Clinical trials: Cannabis Abuse
Cannabis Abuse, Cannabis Dependence
Biobehavioral Effects of Topiramate on Cannabis-Related Outcomes in Adolescents
Cannabis use is a significant public health concern that disproportionately affect youth. Although promising psychosocial interventions are being developed, most youth do not benefit from these interventions alone.
- Trial name
- NCT01110434
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Brown University
Cannabis Dependence, Posttraumatic Stress Disorder
Reducing Cannabis Overuse With Prazosin
Cannabis use disorder (CUD) is a significant and expanding health problem, and no FDA approved treatments are currently available. Persons with posttraumatic stress disorder (PTSD) may use cannabis to help control symptoms.
- Conditions
- Cannabis Dependence, Posttraumatic Stress Disorder, Cannabis Use Disorder
- Trial name
- ReCOUP (NCT04721353)
- Testing
- Prazosin Hydrochloride
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- VA Puget Sound Health Care System
Cannabis Use, Tobacco Use
Effect of Cannabis on Cigarette Use Behavior
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of cigarettes.
- Conditions
- Cannabis Use, Tobacco Use, Cigarette Smoking
- Trial name
- NCT06609083
- Testing
- THC 30mg, THC 5mg, THC 0mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Hypotension, Tachycardia
Processing and Effects of Cannabis
The purpose of this study is to investigate the processing of cannabis, and to investigate the occurrence of effects of cannabis on the cardiovascular system and the central nervous system; at higher levels of exposure.
- Trial name
- NCT00225407
- Testing
- Smoking of cannabis cigarettes (different strength)
- Where
- Netherlands
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Cannabis Dependence
Achieving Cannabis Cessation-Evaluating N-Acetylcysteine Treatment
The primary objective of this study is to evaluate the impact of N-acetylcysteine (NAC) 1200 mg versus matched placebo (PBO) twice daily, added to contingency management (CM), on cannabis use among treatment-seeking…
- Trial name
- ACCENT (NCT01675661)
- Testing
- N-Acetylcysteine
- Where
- 6 sites in United States
- Volunteers
- 302 people
- Sponsor
- Medical University of South Carolina
Behavioural Disturbances, Pain
Delta-THC in Dementia
This is a phase II, randomized, placebo-controlled, double-blind, parallel-group, multicentre study to the efficacy and safety of low dose delta-9-THC in behavioural disturbances and pain in patients with mild to severe dementia…
- Conditions
- Behavioural Disturbances, Pain, Dementia, Alzheimer's Dementia
- Trial name
- NCT01608217
- Testing
- delta-9-tetrahydrocannabinol (delta-THC), Acetaminophen
- Where
- 2 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Cannabis Use
A Trial of Guanfacine-er for Cannabis Use Disorder
The primary purpose of this study is to investigate the effect of guanfacine-ER on reductions in cannabis use and explore its effects on impulsivity and withdrawal through a hybrid in-person and virtual trial of treatment-seeking…
- Trial name
- NCT05273567
- Testing
- guanfacine-ER
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- New York State Psychiatric Institute
Marijuana Impairment
Standardized Field Test for Marijuana Impairment II
This research responds to NHTSA's request with a proposal to increase our understanding of smoked cannabis' (CNB's) acute effects on driving-relevant cognition and simulated driving performance, the persistence of these deficits…
- Trial name
- NHTSA-II (NCT05115513)
- Testing
- Medium THC
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Yale University
Cannabis Use
Acute Effects of Cannabis on Cognition and Affect
This study will examine how a moderate dose of THC affects mood and cognitive functioning in regular cannabis users. The study uses a double-blind, placebo-controlled, crossover design, meaning each participant will complete two…
- Trial name
- NCT07296874
- Testing
- THC 20mg
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Washington State University
Pain, Pain Syndrome
Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06071949
- Testing
- Adezunap
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
Cannabis Intoxication
Cannabis Impairment Detection Device Study
The goal of this study is to develop a cannabis impairment detection device in adult cannabis users. The main question[s] it aims to answer are: Is the investigational device accurate and reliable at detecting cannabis…
- Trial name
- NCT07122349
- Testing
- Cannabis Impairment Test
- Where
- Canada
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- Gaize
Multiple Sclerosis
Short-Term Effects of Medicinal Cannabis Therapy on Spasticity in Multiple Sclerosis
The purpose of this study is to determine whether or not smoked marijuana improves spasticity in patients with multiple sclerosis.
- Trial name
- NCT00248378
- Testing
- Smoked Cannabis
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Center for Medicinal Cannabis Research
Alcoholic Intoxication, Automobile Accident
Responsible Marijuana Sales Practices to Reduce the Risk of Selling to Intoxicated Customers
The new recreational marijuana markets are contributing to polysubstance-impaired driving and other harms, especially when marijuana is used in combination with alcohol, by selling marijuana to obviously-intoxicated customers.
- Conditions
- Alcoholic Intoxication, Automobile Accident, Cannabis
- Trial name
- NCT06235632
- Testing
- Policy and Training Intervention, Usual and Customary Policy and Training (UC-PT) (Control) Condition
- Where
- United States
- Volunteers
- 229 people
- Sponsor
- Klein Buendel, Inc.
COPD, Insomnia
Colorado Marijuana Users Health Cohort
In Colorado, marijuana is currently used for both recreational and medicinal purposes.To learn more about the positive and negative long term medical effects of marijuana use.
- Conditions
- COPD, Insomnia, Cannabis
- Trial name
- NCT02735954
- Testing
- Marijuana
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Microbiome Analysis, Drug Abuse in Pregnancy
Alcohol and Cannabis Use Among Pregnant Slovenian Women
The aim of the study is to determine the prevalence of alcohol and drug use among Slovenian pregnant women. Alcohol and drug use during pregnancy has significant effects on the foetus and has short- and long-term health…
- Conditions
- Microbiome Analysis, Drug Abuse in Pregnancy, Alcohol Abuse in Pregnancy, Health Behavior, Risky
- Trial name
- NCT07456579
- Where
- Slovenia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Cannabis Use
An App to Reduce Cannabis Use Among Emerging Adults
This study is being completed to pilot prevention methods to promote wellness and reduce risky behaviors, including the use of substances such as cannabis.
- Trial name
- NCT05824754
- Testing
- Just-In-Time-Adaptive-Intervention (JITAI)
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- University of Michigan
Neuropathic Pain
Medicinal Cannabis for Painful HIV Neuropathy
The purpose of this study is to determine if medicinal cannabis (marijuana) is safe and effective for treating pain in individuals with HIV-associated distal, sensory-predominant polyneuropathy (DSPN).
- Trial name
- NCT00255580
- Testing
- Smoked cannabis
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Center for Medicinal Cannabis Research
Spinal Cord Injury
Effects of Marijuana on Neuropathic Pain and Spasticity in Spinal Cord Injury Patients
The goal of this clinical trial is to compare effects of marijuana or cannabis on neuropathic pain and spasticity in spinal cord injury patients.
- Trial name
- NCT06190470
- Testing
- Cannabis
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Khon Kaen University
Cannabis Use
Effect of Cannabidiol (CBD) on Vision and Driving
The use of cannabis with ∆9-tetrahydrocannabinol (THC) content has been shown to have negative effects on vision and driving. The use of other cannabinoids, such as cannabidiol (CBD), which is not attributed with a psychoactive…
- Trial name
- NCT06322303
- Testing
- CBD 15%, CBD 30%
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Drug Overdose, Substance Abuse
EEG Monitoring in the Emergency Department
This study seeks to investigate whether drug effects in suspected overdose patients could be identified using the electroencephalogram (EEG).
- Conditions
- Drug Overdose, Substance Abuse, Alcohol Abuse
- Trial name
- NCT04070521
- Testing
- Observational EEG Monitoring
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital