Clinical trials: Capsaicin
Cough
The Safety, Tolerability, PK and PD of GSK2339345 in Healthy Subjects
This is a First Time in Human (FTIH) study for the sodium channel inhibitor, GSK2339345. The study is split into two parts. Part A will assess the safety and tolerability of the new drug.
- Trial name
- FTIH (NCT01494636)
- Testing
- GSK2339345 (solution), GSK2339345 (nebulised), Lidocaine
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pain
A Study to Investigate the Tolerability and Effects on Epidermal Nerve Fiber Density of Multiple Low-Concentrations of NGX-1998 in Healthy Volunteers
The purpose of this single-blinded study in healthy volunteers is to select a Low-Concentration Capsaicin Topical Liquid (LC-CTL) to serve as a control formulation in the further clinical development of Capsaicin Topical Liquid…
- Trial name
- NCT00912262
- Testing
- Capsaicin Topical Liquid
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- NeurogesX
Capsaicin Evoked Pain, Heat Sensitivity
Study to Investigate the Effects Single Oral Dose of AZD1386 (Capsaicin)
A double-blind, randomized, single-centre, placebo-controlled, crossover study to investigate the effects of a single oral dose of AZD1386 on intradermal capsaicin evoked pain symptoms and heat sensitivity in healthy volunteers
- Trial name
- NCT00692146
- Testing
- AZD1386
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Rhinitis
A Study To Assess The Effect Of SB-705498 In A Capsaicin Challenge Model
This study is designed to look at the affect of SB-705498 on rhinitis symptoms, as induced by capsaicin challenge
- Trial name
- NCT00731250
- Testing
- SB-705498, Caspaicin
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
Effects of ICA-105665 Using the Intradermal Capsaicin and Ultraviolet B (UV-B) Models in Healthy Male Subjects
The purpose of this study is; to determine the pharmacodynamic (PD) effects of ICA-105665 using the intradermal (ID) capsaicin model in healthy male subjects, and to investigate the effect of ICA-105665 on inflammatory…
- Trial name
- NCT00962663
- Testing
- ICA-105665, Ibuprofen
- Where
- 2 sites in United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
Effect Of PF-06305591 On Capsaicin And Capsaicin/Heat-Induced Neurogenic Flare
The purpose of this study is to examine the effect of PF-06305591 on capsaicin and capsaicin/heat-induced neurogenic flare.
- Trial name
- NCT01797796
- Testing
- PF-06305591, Capsaicin challenge
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
A Study of LY3316531 in Healthy Participants
The purpose of this study is to assess study drug activity by giving LY3316531 or placebo into a vein in the arm and then measuring blood flow of the skin, after capsaicin is applied to skin's surface.
- Trial name
- NCT03611608
- Testing
- LY3316531
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy
Acute Response Capsaicin Flare Study
Prior to administering PF-04427429 to patients we wish to increase the understanding of functional effects associated with calcitonin gene related peptide (CGRP) pathways.
- Trial name
- NCT01147432
- Testing
- PF-04427429, Capsaicin challenge, EMLA positive control
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Oral Pain, Oral Pungent Sensation
Efficacy of Oral HA35 for Rapid Relief of Oral Pain and Pungent Sensation
This prospective, open-label, controlled pilot study evaluates oral 10% 35 kDa hyaluronan (HA35) versus four control interventions (C60 grapeseed oil，normal saline) for relief of capsaicin/AITC-induced oral pain and pungent…
- Conditions
- Oral Pain, Oral Pungent Sensation, Capsaicin-Induced Pain, AITC-Induced Irritation
- Trial name
- NCT07630571
- Testing
- Capsaicin Oral Challenge, Allyl Isothiocyanate (AITC) Oral Challenge, 10% 35 kDa Hyaluronan (HA35) Oral Solution
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nakhia Impex LLC
Healthy
A Study to Evaluate Laser Speckle Contrast Imaging to Assess Changes in Chemical Agent-Induced Skin Blood Flow in Healthy Participants (MK-0000-420)
Pain is a significant issue and there is a need for better treatments for pain management. Local changes in skin blood flow can be used as an indicator of pain in the body.
- Trial name
- NCT06809569
- Testing
- Allyl Isothiocyanate (AITC), Capsaicin, Vehicle for AITC
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Osteoarthritis, Knee
The Effect of Injection Site Cooling on Pain Experienced After the Administration of CNTX-4975-05 Into the Knee
A clinical study to measure the effects of injection-site cooling on pain experienced after knee injections of capsaicin in healthy subjects and in patients with knee osteoarthritis.
- Trial name
- NCT03472677
- Testing
- Ice Pack and Cooling Device, CNTX-4975-05 (trans-capsaicin), Capsaicin
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centrexion Therapeutics
Pain
Study of Three Capsaicin Dermal Liquid Formulations on Epidermal Nerve Fiber Immunostaining and Sensory Function
The purpose of this study is to evaluate potential changes in epidermal nerve fiber immunostaining (ENFI) and sensory nerve function in healthy normal volunteers following single applications of three different investigational…
- Trial name
- NCT00528216
- Testing
- Capsaicin Dermal Liquid
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- NeurogesX
Neuropathic Pain
Safety, Tolerability and Pharmacokinetics of Multiple Doses of AV-101 in Healthy Volunteers
This is a Phase 1b study involving multiple oral doses of AV-101 in healthy male and female subjects. The safety, pharmacokinetics, and antihyperalgesic effect of AV-101 on capsaicin-induced hyperalgesia will be assessed.
- Trial name
- NCT01483846
- Testing
- AV-101
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- VistaGen Therapeutics, Inc.
Healthy
Clinical Adhesion Study Between ZTlido 1.8% and Three Over-the-counter External Analgesic Lidocaine-containing Patches
The study is designed to evaluate and compare the clinical adhesion performance of the ZTlido (Lidocaine Topical System) 1.8% of Scilex Pharmaceuticals Inc.
- Trial name
- NCT05106400
- Testing
- ZTlido (Lidocaine Topical System) 1.8%, Salonpas (Lidocaine Patch 4%), Aspercreme (Lidocaine Patch 4%)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Scilex Pharmaceuticals, Inc.
Pain
Study to Investigate the Pharmacodynamic Effects of IP2015 in Healthy Male Subjects Using the Intradermal Capsaicin Model
This is a Phase I, randomised, double-blind, placebo-controlled, 4-way crossover study to investigate the PD effects, safety, tolerability and PK/PD correlation of two single oral dose levels of IP2015 compared to 300 mg…
- Trial name
- NCT05181852
- Testing
- IP2015, dose 1, IP2015, dose 2, Pregabalin
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Initiator Pharma
Pain
Reduction in Pain Intensity Following IV or Oral Pain-relieving Products
The purpose of this study is to evaluate two experimental pain models to see if they would be useful for comparing different products for reduction in pain intensity.
- Trial name
- NCT02678416
- Testing
- IV Acetaminophen (Treatment A), Oral Acetaminophen (Treatment B), Morphine (Treatment D)
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Mallinckrodt
Healthy
A Study of BL1332 on Capsaicin-Induced Ocular Pain in Healthy Trial Participants
Single center, double-masked study of BL1332 on Capsaicin-Induced Ocular Pain in Healthy Subjects
- Trial name
- NCT07717918
- Testing
- BL1332 eye drops
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Dermatitis, Atopic
Investigation of Topical SB705498 on Healthy Volunteers
A two part, randomized, double-blind, placebo controlled study to investigate the effects of topical doses of SB705498 in healthy volunteers.
- Trial name
- NCT01673529
- Testing
- SB705498
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline