marijuana dependence.
- Trial name
- NCT02088177
- Testing
- Long-acting injectable naltrexone
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- New York State Psychiatric Institute
Opioid-use Disorder, Acceptability of Health Care
Patients' Attitudes Toward and Experiences With Buprenorphine Treatment
This study will disseminate five surveys collecting individual's attitudes and experiences during buprenorphine treatment for Opioid Use Disorder during the COVID-19 pandemic.
- Conditions
- Opioid-use Disorder, Acceptability of Health Care, Opioid-Related Disorders
- Trial name
- NCT05121428
- Where
- United States
- Volunteers
- 817 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Cannabis, Cannabis Intoxication
Do Adolescents and Adults Differ in Their Acute Response to Cannabis?
The acute effects of cannabis may differ between adolescents and adults. Furthermore, these effects may be tempered by the presence of cannabidiol.
- Conditions
- Cannabis, Cannabis Intoxication, Cannabis Use, Cannabis Dependence
- Trial name
- CannTeenA (NCT04851392)
- Testing
- Cannabis with delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), Cannabis with THC without CBD
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University College, London
Cannabis Dependence, Healthy
The Neural Correlates of Cannabis Use
The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and…
- Trial name
- Multimodal (NCT03104257)
- Testing
- [11-C]OMAR
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Yale University
Cannabis
Transcranial Magnetic Brain Stimulation to Reduce Cannabis Use in Heavy Cannabis Users
The growing legalization of cannabis across the U.S. is associated with increases in cannabis use, and accordingly, an increase in the number of individuals with cannabis use problems, including cannabis use disorder (CUD).
- Trial name
- iCURE (NCT05401929)
- Testing
- iTBS
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke University
Gastric Emptying, Cannabis
Effect of Cannabis (Marijuana) on Stomach Emptying Before Surgery
The purpose of this research is to study the effect of cannabis (marijuana) on gastric (stomach) emptying before surgery. The study will include people who use cannabis (study group) and people who do not use cannabis (control…
- Trial name
- NCT05436236
- Sponsor
- The Guthrie Clinic
Painful Diabetic Neuropathy
Efficacy of Inhaled Cannabis in Diabetic Painful Peripheral Neuropathy
The purpose of this study is to determine if vaporized cannabis is effective as an analgesic for the treatment of painful diabetic neuropathy.
- Trial name
- NCT00781001
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Center for Medicinal Cannabis Research
Alcohol Abuse, Cannabis Abuse
Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse
The purpose of this study is to determine whether Integrated Cognitive Behavioral Therapy or Twelve Step Facilitation Therapy is most effective for treatment of dually diagnosed veterans with depressive and substance use…
- Conditions
- Alcohol Abuse, Cannabis Abuse, Major Depressive Disorder, Substance-Related Disorders
- Trial name
- NCT00108407
- Testing
- Integrated Cognitive Behavioral Therapy, Twelve Step Facilitation Therapy
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Cannabis, Alcohol Drinking
Effects of THC and Alcohol on Driving Performance
Low blood concentrations of THC and alcohol appear to have a minimal effect on driving performance.However, there is a gap in the literature about the combined effects of THC and alcohol.
- Conditions
- Cannabis, Alcohol Drinking, Accident, Traffic
- Trial name
- NCT03555968
- Testing
- THC 0, THC 5, THC 10
- Volunteers
- healthy volunteers welcome
- Sponsor
- Lakehead University
Cannabis Dependence, Psychosis
The Pharmaco-genetic and Brain Mechanisms Associated With Cannabis- Induced Psychosis
There is growing evidence of high rates of substance use disorders among individuals with psychotic disorders especially in young people with predisposition for psychosis.
- Trial name
- NCT01565174
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Gastric Ultrasound, Point of Care Ultrasound
Gastric Ultrasound Assessment for Patients Taking Cannabis
The aim of this study is to perform bedside gastric point of care ultrasound (POCUS) exams to assess the gastric volume and content (clear liquids vs solid food) perioperatively in patients who report cannabis use.
- Conditions
- Gastric Ultrasound, Point of Care Ultrasound, Cannabis Use
- Trial name
- NCT06567873
- Testing
- Gastric Ultrasound Exam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Hospital for Special Surgery, New York
Alcohol Drinking, Marijuana
Marijuana's Impact on Alcohol Motivation and Consumption
This laboratory study will employ a repeated measures experimental design to examine the effect of high (7.2% THC) and moderate (3.1% THC) dose of marijuana, relative to placebo, on alcohol craving and on behavioral economic…
- Trial name
- NCT02983773
- Testing
- THC 7.2%, THC 3.1%
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Brown University
Pain, Pain Syndrome
Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Diabetic Polyneuropathy
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06072573
- Testing
- Adezunap (AP707)
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
Abuse, Drug, Pain
THC and CBD: A Controlled Human Study Probing a Harm Reduction Strategy
The purpose of this research is to assess the impact of CBD on the effects of THC.
- Trial name
- THC-REDUX (NCT06859710)
- Testing
- THC, CBD 20 mg, CBD 40 mg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Post Traumatic Stress Disorder, Cannabis Use
Warrior CARE: Cannabis Behavioral Health
This study is a randomized, controlled clinical trial to examine the therapeutic potential of cannabinoids for treating veterans with PTSD and suicidal ideation.
- Conditions
- Post Traumatic Stress Disorder, Cannabis Use, Suicide, Veterans
- Trial name
- CBH (NCT06381180)
- Testing
- Tetrahydrocannabinol, Cannabidiol
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Wayne State University
THCCOOH, Pharmacokinetics
Pharmacokinetics of THCCOOH and Its Acyl-glucuronide After Intravenous Administration of THCCOOH
A study on the fate and elimination of 11-Nor-Delta9-carboxy-9-tetrahydrocannabinol was up to now not conducted, except of one single experiment in which (lacking) psychopharmacological activity was tested after intravenous…
- Conditions
- THCCOOH, Pharmacokinetics, Metabolism, Cannabis
- Trial name
- NCT00176085
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Marijuana Abuse, Marijuana Dependence
Attempts to Stop/Reduce Marijuana Among Dependent Users
The purpose of the study is to determine why and how marijuana users stop or reduce their marijuana use.
- Trial name
- NCT01039415
- Where
- United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- University of Vermont